Species | Target name | Source | Bibliographic reference |
---|---|---|---|
West Nile virus | Genome polyprotein | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.4744 | 0.6656 |
Echinococcus multilocularis | tar DNA binding protein | 0.0137 | 0.4744 | 0.6656 |
Schistosoma mansoni | alpha-glucosidase | 0.0148 | 0.5244 | 0.7358 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.4744 | 0.6656 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0103 | 0.315 | 0.3669 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0103 | 0.315 | 0.442 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0038 | 0.0121 | 0.0142 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0038 | 0.0121 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0172 | 0.636 | 0.7409 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0038 | 0.0121 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0038 | 0.0121 | 0.5 |
Echinococcus multilocularis | geminin | 0.0188 | 0.7126 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.3582 | 0.4172 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0172 | 0.636 | 0.8925 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0077 | 0.1924 | 0.2241 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0103 | 0.315 | 0.442 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0137 | 0.4744 | 0.5526 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0038 | 0.0121 | 0.017 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.7126 | 1 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0038 | 0.0121 | 0.017 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0038 | 0.0121 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.022 | 0.8585 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0172 | 0.636 | 0.7409 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.7126 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0103 | 0.315 | 0.442 |
Echinococcus granulosus | geminin | 0.0188 | 0.7126 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0172 | 0.636 | 0.8925 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0172 | 0.636 | 0.8925 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0103 | 0.315 | 0.442 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.4744 | 0.6656 |
Schistosoma mansoni | alpha-glucosidase | 0.0148 | 0.5244 | 0.7358 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0103 | 0.315 | 0.3669 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0112 | 0.3582 | 0.4172 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1924 | 0.2241 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0121 | 0.5 |
Brugia malayi | RNA binding protein | 0.0137 | 0.4744 | 0.5526 |
Trypanosoma brucei | glucosidase, putative | 0.0038 | 0.0121 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0137 | 0.4744 | 0.5526 |
Echinococcus granulosus | tar DNA binding protein | 0.0137 | 0.4744 | 0.6656 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0121 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.4744 | 0.6656 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0103 | 0.315 | 0.442 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0038 | 0.0121 | 0.0142 |
Loa Loa (eye worm) | RNA binding protein | 0.0137 | 0.4744 | 0.5526 |
Loa Loa (eye worm) | TAR-binding protein | 0.0137 | 0.4744 | 0.5526 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0112 | 0.3582 | 0.4172 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.1924 | 0.27 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0103 | 0.315 | 0.442 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0112 | 0.3582 | 0.4172 |
Schistosoma mansoni | alpha glucosidase | 0.0038 | 0.0121 | 0.017 |
Brugia malayi | TAR-binding protein | 0.0137 | 0.4744 | 0.5526 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0103 | 0.315 | 0.442 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.022 | 0.8585 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0137 | 0.4744 | 0.6656 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.03 uM | Inhibition of WNV NS2B-NS3 protease by fluorescence assay | ChEMBL. | 19703770 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.