Detailed information for compound 1068752

Basic information

Technical information
  • TDR Targets ID: 1068752
  • Name: 3,6-bis(2,4-dichloro-5-fluorophenyl)-7H-[1,2, 4]triazolo[3,4-b][1,3,4]thiadiazine
  • MW: 466.119 | Formula: C16H6Cl4F2N4S
  • H donors: 0 H acceptors: 2 LogP: 6.29 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cc(Cl)c(cc1C1=Nn2c(SC1)nnc2c1cc(F)c(cc1Cl)Cl)F
  • InChi: 1S/C16H6Cl4F2N4S/c17-8-3-10(19)12(21)1-6(8)14-5-27-16-24-23-15(26(16)25-14)7-2-13(22)11(20)4-9(7)18/h1-4H,5H2
  • InChiKey: DYGWFOIIUPEKNB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,6-bis(2,4-dichloro-5-fluoro-phenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
  • NSC726625
  • thiadiazines

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0093 0.0093
Echinococcus granulosus tumor protein p63 0.0336 0.4559 0.4918
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.0045
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0253 0.3363 0.3819
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0272 0.0724
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.1049 0.1132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0129 0.0129
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0146 0.0257
Onchocerca volvulus 0.0071 0.0768 0.0592
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.3552 0.3552
Schistosoma mansoni ap endonuclease 0.0058 0.058 0.0626
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.058 0.1649
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0043 0.0378 0.1042
Brugia malayi Latrophilin receptor protein 2 0.0112 0.1356 0.1518
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0251 0.0251
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.0045
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.2416 0.2606
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0252 0.0663
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0272 0.0272
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.1161 0.1252
Brugia malayi Glycosyl hydrolases family 31 protein 0.0162 0.2073 0.2341
Echinococcus granulosus importin subunit beta 1 0.0029 0.017 0.0183
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0031 0.0033
Brugia malayi PHD-finger family protein 0.003 0.0187 0.0179
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0092 0.0092
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.058 0.0626
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0112 0.1356 0.1462
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0043 0.0378 0.1042
Plasmodium falciparum polyprenol reductase, putative 0.0253 0.3363 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0092 0.0092
Entamoeba histolytica hypothetical protein 0.0023 0.0092 0.0184
Plasmodium vivax hypothetical protein, conserved 0.003 0.0187 0.038
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0043 0.0378 0.1082
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0252 0.0663
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0253 0.3363 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0768 0.0828
Mycobacterium tuberculosis Conserved protein 0.0071 0.0768 0.1237
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0272 0.0294
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0266 0.3552 0.4035
Loa Loa (eye worm) hypothetical protein 0.0071 0.0768 0.0845
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0277 0.0299
Schistosoma mansoni hypothetical protein 0.0036 0.0276 0.0298
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.1117 0.3259
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0043 0.0378 0.1082
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.058 0.6572
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0071 0.0768 0.0845
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.1117 0.3259
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0031 0.0091
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0061 0.0091
Mycobacterium ulcerans beta-lactamase 0.0071 0.0768 0.2283
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 0.0883 0.0952
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0768 0.0828
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.0045
Schistosoma mansoni ran 0.0021 0.0061 0.0066
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0452 0.6208 1
Trichomonas vaginalis ran, putative 0.0021 0.0061 0.0061
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0354 0.0382
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0219 0.0219
Echinococcus granulosus synaptic glycoprotein sc2 0.0253 0.3363 0.3628
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0031 0.0033
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.017 0.0329
Mycobacterium leprae Probable lipase LipE 0.0071 0.0768 0.8697
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0883 0.2489
Loa Loa (eye worm) hypothetical protein 0.0071 0.0768 0.0845
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0253 0.3363 0.3363
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0187 0.0179
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0277 0.0299
Loa Loa (eye worm) hypothetical protein 0.0253 0.3363 0.3819
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0768 0.0828
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0768 0.2283
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0031 0.005
Echinococcus multilocularis snurportin 1 0.0308 0.4149 0.4476
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0251 0.0251
Giardia lamblia Synaptic glycoprotein SC2 0.0253 0.3363 1
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0253 0.3363 1
Brugia malayi RNA, U transporter 1 0.0082 0.0928 0.1028
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.0045
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.1049 0.1132
Echinococcus multilocularis tumor protein p63 0.0336 0.4559 0.4918
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0043 0.0378 0.0408
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.017 0.046
Loa Loa (eye worm) hypothetical protein 0.0071 0.0768 0.0845
Loa Loa (eye worm) hypothetical protein 0.0112 0.1356 0.1518
Plasmodium vivax SET domain protein, putative 0.009 0.1049 0.2992
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0187 0.0201
Toxoplasma gondii ABC1 family protein 0.0071 0.0768 0.214
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0768 0.1237
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0043 0.0378 0.1042
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0031 0.0033
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0253 0.3363 0.3363
Echinococcus granulosus dna polymerase eta 0.0019 0.0031 0.0033
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.1117 0.1245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0219 0.0219
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.1117 0.3259
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.0045
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0087 0.1002 0.108
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.2247 0.2247
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0187 0.0201
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0253 0.3363 0.3363
Echinococcus multilocularis GPCR, family 2 0.0112 0.1356 0.1462
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0768 0.2212
Loa Loa (eye worm) latrophilin receptor protein 2 0.0112 0.1356 0.1518
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0272 0.0724
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0883 0.2625
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0061 0.0066
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0253 0.3363 0.3363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0251 0.0251
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.0045
Giardia lamblia PHD finger protein 15 0.003 0.0187 0.0468
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.3552 0.3552
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0219 0.0219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0161 0.0161
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1117 0.1117
Echinococcus granulosus dna polymerase kappa 0.0019 0.0031 0.0033
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.003 0.0187 0.0179
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.1049 0.1132
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0061 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0125 0.0125
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0461 0.0497
Plasmodium falciparum phd finger protein, putative 0.003 0.0187 0.038
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.1117 0.3259
Schistosoma mansoni alpha-glucosidase 0.014 0.1751 0.1889
Plasmodium falciparum importin beta, putative 0.0029 0.017 0.0329
Echinococcus granulosus snurportin 1 0.0308 0.4149 0.4476
Trichomonas vaginalis conserved hypothetical protein 0.0253 0.3363 0.3363
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0061 0.0091
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0146 0.1652
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0272 0.0272
Brugia malayi beta-lactamase 0.0071 0.0768 0.0845
Toxoplasma gondii exonuclease III APE 0.0058 0.058 0.1572
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0031 0.0033
Loa Loa (eye worm) hypothetical protein 0.009 0.1049 0.1167
Echinococcus multilocularis peregrin 0.003 0.0187 0.0201
Echinococcus multilocularis geminin 0.0174 0.2247 0.2424
Brugia malayi Pre-SET motif family protein 0.009 0.1049 0.1167
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.2247 0.2247
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1117 0.1117
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.058 0.1649
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0043 0.0378 0.0408
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0253 0.3363 0.3819
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0768 0.2283
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.058 0.058
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0768 0.0768
Entamoeba histolytica hypothetical protein 0.0253 0.3363 1
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.3552 0.3552
Schistosoma mansoni importin beta-1 0.0029 0.017 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0092 0.0092
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0146 0.1652
Brugia malayi latrophilin 2 splice variant baaae 0.0242 0.3209 0.3642
Brugia malayi beta-lactamase family protein 0.0071 0.0768 0.0845
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0253 0.3363 0.3363
Schistosoma mansoni alpha glucosidase 0.0036 0.0272 0.0294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0378 0.0378
Brugia malayi Bromodomain containing protein 0.003 0.0187 0.0179
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0768 0.0768
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0092 0.0184
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0186 0.2416 0.2733
Schistosoma mansoni hypothetical protein 0.0308 0.4149 0.4476
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0272 0.0639
Schistosoma mansoni hypothetical protein 0.0242 0.3209 0.3462
Loa Loa (eye worm) hypothetical protein 0.0071 0.0768 0.0845
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0253 0.3363 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0496 0.0535
Mycobacterium ulcerans lipase LipD 0.0071 0.0768 0.2283
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0272 0.0277
Leishmania major GTP-binding protein, putative 0.0021 0.0061 0.0091
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0768 0.8697
Loa Loa (eye worm) hypothetical protein 0.0049 0.0461 0.0493
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0768 0.1237
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0061 0.0066
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0146 0.0257
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.058 0.1572
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0768 0.214
Loa Loa (eye worm) hypothetical protein 0.0029 0.017 0.0159
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0277 0.0299
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.4149 0.472
Brugia malayi Probable ClpP-like protease 0.0079 0.0883 0.0977
Schistosoma mansoni hypothetical protein 0.0174 0.2247 0.2424
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1117 0.1117
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0253 0.3363 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0112 0.1356 0.1518
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0253 0.3363 1
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.9271 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0112 0.1356 0.1462
Echinococcus granulosus peregrin 0.003 0.0187 0.0201
Loa Loa (eye worm) beta-lactamase 0.0071 0.0768 0.0845
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.1117 0.1205
Loa Loa (eye worm) hypothetical protein 0.0051 0.0493 0.0529
Leishmania major importin beta-1 subunit, putative 0.0023 0.0092 0.0184
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.2247 0.2247
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 0.0883 0.0952
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.0045
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0768 0.1237
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0883 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.1117 0.1245
Schistosoma mansoni hypothetical protein 0.0112 0.1356 0.1462
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0272 0.0724
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0253 0.3363 1
Loa Loa (eye worm) hypothetical protein 0.0354 0.4806 0.5473
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0768 0.0828
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.2073 0.2236
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0253 0.3363 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0093 0.0093
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0354 0.4806 0.5473
Loa Loa (eye worm) hypothetical protein 0.0242 0.3209 0.3642
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0354 0.4806 0.5473
Onchocerca volvulus Glucosylceramidase homolog 0.0174 0.2247 0.21
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0272 0.0294
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.058 0.1649
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.058 0.1687
Toxoplasma gondii hypothetical protein 0.0027 0.0146 0.0257
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0272 0.0277
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0272 0.0272
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0883 0.2489
Echinococcus multilocularis importin subunit beta 1 0.0029 0.017 0.0183
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.058 0.1649
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0253 0.3363 0.3628
Onchocerca volvulus 0.0049 0.0461 0.028
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.0378 0.0398
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0092 0.0092
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.3552 0.3552
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.1049 0.2992
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.1049 0.1132
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0883 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.1049 0.1132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0251 0.0251
Schistosoma mansoni DNA polymerase eta 0.0019 0.0031 0.0033
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0031 0.0045
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0253 0.3363 0.3628
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.2416 0.2606
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.058 0.063
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0883 0.2489
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0272 0.0272
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0768 0.0768
Schistosoma mansoni alpha-glucosidase 0.014 0.1751 0.1889
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0768 0.2247
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0253 0.3363 1
Echinococcus granulosus geminin 0.0174 0.2247 0.2424
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0051 0.0107
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0253 0.3363 1
Brugia malayi hypothetical protein 0.0036 0.0276 0.0281
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0043 0.0378 0.1042
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.058 0.1725
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1117 0.1117
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.017 0.046
Plasmodium vivax importin-beta 2, putative 0.0029 0.017 0.0329
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0043 0.0378 0.1042
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0266 0.3552 0.4035
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.2416 0.2606
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1117 0.1117
Onchocerca volvulus 0.0253 0.3363 0.3237
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.058 0.0935
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0768 0.1237
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0093 0.0093
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0031 0.0031
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0253 0.3363 1
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0768 0.0768
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.1117 0.1205
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0253 0.3363 0.3628
Entamoeba histolytica hypothetical protein 0.0036 0.0276 0.0736
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.2381 0.2381
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.0045
Loa Loa (eye worm) hypothetical protein 0.0071 0.0768 0.0845
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0186 0.2416 0.2733
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0272 0.0724
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0187 0.038
Schistosoma mansoni hypothetical protein 0.0112 0.1356 0.1462
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0219 0.0219
Brugia malayi Calcitonin receptor-like protein seb-1 0.0354 0.4806 0.5473
Mycobacterium tuberculosis Conserved protein 0.0071 0.0768 0.1237
Schistosoma mansoni kinase 0.0048 0.0449 0.0484
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.058 0.058
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 0.0883 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0112 0.1356 0.1462
Brugia malayi jmjC domain containing protein 0.0036 0.0277 0.0282
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.1117 0.0948
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.145 0.1626
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0031 0.0045
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0277 0.0282
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0643 0.0701
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0129 0.0129
Leishmania major hypothetical protein, conserved 0.0071 0.0768 0.2212
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0253 0.3363 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0092 0.0092
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.1117 0.1205
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0768 0.0845
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.058 0.1649
Mycobacterium tuberculosis Conserved protein 0.0071 0.0768 0.1237
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0061 0.0136
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0431 0.0431
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0276 0.0298
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0093 0.0093
Trypanosoma brucei unspecified product 0.0019 0.0031 0.0045
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0272 0.0272
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0496 0.0535
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.9271 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.058 0.6572
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0378 0.0378
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0112 0.1356 0.1462
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.3552 0.3552
Schistosoma mansoni ran 0.0021 0.0061 0.0066
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.2247 0.2247
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0272 0.0272
Brugia malayi MH2 domain containing protein 0.0119 0.145 0.1626
Trypanosoma brucei polo-like protein kinase 0.0095 0.1117 0.329
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.2416 0.2606
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0272 0.0272
Giardia lamblia Kinase, PLK 0.0095 0.1117 0.3259
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0276 0.0298
Onchocerca volvulus 0.0071 0.0768 0.0592
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0125 0.0125
Entamoeba histolytica hypothetical protein 0.0036 0.0276 0.0736
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0253 0.3363 0.3628
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0496 0.0798
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0253 0.3363 1
Schistosoma mansoni hypothetical protein 0.003 0.0187 0.0201
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0277 0.0299
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1117 0.1117
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0092 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0174 0.0174
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0768 0.1237
Brugia malayi Importin beta-1 subunit 0.0029 0.017 0.0159
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.2073 0.2236
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0043 0.0378 0.1042
Trypanosoma brucei glucosidase, putative 0.0036 0.0272 0.0766
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0768 0.0768
Onchocerca volvulus 0.0071 0.0768 0.0592
Echinococcus granulosus GPCR family 2 0.0112 0.1356 0.1462
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.2416 0.2606
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0187 0.0201
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0187 0.038
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.0045
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0431 0.0431
Brugia malayi jmjC domain containing protein 0.0098 0.1161 0.1295
Brugia malayi beta-lactamase family protein 0.0071 0.0768 0.0845
Trichomonas vaginalis conserved hypothetical protein 0.0253 0.3363 0.3363
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0031 0.0045
Trichomonas vaginalis esterase, putative 0.0071 0.0768 0.0768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.2416 0.2606
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0219 0.0479
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0272 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0378 0.0378
Giardia lamblia GTOR 0.0043 0.0378 0.1042
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0253 0.3363 0.3363
Echinococcus granulosus microtubule associated protein 2 0.0667 0.9271 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0162 0.2073 0.2236
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0253 0.3363 1
Mycobacterium ulcerans hypothetical protein 0.0253 0.3363 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0287 0.0287
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0354 0.0382
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 0.0883 0.2489
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.1049 0.1132
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0496 0.0798
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.2247 0.2247
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0768 0.0845
Loa Loa (eye worm) hypothetical protein 0.0079 0.0883 0.0977
Onchocerca volvulus 0.0094 0.1097 0.0928
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0043 0.0378 0.0408
Mycobacterium ulcerans hypothetical protein 0.0071 0.0768 0.2283
Brugia malayi Synaptic glycoprotein SC2 0.0253 0.3363 0.3819
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0031 0.0045
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.058 0.1572
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.1161 0.1252
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0031 0.005
Entamoeba histolytica Ran family GTPase 0.0021 0.0061 0.0091
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0031 0.0033
Loa Loa (eye worm) phosphatidylinositol 3 0.0043 0.0378 0.0398
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0276 0.0298
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0031 0.0091
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0272 0.0724
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0061 0.0091
Entamoeba histolytica hypothetical protein 0.0036 0.0276 0.0736
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0252 0.0705
Schistosoma mansoni hypothetical protein 0.0112 0.1356 0.1462
Schistosoma mansoni ap endonuclease 0.0058 0.058 0.0626
Schistosoma mansoni hypothetical protein 0.0174 0.2247 0.2424
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0768 0.2212
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0768 0.1237
Echinococcus multilocularis dna polymerase eta 0.0019 0.0031 0.0033
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0272 0.0272
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0883 0.2625
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.058 0.0626
Schistosoma mansoni hypothetical protein 0.0112 0.1356 0.1462
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1117 0.1117
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.2381 0.2381
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0768 0.1237
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0061 0.0035
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 0.0883 1
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0253 0.3363 0.3363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0219 0.0219
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0031 0.0045
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.1049 0.1132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0251 0.0251
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0883 0.5
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.058 0.063
Echinococcus multilocularis synaptic glycoprotein sc2 0.0253 0.3363 0.3628
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0129 0.0129
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.2247 0.2247
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.145 0.1626
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 0.0883 0.0952
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.3552 0.3552
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.2416 0.2606
Plasmodium vivax polyprenol reductase, putative 0.0253 0.3363 1
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.2247 0.2247
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0496 0.5612
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0873 0.0941
Loa Loa (eye worm) hypothetical protein 0.0253 0.3363 0.3819
Onchocerca volvulus 0.009 0.1049 0.0879
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0162 0.2073 0.2341
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0253 0.3363 1
Brugia malayi Pre-SET motif family protein 0.0631 0.8757 1
Entamoeba histolytica hypothetical protein 0.0036 0.0276 0.0736
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0631 0.8757 1

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 6 % Anticancer activity against human NCI-H460 cells assessed as cell growth at 100 uM after 48 hrs by sulforhodamine B assay relative to control ChEMBL. 19822384
Activity (functional) = 26 % Anticancer activity against human SF268 cells assessed as cell growth at 100 uM after 48 hrs by sulforhodamine B assay relative to control ChEMBL. 19822384
Activity (functional) = 44 % Anticancer activity against human MCF7 cells assessed as cell growth at 100 uM after 48 hrs by sulforhodamine B assay relative to control ChEMBL. 19822384
GI50 (functional) = 4.93 uM Anticancer activity against human T47D cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 11.3 uM Anticancer activity against human HOP92 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 11.5 uM Anticancer activity against human OVCAR-3 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 13.3 uM Anticancer activity against human UACC62 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 13.4 uM Anticancer activity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 14.9 uM Anticancer activity against human NCI-H226 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 16.8 uM Anticancer activity against human MCF7 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 16.9 uM Anticancer activity against human MOLT4 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 16.9 uM Anticancer activity against human PC3 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 17.6 uM Anticancer activity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 17.8 uM Anticancer activity against human K562 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 18.4 uM Anticancer activity against human SN12C cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 18.5 uM Anticancer activity against human SF268 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 18.9 uM Anticancer activity against human SF539 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 19 uM Anticancer activity against human COLO205 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 20.1 uM Anticancer activity against human HT-29 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 20.2 uM Anticancer activity against human HCT15 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 20.3 uM Anticancer activity against human SF295 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 20.4 uM Anticancer activity against human U251 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 20.6 uM Anticancer activity against human Caki1 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 21.5 uM Anticancer activity against human SK-MEL-28 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 21.6 uM Anticancer activity against human LOXIMVI cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 21.8 uM Anticancer activity against human NCI-H23 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 22 uM Anticancer activity against human CCRF-CEM cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 22.6 uM Anticancer activity against human SW620 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 22.7 uM Anticancer activity against human SNB19 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 23.2 uM Anticancer activity against human RXF393 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 23.7 uM Anticancer activity against human A549 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 24.2 uM Anticancer activity against human NCI-H522 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 24.6 uM Anticancer activity against human EKVX cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 25.4 uM Anticancer activity against human SR cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 26 uM Anticancer activity against human OVCAR8 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 26.2 uM Anticancer activity against human SNB75 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 26.6 uM Anticancer activity against human ACHN cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 27.4 uM Anticancer activity against human NCI/ADR-RES cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 27.8 uM Anticancer activity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 28.4 uM Anticancer activity against human MALME-3M cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 28.5 uM Anticancer activity against human KM12 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 29.1 uM Anticancer activity against human NCI-H322M cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 29.2 uM Anticancer activity against human SKOV3 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 29.8 uM Anticancer activity against human IGROV1 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 30.2 uM Anticancer activity against human UACC257 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 31.3 uM Anticancer activity against human UO31 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 31.6 uM Anticancer activity against human HCC2998 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 34.5 uM Anticancer activity against human OVCAR4 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 36.6 uM Anticancer activity against human DU145 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 37.4 uM Anticancer activity against human TK10 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 56.8 uM Anticancer activity against human OVCAR5 cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384
GI50 (functional) = 80.4 uM Anticancer activity against human HL-60(TB) cells after 48 hrs by sulforhodamine B assay ChEMBL. 19822384

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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