Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TAR-binding protein | 0.0075 | 0.3341 | 0.4736 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0356 | 0.0504 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0854 | 0.121 |
Echinococcus multilocularis | tar DNA binding protein | 0.0075 | 0.3341 | 0.3341 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0075 | 0.3341 | 0.4736 |
Brugia malayi | hypothetical protein | 0.0146 | 0.7054 | 1 |
Onchocerca volvulus | 0.0028 | 0.0854 | 0.121 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.3341 | 0.3341 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0854 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0028 | 0.0854 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0356 | 0.0356 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0854 | 0.121 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0356 | 0.0356 |
Onchocerca volvulus | Huntingtin homolog | 0.0146 | 0.7054 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0854 | 0.121 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0477 | 0.0677 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0477 | 0.0677 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.0854 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.0854 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0356 | 0.0356 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0477 | 0.0677 |
Onchocerca volvulus | Huntingtin homolog | 0.0146 | 0.7054 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.0854 | 0.121 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0028 | 0.0854 | 0.5 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0028 | 0.0854 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.3341 | 0.3341 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0854 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.1504 | 0.2133 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0028 | 0.0854 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0477 | 0.0677 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0028 | 0.0854 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0021 | 0.0477 | 0.139 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0059 | 0.2494 | 0.3536 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0028 | 0.0854 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0021 | 0.0477 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0356 | 0.0504 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.1504 | 0.1504 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0356 | 0.0356 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0028 | 0.0854 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0356 | 0.0356 |
Echinococcus granulosus | tar DNA binding protein | 0.0075 | 0.3341 | 0.3341 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0028 | 0.0854 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0854 | 0.121 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0021 | 0.0477 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0028 | 0.0854 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0356 | 0.0356 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0021 | 0.0477 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0356 | 0.0356 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.0854 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0075 | 0.3341 | 0.4736 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0356 | 0.0504 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0028 | 0.0854 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0059 | 0.2494 | 0.3536 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.3341 | 0.3341 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.7054 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.3341 | 0.3341 |
Brugia malayi | TAR-binding protein | 0.0075 | 0.3341 | 0.4736 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0075 | 0.3341 | 0.4736 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0477 | 0.0677 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0356 | 0.0356 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1504 | 0.2133 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.0854 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.3341 | 0.3341 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0059 | 0.2494 | 0.3536 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0356 | 0.0356 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0356 | 0.0356 |
Brugia malayi | RNA binding protein | 0.0075 | 0.3341 | 0.4736 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0356 | 0.0504 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.7054 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0854 | 0.121 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.0854 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.0854 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.2494 | 0.3536 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 113.4 uM | Cytotoxicity against human HFL1 cells | ChEMBL. | 19818608 |
IC50 (functional) | = 161.1 uM | Cytotoxicity against human HeLa cells | ChEMBL. | 19818608 |
MFC (functional) | = 19.3 uM | Antifungal activity against Candida albicans | ChEMBL. | 19818608 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.