Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Fructose-1,6-bisphosphatase | Starlite/ChEMBL | References |
Homo sapiens | fructose-1,6-bisphosphatase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | fructose-bisphospatase I | fructose-1,6-bisphosphatase 1 | 338 aa | 326 aa | 31.0 % |
Neospora caninum | fructose-1,6-bisphosphatase, putative | Fructose-1,6-bisphosphatase | 363 aa | 298 aa | 32.5 % |
Toxoplasma gondii | fructose-bisphospatase I | Fructose-1,6-bisphosphatase | 363 aa | 326 aa | 31.3 % |
Onchocerca volvulus | CES-1 homolog | Fructose-1,6-bisphosphatase | 363 aa | 319 aa | 60.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 0.0378 | 0.6745 | 1 | |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0378 | 0.6745 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0039 | 0.02 | 0.0297 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0378 | 0.6745 | 0.6745 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.0141 | 0.2157 | 0.3199 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0141 | 0.2157 | 0.3199 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0378 | 0.6745 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0378 | 0.6745 | 1 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0141 | 0.2157 | 0.3199 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0039 | 0.02 | 0.0297 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0039 | 0.02 | 0.0297 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0378 | 0.6745 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0039 | 0.02 | 0.0297 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.3141 | 0.4657 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0039 | 0.02 | 1 |
Echinococcus granulosus | geminin | 0.0191 | 0.3141 | 0.3141 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0378 | 0.6745 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0039 | 0.02 | 0.0297 |
Brugia malayi | Cytochrome P450 family protein | 0.0039 | 0.02 | 0.0297 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0141 | 0.2157 | 0.3199 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0378 | 0.6745 | 0.6745 |
Leishmania major | cytochrome p450-like protein | 0.0039 | 0.02 | 0.0297 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.3141 | 0.4657 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0378 | 0.6745 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0117 | 0.1704 | 0.2527 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0141 | 0.2157 | 0.3199 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0039 | 0.02 | 0.0297 |
Echinococcus multilocularis | geminin | 0.0191 | 0.3141 | 0.3141 |
Brugia malayi | Cytochrome P450 family protein | 0.0039 | 0.02 | 0.0297 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0378 | 0.6745 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0117 | 0.1704 | 0.2527 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.