Detailed information for compound 1069425

Basic information

Technical information
  • TDR Targets ID: 1069425
  • Name: 6-(4-methoxyphenyl)-2-(2-morpholin-4-yl-2-oxo ethyl)sulfanyl-4-phenylpyridine-3-carbonitril e
  • MW: 445.533 | Formula: C25H23N3O3S
  • H donors: 0 H acceptors: 3 LogP: 3.83 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1nc(SCC(=O)N2CCOCC2)c(c(c1)c1ccccc1)C#N
  • InChi: 1S/C25H23N3O3S/c1-30-20-9-7-19(8-10-20)23-15-21(18-5-3-2-4-6-18)22(16-26)25(27-23)32-17-24(29)28-11-13-31-14-12-28/h2-10,15H,11-14,17H2,1H3
  • InChiKey: WRMFCJVXJBOXQX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-(4-methoxyphenyl)-2-(2-morpholino-2-oxo-ethyl)sulfanyl-4-phenyl-pyridine-3-carbonitrile
  • 6-(4-methoxyphenyl)-2-[(2-morpholino-2-oxoethyl)thio]-4-phenyl-3-pyridinecarbonitrile
  • 2-[(2-keto-2-morpholino-ethyl)thio]-6-(4-methoxyphenyl)-4-phenyl-nicotinonitrile
  • 6-(4-methoxyphenyl)-2-(2-morpholin-4-yl-2-oxo-ethyl)sulfanyl-4-phenyl-pyridine-3-carbonitrile
  • ASN 01516544

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0273 0.0956
Loa Loa (eye worm) hypothetical protein 0.0036 0.0613 0.1026
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0043 0.0787 0.1264
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0273 0.0692
Brugia malayi hypothetical protein 0.002 0.0179 0.024
Trichomonas vaginalis esterase, putative 0.0036 0.0613 0.0835
Echinococcus multilocularis RUN 0.002 0.0179 0.0216
Brugia malayi beta-lactamase family protein 0.0036 0.0613 0.097
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0148 0.009
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0043 0.0787 0.4169
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0043 0.0787 0.2515
Trypanosoma cruzi ISWI complex protein 0.0018 0.0127 0.0175
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0281 0.7039 0.8943
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.1554 0.1872
Toxoplasma gondii thioredoxin reductase 0.0123 0.2899 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0281 0.7039 0.8943
Schistosoma mansoni hypothetical protein 0.0024 0.0287 0.0211
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0345 0.0415
Schistosoma mansoni smad 0.0016 0.0097 0.002
Schistosoma mansoni hypothetical protein 0.0035 0.0587 0.0513
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0375 0.1442
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0095 0.0023
Schistosoma mansoni smad1 5 8 and 0.0016 0.0097 0.002
Plasmodium vivax thioredoxin reductase, putative 0.0123 0.2899 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.2037 0.2455
Entamoeba histolytica hypothetical protein 0.0035 0.0587 0.8049
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.1721 0.5823
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.1013 0.0975
Loa Loa (eye worm) hypothetical protein 0.0036 0.0613 0.1026
Onchocerca volvulus Huntingtin homolog 0.0119 0.2797 0.4726
Leishmania major trypanothione reductase 0.0123 0.2899 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.1721 0.5823
Mycobacterium ulcerans hypothetical protein 0.0023 0.0273 0.0956
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0043 0.0787 0.2515
Loa Loa (eye worm) Smad1 0.0016 0.0097 0.0163
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.1721 0.1656
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0273 0.0956
Echinococcus multilocularis lamin dm0 0.0026 0.0357 0.043
Schistosoma mansoni single-minded 0.0048 0.0931 0.086
Loa Loa (eye worm) hypothetical protein 0.005 0.0984 0.1647
Mycobacterium leprae Probable lipase LipE 0.0036 0.0613 0.0448
Brugia malayi Doublecortin family protein 0.002 0.0179 0.024
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0043 0.0787 0.4169
Loa Loa (eye worm) hypothetical protein 0.0049 0.0942 0.1577
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0078 0.0069
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0613 0.1897
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0858 0.2764
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.1721 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.012 0.0201
Schistosoma mansoni rab6-interacting 0.002 0.0179 0.0103
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0097 0.0117
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.5808 0.6999
Onchocerca volvulus 0.0029 0.043 0.0452
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0043 0.0787 0.2515
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0613 0.0688
Echinococcus granulosus single minded 2 0.0036 0.0602 0.0726
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.2037 0.1975
Brugia malayi MH1 domain containing protein 0.0016 0.0097 0.0102
Plasmodium vivax glutathione reductase, putative 0.0123 0.2899 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0613 0.054
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.1721 0.2073
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0613 0.0688
Loa Loa (eye worm) hypothetical protein 0.0119 0.2797 0.468
Echinococcus multilocularis tumor protein p63 0.0329 0.8298 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0097 0.0117
Brugia malayi MH2 domain containing protein 0.0016 0.0097 0.0102
Echinococcus granulosus RUN 0.002 0.0179 0.0216
Onchocerca volvulus 0.0023 0.0273 0.0169
Schistosoma mansoni hypothetical protein 0.0018 0.0127 0.005
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.2037 0.3409
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.3544 0.3493
Plasmodium falciparum glutathione reductase 0.0043 0.0787 0.2515
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0602 0.0726
Mycobacterium tuberculosis Probable reductase 0.0281 0.7039 0.8943
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0942 0.1135
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0858 0.1033
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0273 0.0398
Trichomonas vaginalis set domain proteins, putative 0.0231 0.5718 1
Brugia malayi hypothetical protein 0.002 0.0179 0.024
Onchocerca volvulus 0.0036 0.0613 0.0783
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0148 0.0249
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0587 0.0707
Onchocerca volvulus 0.0026 0.0357 0.032
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.0787 0.2515
Schistosoma mansoni zinc finger protein 0.0026 0.0349 0.0273
Brugia malayi follicle stimulating hormone receptor 0.0226 0.5584 0.9339
Entamoeba histolytica hypothetical protein 0.0035 0.0587 0.8049
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.012 0.015
Schistosoma mansoni smad1 5 8 and 0.0016 0.0097 0.002
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0148 0.0178
Schistosoma mansoni lipoxygenase 0.0117 0.273 0.2673
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0613 0.0688
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.043 0.0518
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.0787 0.2515
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0078 0.0094
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0043 0.0787 0.4065
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0043 0.0787 0.0715
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0931 0.086
Mycobacterium tuberculosis Conserved protein 0.0036 0.0613 0.0688
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0078 0.0094
Brugia malayi PHD-finger family protein 0.0032 0.0509 0.0795
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0097 0.002
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0179 0.0216
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.012 0.015
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0148 0.0249
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.018 0.0103
Loa Loa (eye worm) hypothetical protein 0.0023 0.0273 0.0457
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0031 0.049 0.0763
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.1013 0.1221
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.1721 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0179 0.0216
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.2037 0.1975
Leishmania major hypothetical protein, conserved 0.0018 0.0127 0.0175
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.3544 0.427
Schistosoma mansoni Smad4 0.0016 0.0097 0.002
Loa Loa (eye worm) hypothetical protein 0.0017 0.012 0.0201
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0587 0.0513
Schistosoma mansoni polycystin 1-related 0.002 0.0179 0.0103
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0858 0.2764
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0097 0.0117
Loa Loa (eye worm) hypothetical protein 0.0048 0.0931 0.1557
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0148 0.0249
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0858 0.1274
Brugia malayi hypothetical protein 0.0035 0.0587 0.0926
Trypanosoma cruzi trypanothione reductase, putative 0.0123 0.2899 1
Schistosoma mansoni hypothetical protein 0.002 0.0179 0.0103
Schistosoma mansoni intermediate filament proteins 0.0026 0.0357 0.0281
Loa Loa (eye worm) hypothetical protein 0.0036 0.0613 0.1026
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.3544 0.5905
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0043 0.0787 0.2515
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0179 0.0216
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0587 0.0707
Loa Loa (eye worm) hypothetical protein 0.0162 0.3905 0.6535
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0613 0.1026
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0602 0.3014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0095 0.0023
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0345 0.0269
Echinococcus granulosus intermediate filament protein 0.0026 0.0357 0.043
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0693 0.2182
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0357 0.0597
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0148 0.0176
Brugia malayi glutathione reductase 0.0123 0.2899 0.4819
Onchocerca volvulus 0.0036 0.0613 0.0783
Onchocerca volvulus 0.0026 0.0357 0.032
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.1721 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0095 0.0023
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0179 0.0216
Loa Loa (eye worm) hypothetical protein 0.0017 0.012 0.0201
Trichomonas vaginalis glutathione reductase, putative 0.0043 0.0787 0.1148
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0078 0.0094
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0148 0.0249
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0942 0.1135
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.043 0.1249
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0226 0.5584 0.9343
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0613 0.0688
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.2037 0.2455
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0402 0.0484
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0273 0.0251
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0043 0.0787 0.2515
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0095 0.0023
Loa Loa (eye worm) hypothetical protein 0.0119 0.2797 0.468
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0942 0.0871
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0273 0.0956
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0693 1
Loa Loa (eye worm) transcription factor SMAD2 0.0241 0.5976 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0273 0.0956
Echinococcus multilocularis thioredoxin glutathione reductase 0.0124 0.2926 0.3526
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0043 0.0787 0.2515
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0043 0.0787 0.0949
Brugia malayi hypothetical protein 0.0119 0.2797 0.4647
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0357 0.0539
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0613 0.0739
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0078 0.0094
Loa Loa (eye worm) hypothetical protein 0.0017 0.012 0.0201
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0179 0.0216
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0613 0.0688
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0613 0.054
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0043 0.0787 0.2515
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0281 0.7039 0.8943
Echinococcus granulosus thioredoxin glutathione reductase 0.0124 0.2926 0.3526
Mycobacterium tuberculosis Probable oxidoreductase 0.0313 0.7861 1
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.5808 0.6999
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0345 0.0415
Loa Loa (eye worm) thioredoxin reductase 0.0123 0.2899 0.4851
Loa Loa (eye worm) doublecortin family protein 0.002 0.0179 0.03
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0273 0.0956
Echinococcus granulosus geminin 0.0168 0.4068 0.4902
Loa Loa (eye worm) hypothetical protein 0.0044 0.082 0.1372
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0097 0.0163
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0148 0.0188
Loa Loa (eye worm) hypothetical protein 0.0078 0.1721 0.2879
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.018 0.0103
Echinococcus granulosus smad 0.0016 0.0097 0.0117
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0031 0.049 0.0763
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0313 0.7861 1
Mycobacterium ulcerans hypothetical protein 0.0036 0.0613 0.3081
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.2037 0.1975
Plasmodium falciparum thioredoxin reductase 0.0123 0.2899 1
Brugia malayi isocitrate dehydrogenase 0.0016 0.0078 0.0069
Echinococcus granulosus lamin dm0 0.0026 0.0357 0.043
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.1013 0.1202
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.1721 0.2073
Schistosoma mansoni lamin 0.0026 0.0357 0.0281
Loa Loa (eye worm) hypothetical protein 0.0026 0.0344 0.0576
Mycobacterium tuberculosis Conserved protein 0.0036 0.0613 0.0688
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.1721 0.5823
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0942 0.0871
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0148 0.0178
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0043 0.0787 0.2515
Mycobacterium tuberculosis Conserved protein 0.0036 0.0613 0.0688
Loa Loa (eye worm) hypoxia-induced factor 1 0.0149 0.3577 0.5986
Loa Loa (eye worm) hypothetical protein 0.0023 0.0273 0.0457
Loa Loa (eye worm) hypothetical protein 0.0052 0.1042 0.1743
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0097 0.0117
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0043 0.0787 0.0949
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.3366 0.4056
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0375 0.1053
Loa Loa (eye worm) hypothetical protein 0.0036 0.0613 0.1026
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.273 0.329
Loa Loa (eye worm) hypothetical protein 0.002 0.0179 0.03
Echinococcus multilocularis musashi 0.0026 0.0357 0.043
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0273 0.0956
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0043 0.0787 0.2515
Brugia malayi MH2 domain containing protein 0.0016 0.0097 0.0102
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.1721 0.5823
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0078 0.013
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0043 0.0787 0.2515
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0613 0.3081
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.0291 0.0487
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.1721 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0747 0.09
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0613 0.1897
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0043 0.0787 0.2515
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.1013 0.1221
Brugia malayi MH2 domain containing protein 0.0241 0.5976 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0613 0.0835
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.043 0.0355
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0078 0.0094
Brugia malayi MH1 domain containing protein 0.0016 0.0097 0.0102
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0043 0.0787 0.2515
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0273 0.0398
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.0787 0.2515
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0043 0.0787 0.0912
Loa Loa (eye worm) glutathione reductase 0.0123 0.2899 0.4851
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0613 0.097
Toxoplasma gondii exonuclease III APE 0.0018 0.0148 0.0249
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0078 0.0094
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0281 0.7039 0.8943
Onchocerca volvulus 0.0231 0.5718 1
Trypanosoma brucei trypanothione reductase 0.0123 0.2899 1
Echinococcus granulosus zinc finger protein 0.0026 0.0349 0.042
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0281 0.7039 0.8943
Schistosoma mansoni lipoxygenase 0.0082 0.1808 0.1744
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0613 0.0835
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0602 0.0953
Schistosoma mansoni smad1 5 8 and 0.0016 0.0097 0.002
Onchocerca volvulus Huntingtin homolog 0.0119 0.2797 0.4726
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0043 0.0787 0.2515
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0375 0.1053
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0148 0.0248
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.1721 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0613 0.1026
Plasmodium falciparum glutathione reductase 0.0123 0.2899 1
Brugia malayi Bromodomain containing protein 0.0047 0.0911 0.1472
Trypanosoma brucei ISWI complex protein 0.0018 0.0127 0.0175
Brugia malayi intermediate filament protein 0.0026 0.0357 0.0539
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0097 0.0163
Onchocerca volvulus 0.0036 0.0602 0.0764
Brugia malayi Thioredoxin reductase 0.0123 0.2899 0.4819
Loa Loa (eye worm) hypothetical protein 0.0017 0.012 0.0201
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.4984 0.8339
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0287 0.048
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0747 0.09
Schistosoma mansoni ap endonuclease 0.0018 0.0148 0.0071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.2037 0.2455
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0037 0.0061
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.2037 0.3369
Echinococcus granulosus Smad4 0.0016 0.0097 0.0117
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0273 0.2292
Giardia lamblia NADH oxidase lateral transfer candidate 0.0043 0.0787 1
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0179 0.0361
Leishmania major hypothetical protein, conserved 0.0036 0.0613 0.1897
Loa Loa (eye worm) hypothetical protein 0.0026 0.0357 0.0597
Brugia malayi PAS domain containing protein 0.0048 0.0931 0.1505
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0613 0.0835
Brugia malayi hypoxia-induced factor 1 0.0149 0.3577 0.5961
Schistosoma mansoni survival motor neuron protein 0.0048 0.092 0.0849
Echinococcus multilocularis lamin 0.0026 0.0357 0.043
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0613 0.1897
Brugia malayi Pre-SET motif family protein 0.0203 0.4984 0.8329
Brugia malayi Smad1 0.0016 0.0097 0.0102
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0613 0.1897
Schistosoma mansoni lamin 0.0026 0.0357 0.0281
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0613 0.0448
Schistosoma mansoni loxhd1 0.002 0.0179 0.0103
Toxoplasma gondii hypothetical protein 0.0027 0.0375 0.1053
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.018 0.0216
Loa Loa (eye worm) hypothetical protein 0.0234 0.5808 0.9719
Echinococcus multilocularis Smad4 0.0016 0.0097 0.0117
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0357 0.0597
Echinococcus granulosus tumor protein p63 0.0329 0.8298 1
Schistosoma mansoni hypothetical protein 0.0048 0.092 0.0849
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0613 0.0688
Trypanosoma cruzi ISWI complex protein 0.0018 0.0127 0.0175
Brugia malayi Pre-SET motif family protein 0.0029 0.043 0.0662
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0375 0.0134
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0273 0.0398
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0043 0.0787 0.4169
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0273 0.2292
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.0787 0.2515
Loa Loa (eye worm) beta-lactamase 0.0036 0.0613 0.1026
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.092 0.1487
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.018 0.0216
Schistosoma mansoni zinc finger protein 0.0018 0.0127 0.005
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0273 0.0692
Mycobacterium ulcerans beta-lactamase 0.0036 0.0613 0.3081
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.043 0.0355
Brugia malayi hypothetical protein 0.0234 0.5808 0.9717
Toxoplasma gondii ABC1 family protein 0.0036 0.0613 0.1897
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0273 0.0251
Schistosoma mansoni hypothetical protein 0.0168 0.4068 0.4021
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0043 0.0787 0.4169
Onchocerca volvulus 0.0048 0.092 0.1337
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0858 0.1274
Echinococcus granulosus lamin 0.0026 0.0357 0.043
Trichomonas vaginalis mercuric reductase, putative 0.0043 0.0787 0.1148
Plasmodium falciparum thioredoxin reductase 0.0043 0.0787 0.2515
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0273 0.0956
Loa Loa (eye worm) hypothetical protein 0.002 0.0179 0.03
Schistosoma mansoni bromodomain containing protein 0.0076 0.1661 0.1596
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0931 0.086
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.1013 0.1202
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0613 0.0739
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0123 0.2899 0.3625
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0043 0.0787 0.2515
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0613 0.3081
Entamoeba histolytica hypothetical protein 0.0035 0.0587 0.8049
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0313 0.7861 1
Brugia malayi Bromodomain containing protein 0.0089 0.2013 0.3328
Schistosoma mansoni rab6-interacting 0.002 0.0179 0.0103
Brugia malayi beta-lactamase 0.0036 0.0613 0.097
Loa Loa (eye worm) MH2 domain-containing protein 0.0241 0.5976 1
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0179 0.0216
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0281 0.7039 0.8916
Schistosoma mansoni hypothetical protein 0.0168 0.4068 0.4021
Loa Loa (eye worm) hypothetical protein 0.0081 0.1792 0.2998
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0613 0.0688
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.0787 0.2515
Entamoeba histolytica hypothetical protein 0.0035 0.0587 0.8049
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.5709 0.7234
Toxoplasma gondii NADPH-glutathione reductase 0.0043 0.0787 0.2515
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0313 0.7861 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0613 0.0835
Treponema pallidum NADH oxidase 0.0043 0.0787 0.4065
Schistosoma mansoni ap endonuclease 0.0018 0.0148 0.0071
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0693 0.8529
Echinococcus multilocularis smad 0.0016 0.0097 0.0117
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.2037 0.2455
Mycobacterium ulcerans lipase LipD 0.0036 0.0613 0.3081
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.1554 0.1872
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0613 0.0835
Brugia malayi beta-lactamase family protein 0.0036 0.0613 0.097
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.0787 0.2515
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0273 0.2292
Loa Loa (eye worm) hypothetical protein 0.0036 0.0613 0.1026
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0858 0.2764
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0043 0.0787 0.4065
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0179 0.0361
Echinococcus multilocularis geminin 0.0168 0.4068 0.4902
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0148 0.0249
Brugia malayi Probable ClpP-like protease 0.0078 0.1721 0.2835
Echinococcus multilocularis zinc finger protein 0.0026 0.0349 0.042
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.1721 0.1908
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.273 0.329
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.0787 0.2515
Loa Loa (eye worm) hypothetical protein 0.0023 0.0273 0.0457
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.012 0.0054
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0273 0.0692
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.1721 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0148 0.0249
Plasmodium vivax SET domain protein, putative 0.0029 0.043 0.1249
Onchocerca volvulus 0.0048 0.0931 0.1356
Onchocerca volvulus 0.0036 0.0613 0.0783
Brugia malayi hypothetical protein 0.0162 0.3905 0.6514
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0043 0.0787 0.2515
Loa Loa (eye worm) acetyltransferase 0.0148 0.3544 0.593

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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