Detailed information for compound 107082

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 744.903 | Formula: C38H48N8O6S
  • H donors: 6 H acceptors: 8 LogP: 4.73 Rotable bonds: 20
    Rule of 5 violations (Lipinski): 3
  • SMILES: COc1ccc(cc1)CN[C@H]([C@@H]([C@H](Cc1ccccc1)NC(=O)[C@H](C(C)(C)C)NC(=O)CSc1nnn(n1)C)O)C(=O)NC1[C@H](O)Cc2c1cccc2
  • InChi: 1S/C38H48N8O6S/c1-38(2,3)34(41-30(48)22-53-37-43-45-46(4)44-37)36(51)40-28(19-23-11-7-6-8-12-23)33(49)32(39-21-24-15-17-26(52-5)18-16-24)35(50)42-31-27-14-10-9-13-25(27)20-29(31)47/h6-18,28-29,31-34,39,47,49H,19-22H2,1-5H3,(H,40,51)(H,41,48)(H,42,50)/t28-,29+,31?,32+,33+,34+/m0/s1
  • InChiKey: NHWNXKDOKRJFCA-CSEPWFRMSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) Get druggable targets OG5_131408 All targets in OG5_131408
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Mycobacterium leprae Hypothetical protein Human immunodeficiency virus type 1 protease   99 aa 86 aa 27.9 %
Trypanosoma brucei variant surface glycoprotein (VSG), putative Human immunodeficiency virus type 1 protease   99 aa 80 aa 27.5 %
Giardia lamblia DNA-directed RNA polymerase subunit D Human immunodeficiency virus type 1 protease   99 aa 90 aa 27.8 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Echinococcus multilocularis Chromobox protein 3 Human immunodeficiency virus type 1 protease   99 aa 95 aa 28.4 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0182 0.0144 0.0142
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0075 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0745 0.0696 0.0694
Trichomonas vaginalis conserved hypothetical protein 0.0451 0.0407 0.0662
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0107 0.0071 0.171
Plasmodium vivax plasmepsin V, putative 0.0436 0.0393 0.9647
Echinococcus granulosus high affinity choline transporter 1 0.0075 0.0039 0.0039
Echinococcus multilocularis integrin beta 2 0.2617 0.2528 0.3159
Echinococcus granulosus solute carrier family 5 0.0295 0.0254 0.0254
Mycobacterium ulcerans polyketide synthase 0.0086 0.005 0.0843
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0113 0.0077 0.012
Schistosoma mansoni serine/threonine protein kinase 0.0182 0.0144 0.0144
Echinococcus granulosus protein arginine methyltransferase 0.0191 0.0153 0.0153
Plasmodium vivax aspartyl protease, putative 0.0039 0.0004 0.0053
Brugia malayi Will die slowly protein 0.021 0.0171 0.017
Toxoplasma gondii subtilisin SUB5 0.0451 0.0407 1
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0018 0.0023
Echinococcus multilocularis integrin alpha 3 0.0345 0.0304 0.038
Toxoplasma gondii F5/8 type C domain-containing protein 0.0053 0.0018 0.0393
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0091 0.0055 0.0083
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0039 0.0004 0.0004
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0075 0.0039 0.0933
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0064 0.0029 0.0301
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0191 0.0153 0.0153
Schistosoma mansoni sodium/solute symporter 0.0075 0.0039 0.0039
Plasmodium vivax aspartyl proteinase, putative 0.0039 0.0004 0.0053
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0113 0.0077 0.012
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0298 0.0258 0.2882
Echinococcus multilocularis solute carrier family 5 0.0295 0.0254 0.0318
Giardia lamblia High cysteine protein 0.0091 0.0055 0.0087
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0081 0.0045 0.0833
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0056 0.0021 0.0019
Echinococcus granulosus integrin beta 2 0.2617 0.2528 0.2528
Loa Loa (eye worm) hypothetical protein 0.0107 0.0071 0.0069
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0107 0.0071 0.0071
Plasmodium vivax subtilisin-like protease 2, putative 0.0451 0.0407 1
Loa Loa (eye worm) hypothetical protein 0.0341 0.03 0.0298
Loa Loa (eye worm) hypothetical protein 0.0056 0.0021 0.0019
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0082 0.0047 0.0754
Schistosoma mansoni protein kinase 0.0256 0.0217 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0018 0.0023
Loa Loa (eye worm) hypothetical protein 0.0099 0.0063 0.0061
Loa Loa (eye worm) TK/ALK protein kinase 0.0099 0.0063 0.0061
Toxoplasma gondii subtilisin SUB12 0.0451 0.0407 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0451 0.0407 0.0662
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.014 0.0103 0.249
Toxoplasma gondii F5/8 type C domain-containing protein 0.0053 0.0018 0.0393
Plasmodium falciparum plasmepsin VII 0.0039 0.0004 0.0053
Schistosoma mansoni protein kinase 0.0256 0.0217 0.0217
Echinococcus granulosus protein arginine N methyltransferase 8 0.0191 0.0153 0.0153
Mycobacterium ulcerans protoporphyrinogen oxidase 0.014 0.0103 0.219
Loa Loa (eye worm) hypothetical protein 0.0058 0.0023 0.0021
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0451 0.0407 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0451 0.0407 0.0662
Echinococcus granulosus discoidin domain containing receptor 2 0.0053 0.0018 0.0018
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0295 0.0254 0.0318
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0451 0.0407 0.0662
Loa Loa (eye worm) hypothetical protein 0.0097 0.0061 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.2039 0.1963 0.3214
Loa Loa (eye worm) hypothetical protein 0.0039 0.0004 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0451 0.0407 0.0662
Loa Loa (eye worm) WD40 repeat protein 0.021 0.0171 0.017
Schistosoma mansoni hypothetical protein 0.021 0.0171 0.0171
Loa Loa (eye worm) aspartyl protease 6 0.0039 0.0004 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0018 0.0023
Brugia malayi Eukaryotic aspartyl protease family protein 0.0039 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0091 0.0055 0.0053
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0082 0.0047 0.5
Brugia malayi hypothetical protein 0.014 0.0103 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.2039 0.1963 0.3214
Schistosoma mansoni discoidin domain receptor 0.0053 0.0018 0.0018
Brugia malayi Kelch motif family protein 0.0573 0.0527 0.0525
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0113 0.0077 0.0077
Loa Loa (eye worm) apoptosis regulator protein 0.0056 0.0021 0.0019
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0451 0.0407 1
Brugia malayi hypothetical protein 0.0116 0.008 0.0078
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0113 0.0077 0.0096
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0064 0.0029 0.0301
Plasmodium vivax aspartyl protease, putative 0.0039 0.0004 0.0053
Onchocerca volvulus 0.0053 0.0018 0.023
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.014 0.0103 0.219
Toxoplasma gondii subtilisin SUB11 0.0451 0.0407 1
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0037 0.0002 0.0002
Giardia lamblia Transcriptional regulator, Sir2 family 0.0113 0.0077 0.0149
Loa Loa (eye worm) acyl carrier protein 0.0038 0.0004 0.0002
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0278 0.0238 0.0238
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.014 0.0103 0.219
Schistosoma mansoni amine oxidase 0.014 0.0103 0.0103
Giardia lamblia Furin precursor putative serine protease 0.2039 0.1963 0.5332
Trichomonas vaginalis hypothetical protein 0.2039 0.1963 0.3214
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0191 0.0153 0.3721
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0113 0.0077 0.0091
Brugia malayi hypothetical protein 0.0039 0.0004 0.0002
Plasmodium vivax hypothetical protein, conserved 0.014 0.0103 0.249
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0237 0.0198 0.0196
Loa Loa (eye worm) endoprotease bli-4 1.0245 1 1
Trichomonas vaginalis conserved hypothetical protein 0.2039 0.1963 0.3214
Schistosoma mansoni chromatin regulatory protein sir2 0.0769 0.0719 0.0719
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0089 0.0053 0.0053
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0451 0.0407 0.0407
Schistosoma mansoni dock 0.0053 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0075 0.0039 0.0038
Schistosoma mansoni hypothetical protein 0.0056 0.0021 0.0021
Schistosoma mansoni high-affinity choline transporter 0.0075 0.0039 0.0039
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0053 0.0018 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0018 0.0023
Echinococcus multilocularis adam 0.0207 0.0168 0.0211
Onchocerca volvulus Deterin homolog 0.0107 0.0071 0.0996
Leishmania major sir2-family protein-like protein 0.0113 0.0077 0.0091
Plasmodium vivax aspartyl protease, putative 0.0039 0.0004 0.0053
Echinococcus multilocularis protein jagged 2 0.0091 0.0055 0.0068
Brugia malayi hypothetical protein 0.0542 0.0496 0.0495
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0075 0.0039 0.0049
Onchocerca volvulus 0.0099 0.0063 0.0883
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0451 0.0407 1
Loa Loa (eye worm) hypothetical protein 0.0249 0.0209 0.0208
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0077 0.0041 0.0041
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0081 0.0045 0.0833
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0078 0.0042 0.0041
Loa Loa (eye worm) hypothetical protein 0.0091 0.0055 0.0053
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0113 0.0077 0.1857
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0023 0.0031
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0451 0.0407 0.0662
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0054 0.0019 0.0429
Plasmodium falciparum plasmepsin I 0.0039 0.0004 0.0053
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0769 0.0719 0.1173
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.6263 0.6099 1
Toxoplasma gondii histone deacetylase SIR2-like 0.0113 0.0077 0.1857
Brugia malayi EGF-like domain containing protein 0.0091 0.0055 0.0053
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0113 0.0077 0.0096
Echinococcus multilocularis neuroendocrine convertase 2 0.6472 0.6305 0.7878
Schistosoma mansoni chromatin regulatory protein sir2 0.0113 0.0077 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0018 0.0023
Leishmania major arginine N-methyltransferase-like protein 0.0191 0.0153 0.1259
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0482 0.0438 0.5662
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0018 0.0023
Echinococcus granulosus discoidin domain containing receptor 2 0.0053 0.0018 0.0018
Giardia lamblia Tenascin-X 0.0091 0.0055 0.0087
Schistosoma mansoni discoidin domain receptor 0.0053 0.0018 0.0018
Schistosoma mansoni growth factor receptor-bound protein 0.0133 0.0097 0.0097
Toxoplasma gondii aspartyl protease ASP5 0.0397 0.0355 0.8711
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0039 0.0004 0.0004
Plasmodium vivax plasmepsin IV, putative 0.0039 0.0004 0.0053
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0056 0.0021 0.0021
Schistosoma mansoni growth factor receptor-bound protein 0.0133 0.0097 0.0097
Onchocerca volvulus 0.0745 0.0696 1
Echinococcus granulosus sodium:myo inositol cotransporter 0.0295 0.0254 0.0254
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0256 0.0217 0.0271
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0039 0.0004 0.0004
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0451 0.0407 0.5189
Loa Loa (eye worm) hypothetical protein 0.0089 0.0053 0.0051
Echinococcus multilocularis discoidin domain receptor 0.0053 0.0018 0.0022
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0451 0.0407 0.0405
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0769 0.0719 1
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0023 0.0031
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0049 0.0014 0.0014
Loa Loa (eye worm) subtilase 0.0451 0.0407 0.0405
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0039 0.0004 0.0053
Echinococcus granulosus protein arginine N methyltransferase 7 0.0107 0.0071 0.0071
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0769 0.0719 0.0898
Echinococcus granulosus chromatin regulatory protein sir2 0.0769 0.0719 0.0719
Echinococcus granulosus sodium:glucose cotransporter 0.0295 0.0254 0.0254
Giardia lamblia Sirtuin type 2 0.0113 0.0077 0.0149
Brugia malayi SWIRM domain containing protein 0.0058 0.0023 0.0021
Schistosoma mansoni cathepsin D (A01 family) 0.0039 0.0004 0.0004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0451 0.0407 0.0662
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0451 0.0407 0.0407
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2489 0.2404 0.3938
Mycobacterium ulcerans dehydrogenase 0.014 0.0103 0.219
Echinococcus multilocularis protein kinase c epsilon type 0.0182 0.0144 0.018
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0451 0.0407 0.0662
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0014 0.0017
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0082 0.0047 0.0865
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0769 0.0719 1
Mycobacterium ulcerans polyketide synthase 0.0081 0.0045 0.0712
Loa Loa (eye worm) hypothetical protein 0.0687 0.0639 0.0637
Echinococcus granulosus adam 17 protease 0.0037 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0451 0.0407 0.0662
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0058 0.0023 0.0028
Entamoeba histolytica PH domain containing protein kinase, putative 0.0149 0.0111 0.1272
Plasmodium vivax hypothetical protein, conserved 0.014 0.0103 0.249
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0107 0.0071 0.0089
Leishmania major silent information regulator 2, putative 0.0769 0.0719 1
Echinococcus multilocularis protein will die slowly 0.021 0.0171 0.0214
Mycobacterium tuberculosis Conserved hypothetical protein 0.014 0.0103 0.2284
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0039 0.0004 0.0004
Mycobacterium leprae Probable polyketide synthase Pks1 0.0086 0.005 0.0843
Plasmodium falciparum subtilisin-like protease 3 0.0451 0.0407 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0039 0.0004 0.0004
Chlamydia trachomatis protoporphyrinogen oxidase 0.014 0.0103 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0451 0.0407 0.0662
Giardia lamblia Hypothetical protein 0.0769 0.0719 0.1913
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0081 0.0045 0.0712
Brugia malayi NAD-dependent deacetylase SIRT1 0.0113 0.0077 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.2039 0.1963 0.3214
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0451 0.0407 0.0662
Schistosoma mansoni hypothetical protein 0.0053 0.0018 0.0018
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0081 0.0045 0.0823
Echinococcus granulosus integrin alpha ps 0.0097 0.0061 0.0061
Brugia malayi angiogenesis inhibito 0.0052 0.0017 0.0015
Echinococcus multilocularis disintegrin and metalloproteinase 0.0037 0.0002 0.0002
Toxoplasma gondii histone lysine-specific demethylase 0.014 0.0103 0.249
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0451 0.0407 0.0662
Mycobacterium ulcerans Type I modular polyketide synthase 0.0081 0.0045 0.0712
Toxoplasma gondii type I fatty acid synthase, putative 0.0086 0.005 0.1193
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0113 0.0077 0.0077
Trypanosoma cruzi subtilisin peptidase 0.0451 0.0407 0.5189
Schistosoma mansoni chromatin regulatory protein sir2 0.0113 0.0077 0.0077
Echinococcus granulosus neuroendocrine convertase 2 0.6472 0.6305 0.6305
Plasmodium falciparum plasmepsin X 0.0039 0.0004 0.0053
Loa Loa (eye worm) hypothetical protein 0.0091 0.0055 0.0053
Schistosoma mansoni btb and poz domain-containing protein 0.0053 0.0018 0.0018
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0089 0.0053 0.0066
Brugia malayi Protein kinase domain containing protein 0.0053 0.0018 0.0016
Echinococcus multilocularis glutamate receptor 2 0.0049 0.0014 0.0017
Brugia malayi Carm1-pending protein 0.0107 0.0071 0.0069
Echinococcus granulosus nmda type glutamate receptor 0.0115 0.0078 0.0078
Echinococcus multilocularis integrin alpha ps 0.0202 0.0164 0.0205
Schistosoma mansoni protein arginine n-methyltransferase 0.0107 0.0071 0.0071
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0037 0.0002 0.0002
Schistosoma mansoni chromatin regulatory protein sir2 0.0113 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0099 0.0063 0.0061
Brugia malayi hypothetical protein 0.0298 0.0258 0.0256
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0451 0.0407 0.0662
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0113 0.0077 0.012
Mycobacterium ulcerans oxidoreductase 0.014 0.0103 0.219
Brugia malayi transcriptional regulator, Sir2 family protein 0.0113 0.0077 0.0075
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0053 0.0018 0.0023
Plasmodium falciparum plasmepsin III 0.0039 0.0004 0.0053
Plasmodium vivax NAD-dependent deacetylase, putative 0.0113 0.0077 0.1857
Schistosoma mansoni hypothetical protein 0.2039 0.1963 0.1963
Brugia malayi Integrin beta pat-3 precursor 0.3541 0.3433 0.3432
Plasmodium vivax aspartyl proteinase, putative 0.0039 0.0004 0.0053
Onchocerca volvulus Fatty acid synthase homolog 0.0151 0.0114 0.1613
Schistosoma mansoni serine/threonine protein kinase 0.0237 0.0198 0.0198
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0081 0.0045 0.0712
Onchocerca volvulus 0.0039 0.0004 0.0031
Plasmodium falciparum subtilisin-like protease 2 0.0451 0.0407 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0014 0.0014
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0053 0.0018 0.0022
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0237 0.0198 0.0247
Plasmodium falciparum plasmepsin VIII, putative 0.0039 0.0004 0.0053
Toxoplasma gondii subtilisin SUB1 0.0451 0.0407 1
Brugia malayi protein kinase C II. 0.0182 0.0144 0.0142
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0113 0.0077 0.012
Echinococcus granulosus c-Jun N-terminal kinases 0.0237 0.0198 0.0198
Trichomonas vaginalis hypothetical protein 0.0091 0.0055 0.0083
Echinococcus granulosus c4b binding protein beta chain 0.0037 0.0002 0.0002
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0113 0.0077 0.012
Brugia malayi Calcium binding EGF domain containing protein 0.0041 0.0006 0.0004
Brugia malayi Sodium:solute symporter family protein 0.0075 0.0039 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0451 0.0407 0.0662
Trichomonas vaginalis conserved hypothetical protein 0.0451 0.0407 0.0662
Echinococcus granulosus fibrillin 2 0.0091 0.0055 0.0055
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2489 0.2404 0.3938
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0009
Loa Loa (eye worm) transcriptional regulator 0.0113 0.0077 0.0075
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0042 0.0007 0.0139
Loa Loa (eye worm) transcriptional regulator 0.0113 0.0077 0.0075
Loa Loa (eye worm) hypothetical protein 0.0052 0.0017 0.0015
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0341 0.03 0.0298
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.014 0.0103 0.249
Loa Loa (eye worm) hypothetical protein 0.0091 0.0055 0.0053
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0451 0.0407 1
Schistosoma mansoni inositol transporter 0.0295 0.0254 0.0254
Toxoplasma gondii hypothetical protein 0.0091 0.0055 0.1304
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0451 0.0407 0.0662
Brugia malayi EGF-like domain containing protein 0.0091 0.0055 0.0053
Mycobacterium ulcerans NAD-dependent deacetylase 0.0113 0.0077 0.1532
Echinococcus granulosus glutamate NMDA receptor subunit 0.0271 0.0231 0.0231
Schistosoma mansoni site-1 peptidase (S08 family) 0.0451 0.0407 0.0407
Echinococcus granulosus Furin 1 0.2489 0.2404 0.2404
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0039 0.0004 0.0004
Brugia malayi hypothetical protein 0.0039 0.0004 0.0002
Echinococcus multilocularis membrane bound transcription factor site 1 0.0451 0.0407 0.0509
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0086 0.005 0.0843
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0451 0.0407 0.0662
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0018 0.0023
Echinococcus granulosus growth factor receptor bound protein 2 0.0133 0.0097 0.0097
Echinococcus multilocularis MAM 0.0099 0.0063 0.0079
Schistosoma mansoni hypothetical protein 0.0099 0.0063 0.0063
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0113 0.0077 0.0149
Onchocerca volvulus 0.0107 0.0071 0.0996
Schistosoma mansoni dihydroceramide desaturase 0.0037 0.0002 0.0002
Brugia malayi Protein kinase domain containing protein 0.0099 0.0063 0.0061
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0039 0.0004 0.0002
Plasmodium vivax subtilisin-like serine protease, putative 0.0451 0.0407 1
Toxoplasma gondii aspartyl protease ASP3 0.0039 0.0004 0.0053
Brugia malayi EGF-like domain containing protein 0.0091 0.0055 0.0053
Echinococcus multilocularis nmda type glutamate receptor 0.0115 0.0078 0.0098
Brugia malayi Furin-like cysteine rich region family protein 0.065 0.0603 0.0601
Mycobacterium tuberculosis Probable thioesterase TesA 0.007 0.0034 0.055
Mycobacterium leprae Polyketide synthase Pks13 0.0122 0.0085 0.1752
Mycobacterium ulcerans polyketide synthase Pks13 0.0122 0.0085 0.1752
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0191 0.0153 0.0244
Echinococcus granulosus fibrillin 1 0.0093 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0099 0.0063 0.0061
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0113 0.0077 0.0091
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0078 0.0042 0.076
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0769 0.0719 0.1173
Onchocerca volvulus 0.0178 0.014 0.199
Loa Loa (eye worm) hypothetical protein 0.0052 0.0017 0.0015
Loa Loa (eye worm) hypothetical protein 0.0075 0.0039 0.0038
Plasmodium falciparum protoporphyrinogen oxidase 0.014 0.0103 0.249
Schistosoma mansoni c4b-binding protein beta chain 0.0037 0.0002 0.0002
Echinococcus multilocularis integrin alpha ps 0.0097 0.0061 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0451 0.0407 0.0662
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0769 0.0719 1
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.2039 0.1963 0.3214
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0687 0.0639 0.0639
Schistosoma mansoni site-1 peptidase (S08 family) 0.0451 0.0407 0.0407
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.2039 0.1963 0.3214
Brugia malayi amine oxidase, flavin-containing family protein 0.0198 0.016 0.0158
Plasmodium vivax subtilisin-like protease 1 0.0451 0.0407 1
Trypanosoma brucei subtilisin peptidase 0.0451 0.0407 0.5189
Mycobacterium tuberculosis Possible oxidoreductase 0.014 0.0103 0.2284
Giardia lamblia Tenascin-37 0.0091 0.0055 0.0087
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0089 0.0053 0.0053
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0039 0.0004 0.0004
Loa Loa (eye worm) fatty acid synthase 0.0083 0.0047 0.0045
Mycobacterium ulcerans Sir2-like regulatory protein 0.0113 0.0077 0.1532
Echinococcus multilocularis serine:threonine protein kinase N2 0.0166 0.0129 0.0161
Echinococcus multilocularis high affinity choline transporter 1 0.0075 0.0039 0.0049
Echinococcus multilocularis fibrillin 1 0.0093 0.0057 0.0071
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0256 0.0217 0.0217
Brugia malayi Integrin alpha pat-2 precursor 0.0451 0.0407 0.0406
Loa Loa (eye worm) reprolysin 0.0089 0.0053 0.0051
Echinococcus granulosus protein kinase c epsilon type 0.0182 0.0144 0.0144
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0113 0.0077 0.1857
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0081 0.0045 0.0823
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0295 0.0254 0.0318
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0056 0.0021 0.0026
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0116 0.008 0.008
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0107 0.0071 0.0088
Schistosoma mansoni glutamate receptor NMDA 0.0049 0.0014 0.0014
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0703 0.0655 0.0655
Trichomonas vaginalis conserved hypothetical protein 0.2039 0.1963 0.3214
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0769 0.0719 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0224 0.0185 0.0184
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0156 0.0118 0.0117
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0451 0.0407 1
Trypanosoma brucei SIR2-like protein 4, putative 0.0113 0.0077 0.0091
Schistosoma mansoni hypothetical protein 0.0107 0.0071 0.0071
Brugia malayi AMP-binding enzyme family protein 0.0078 0.0042 0.0041
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0451 0.0407 0.0662
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0191 0.0153 0.0191
Toxoplasma gondii subtilisin SUB7 0.0451 0.0407 1
Loa Loa (eye worm) hypothetical protein 0.0298 0.0258 0.0256
Plasmodium falciparum LCCL domain-containing protein 0.0053 0.0018 0.0393
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0191 0.0153 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.2039 0.1963 0.3214
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0122 0.0085 0.1851
Echinococcus granulosus protein will die slowly 0.021 0.0171 0.0171
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0298 0.0258 0.3375
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0058 0.0023 0.0023
Brugia malayi Sex muscle abnormal protein 5 0.0133 0.0097 0.0095
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0451 0.0407 1
Echinococcus granulosus glutamate receptor 2 0.0049 0.0014 0.0014
Schistosoma mansoni chromatin regulatory protein sir2 0.0113 0.0077 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.2039 0.1963 0.3214
Toxoplasma gondii subtilisin SUB9 0.0451 0.0407 1
Echinococcus granulosus methyltransferase protein 5 0.0107 0.0071 0.0071
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0451 0.0407 1
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0482 0.0438 0.5662
Echinococcus multilocularis epidermal growth factor receptor 0.065 0.0603 0.0753
Brugia malayi proprotein convertase 2 0.6472 0.6305 0.6304
Giardia lamblia High cysteine membrane protein Group 2 0.3773 0.3661 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0081 0.0045 0.0712
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0451 0.0407 0.0407
Loa Loa (eye worm) hypothetical protein 0.0687 0.0639 0.0637
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0045 0.001 0.001
Onchocerca volvulus Putative cubilin 0.0041 0.0006 0.0059
Loa Loa (eye worm) proprotein convertase 2 0.2489 0.2404 0.2403
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0064 0.0029 0.0301
Echinococcus granulosus serine:threonine protein kinase N2 0.0149 0.0111 0.0111
Toxoplasma gondii subtilisin SUB4 0.0451 0.0407 1
Loa Loa (eye worm) hypothetical protein 0.014 0.0103 0.0101
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0113 0.0077 0.0778
Onchocerca volvulus 0.0451 0.0407 0.5842
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0107 0.0071 0.0089
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0191 0.0153 0.0244
Schistosoma mansoni hypothetical protein 0.0107 0.0071 0.0071
Mycobacterium ulcerans thioesterase 0.007 0.0034 0.0435
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0687 0.0639 0.0798
Giardia lamblia Neurogenic locus Notch protein precursor 0.0091 0.0055 0.0087
Schistosoma mansoni inositol transporter 0.0295 0.0254 0.0254
Brugia malayi hypothetical protein 0.0099 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 1.0245 1 1
Brugia malayi ADAM-TS Spacer 1 family protein 0.0052 0.0017 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0018 0.0023
Loa Loa (eye worm) hypothetical protein 0.0039 0.0004 0.0002
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.2039 0.1963 0.3214
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0107 0.0071 0.0069
Schistosoma mansoni amine oxidase 0.014 0.0103 0.0103
Plasmodium vivax LCCL domain-containing protein 0.0053 0.0018 0.0393
Brugia malayi neuroendocrine convertase 1 precursor 0.6472 0.6305 0.6304
Echinococcus granulosus adam 0.0207 0.0168 0.0168
Plasmodium falciparum LCCL domain-containing protein 0.0053 0.0018 0.0393
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0039 0.0004 0.0004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2489 0.2404 0.3938
Echinococcus multilocularis C type lectin domian containing protein 0.0037 0.0002 0.0002
Loa Loa (eye worm) sirtuin 4 0.0113 0.0077 0.0075
Onchocerca volvulus 0.021 0.0171 0.2444
Brugia malayi ADAMTS-like protease 0.0052 0.0017 0.0015
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0081 0.0045 0.0823
Leishmania major subtilisin-like serine peptidase 0.0451 0.0407 0.5189
Toxoplasma gondii SWIRM domain-containing protein 0.0058 0.0023 0.0521
Echinococcus granulosus sodium:glucose cotransporter 2 0.0295 0.0254 0.0254
Echinococcus multilocularis protoporphyrinogen oxidase 0.014 0.0103 0.0128
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0191 0.0153 0.3721
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0107 0.0071 0.0069
Brugia malayi GCC2 and GCC3 family protein 0.0046 0.0011 0.0009
Schistosoma mansoni hypothetical protein 0.0099 0.0063 0.0063
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0107 0.0071 0.0071
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0113 0.0077 0.012
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.014 0.0103 0.249
Trypanosoma cruzi UDP-galactopyranose mutase 0.014 0.0103 0.0488
Schistosoma mansoni integrin alpha-ps 0.0105 0.0069 0.0069
Echinococcus multilocularis discoidin domain containing receptor 2 0.0053 0.0018 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0018 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0018 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0018 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0018 0.0023
Loa Loa (eye worm) hypothetical protein 0.0041 0.0006 0.0004
Schistosoma mansoni protein kinase 0.0256 0.0217 0.0217
Echinococcus granulosus discoidin domain receptor 0.0053 0.0018 0.0018
Schistosoma mansoni integrin alpha-ps 0.0202 0.0164 0.0164
Toxoplasma gondii F5/8 type C domain-containing protein 0.0053 0.0018 0.0393
Echinococcus multilocularis growth factor receptor bound protein 2 0.0133 0.0097 0.0121
Onchocerca volvulus 0.0099 0.0063 0.0883
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0039 0.0004 0.0053
Brugia malayi Protein arginine N-methyltransferase 0.0107 0.0071 0.0069
Onchocerca volvulus 0.0039 0.0004 0.0031
Toxoplasma gondii PA14 domain-containing protein 0.0053 0.0018 0.0393
Plasmodium falciparum plasmepsin VI 0.0039 0.0004 0.0053
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0769 0.0719 0.0719
Echinococcus granulosus MAM 0.0099 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0542 0.0496 0.0495
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0482 0.0438 0.5662
Toxoplasma gondii subtilisin SUB2 0.0451 0.0407 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0451 0.0407 0.0662
Toxoplasma gondii type I fatty acid synthase, putative 0.006 0.0024 0.0556
Trichomonas vaginalis WD repeat domain, putative 0.021 0.0171 0.0275
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0039 0.0004 0.0005
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.006 0.0025 0.0311
Giardia lamblia Tenascin-like 0.0091 0.0055 0.0087
Schistosoma mansoni integrin beta subunit 0.2075 0.1998 0.1998
Trichomonas vaginalis conserved hypothetical protein 0.2039 0.1963 0.3214
Brugia malayi Reprolysin 0.0052 0.0017 0.0015
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0113 0.0077 0.0096
Giardia lamblia Neurogenic locus notch-like protein 0.0091 0.0055 0.0087
Giardia lamblia High cysteine protein 0.0091 0.0055 0.0087
Loa Loa (eye worm) hypothetical protein 0.0121 0.0084 0.0082
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0053 0.0018 0.0023
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0107 0.0071 0.011
Echinococcus multilocularis integrin alpha ps 0.0202 0.0164 0.0205
Entamoeba histolytica hypothetical protein 0.0298 0.0258 0.3375
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0191 0.0153 0.0153
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.6263 0.6099 0.7621
Echinococcus granulosus lysine specific histone demethylase 1A 0.014 0.0103 0.0103
Plasmodium vivax protoporphyrinogen oxidase, putative 0.014 0.0103 0.249
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0039 0.0004 0.0004
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0703 0.0655 0.0818
Brugia malayi EGF-like domain containing protein 0.0091 0.0055 0.0053
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0066 0.003 0.0445
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0107 0.0071 0.171
Echinococcus multilocularis c4b binding protein beta chain 0.0037 0.0002 0.0002
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1528 0.1462 0.1462
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 1.0245 1 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0451 0.0407 0.0662
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0018 0.0023
Schistosoma mansoni integrin alpha 0.0451 0.0407 0.0407
Schistosoma mansoni memapsin-2 (A01 family) 0.0039 0.0004 0.0004
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0133 0.0097 0.0095
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0113 0.0077 0.1634
Brugia malayi transcriptional regulator, Sir2 family protein 0.0113 0.0077 0.0075
Echinococcus granulosus inhibitor of apoptosis protein 0.0107 0.0071 0.0071
Loa Loa (eye worm) integrin beta-2 0.3541 0.3433 0.3432
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0451 0.0407 0.0509
Leishmania major UDP-galactopyranose mutase 0.014 0.0103 0.0488
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.007 0.0034 0.0435
Schistosoma mansoni furin-1 (S08 family) 0.4433 0.4308 0.4308
Echinococcus multilocularis discoidin domain containing receptor 2 0.0053 0.0018 0.0022
Mycobacterium ulcerans Type I modular polyketide synthase 0.0081 0.0045 0.0712
Trichomonas vaginalis conserved hypothetical protein 0.2039 0.1963 0.3214
Mycobacterium ulcerans monoamine oxidase 0.014 0.0103 0.219
Loa Loa (eye worm) hypothetical protein 0.0138 0.0101 0.0099
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0039 0.0004 0.0004
Trypanosoma cruzi UDP-galactopyranose mutase 0.014 0.0103 0.0488
Brugia malayi SWIRM domain containing protein 0.0745 0.0696 0.0694
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.2489 0.2404 0.2404
Trichomonas vaginalis hypothetical protein 0.0053 0.0018 0.0023
Mycobacterium leprae Possible secreted protease 0.0451 0.0407 1
Toxoplasma gondii aspartyl protease 0.0039 0.0004 0.0053
Brugia malayi aspartic protease BmAsp-2, identical 0.0039 0.0004 0.0002
Echinococcus multilocularis fibrillin 2 0.0091 0.0055 0.0068
Schistosoma mansoni apoptosis regulator bax 0.0056 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.3983 0.3867 0.3865
Onchocerca volvulus 0.0053 0.0018 0.023
Brugia malayi Stress-activated protein kinase jnk-1 0.0237 0.0198 0.0196
Schistosoma mansoni hypothetical protein 0.0056 0.0021 0.0021
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0053 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0198 0.016 0.0158
Plasmodium falciparum plasmepsin II 0.0039 0.0004 0.0053
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0451 0.0407 0.0662
Toxoplasma gondii histone deacetylase SIR2 0.0113 0.0077 0.1857
Schistosoma mansoni septate junction protein 0.0062 0.0027 0.0027
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0271 0.0231 0.0289
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0451 0.0407 0.0405
Toxoplasma gondii bicoid-interacting protein BIN3 0.0107 0.0071 0.171
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0224 0.0185 0.0184
Onchocerca volvulus 0.0078 0.0042 0.0588
Giardia lamblia Tenascin precursor 0.0091 0.0055 0.0087
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0573 0.0527 0.0525
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0769 0.0719 1
Schistosoma mansoni inhibitor of apoptosis protein 0.0107 0.0071 0.0071
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.014 0.0103 0.219
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2489 0.2404 0.3938
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0014 0.0014
Onchocerca volvulus 0.0075 0.0039 0.0545
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0086 0.005 0.0843
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0014 0.0017
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0039 0.0004 0.0002
Giardia lamblia hypothetical protein 0.0091 0.0055 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.2039 0.1963 0.3214
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0086 0.005 0.0843
Schistosoma mansoni SWI/SNF complex-related 0.0058 0.0023 0.0023
Plasmodium falciparum plasmepsin IV 0.0039 0.0004 0.0053
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0089 0.0053 0.0053
Brugia malayi aspartic protease BmAsp-1, identical 0.0039 0.0004 0.0002
Echinococcus multilocularis chromatin regulatory protein sir2 0.0769 0.0719 0.0898
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0107 0.0071 0.011
Loa Loa (eye worm) hypothetical protein 0.0113 0.0077 0.0075
Toxoplasma gondii subtilisin SUB8 0.0451 0.0407 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0451 0.0407 0.0662
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0082 0.0047 0.5
Echinococcus granulosus integrin alpha ps 0.0202 0.0164 0.0164
Echinococcus granulosus furin 1.0245 1 1
Mycobacterium ulcerans thioesterase TesA 0.007 0.0034 0.0435
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0014 0.0017
Brugia malayi celfurPC protein 0.8206 0.8003 0.8003
Plasmodium vivax hypothetical protein, conserved 0.0113 0.0077 0.1857
Plasmodium falciparum plasmepsin IX 0.0039 0.0004 0.0053
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0107 0.0071 0.011
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0045 0.001 0.001
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0086 0.005 0.0843
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0053 0.0018 0.013
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0113 0.0077 0.012
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0451 0.0407 1
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0122 0.0085 0.1851
Echinococcus multilocularis inhibitor of apoptosis protein 0.0107 0.0071 0.0088
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0107 0.0071 0.0071
Loa Loa (eye worm) transcriptional regulator 0.0769 0.0719 0.0717
Schistosoma mansoni hypothetical protein 0.0056 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0044 0.0009 0.0007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2489 0.2404 0.3938
Loa Loa (eye worm) hypothetical protein 0.0354 0.0312 0.0311
Brugia malayi transcriptional regulator, Sir2 family protein 0.0769 0.0719 0.0717
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0081 0.0045 0.0043
Loa Loa (eye worm) hypothetical protein 0.0451 0.0407 0.0405
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2489 0.2404 0.3938
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.014 0.0103 0.0103
Mycobacterium leprae PROBABLE CONSERVED TRANSMEMBRANE PROTEIN 0.0053 0.0018 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0018 0.0023
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0056 0.0021 0.0021
Echinococcus granulosus disintegrin and metalloproteinase 0.0037 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0451 0.0407 0.0662
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.6263 0.6099 1
Schistosoma mansoni hypothetical protein 0.0097 0.0061 0.0061
Echinococcus multilocularis protein arginine methyltransferase 0.0191 0.0153 0.0191
Toxoplasma gondii aspartyl protease ASP1 0.0039 0.0004 0.0053
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0107 0.0071 0.0693
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0086 0.005 0.0952
Echinococcus multilocularis 0.8206 0.8003 1
Brugia malayi Angiotensin-converting enzyme family protein 0.0657 0.061 0.0608
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0086 0.005 0.0952
Echinococcus multilocularis 0.014 0.0103 0.0128
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0053 0.0018 0.0022
Brugia malayi GH02984p 0.0075 0.0039 0.0038
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0451 0.0407 0.0662
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0113 0.0077 0.0091
Plasmodium vivax LCCL domain-containing protein 0.0053 0.0018 0.0393
Loa Loa (eye worm) hypothetical protein 0.0107 0.0071 0.0069
Onchocerca volvulus 0.0091 0.0055 0.0762
Loa Loa (eye worm) hypothetical protein 0.0053 0.0018 0.0016
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0451 0.0407 0.0662
Loa Loa (eye worm) hypothetical protein 0.0105 0.0069 0.0067
Echinococcus multilocularis discoidin domain containing receptor 2 0.0053 0.0018 0.0022
Echinococcus granulosus discoidin domain containing receptor 2 0.0053 0.0018 0.0018
Brugia malayi Subtilase family protein 0.0451 0.0407 0.0405
Mycobacterium ulcerans Type I modular polyketide synthase 0.0081 0.0045 0.0712
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0049 0.0014 0.0017
Schistosoma mansoni chromatin regulatory protein sir2 0.0769 0.0719 0.0719
Schistosoma mansoni chromatin regulatory protein sir2 0.0769 0.0719 0.0719
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0451 0.0407 0.0662
Echinococcus granulosus epidermal growth factor receptor 0.065 0.0603 0.0603
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.2039 0.1963 0.3214
Toxoplasma gondii subtilisin SUB10 0.0451 0.0407 1
Entamoeba histolytica hypothetical protein, conserved 0.0113 0.0077 0.0778
Schistosoma mansoni glutamate receptor NMDA 0.0271 0.0231 0.0231
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0107 0.0071 0.0069
Onchocerca volvulus 0.0146 0.0109 0.154
Echinococcus granulosus membrane bound transcription factor site 1 0.0451 0.0407 0.0407
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0113 0.0077 0.012
Plasmodium falciparum subtilisin-like protease 1 0.0451 0.0407 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.065 0.0603 0.0601
Echinococcus granulosus integrin alpha 3 0.0345 0.0304 0.0304
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0086 0.005 0.0952
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.014 0.0103 0.249
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0113 0.0077 0.0077
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.6263 0.6099 0.6099
Loa Loa (eye worm) Carm1-pending protein 0.0107 0.0071 0.0069
Echinococcus granulosus lysine specific histone demethylase 1A 0.0687 0.0639 0.0639
Loa Loa (eye worm) integrin alpha pat-2 0.0695 0.0646 0.0645
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0113 0.0077 0.0091
Echinococcus multilocularis Furin 1 0.2489 0.2404 0.3004
Schistosoma mansoni tyrosine kinase 0.065 0.0603 0.0603
Loa Loa (eye worm) hypothetical protein 0.0053 0.0018 0.0016
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0451 0.0407 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0113 0.0077 0.012
Schistosoma mansoni cathepsin D (A01 family) 0.0039 0.0004 0.0004
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0113 0.0077 0.0778
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0451 0.0407 0.0662
Plasmodium falciparum plasmepsin V 0.0436 0.0393 0.9647
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0657 0.061 0.0608
Brugia malayi Pepsin A precursor 0.0039 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.014 0.0103 0.0101
Toxoplasma gondii subtilisin SUB6 0.0451 0.0407 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0004 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0451 0.0407 0.0662
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0298 0.0258 0.2882
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0018 0.0023
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0298 0.0258 0.2882
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0115 0.0078 0.0098
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0191 0.0153 0.0244
Echinococcus granulosus C type lectin domian containing protein 0.0037 0.0002 0.0002
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0191 0.0153 0.3721

Activities

Activity type Activity value Assay description Source Reference
AUC (ADMET) = 7.4 uM hr Oral Bioavailability of the compound was measured as area-under-curve(AUC) value at dose 125 mg/kg ChEMBL. 8642565
Cmax (ADMET) = 2.8 uM Oral Bioavailability of the compound was measured as Maximal observed concentration(Cmax) value at dose 125 mg/kg ChEMBL. 8642565
IC50 (functional) = 180 nM Antiviral activity against HIV-1, IIIB, in MT-4 Cells ChEMBL. 8642565
Ki (binding) = 12 nM Binding affinity against HIV-1 protease ChEMBL. 8642565
Ki (binding) = 12 nM Binding affinity against HIV-1 protease ChEMBL. 8642565
S = 78 uM Solubility (phosphate-buffered saline, pH =7.4) ChEMBL. 8642565

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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