Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.7857 | 0.7673 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.2822 | 0.3592 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0032 | 0.2287 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.2999 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.2822 | 0.3592 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.7857 | 0.7673 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.7857 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.2999 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.7857 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.2999 | 1 |
Brugia malayi | RNA binding protein | 0.0062 | 0.7857 | 0.7673 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.7186 | 0.9107 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.2999 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.7857 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.2822 | 0.3292 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.7857 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.2999 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.7857 | 0.8527 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.7857 | 0.8527 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.7844 | 0.9985 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.7857 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.2999 | 0.3527 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3262 | 0.3541 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.2814 | 0.3281 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.7857 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.2999 | 0.3527 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.2999 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.2999 | 0.5 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.2999 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.2999 | 0.3817 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.7857 | 1 |
Brugia malayi | hypothetical protein | 0.0035 | 0.2822 | 0.2209 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.3249 | 0.2673 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.2814 | 0.3281 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0.2287 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.2822 | 0.3292 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.2999 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.2999 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.7857 | 0.8527 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.9213 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0351 | 0.0447 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.7186 | 0.9107 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.2999 | 0.5 |
Brugia malayi | Inositol-1 | 0.0036 | 0.2999 | 0.2401 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.3698 | 0.4014 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.2999 | 0.3817 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.2999 | 0.3255 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.4049 | 0.4395 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.6964 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 141.2538 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.