Detailed information for compound 1068895

Basic information

Technical information
  • TDR Targets ID: 1068895
  • Name: 4-(cyclopropanecarbonylamino)-N-(2-methoxyphe nyl)benzamide
  • MW: 310.347 | Formula: C18H18N2O3
  • H donors: 2 H acceptors: 2 LogP: 2.36 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1NC(=O)c1ccc(cc1)NC(=O)C1CC1
  • InChi: 1S/C18H18N2O3/c1-23-16-5-3-2-4-15(16)20-18(22)13-8-10-14(11-9-13)19-17(21)12-6-7-12/h2-5,8-12H,6-7H2,1H3,(H,19,21)(H,20,22)
  • InChiKey: UDNFABZFHFICHC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(cyclopropyl-oxomethyl)amino]-N-(2-methoxyphenyl)benzamide
  • 4-(cyclopropylcarbonylamino)-N-(2-methoxyphenyl)benzamide
  • STK296143
  • ZINC04843070

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni bromodomain containing protein 0.0064 0.3604 0.5225
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0279 0.0279
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.3325 0.4821
Loa Loa (eye worm) hypothetical protein 0.0041 0.1847 0.1847
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.0021 0.0279 0.0405
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0106 0.6898 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0428 0.0621
Brugia malayi Bromodomain containing protein 0.0039 0.1657 0.1112
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0106 0.6898 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.1472 0.2134
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0106 0.6898 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0106 0.6898 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0106 0.6898 0.6696
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0106 0.6898 1
Echinococcus granulosus zinc finger protein 0.002 0.0197 0.0285
Schistosoma mansoni zinc finger protein 0.002 0.0197 0.0285
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.3325 0.4821
Brugia malayi Bromodomain containing protein 0.0075 0.4518 0.416
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0428 0.0621
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.1472 0.2134
Loa Loa (eye worm) hypothetical protein 0.0039 0.1662 0.1662
Loa Loa (eye worm) hypothetical protein 0.0043 0.1996 0.1996
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0106 0.6898 0.6898
Loa Loa (eye worm) hypothetical protein 0.0071 0.4185 0.4185
Echinococcus multilocularis zinc finger protein 0.002 0.0197 0.0285
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0106 0.6898 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0106 0.6898 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0428 0.0621

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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