Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.7424 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.7424 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0061 | 0.7424 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0063 | 0.7886 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.006 | 0.724 | 0.9752 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0061 | 0.7424 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0535 | 0.0679 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0061 | 0.7424 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.2951 | 0.3975 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0191 | 0.0242 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.7424 | 0.9414 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0535 | 0.0721 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.3378 | 0.2673 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.7424 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.2951 | 0.3975 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0061 | 0.7424 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.7424 | 0.9414 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.9228 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3391 | 0.3541 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.4163 | 0.4395 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.006 | 0.724 | 0.9752 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.3818 | 0.4014 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0061 | 0.7424 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0535 | 0.0721 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 322 umol/Kg | Anticonvulsant activity in ip dosed albino mouse assessed as absence of hind limb tonic extension after 0.5 hrs by MES test | ChEMBL. | 19853976 |
TD50 (ADMET) | = 413 umol/Kg | Neurotoxicity in ip dosed albino mouse during 1 min by rotarod test | ChEMBL. | 19853976 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.