Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 5A, cGMP-specific | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Plasmodium falciparum | cytochrome b | 0.0135 | 0.1644 | 0.5 |
Schistosoma mansoni | patched 1 | 0.0234 | 0.3546 | 0.324 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0234 | 0.3546 | 0.324 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0568 | 1 | 0.5 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0568 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0266 | 0.4176 | 1 |
Trichomonas vaginalis | cAMP-specific phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0065 | 0.0278 | 0.0667 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0074 | 0.0453 | 0.0453 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0234 | 0.3546 | 0.324 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0135 | 0.1644 | 0.5 |
Trichomonas vaginalis | cone cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0065 | 0.0278 | 0.0667 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0266 | 0.4176 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0065 | 0.0278 | 0.0667 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Trichomonas vaginalis | cGMP-inhibited 3,5-cyclic phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0266 | 0.4176 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0234 | 0.3546 | 0.324 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0074 | 0.0453 | 0.0453 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Trichomonas vaginalis | cAMP-specific phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Trichomonas vaginalis | cAMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0568 | 1 | 1 |
Schistosoma mansoni | cytochrome b | 0.0135 | 0.1644 | 0.1247 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Plasmodium vivax | cytochrome b | 0.0135 | 0.1644 | 0.5 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0234 | 0.3546 | 0.2276 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0568 | 1 | 1 |
Trichomonas vaginalis | cone cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0568 | 1 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0568 | 1 | 1 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Trichomonas vaginalis | cAMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0074 | 0.0453 | 0.0453 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0234 | 0.3546 | 0.324 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0568 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0234 | 0.3546 | 0.8491 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Trichomonas vaginalis | cAMP/cGMP cyclic nucleotide phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0266 | 0.4176 | 1 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0234 | 0.3546 | 0.324 |
Toxoplasma gondii | cytochrome b | 0.0135 | 0.1644 | 1 |
Toxoplasma gondii | apocytochrome b, putative | 0.0135 | 0.1644 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.3546 | 0.2276 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Echinococcus multilocularis | protein dispatched 1 | 0.0234 | 0.3546 | 0.324 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0074 | 0.0453 | 0.1086 |
Echinococcus multilocularis | protein patched | 0.0234 | 0.3546 | 0.324 |
Brugia malayi | CHE-14 protein | 0.0234 | 0.3546 | 0.2276 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Echinococcus granulosus | cytochrome B | 0.0135 | 0.1644 | 0.1247 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Loa Loa (eye worm) | hypothetical protein | 0.0568 | 1 | 1 |
Schistosoma mansoni | cytochrome b | 0.0135 | 0.1644 | 0.1247 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0234 | 0.3546 | 0.324 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0074 | 0.0453 | 0.1086 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0568 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.