Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | neuropeptide Y receptor Y5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Bromodomain containing protein | 0.008 | 0.4379 | 0.4304 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0133 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0041 | 0.1606 | 0.1493 |
Schistosoma mansoni | bromodomain containing protein | 0.0067 | 0.3493 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0133 | 0.0133 |
Echinococcus granulosus | zinc finger protein | 0.0021 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0019 | 0.0046 | 0.0046 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0133 | 0.0133 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0133 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0022 | 0.0271 | 0.0271 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0133 | 0.0379 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.0415 | 0.0415 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0133 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0133 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0133 | 0.5 |
Brugia malayi | PHD-finger family protein | 0.0027 | 0.0594 | 0.0467 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0133 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.0021 | 0.0191 | 0.0191 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0064 | 0.3223 | 0.3223 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0133 | 0.0379 |
Schistosoma mansoni | zinc finger protein | 0.0021 | 0.0191 | 0.0546 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0133 | 0.0133 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0133 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0271 | 0.0774 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0133 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0133 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1611 | 0.1611 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0415 | 0.1188 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.4056 | 0.4056 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.0415 | 0.0415 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0133 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0064 | 0.3223 | 0.3223 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1934 | 0.1934 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0038 | 0.1427 | 0.1427 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0133 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.0133 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0038 | 0.1427 | 0.1427 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0133 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0133 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.179 | 0.179 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0133 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.1 nM | Displacement of [125I]PYY from human recombinant NPY Y5 receptor expressed in mouse LMtk cells | ChEMBL. | 19679469 |
IC50 (binding) | = 2.1 nM | Displacement of [125I]PYY from human recombinant Y5 receptor | ChEMBL. | 19720539 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.