Detailed information for compound 1069962

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 387.469 | Formula: C22H29NO5
  • H donors: 1 H acceptors: 3 LogP: 0.83 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCOCC1)OCCCC1=C(C)C=C2C1=C(C)C1([C@@](C2=O)(C)O)CC1
  • InChi: 1S/C22H29NO5/c1-14-13-17-18(15(2)22(6-7-22)21(3,26)19(17)24)16(14)5-4-10-28-20(25)23-8-11-27-12-9-23/h13,26H,4-12H2,1-3H3/t21-/m0/s1
  • InChiKey: ZYPFDFDUNMRLAI-NRFANRHFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cytochrome p450-like protein 0.0022 0.0148 0.0592
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.079 0.0793
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0315 0.0432
Loa Loa (eye worm) TAR-binding protein 0.0128 0.2581 0.2591
Loa Loa (eye worm) hypothetical protein 0.0036 0.0455 0.0457
Leishmania major pyruvate kinase 0.0032 0.0383 0.157
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0133 0.2703 0.2714
Mycobacterium ulcerans lipase LipD 0.0036 0.0455 0.1614
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0018 0.0051
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.079 0.0793
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0455 0.0457
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0016 0.0006 0.0006
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0156 0.0157
Loa Loa (eye worm) Smad1 0.0016 0.0009 0.0009
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0315 0.0315
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.2403 0.3292
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0193 0.0372
Schistosoma mansoni smad 0.0016 0.0009 0.0012
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0024 0.0193 0.4163
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0018 0.0019
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0383 0.8383
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0016 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0032 0.0383 0.0384
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0383 0.8383
Mycobacterium tuberculosis Conserved protein 0.0036 0.0455 0.0921
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0455 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.4379 0.4396
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0148 0.0149
Loa Loa (eye worm) hypothetical protein 0.005 0.079 0.0793
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0455 0.3931
Chlamydia trachomatis pyruvate kinase 0.0032 0.0383 1
Brugia malayi metallo-beta-lactamase superfamily protein 0.0016 0.0006 0.0006
Echinococcus multilocularis pyruvate kinase 0.0026 0.0225 0.0225
Echinococcus multilocularis smad 0.0016 0.0009 0.0009
Mycobacterium ulcerans pyruvate kinase 0.0032 0.0383 0.1353
Loa Loa (eye worm) gopc protein 0.0448 0.9962 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0455 0.0921
Echinococcus granulosus tar DNA binding protein 0.0128 0.2581 0.2581
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.0383 0.157
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2581 0.3537
Echinococcus multilocularis ETHE1 protein 0.0016 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0034 0.0424 0.0426
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0315 0.0315
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0156 0.8024
Brugia malayi RNA binding protein 0.0128 0.2581 0.2591
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0298 0.6487 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0455 0.1614
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0016 0.0006 0.0006
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0193 0.0194
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0009 0.0009
Brugia malayi ethe1-prov protein 0.0016 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0023 0.0156 0.0157
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0009 0.0009
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0024 0.0193 0.0384
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0016 0.0006 0.0006
Brugia malayi beta-lactamase family protein 0.0036 0.0455 0.0457
Echinococcus multilocularis tar DNA binding protein 0.0128 0.2581 0.2581
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.0383 0.0384
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0133 0.2703 0.2703
Plasmodium falciparum pyruvate kinase 0.0032 0.0383 1
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0455 0.1614
Trichomonas vaginalis esterase, putative 0.0036 0.0455 0.0893
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0424 0.0426
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0455 0.0893
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.5128 0.5148
Brugia malayi Pre-SET motif family protein 0.0206 0.4379 0.4396
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0133 0.2703 0.2703
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.023 0.0346
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0133 0.2703 0.2703
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.2403 0.2403
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0383 0.0748
Loa Loa (eye worm) hypothetical protein 0.0036 0.0455 0.0457
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0066 0.1148 0.2344
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.2403 0.8614
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.2403 0.3292
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0137 0.2788 0.5711
Giardia lamblia Pyruvate kinase 0.0032 0.0383 1
Leishmania major eukaryotic initiation factor 4a, putative 0.0024 0.0193 0.078
Brugia malayi hypothetical protein 0.0016 0.0006 0.0006
Echinococcus multilocularis pyruvate kinase 0.0032 0.0383 0.0383
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0148 0.051
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0024 0.0193 0.0265
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.4878 1
Brugia malayi Smad1 0.0016 0.0009 0.0009
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0148 0.316
Trypanosoma brucei beta lactamase 0.0066 0.1148 1
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0016 0.0006 0.0009
Onchocerca volvulus 0.0036 0.0455 0.0893
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0006
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0455 0.0893
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0024 0.0193 0.1636
Echinococcus granulosus pyruvate kinase 0.0017 0.0018 0.0018
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0016 0.0006 0.0006
Echinococcus granulosus smad 0.0016 0.0009 0.0009
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0024 0.0193 0.0193
Echinococcus granulosus pyruvate kinase 0.0032 0.0383 0.0383
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.023 0.5953
Brugia malayi MH1 domain containing protein 0.0016 0.0009 0.0009
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0024 0.0193 0.0193
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0455 1
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.2403 1
Treponema pallidum ATP-dependent RNA helicase 0.0024 0.0193 1
Leishmania major eukaryotic initiation factor 4a, putative 0.0024 0.0193 0.078
Brugia malayi eukaryotic initiation factor 4A 0.0024 0.0193 0.0194
Loa Loa (eye worm) hypothetical protein 0.0036 0.0455 0.0457
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0133 0.2703 0.2703
Schistosoma mansoni hypothetical protein 0.0333 0.7298 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0315 0.0432
Mycobacterium ulcerans beta-lactamase 0.0036 0.0455 0.1614
Echinococcus multilocularis zinc phosphodiesterase 0.0016 0.0006 0.0006
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0455 0.0893
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0193 0.0372
Brugia malayi MH2 domain containing protein 0.0016 0.0009 0.0009
Schistosoma mansoni smad1 5 8 and 0.0016 0.0009 0.0012
Leishmania major hypothetical protein, conserved 0.0026 0.023 0.0935
Plasmodium vivax pyruvate kinase, putative 0.0032 0.0383 0.0581
Echinococcus multilocularis pyruvate kinase 0.0017 0.0018 0.0018
Schistosoma mansoni pyruvate kinase 0.0017 0.0018 0.0025
Loa Loa (eye worm) hypothetical protein 0.0036 0.0455 0.0457
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0148 0.0149
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0455 0.0455
Brugia malayi beta-lactamase family protein 0.0036 0.0455 0.0457
Brugia malayi MH2 domain containing protein 0.0016 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0036 0.0455 0.0457
Leishmania major hypothetical protein, conserved 0.0036 0.0455 0.1873
Brugia malayi TAR-binding protein 0.0128 0.2581 0.2591
Plasmodium vivax RNA helicase-1, putative 0.0024 0.0193 0.0288
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0024 0.0193 0.4966
Echinococcus granulosus eukaryotic initiation factor 4A 0.0024 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0026 0.023 0.0231
Mycobacterium ulcerans hypothetical protein 0.0036 0.0455 0.1614
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.079 0.0793
Plasmodium falciparum eukaryotic initiation factor 4A 0.0024 0.0193 0.4966
Plasmodium vivax SET domain protein, putative 0.003 0.0315 0.0476
Onchocerca volvulus 0.0036 0.0455 0.0893
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.2403 0.4919
Wolbachia endosymbiont of Brugia malayi metallo-beta-lactamase superfamily hydrolase 0.0016 0.0006 0.5
Mycobacterium leprae Probable pyruvate kinase PykA 0.0032 0.0383 0.3295
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0016 0.0006 0.0006
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.023 0.0935
Brugia malayi MH2 domain containing protein 0.0239 0.5128 0.5148
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0009 0.0009
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0315 0.1288
Echinococcus granulosus pyruvate kinase 0.0032 0.0383 0.0383
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0455 0.0624
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.2581 0.2591
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.023 0.499
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.2403 0.2403
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0455 0.0624
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0315 0.0432
Schistosoma mansoni pyruvate kinase 0.0032 0.0383 0.0524
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0006
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.0383 0.3295
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2581 0.3537
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0148 0.1242
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0455 0.0921
Echinococcus granulosus ETHE1 protein 0.0016 0.0006 0.0006
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0807 0.081
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0455 0.0921
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0455 0.0921
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0455 0.0893
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0148 0.316
Brugia malayi beta-lactamase 0.0036 0.0455 0.0457
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0383 0.0748
Schistosoma mansoni hypothetical protein 0.0016 0.0006 0.0009
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0193 0.0372
Schistosoma mansoni zinc phosphodiesterase 0.0016 0.0006 0.0009
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.2403 0.8614
Schistosoma mansoni smad1 5 8 and 0.0016 0.0009 0.0012
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0024 0.0193 0.0372
Echinococcus granulosus zinc phosphodiesterase 0.0016 0.0006 0.0006
Onchocerca volvulus 0.0036 0.0455 0.0893
Schistosoma mansoni Smad4 0.0016 0.0009 0.0012
Trichomonas vaginalis set domain proteins, putative 0.0234 0.5034 1
Loa Loa (eye worm) RNA binding protein 0.0128 0.2581 0.2591
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0009 0.0009
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0455 0.0457
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0016 0.0006 0.0006
Mycobacterium leprae Probable lipase LipE 0.0036 0.0455 0.3931
Loa Loa (eye worm) beta-lactamase 0.0036 0.0455 0.0457
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0383 0.0384
Schistosoma mansoni hypothetical protein 0.0034 0.0424 0.0581
Mycobacterium tuberculosis Conserved protein 0.0036 0.0455 0.0921
Giardia lamblia Pyruvate kinase 0.0017 0.0018 0.0323
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0009 0.0009
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0024 0.0193 0.0193
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0024 0.0193 0.0265
Onchocerca volvulus 0.003 0.0315 0.0614
Trypanosoma brucei pyruvate kinase 1 0.0032 0.0383 0.3295
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0455 0.0921
Brugia malayi Pre-SET motif family protein 0.003 0.0315 0.0316
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0032 0.0383 0.0772
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0455 0.3931
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0133 0.2703 0.3704
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0455 0.0693
Brugia malayi Cytochrome P450 family protein 0.0022 0.0148 0.0149
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.029 0.029
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0455 0.0921
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.023 0.1962
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0016 0.0006 0.0006
Brugia malayi hypothetical protein 0.0026 0.023 0.0231
Echinococcus granulosus pyruvate kinase 0.0017 0.0018 0.0018
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0016 0.0006 0.0006
Echinococcus multilocularis pyruvate kinase 0.0017 0.0018 0.0018
Onchocerca volvulus 0.0234 0.5034 1
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0383 0.0384
Schistosoma mansoni hypothetical protein 0.0333 0.7298 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0148 0.0149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0133 0.2703 0.3704
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0009 0.0012
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0383 0.0748
Brugia malayi MH1 domain containing protein 0.0016 0.0009 0.0009
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0455 0.0455
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0383 0.0748
Loa Loa (eye worm) hypothetical protein 0.0036 0.0455 0.0457
Schistosoma mansoni hypothetical protein 0.0016 0.0006 0.0009
Brugia malayi metallo-beta-lactamase superfamily protein 0.0016 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0016 0.0006 0.0009
Schistosoma mansoni pyruvate kinase 0.0032 0.0383 0.0524
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2581 0.3537
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0455 0.0921
Brugia malayi Cytochrome P450 family protein 0.0051 0.0807 0.081
Echinococcus granulosus geminin 0.0333 0.7298 0.7298
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0024 0.0193 1
Echinococcus multilocularis pyruvate kinase 0.0032 0.0383 0.0383
Loa Loa (eye worm) hypothetical protein 0.003 0.0315 0.0316
Brugia malayi gopc protein 0.0448 0.9962 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0133 0.2703 0.2714
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2581 0.3537
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0315 0.0432
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.0383 0.0384
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0066 0.1148 1
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0024 0.0193 0.078
Mycobacterium tuberculosis Conserved protein 0.0036 0.0455 0.0921
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0137 0.2788 1
Toxoplasma gondii ABC1 family protein 0.0036 0.0455 0.1873
Mycobacterium ulcerans lipoprotein LpqF 0.0066 0.1148 0.4105
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0016 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2581 0.3537
Schistosoma mansoni zinc phosphodiesterase 0.0016 0.0006 0.0009
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0315 0.0315
Echinococcus multilocularis pyruvate kinase 0.0017 0.0018 0.0018
Echinococcus granulosus Smad4 0.0016 0.0009 0.0009
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.2581 0.2591
Echinococcus multilocularis Smad4 0.0016 0.0009 0.0009
Echinococcus multilocularis geminin 0.0333 0.7298 0.7298
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0455 0.0893
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0383 0.0384
Brugia malayi Cytochrome P450 family protein 0.0022 0.0148 0.0149
Brugia malayi hypothetical protein 0.0017 0.0019 0.0019
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.2403 0.8614
Leishmania major pyruvate kinase 0.0032 0.0383 0.157
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.023 0.5953
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.2403 1
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0018 0.0323
Echinococcus granulosus pyruvate kinase 0.0017 0.0018 0.0018
Schistosoma mansoni smad1 5 8 and 0.0016 0.0009 0.0012
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0383 0.0748
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0024 0.0193 0.4163
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.023 0.499
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0133 0.2703 0.3704
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.5128 0.5148

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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