Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | activin A receptor, type IB | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04674 transforming growth factor, beta receptor I, putative | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Echinococcus multilocularis | TGF beta receptor type 1 | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Schistosoma mansoni | protein kinase | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Echinococcus granulosus | TGF-beta receptor type-1 | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Brugia malayi | bone morphogenetic protein type 1 receptor | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Echinococcus granulosus | TGF beta receptor type 1 | Get druggable targets OG5_129709 | All targets in OG5_129709 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TAR-binding protein | 0.0125 | 0.3694 | 0.3151 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0125 | 0.3694 | 0.3151 |
Loa Loa (eye worm) | RNA binding protein | 0.0125 | 0.3694 | 0.3151 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.0805 | 0.0805 |
Echinococcus granulosus | muscleblind protein | 0.0149 | 0.5982 | 0.5972 |
Echinococcus multilocularis | tar DNA binding protein | 0.0125 | 0.3694 | 0.3677 |
Brugia malayi | Muscleblind-like protein | 0.0149 | 0.5982 | 0.5647 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3694 | 0.3694 |
Echinococcus granulosus | tar DNA binding protein | 0.0125 | 0.3694 | 0.3677 |
Brugia malayi | bone morphogenetic protein type 1 receptor | 0.0191 | 0.9974 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.0805 | 0.0781 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.0805 | 0.0805 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3694 | 0.3694 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.0805 | 0.0781 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0125 | 0.3694 | 0.3151 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.0805 | 0.0781 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3694 | 0.3694 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.5982 | 0.5647 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.0805 | 0.0805 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3694 | 0.3694 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.0805 | 0.0781 |
Echinococcus multilocularis | muscleblind protein | 0.0149 | 0.5982 | 0.5972 |
Brugia malayi | TAR-binding protein | 0.0125 | 0.3694 | 0.3151 |
Brugia malayi | RNA binding protein | 0.0125 | 0.3694 | 0.3151 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.5982 | 0.5647 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0149 | 0.5982 | 0.5972 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.3694 | 0.3694 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0191 | 0.9974 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 27 nM | Inhibition of TGFR1 | ChEMBL. | 19640613 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.