Detailed information for compound 1070667

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 346.389 | Formula: C18H18N8
  • H donors: 1 H acceptors: 5 LogP: 1.17 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1ncnc(c1)c1c(N)nn2c1nccc2)Cc1ccncc1
  • InChi: 1S/C18H18N8/c1-2-25(11-13-4-7-20-8-5-13)15-10-14(22-12-23-15)16-17(19)24-26-9-3-6-21-18(16)26/h3-10,12H,2,11H2,1H3,(H2,19,24)
  • InChiKey: XTSLTQZNZBRQCY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Janus kinase 2 Starlite/ChEMBL References
Homo sapiens Janus kinase 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.1331 0.2578
Loa Loa (eye worm) ets-domain-containing protein 0.0023 0.0182 0.0184
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0773 0.1034
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0042 0.0578 0.3639
Loa Loa (eye worm) D-ets-2 protein 0.0023 0.0182 0.0184
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0199 0.0961
Trichomonas vaginalis set domain proteins, putative 0.0249 0.4806 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0199 0.0961
Treponema pallidum exodeoxyribonuclease (exoA) 0.0042 0.0578 0.5
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0125 0.091
Brugia malayi beta-lactamase 0.0079 0.1331 0.1376
Echinococcus granulosus ETS transcription factor Elf 2 0.0023 0.0182 0.0221
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0378 0.2034
Brugia malayi beta-lactamase family protein 0.0079 0.1331 0.1376
Mycobacterium tuberculosis Conserved protein 0.0079 0.1331 0.128
Schistosoma mansoni tar DNA-binding protein 0.0207 0.3939 0.4143
Schistosoma mansoni hypothetical protein 0.0076 0.1264 0.1238
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0195 0.0198
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0125 0.0142
Loa Loa (eye worm) hypothetical protein 0.003 0.0331 0.0344
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.1264 0.171
Brugia malayi intermediate filament protein 0.003 0.0342 0.031
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.1331 0.2578
Echinococcus granulosus importin subunit beta 1 0.0031 0.0364 0.0472
Brugia malayi hypothetical protein 0.0076 0.1264 0.1304
Trypanosoma brucei unspecified product 0.002 0.0125 0.091
Leishmania major GTP-binding protein, putative 0.0023 0.0195 0.0564
Plasmodium vivax hypothetical protein, conserved 0.0079 0.1331 0.9698
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0199 0.0651
Loa Loa (eye worm) hypothetical protein 0.0081 0.137 0.1459
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0125 0.0066
Mycobacterium tuberculosis Conserved protein 0.0079 0.1331 0.128
Schistosoma mansoni hypothetical protein 0.0359 0.704 0.7511
Onchocerca volvulus 0.003 0.0342 0.031
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0378 0.1557
Schistosoma mansoni lamin 0.003 0.0342 0.0236
Mycobacterium ulcerans lipase LipD 0.0079 0.1331 1
Brugia malayi Ets-domain containing protein 0.0155 0.2888 0.3054
Loa Loa (eye worm) hypothetical protein 0.0031 0.0364 0.038
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0079 0.1331 0.128
Echinococcus granulosus tar DNA binding protein 0.0207 0.3939 0.5389
Schistosoma mansoni tar DNA-binding protein 0.0207 0.3939 0.4143
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0199 0.0961
Schistosoma mansoni hypothetical protein 0.0359 0.704 0.7511
Onchocerca volvulus 0.0079 0.1331 0.2458
Entamoeba histolytica Ran family GTPase 0.0023 0.0195 0.0617
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.1264 0.171
Mycobacterium leprae Probable lipase LipE 0.0079 0.1331 1
Echinococcus granulosus ETS transcription factor Elf 2 0.0023 0.0182 0.0221
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0363 0.047
Mycobacterium tuberculosis Probable hydrolase 0.0079 0.1331 0.128
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0125 0.0123
Schistosoma mansoni ran 0.0023 0.0195 0.0076
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0125 0.091
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.1331 0.2578
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0342 0.0356
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.4189 0.4483
Echinococcus multilocularis GA binding protein alpha chain 0.0155 0.2888 0.3943
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0578 0.0968
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.1331 0.1417
Brugia malayi hypothetical protein 0.0081 0.137 0.1419
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0125 0.0076
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.137 1
Trypanosoma brucei DNA polymerase eta, putative 0.0046 0.0655 0.4782
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0199 0.0141
Echinococcus granulosus geminin 0.0359 0.704 0.9655
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0023 0.0182 0.0184
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0195 0.0901
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0042 0.0578 1
Echinococcus granulosus ewsr:fli fusion protein type 0.0023 0.0182 0.0221
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0195 0.0239
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0125 0.091
Echinococcus granulosus ETS transcription factor Elf 1 0.0023 0.0182 0.0221
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0195 0.1551
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0363 0.1432
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0079 0.002
Loa Loa (eye worm) hypothetical protein 0.0079 0.1331 0.1417
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0155 0.2888 0.3087
Loa Loa (eye worm) hypothetical protein 0.0017 0.0079 0.0073
Mycobacterium ulcerans hypothetical protein 0.0079 0.1331 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0363 0.0259
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0578 0.3866
Loa Loa (eye worm) hypothetical protein 0.0017 0.0079 0.0073
Schistosoma mansoni lamin 0.003 0.0342 0.0236
Schistosoma mansoni ran 0.0023 0.0195 0.0076
Schistosoma mansoni ets-related 0.0023 0.0182 0.0062
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0054 0.0047
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0195 0.0901
Brugia malayi DNA-binding protein D-ETS-3 0.0023 0.0182 0.0137
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.1331 0.1802
Echinococcus granulosus snurportin 1 0.0336 0.6573 0.9012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0773 0.1034
Loa Loa (eye worm) hypothetical protein 0.0046 0.0655 0.0692
Mycobacterium ulcerans hypothetical protein 0.0023 0.0199 0.0961
Schistosoma mansoni gabp alpha 0.0155 0.2888 0.3001
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.1331 0.2578
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0079 0.1331 0.128
Trypanosoma brucei PAB1-binding protein , putative 0.0081 0.137 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.1331 0.1417
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0125 0.091
Schistosoma mansoni ets 0.0023 0.0182 0.0062
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0079 0.5
Echinococcus multilocularis tar DNA binding protein 0.0207 0.3939 0.5389
Echinococcus granulosus intermediate filament protein 0.003 0.0342 0.0441
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0079 0.1331 0.128
Schistosoma mansoni ap endonuclease 0.0042 0.0578 0.0492
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0125 0.091
Leishmania major importin beta-1 subunit, putative 0.0026 0.0243 0.095
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0125 0.091
Mycobacterium tuberculosis Conserved protein 0.0079 0.1331 0.128
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.1331 0.9715
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0199 0.0651
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0243 0.0253
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.1331 0.1311
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0125 0.091
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0042 0.0578 0.3639
Mycobacterium ulcerans esterase/lipase LipP 0.0079 0.1331 1
Entamoeba histolytica hypothetical protein 0.0076 0.1264 1
Schistosoma mansoni tar DNA-binding protein 0.0207 0.3939 0.4143
Plasmodium vivax SET domain protein, putative 0.0031 0.0363 0.2204
Schistosoma mansoni hypothetical protein 0.0023 0.0182 0.0062
Loa Loa (eye worm) intermediate filament protein 0.003 0.0342 0.0356
Echinococcus multilocularis ets variant gene 4 0.0023 0.0182 0.0221
Trichomonas vaginalis esterase, putative 0.0079 0.1331 0.2578
Loa Loa (eye worm) hypothetical protein 0.0031 0.0363 0.0379
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0195 0.0239
Loa Loa (eye worm) hypothetical protein 0.0054 0.083 0.088
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0199 0.0961
Echinococcus granulosus lamin dm0 0.003 0.0342 0.0441
Toxoplasma gondii LsmAD domain-containing protein 0.0081 0.137 1
Schistosoma mansoni hypothetical protein 0.0036 0.0462 0.0366
Echinococcus multilocularis dna polymerase kappa 0.002 0.0125 0.0142
Schistosoma mansoni tar DNA-binding protein 0.0207 0.3939 0.4143
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0125 0.0368
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0125 0.091
Brugia malayi RNA, U transporter 1 0.0089 0.1547 0.1609
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.1331 0.9687
Schistosoma mansoni importin beta-1 0.0031 0.0364 0.026
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0199 0.0961
Echinococcus granulosus lamin 0.003 0.0342 0.0441
Loa Loa (eye worm) hypothetical protein 0.0017 0.0079 0.0073
Schistosoma mansoni elf1 0.0023 0.0182 0.0062
Toxoplasma gondii exonuclease III APE 0.0042 0.0578 0.3258
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0199 0.0141
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0243 0.0253
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0042 0.0578 0.3978
Loa Loa (eye worm) TAR-binding protein 0.0207 0.3939 0.4215
Echinococcus granulosus ETS domain containing protein Elk 1 0.0023 0.0182 0.0221
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0773 0.0704
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0199 0.0156
Schistosoma mansoni ets-related 0.0471 0.9331 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0125 0.0066
Loa Loa (eye worm) hypothetical protein 0.0017 0.0079 0.0073
Trichomonas vaginalis ap endonuclease, putative 0.0042 0.0578 0.0968
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0195 0.0564
Loa Loa (eye worm) hypothetical protein 0.0079 0.1331 0.1417
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0125 0.0142
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0125 0.091
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0042 0.0578 0.0522
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0243 0.095
Brugia malayi transcription factor E74 isoform 0.0023 0.0182 0.0137
Echinococcus granulosus protein C ets 2 0.0023 0.0182 0.0221
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0125 0.091
Leishmania major DNA polymerase eta, putative 0.0046 0.0655 0.4259
Mycobacterium tuberculosis Probable lipase LipD 0.0079 0.1331 0.128
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.137 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.137 1
Entamoeba histolytica hypothetical protein 0.0076 0.1264 1
Echinococcus multilocularis dna polymerase eta 0.0046 0.0655 0.0872
Brugia malayi RNA recognition motif domain containing protein 0.0207 0.3939 0.4187
Loa Loa (eye worm) hypothetical protein 0.0079 0.1331 0.1417
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0042 0.0578 0.0765
Schistosoma mansoni hypothetical protein 0.0336 0.6573 0.7004
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.034 0.0438
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0462 0.0606
Echinococcus granulosus GA binding protein alpha chain 0.0155 0.2888 0.3943
Schistosoma mansoni ap endonuclease 0.0042 0.0578 0.0492
Mycobacterium leprae conserved hypothetical protein 0.0079 0.1331 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.1331 0.2578
Echinococcus granulosus dna polymerase kappa 0.002 0.0125 0.0142
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0363 0.047
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.1331 0.1376
Entamoeba histolytica hypothetical protein 0.0026 0.0243 0.1039
Echinococcus granulosus tumor protein p63 0.0371 0.7291 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0364 0.2659
Mycobacterium ulcerans beta-lactamase 0.0079 0.1331 1
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0342 0.031
Echinococcus multilocularis lamin 0.003 0.0342 0.0441
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0199 0.0961
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0363 0.0259
Loa Loa (eye worm) hypothetical protein 0.0133 0.2429 0.2595
Trypanosoma cruzi DNA polymerase eta, putative 0.0046 0.0655 0.4259
Loa Loa (eye worm) hypothetical protein 0.0017 0.0079 0.0073
Schistosoma mansoni tar DNA-binding protein 0.0207 0.3939 0.4143
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.1331 0.9687
Schistosoma mansoni DNA polymerase eta 0.0046 0.0655 0.0576
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0363 0.0259
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.137 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0042 0.0578 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.1331 0.1311
Brugia malayi RNA binding protein 0.0207 0.3939 0.4187
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0199 0.0156
Loa Loa (eye worm) hypothetical protein 0.0023 0.0199 0.0202
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.1264 0.1238
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0207 0.3939 0.4215
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0042 0.0578 0.4218
Leishmania major hypothetical protein, conserved 0.0079 0.1331 0.9687
Echinococcus multilocularis musashi 0.003 0.0342 0.0441
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0773 0.0704
Loa Loa (eye worm) hypothetical protein 0.0023 0.0182 0.0184
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0042 0.0578 0.0609
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0364 0.2659
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0773 0.0818
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0042 0.0578 0.3866
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0773 0.1034
Schistosoma mansoni intermediate filament proteins 0.003 0.0342 0.0236
Leishmania major hypothetical protein, conserved 0.0081 0.137 1
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0023 0.0182 0.0062
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0363 0.0259
Onchocerca volvulus 0.0079 0.1331 0.2458
Echinococcus multilocularis ewsr:fli fusion protein type 0.0023 0.0182 0.0221
Echinococcus multilocularis ETS transcription factor Elf 2 0.0023 0.0182 0.0221
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0199 0.0596
Echinococcus multilocularis ETS transcription factor Elf 1 0.0023 0.0182 0.0221
Onchocerca volvulus 0.0079 0.1331 0.2458
Brugia malayi Importin beta-1 subunit 0.0031 0.0364 0.0334
Loa Loa (eye worm) hypothetical protein 0.0023 0.0182 0.0184
Loa Loa (eye worm) hypothetical protein 0.003 0.0342 0.0356
Trichomonas vaginalis ran, putative 0.0023 0.0195 0.015
Mycobacterium tuberculosis Probable lipase LipE 0.0079 0.1331 0.128
Brugia malayi Pre-SET motif family protein 0.0031 0.0363 0.0333
Brugia malayi Ets-domain containing protein 0.0155 0.2888 0.3054
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0125 0.091
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0195 0.0564
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0199 0.0651
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0363 0.047
Echinococcus multilocularis tumor protein p63 0.0371 0.7291 1
Plasmodium falciparum importin beta, putative 0.0031 0.0364 0.2213
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0773 0.1034
Brugia malayi Ets-domain containing protein 0.0023 0.0182 0.0137
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0199 0.0961
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.1331 0.1802
Echinococcus multilocularis ETS transcription factor Elf 2 0.0023 0.0182 0.0221
Plasmodium vivax ataxin-2 like protein, putative 0.0081 0.137 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0125 0.091
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0773 0.0704
Plasmodium vivax importin-beta 2, putative 0.0031 0.0364 0.2213
Echinococcus granulosus dna polymerase eta 0.0046 0.0655 0.0872
Echinococcus multilocularis lamin dm0 0.003 0.0342 0.0441
Echinococcus multilocularis snurportin 1 0.0336 0.6573 0.9012
Echinococcus multilocularis protein C ets 2 0.0023 0.0182 0.0221
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0023 0.0182 0.0221
Loa Loa (eye worm) hypothetical protein 0.0023 0.0199 0.0202
Onchocerca volvulus 0.003 0.0342 0.031
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0079 0.1331 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0199 0.0596
Brugia malayi Pre-SET motif family protein 0.0219 0.4189 0.4456
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0364 0.0472
Toxoplasma gondii ABC1 family protein 0.0079 0.1331 0.9668
Leishmania major DNA polymerase eta, putative 0.0032 0.0378 0.2034
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0125 0.0368
Schistosoma mansoni hypothetical protein 0.0023 0.0182 0.0062
Brugia malayi hypothetical protein 0.0052 0.0786 0.0789
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0773 0.0774
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.083 0.0767
Loa Loa (eye worm) beta-lactamase 0.0079 0.1331 0.1417
Brugia malayi Fli-1 protein 0.0471 0.9331 1
Onchocerca volvulus 0.0031 0.0363 0.0357
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0125 0.091
Brugia malayi TAR-binding protein 0.0207 0.3939 0.4187
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0023 0.0182 0.0184
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0199 0.0596
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0042 0.0578 0.3639
Brugia malayi exodeoxyribonuclease III family protein 0.0042 0.0578 0.0564
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0199 0.0156
Entamoeba histolytica hypothetical protein 0.0076 0.1264 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0462 0.0606
Loa Loa (eye worm) hypothetical protein 0.0023 0.0199 0.0202
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0195 0.0152
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0195 0.1423
Echinococcus multilocularis ETS transcription factor Elf 5 0.0023 0.0182 0.0221
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0336 0.6573 0.704
Loa Loa (eye worm) RNA binding protein 0.0207 0.3939 0.4215
Echinococcus granulosus ETS transcription factor Elf 5 0.0023 0.0182 0.0221
Echinococcus multilocularis geminin 0.0359 0.704 0.9655
Onchocerca volvulus 0.0249 0.4806 1
Brugia malayi beta-lactamase family protein 0.0079 0.1331 0.1376
Loa Loa (eye worm) hypothetical protein 0.0079 0.1331 0.1417
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0042 0.0578 0.3986
Loa Loa (eye worm) hypothetical protein 0.0079 0.1331 0.1417
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0012
Onchocerca volvulus 0.0054 0.083 0.1371
Entamoeba histolytica hypothetical protein 0.0076 0.1264 1
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0364 0.1441
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0042 0.0578 0.0765
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0243 0.0253
Mycobacterium tuberculosis Probable esterase LipL 0.0079 0.1331 0.128
Loa Loa (eye worm) fli-1 protein 0.0471 0.9331 1
Brugia malayi ImpB/MucB/SamB family protein 0.0046 0.0655 0.0648

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.56 uM Inhibition of JAK2 by radiometric assay ChEMBL. 19857967
IC50 (binding) = 4.4 uM Inhibition of JAK3 by radiometric assay ChEMBL. 19857967

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.