Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | rac serine:threonine kinase | 0.1001 | 0.6568 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.1001 | 0.6568 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0252 | 0.1129 | 0.1129 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.1409 | 0.9536 | 0.9536 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0483 | 0.2809 | 0.2809 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0937 | 0.6104 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.1409 | 0.9536 | 0.9355 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0926 | 0.6029 | 0.8564 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.1001 | 0.6568 | 0.5228 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0926 | 0.6029 | 0.8564 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0483 | 0.2809 | 0.2809 |
Echinococcus granulosus | nervana 2 | 0.0926 | 0.6029 | 0.8564 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.1001 | 0.6568 | 0.5228 |
Echinococcus multilocularis | nervana 2 | 0.0926 | 0.6029 | 0.8564 |
Brugia malayi | Cytochrome P450 family protein | 0.0252 | 0.1129 | 0.1129 |
Echinococcus granulosus | nervana 2 | 0.0926 | 0.6029 | 0.8564 |
Loa Loa (eye worm) | hypothetical protein | 0.0483 | 0.2809 | 0.2809 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0937 | 0.6104 | 0.8766 |
Entamoeba histolytica | protein kinase 2, putative | 0.0937 | 0.6104 | 0.4583 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.1001 | 0.6568 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0483 | 0.2809 | 0.2809 |
Trichomonas vaginalis | AGC family protein kinase | 0.0547 | 0.3273 | 0.0743 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0926 | 0.6029 | 0.8564 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0926 | 0.6029 | 0.8564 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0937 | 0.6104 | 0.9293 |
Echinococcus granulosus | serine/threonine protein kinase | 0.1001 | 0.6568 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0483 | 0.2809 | 0.2809 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0937 | 0.6104 | 0.8766 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0483 | 0.2809 | 0.2809 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.1001 | 0.6568 | 1 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0483 | 0.2809 | 0.2809 |
Brugia malayi | protein kinase C II. | 0.0483 | 0.2809 | 0.2809 |
Trichomonas vaginalis | AGC family protein kinase | 0.0483 | 0.2809 | 0.0104 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0937 | 0.6104 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0483 | 0.2809 | 0.0104 |
Trypanosoma cruzi | Protein kinase B | 0.1001 | 0.6568 | 1 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.1409 | 0.9536 | 0.9536 |
Trichomonas vaginalis | AGC family protein kinase | 0.0483 | 0.2809 | 0.0104 |
Toxoplasma gondii | AGC kinase | 0.1409 | 0.9536 | 0.5 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0937 | 0.6104 | 0.8766 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0483 | 0.2809 | 0.2809 |
Giardia lamblia | Kinase, AGC PKA | 0.0937 | 0.6104 | 0.5 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0483 | 0.2809 | 0.2809 |
Echinococcus multilocularis | nervana 2 | 0.0926 | 0.6029 | 0.8564 |
Brugia malayi | Hr1 repeat family protein | 0.0483 | 0.2809 | 0.2809 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.0787 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.