TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 321.33 | Formula: C18H15N3O3
H donors: 1 H acceptors: 2 LogP: 2.69 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc2ncc3c(c2cc1OC)cc(nc3N)c1ccoc1
InChi: 1S/C18H15N3O3/c1-22-16-6-12-11-5-14(10-3-4-24-9-10)21-18(19)13(11)8-20-15(12)7-17(16)23-2/h3-9H,1-2H3,(H2,19,21)
InChiKey: JENKQRHHCRKJCU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	3-phosphoinositide dependent protein kinase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	AGC/PDK1 protein kinase	Get druggable targets OG5_128785	All targets in OG5_128785
Candida albicans	similar to S. cerevisiae protein kinases PKH1 (YDR490C) and PKH2 (YOL100W) involved in MAPKKK cascade	Get druggable targets OG5_128785	All targets in OG5_128785
Echinococcus granulosus	3-phosphoinositide-dependent protein kinase 1	Get druggable targets OG5_128785	All targets in OG5_128785
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_128785	All targets in OG5_128785
Echinococcus multilocularis	3 phosphoinositide dependent protein kinase 1	Get druggable targets OG5_128785	All targets in OG5_128785
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_128785	All targets in OG5_128785
Loa Loa (eye worm)	AGC/PDK1 protein kinase	Get druggable targets OG5_128785	All targets in OG5_128785
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_128785	All targets in OG5_128785
Brugia malayi	phosphoinositide-dependent protein kinase I	Get druggable targets OG5_128785	All targets in OG5_128785
Schistosoma japonicum	ko:K06276 3-phosphoinositide dependent protein kinase-1, putative	Get druggable targets OG5_128785	All targets in OG5_128785
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128785	All targets in OG5_128785
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128785	All targets in OG5_128785
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_128785	All targets in OG5_128785
Candida albicans	similar to S. cerevisiae protein kinases PKH1 (YDR490C) and PKH2 (YOL100W) involved in MAPKKK cascade	Get druggable targets OG5_128785	All targets in OG5_128785

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0211	0.312
Trichomonas vaginalis	DNA polymerase eta, putative	0.011	0.343	0.9643
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.1641	0.1701
Mycobacterium ulcerans	ATP-dependent DNA ligase	0.0025	0.0424	0.0442
Echinococcus multilocularis	dna polymerase eta	0.0163	0.5276	0.5469
Trypanosoma brucei	DNA polymerase eta, putative	0.0163	0.5276	0.5276
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.008	0.2348	0.2434
Echinococcus multilocularis	dna polymerase kappa	0.011	0.343	0.3556
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.1094	0.3075
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.1334	0.1334
Loa Loa (eye worm)	hypothetical protein	0.003	0.0585	0.0607
Echinococcus granulosus	chromobox protein 1	0.0073	0.2115	0.2193
Loa Loa (eye worm)	hypothetical protein	0.0057	0.1569	0.1627
Schistosoma mansoni	serine/threonine protein kinase	0.0287	0.9647	1
Schistosoma mansoni	chromobox protein	0.0073	0.2115	0.2193
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0626	0.1761
Schistosoma mansoni	hypothetical protein	0.0039	0.0928	0.0962
Entamoeba histolytica	hypothetical protein	0.003	0.0585	0.1645
Schistosoma mansoni	axis inhibition protein axin	0.003	0.0585	0.0607
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0042	0.1012	0.1012
Echinococcus multilocularis	Regulator of G protein signaling 20	0.003	0.0585	0.0607
Brugia malayi	Heterochromatin protein 1	0.0073	0.2115	0.4009
Brugia malayi	ImpB/MucB/SamB family protein	0.008	0.2348	0.4451
Trichomonas vaginalis	AGC family protein kinase	0.006	0.1641	0.4614
Schistosoma mansoni	serine/threonine protein kinase	0.0287	0.9647	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0626	0.1761
Brugia malayi	DNA ligase	0.0025	0.0424	0.0804
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0147	0.4719	0.4892
Loa Loa (eye worm)	hypothetical protein	0.0163	0.5276	0.5469
Schistosoma mansoni	regulator of G protein signaling	0.003	0.0585	0.0607
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0147	0.4719	0.4892
Echinococcus multilocularis	Small ubiquitin modifier 2	0.0032	0.0675	0.07
Brugia malayi	hypothetical protein	0.003	0.0585	0.1109
Loa Loa (eye worm)	hypothetical protein	0.003	0.0585	0.0607
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.003	0.0585	0.0607
Brugia malayi	ImpB/MucB/SamB family protein	0.0163	0.5276	1
Schistosoma mansoni	hypothetical protein	0.0018	0.0183	0.019
Echinococcus multilocularis	regulator of G protein signaling 3	0.003	0.0585	0.0607
Plasmodium vivax	flap endonuclease 1, putative	0.0026	0.0468	0.6933
Schistosoma mansoni	regulator of G protein signaling	0.003	0.0585	0.0607
Echinococcus multilocularis	regulator of G protein signaling 7	0.003	0.0585	0.0607
Trypanosoma cruzi	DNA polymerase kappa, putative	0.011	0.343	0.343
Echinococcus multilocularis	axis inhibition protein axin	0.003	0.0585	0.0607
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0156	0.505	1
Echinococcus multilocularis	3 phosphoinositide dependent protein kinase 1	0.006	0.1641	0.1701
Schistosoma mansoni	ubiquitin-like protein sumo/smt3-related	0.0032	0.0675	0.07
Trypanosoma brucei	DNA polymerase kappa, putative	0.0055	0.1494	0.1494
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0585	0.1645
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.006	0.1641	0.1701
Echinococcus granulosus	3-phosphoinositide-dependent protein kinase 1	0.006	0.1641	0.1701
Trypanosoma cruzi	small ubiquitin protein, putative	0.0032	0.0675	0.0675
Trypanosoma brucei	DNA polymerase kappa, putative	0.011	0.343	0.343
Echinococcus granulosus	Small ubiquitin modifier 2	0.0032	0.0675	0.07
Giardia lamblia	DNA damage repair protein	0.0025	0.0413	0.1577
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0211	0.0592
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0585	0.1645
Schistosoma mansoni	chromobox protein	0.0073	0.2115	0.2193
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0673	0.0697
Loa Loa (eye worm)	6-phosphofructokinase	0.0114	0.3557	0.3687
Trypanosoma cruzi	hypothetical protein, conserved	0.0025	0.0413	0.0413
Brugia malayi	PXA domain containing protein	0.003	0.0585	0.1109
Brugia malayi	Flap endonuclease-1	0.0026	0.0468	0.0887
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0183	0.019
Brugia malayi	Ubiquitin-like protein SMT3	0.0032	0.0675	0.1279
Leishmania major	DNA polymerase kappa, putative	0.0025	0.0413	0.0413
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0031	0.0626	0.9282
Echinococcus granulosus	regulator of G protein signaling 7	0.003	0.0585	0.0607
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0183	0.019
Echinococcus granulosus	Regulator of G protein signaling 20	0.003	0.0585	0.0607
Echinococcus granulosus	regulator of G protein signaling 3	0.003	0.0585	0.0607
Trypanosoma brucei	DNA polymerase kappa, putative	0.0087	0.2617	0.2617
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0211	0.0592
Schistosoma mansoni	6-phosphofructokinase	0.0114	0.3557	0.3687
Entamoeba histolytica	DNA ligase, putative	0.0025	0.0424	0.1193
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0626	0.1761
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0287	0.9647	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0626	0.1761
Brugia malayi	phosphoinositide-dependent protein kinase I	0.006	0.1641	0.3111
Loa Loa (eye worm)	hypothetical protein	0.003	0.0585	0.0607
Schistosoma mansoni	regulator of G protein signaling	0.003	0.0585	0.0607
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0114	0.3557	0.3557
Entamoeba histolytica	Flap nuclease, putative	0.0026	0.0468	0.1316
Toxoplasma gondii	6-phosphofructokinase	0.0031	0.0626	0.1875
Echinococcus granulosus	chromobox protein 1	0.0073	0.2115	0.2193
Brugia malayi	PXA domain containing protein	0.003	0.0585	0.1109
Schistosoma mansoni	regulator of G protein signaling	0.003	0.0585	0.0607
Brugia malayi	Protein kinase domain containing protein	0.006	0.1641	0.3111
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.1012	0.1012
Trichomonas vaginalis	AGC family protein kinase	0.006	0.1641	0.4614
Entamoeba histolytica	deoxycytidyl transferase, putative	0.008	0.2348	0.6603
Echinococcus granulosus	expressed protein	0.003	0.0585	0.0607
Loa Loa (eye worm)	PXA domain-containing protein	0.003	0.0585	0.0607
Echinococcus multilocularis	flap endonuclease 1	0.0026	0.0468	0.0485
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0147	0.4719	0.4892
Trichomonas vaginalis	flap endonuclease-1, putative	0.0026	0.0468	0.1316
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.014	0.4491	0.4491
Trypanosoma brucei	unspecified product	0.0055	0.1477	0.1477
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0626	0.1761
Trypanosoma brucei	DNA polymerase kappa, putative	0.011	0.343	0.343
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0114	0.3557	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0044	0.1094	1
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0114	0.3557	0.7041
Echinococcus multilocularis	regulator of G protein signaling	0.003	0.0585	0.0607
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.1569	0.2974
Giardia lamblia	Sentrin	0.0032	0.0675	0.2579
Trypanosoma brucei	hypothetical protein, conserved	0.0025	0.0413	0.0413
Toxoplasma gondii	phosphofructokinase PFKII	0.0031	0.0626	0.1875
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0147	0.4719	0.4892
Loa Loa (eye worm)	heterochromatin protein 1	0.0073	0.2115	0.2193
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0984	0.7399
Trypanosoma brucei	unspecified product	0.0103	0.3162	0.3162
Loa Loa (eye worm)	6-phosphofructokinase	0.0114	0.3557	0.3687
Trypanosoma cruzi	DNA polymerase kappa, putative	0.011	0.343	0.343
Plasmodium vivax	DNA repair protein REV1, putative	0.0025	0.0413	0.6117
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0031	0.0626	0.1761
Schistosoma mansoni	axis inhibition protein axin	0.003	0.0585	0.0607
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.1094	0.3075
Trypanosoma cruzi	DNA polymerase eta, putative	0.0163	0.5276	0.5276
Plasmodium vivax	small ubiquitin-related modifier, putative	0.0032	0.0675	1
Schistosoma mansoni	regulator of G protein signaling	0.003	0.0585	0.0607
Brugia malayi	phosphofructokinase	0.0114	0.3557	0.6741
Trypanosoma brucei	small ubiquitin-related modifier	0.0032	0.0675	0.0675
Trypanosoma brucei	DNA polymerase kappa, putative	0.011	0.343	0.343
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0183	0.019
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0114	0.3557	0.5
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0211	0.0592
Brugia malayi	polk-prov protein	0.0055	0.1494	0.2832
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0211	0.0218
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0287	0.9647	1
Trypanosoma cruzi	small ubiquitin protein, putative	0.0032	0.0675	0.0675
Trypanosoma cruzi	DNA polymerase kappa, putative	0.011	0.343	0.343
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.063	0.0653
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0585	0.1645
Leishmania major	small ubiquitin protein, putative	0.0032	0.0675	0.0675
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.003	0.0585	0.0607
Trypanosoma brucei	DNA damage repair protein, putative	0.0025	0.0413	0.0413
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0026	0.0468	0.0468
Toxoplasma gondii	DNA ligase 1, putative	0.0025	0.0424	0.127
Schistosoma mansoni	flap endonuclease-1	0.0024	0.0379	0.0393
Trypanosoma brucei	chrX additional, unordered contigs	0.0025	0.0413	0.0413
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0984	0.2767
Brugia malayi	Regulator of G protein signaling domain containing protein	0.003	0.0585	0.1109
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0147	0.4719	0.8944
Loa Loa (eye worm)	phosphofructokinase	0.0114	0.3557	0.3687
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0183	0.019
Leishmania major	DNA polymerase kappa, putative	0.0087	0.2617	0.2617
Brugia malayi	6-phosphofructokinase	0.0114	0.3557	0.6741
Schistosoma mansoni	6-phosphofructokinase	0.0114	0.3557	0.3687
Trypanosoma brucei	unspecified product	0.0055	0.1477	0.1477
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0183	0.019
Trypanosoma brucei	DNA polymerase kappa, putative	0.0062	0.1746	0.1746
Trypanosoma brucei	DNA polymerase kappa, putative	0.0055	0.1494	0.1494
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0211	0.0218
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0928	0.1758
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0563	0.1583
Loa Loa (eye worm)	hypothetical protein	0.003	0.0585	0.0607
Schistosoma mansoni	hypothetical protein	0.0018	0.0183	0.019
Toxoplasma gondii	hypothetical protein	0.0048	0.1228	0.3677
Echinococcus granulosus	axis inhibition protein axin	0.003	0.0585	0.0607
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0147	0.4719	0.4892
Trypanosoma cruzi	DNA damage repair protein, putative	0.0025	0.0413	0.0413
Schistosoma mansoni	DNA ligase I	0.0025	0.0424	0.044
Trichomonas vaginalis	phosphofructokinase, putative	0.0114	0.3557	1
Schistosoma mansoni	terminal deoxycytidyl transferase	0.008	0.2348	0.2434
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0031	0.0626	0.5
Brugia malayi	regulator of G-protein signaling rgs-7	0.003	0.0585	0.1109
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0585	0.1645
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0211	0.0218
Brugia malayi	chromobox protein homolog 3	0.0041	0.0984	0.1866
Echinococcus granulosus	regulator of G protein signaling 7	0.003	0.0585	0.0607
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0211	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.011	0.343	0.343
Brugia malayi	Regulator of G protein signaling domain containing protein	0.003	0.0585	0.1109
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.1569	0.2974
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0413	0.0418
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0211	0.0211
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0287	0.9647	1
Giardia lamblia	DNA ligase	0.0025	0.0424	0.1622
Trypanosoma brucei	DNA polymerase kappa, putative	0.0062	0.1746	0.1746
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0183	0.019
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0147	0.4719	0.4892
Entamoeba histolytica	hypothetical protein	0.003	0.0585	0.1645
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0031	0.0626	0.5
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0031	0.0626	0.1875
Echinococcus granulosus	flap endonuclease 1	0.0026	0.0468	0.0485
Brugia malayi	hypothetical protein	0.003	0.0585	0.1109
Trypanosoma brucei	DNA polymerase kappa, putative	0.011	0.343	0.343
Echinococcus granulosus	DNA ligase 1	0.0025	0.0424	0.044
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.008	0.2348	0.2434
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0675	0.1897
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0211	0.0211
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.006	0.1641	0.1701
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.003	0.0585	0.0607
Schistosoma mansoni	z-protein (S1r protein)	0.003	0.0585	0.0607
Entamoeba histolytica	phosphofructokinase, putative	0.0114	0.3557	1
Toxoplasma gondii	small ubiquitin family modifier, putative	0.0032	0.0675	0.202
Trypanosoma cruzi	DNA ligase I, putative	0.0025	0.0424	0.0424
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.014	0.4491	0.4491
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0626	0.1761
Brugia malayi	A-kinase anchor protein 10, precursor	0.003	0.0585	0.1109
Trypanosoma brucei	DNA polymerase kappa, putative	0.011	0.343	0.343
Entamoeba histolytica	hypothetical protein	0.003	0.0585	0.1645
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0183	0.0347
Trichomonas vaginalis	DNA ligase IV, putative	0.0025	0.0424	0.1193
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0026	0.0468	0.0468
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0183	0.019
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0211	0.0211
Trichomonas vaginalis	phosphofructokinase, putative	0.0114	0.3557	1
Echinococcus granulosus	dna polymerase kappa	0.011	0.343	0.3556
Trichomonas vaginalis	chromobox protein, putative	0.0073	0.2115	0.5947
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0114	0.3557	0.3557
Mycobacterium ulcerans	DNA polymerase IV	0.011	0.343	0.6652
Trypanosoma cruzi	DNA polymerase eta, putative	0.0108	0.3341	0.3341
Schistosoma mansoni	DNA ligase I	0.0025	0.0424	0.044
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0087	0.2617	0.5178
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0031	0.0626	0.9282
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0147	0.4719	0.4892
Leishmania major	DNA polymerase eta, putative	0.0108	0.3341	0.3341
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.1012	0.1012
Trypanosoma cruzi	DNA damage repair protein, putative	0.0025	0.0413	0.0413
Echinococcus multilocularis	expressed protein	0.003	0.0585	0.0607
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0211	0.312
Plasmodium vivax	6-phosphofructokinase, putative	0.0031	0.0626	0.9282
Echinococcus granulosus	GPCR family 2	0.0018	0.0183	0.019
Echinococcus multilocularis	axis inhibition protein axin	0.003	0.0585	0.0607
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0211	0.0211
Trypanosoma brucei	DNA polymerase IV, putative	0.011	0.343	0.343
Brugia malayi	6-phosphofructokinase	0.0114	0.3557	0.6741
Toxoplasma gondii	exonuclease III APE	0.0019	0.0211	0.063
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0031	0.063	0.0653
Trypanosoma brucei	DNA polymerase IV, putative	0.0103	0.3162	0.3162
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0984	0.102
Echinococcus multilocularis	6 phosphofructokinase	0.0114	0.3557	0.3687
Schistosoma mansoni	DNA polymerase eta	0.0163	0.5276	0.5469
Trichomonas vaginalis	AGC family protein kinase	0.006	0.1641	0.4614
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.1569	0.1627
Echinococcus granulosus	regulator of G protein signaling 3	0.003	0.0585	0.0607
Echinococcus multilocularis	regulator of G protein signaling 7	0.003	0.0585	0.0607
Schistosoma mansoni	ap endonuclease	0.0019	0.0211	0.0218
Echinococcus granulosus	axis inhibition protein axin	0.003	0.0585	0.0607
Plasmodium falciparum	flap endonuclease 1	0.0026	0.0468	0.6933
Entamoeba histolytica	phosphofructokinase, putative	0.0114	0.3557	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0211	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1494	0.1549
Loa Loa (eye worm)	hypothetical protein	0.003	0.0585	0.0607
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0984	0.2767
Mycobacterium tuberculosis	Conserved hypothetical protein	0.008	0.2348	0.4646
Plasmodium falciparum	DNA ligase I	0.0025	0.0424	0.6288
Entamoeba histolytica	phosphofructokinase, putative	0.0114	0.3557	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0025	0.0413	0.0413
Leishmania major	DNA ligase I, putative	0.0025	0.0424	0.0424
Giardia lamblia	Flap structure-specific endonuclease	0.0026	0.0468	0.1788
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0026	0.0468	0.1401
Loa Loa (eye worm)	SMO-1 protein	0.0032	0.0675	0.07
Echinococcus granulosus	G protein coupled receptor kinase 1	0.0257	0.8603	0.8918
Echinococcus multilocularis	DNA ligase 1	0.0025	0.0424	0.044
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0026	0.0468	0.0468
Loa Loa (eye worm)	RGS-3 protein	0.003	0.0585	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0928	0.0962
Trypanosoma brucei	DNA polymerase kappa, putative	0.0062	0.1746	0.1746
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.011	0.343	0.9643
Schistosoma mansoni	hypothetical protein	0.0018	0.0183	0.019
Trichomonas vaginalis	phosphofructokinase, putative	0.0114	0.3557	1
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.003	0.0585	0.0607
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.0257	0.8603	0.8918
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.008	0.2348	0.2434
Echinococcus multilocularis	regulator of G protein signaling 3	0.003	0.0585	0.0607
Mycobacterium ulcerans	hypothetical protein	0.0156	0.505	1
Echinococcus granulosus	6 phosphofructokinase	0.0114	0.3557	0.3687
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0585	0.1645
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0087	0.2617	0.2617
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0031	0.0626	0.1761
Schistosoma mansoni	DNA polymerase IV / kappa	0.0025	0.0413	0.0428
Loa Loa (eye worm)	flap endonuclease-1	0.0026	0.0468	0.0485
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0211	0.041
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0025	0.0413	0.1236
Mycobacterium ulcerans	DNA polymerase IV	0.011	0.343	0.6652
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0031	0.0626	0.2394
Schistosoma mansoni	ap endonuclease	0.0019	0.0211	0.0218
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0563	0.1583
Leishmania major	ATP-dependent phosphofructokinase	0.0114	0.3557	0.3557
Trypanosoma brucei	hypothetical protein, conserved	0.0025	0.0413	0.0413
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0031	0.0626	0.1243
Trichomonas vaginalis	chromobox protein, putative	0.0073	0.2115	0.5947
Loa Loa (eye worm)	DNA ligase	0.0025	0.0424	0.044
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.003	0.0585	0.0607
Trypanosoma brucei	DNA polymerase kappa, putative	0.011	0.343	0.343
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0183	0.0347
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.003	0.0585	0.1645
Trypanosoma cruzi	DNA polymerase kappa, putative	0.011	0.343	0.343
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0031	0.063	0.1194
Trichomonas vaginalis	phosphofructokinase, putative	0.0114	0.3557	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.011	0.343	0.343
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0147	0.4719	0.4892
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0108	0.3341	1
Schistosoma mansoni	hypothetical protein	0.0018	0.0183	0.019
Echinococcus granulosus	dna polymerase eta	0.0163	0.5276	0.5469
Loa Loa (eye worm)	hypothetical protein	0.003	0.0585	0.0607
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.0032	0.0681	0.2039
Leishmania major	DNA polymerase eta, putative	0.0163	0.5276	0.5276
Mycobacterium ulcerans	6-phosphofructokinase	0.0114	0.3557	0.6914
Entamoeba histolytica	protein kinase, putative	0.006	0.1641	0.4614
Leishmania major	DNA damage repair protein, putative	0.0025	0.0413	0.0413
Entamoeba histolytica	ubiquitin like protein	0.0032	0.0675	0.1897
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0211	0.0805
Trypanosoma brucei	DNA ligase I, putative	0.0025	0.0424	0.0424
Brugia malayi	regulator of G-protein signaling egl-10	0.003	0.0585	0.1109
Plasmodium falciparum	DNA repair protein REV1, putative	0.0025	0.0413	0.6117
Echinococcus multilocularis	chromobox protein 1	0.0073	0.2115	0.2193
Plasmodium vivax	DNA ligase I, putative	0.0025	0.0424	0.6288
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0585	0.1645
Echinococcus multilocularis	chromobox protein 1	0.0073	0.2115	0.2193
Plasmodium vivax	6-phosphofructokinase, putative	0.0031	0.0626	0.9282
Trypanosoma brucei	DNA polymerase IV, putative	0.011	0.343	0.343
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.003	0.0585	0.0607
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0042	0.1012	0.1012
Trypanosoma cruzi	DNA ligase I, putative	0.0025	0.0424	0.0424
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.008	0.2348	0.2434
Giardia lamblia	DINP protein human, muc B family	0.0087	0.2617	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.011	0.343	0.343
Plasmodium falciparum	small ubiquitin-related modifier	0.0032	0.0675	1
Trypanosoma brucei	DNA damage repair protein, putative	0.0025	0.0413	0.0413
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.014	0.4491	0.4491

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 1000 nM	Inhibition of PDPK1 by ELISA assay	ChEMBL.	19628388

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL569346

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1068963