Detailed information for compound 1070859

Basic information

Technical information
  • TDR Targets ID: 1070859
  • Name: [5-[4-amino-5-fluoro-7-(3-hydroxypropyl)-1-(2 -methylpropyl)benzimidazol-2-yl]furan-2-yl]ph osphonic acid
  • MW: 411.364 | Formula: C18H23FN3O5P
  • H donors: 4 H acceptors: 5 LogP: 1.19 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCCc1cc(F)c(c2c1n(CC(C)C)c(n2)c1ccc(o1)P(=O)(O)O)N
  • InChi: 1S/C18H23FN3O5P/c1-10(2)9-22-17-11(4-3-7-23)8-12(19)15(20)16(17)21-18(22)13-5-6-14(27-13)28(24,25)26/h5-6,8,10,23H,3-4,7,9,20H2,1-2H3,(H2,24,25,26)
  • InChiKey: OXCXRNSTZLBRCN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [5-[4-amino-5-fluoro-7-(3-hydroxypropyl)-1-isobutyl-benzimidazol-2-yl]-2-furyl]phosphonic acid
  • [5-[4-amino-5-fluoro-7-(3-hydroxypropyl)-1-isobutyl-2-benzimidazolyl]-2-furyl]phosphonic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens fructose-1,6-bisphosphatase 1 Starlite/ChEMBL References
Rattus norvegicus Fructose-1,6-bisphosphatase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma congolense fructose-1,6-bisphosphate, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Echinococcus granulosus fructose 16 bisphosphatase 1 Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania mexicana fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania major Get druggable targets OG5_127400 All targets in OG5_127400
Schistosoma mansoni fructose-16-bisphosphatase-related Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma brucei fructose-1,6-bisphosphatase Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma brucei gambiense fructose-1,6-bisphosphate, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Candida albicans similar to S. cerevisiae FBP1 (YLR377C) Fructose-1,6-bisphosphatase Get druggable targets OG5_127400 All targets in OG5_127400
Toxoplasma gondii fructose-bisphospatase II Get druggable targets OG5_127400 All targets in OG5_127400
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania donovani fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Loa Loa (eye worm) fructose-1,6-bisphosphatase Get druggable targets OG5_127400 All targets in OG5_127400
Schistosoma japonicum ko:K03841 fructose-1,6-bisphosphatase I, putative Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania braziliensis fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Leishmania infantum fructose-1,6-bisphosphatase, cytosolic, putative Get druggable targets OG5_127400 All targets in OG5_127400
Neospora caninum Fructose-1 6-biphosphatase, related Get druggable targets OG5_127400 All targets in OG5_127400
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii fructose-bisphospatase I Fructose-1,6-bisphosphatase   363 aa 326 aa 31.3 %
Neospora caninum fructose-1,6-bisphosphatase, putative Fructose-1,6-bisphosphatase   363 aa 298 aa 32.5 %
Toxoplasma gondii fructose-bisphospatase I fructose-1,6-bisphosphatase 1 338 aa 326 aa 31.0 %
Onchocerca volvulus CES-1 homolog Fructose-1,6-bisphosphatase   363 aa 319 aa 60.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0019 0.0039 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0151 0.0315
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0363 0.0363
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.003 0.0202 0.0369
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0302 0.0631
Echinococcus granulosus g protein coupled receptor 0.0019 0.0039 0.0039
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0191 0.0349
Loa Loa (eye worm) hypothetical protein 0.007 0.0812 0.1484
Echinococcus multilocularis musashi 0.0019 0.004 0.004
Brugia malayi hypothetical protein 0.0019 0.0039 0.0072
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0019 0.0039 0.0039
Echinococcus multilocularis g-protein coupled receptor 0.0019 0.0039 0.0039
Brugia malayi Fli-1 protein 0.0155 0.2099 0.3834
Echinococcus granulosus g protein coupled receptor 0.0019 0.0039 0.0039
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0019 0.0039 0.0039
Brugia malayi Pre-SET motif family protein 0.0042 0.0387 0.0706
Brugia malayi Pre-SET motif family protein 0.0292 0.418 0.7635
Schistosoma mansoni hypothetical protein 0.0048 0.0477 0.0477
Brugia malayi hypothetical protein 0.0019 0.0039 0.0072
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Schistosoma mansoni amine GPCR 0.0019 0.0039 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0194 0.0405
Echinococcus multilocularis neuropeptide s receptor 0.0019 0.0039 0.0039
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0022 0.0087 0.0087
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0039 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0023 0.0102 0.0187
Brugia malayi Serotonin receptor 0.0019 0.0039 0.0072
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0206 0.2872 0.5994
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0144 0.03
Echinococcus granulosus g protein coupled receptor 0.0019 0.0039 0.0039
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0039 0.0039
Brugia malayi chromobox protein homolog 3 0.0039 0.034 0.0621
Schistosoma mansoni biogenic amine receptor 0.0019 0.0039 0.0039
Brugia malayi G-protein coupled receptor 0.0019 0.0039 0.0072
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0036 0.0292 0.0533
Brugia malayi larval opioid receptor 0.0019 0.0039 0.0072
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0019 0.0039 0.0072
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0341 0.0711
Trypanosoma cruzi target of rapamycin kinase 3 0.0039 0.0341 0.0623
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0378 0.5475 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0492 0.1027
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.1702 0.3108
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0022 0.0087 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0152 0.0316
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0026 0.0144 0.0262
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0019 0.0039 0.0039
Plasmodium falciparum phd finger protein, putative 0.0029 0.0191 0.5
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0141 0.188 0.3197
Echinococcus granulosus transient receptor potential gamma protein 0.0068 0.0788 0.0788
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0049 0.0492 0.0492
Schistosoma mansoni hypothetical protein 0.0019 0.0039 0.0039
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0895 0.0895
Echinococcus granulosus hypothetical protein 0.0019 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0019 0.0039 0.0039
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0039 0.0039
Schistosoma mansoni lamin 0.0019 0.004 0.004
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0026 0.0144 0.03
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0049 0.0492 0.0899
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0039 0.0039
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0385 0.0803
Echinococcus granulosus neuropeptide s receptor 0.0019 0.0039 0.0039
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0206 0.2872 0.5994
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0283 0.0283
Brugia malayi jmjC domain containing protein 0.0035 0.0283 0.0517
Schistosoma mansoni hypothetical protein 0.0022 0.0087 0.0087
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0019 0.0039 0.0072
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0036 0.0292 0.0533
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0039 0.0039
Brugia malayi jmjC domain containing protein 0.0095 0.119 0.2174
Echinococcus granulosus peregrin 0.0029 0.0191 0.0191
Echinococcus multilocularis orexin receptor type 2 0.0019 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0039 0.034 0.0621
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0039 0.0039
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0049 0.0492 0.0899
Schistosoma mansoni biogenic amine receptor 0.0019 0.0039 0.0039
Schistosoma mansoni cellular tumor antigen P53 0.0035 0.0276 0.0276
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0206 0.2872 0.5994
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.119 0.119
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0039 0.0072
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0042 0.0387 0.0387
Brugia malayi hypothetical protein 0.0019 0.0039 0.0072
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0022 0.0087 0.0087
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.007 0.0812 0.1484
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.019 0.0396
Echinococcus granulosus g-protein coupled receptor 0.0019 0.0039 0.0039
Brugia malayi hypothetical protein 0.0019 0.0039 0.0072
Echinococcus granulosus lamin 0.0019 0.004 0.004
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0141 0.188 0.3434
Onchocerca volvulus 0.0035 0.0276 0.0498
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0036 0.0292 0.0191
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0378 0.5475 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0039 0.0039
Plasmodium vivax SET domain protein, putative 0.0042 0.0387 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0042 0.0387 0.0387
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0152 0.0316
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0039 0.0039
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0039 0.0039
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0039 0.0039
Echinococcus multilocularis G protein coupled receptor 139 0.0019 0.0039 0.0039
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0019 0.0039 0.0072
Echinococcus multilocularis ubiquitin specific protease 41 0.0026 0.0144 0.0144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0492 0.1027
Echinococcus multilocularis dro:myosuppressin receptor 0.0019 0.0039 0.0039
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0026 0.0144 0.0262
Schistosoma mansoni transient receptor potential channel 0.0045 0.0437 0.0437
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0441 0.0441
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0039 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0151 0.0315
Mycobacterium ulcerans hypothetical protein 0.0111 0.1438 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0022 0.0087 0.0159
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.034 0.0633
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0019 0.0039 0.0039
Brugia malayi GnHR receptor homolog 0.0019 0.0039 0.0072
Echinococcus granulosus mitogen activated protein kinase 0.0036 0.0292 0.0292
Schistosoma mansoni histamine h1 receptor 0.0019 0.0039 0.0039
Trichomonas vaginalis CMGC family protein kinase 0.0036 0.0292 0.0609
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0026 0.0144 0.0262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0341 0.0711
Echinococcus multilocularis serotonin receptor 0.0019 0.0039 0.0039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Treponema pallidum fructose-bisphosphate aldolase 0.0206 0.2872 0.5
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0039 0.0039
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.119 0.119
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0378 0.5475 0.5475
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0039 0.0039
Brugia malayi Calcitonin receptor-like protein seb-1 0.007 0.0812 0.1484
Brugia malayi Tachykinin-like peptides receptor 99D 0.0019 0.0039 0.0072
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0039 0.0039
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0026 0.0144 0.0144
Echinococcus multilocularis serotonin receptor 0.0019 0.0039 0.0039
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0019 0.0039 0.0072
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.01 0.1267 0.2314
Echinococcus multilocularis sex peptide receptor 0.0019 0.0039 0.0039
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0059 0.0108
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0036 0.0292 0.0533
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0039 0.0039
Echinococcus granulosus G protein coupled receptor 139 0.0019 0.0039 0.0039
Echinococcus granulosus alpha 1A adrenergic receptor 0.0019 0.0039 0.0039
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0101 0.1276 0.5
Brugia malayi sulfakinin receptor protein 0.0019 0.0039 0.0072
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0206 0.2872 0.5994
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Echinococcus granulosus lamin dm0 0.0019 0.004 0.004
Brugia malayi fructose-1,6-bisphosphatase 0.0378 0.5475 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0039 0.0039
Loa Loa (eye worm) melatonin receptor type 1A 0.0019 0.0039 0.0072
Echinococcus granulosus TRP transient receptor potential channel 0.0025 0.0137 0.0137
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0039 0.0039
Echinococcus granulosus neuropeptide FF receptor 2 0.0019 0.0039 0.0039
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0492 0.0899
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0019 0.0039 0.0039
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0019 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0169 0.2305 0.2305
Loa Loa (eye worm) intermediate filament protein 0.0019 0.004 0.0072
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0141 0.188 0.3434
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0152 0.0316
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.004 0.0363 0.0363
Echinococcus granulosus mitogen activated protein kinase 3 0.0036 0.0292 0.0292
Brugia malayi neuropeptide F receptor 0.0019 0.0039 0.0072
Schistosoma mansoni myosin xvIII 0.0019 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0025 0.0137 0.025
Brugia malayi MAP kinase sur-1 0.0036 0.0292 0.0533
Echinococcus granulosus 7tm_1 domain containing protein 0.0019 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Echinococcus granulosus neuropeptide receptor 0.0019 0.0039 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.034 0.071
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0036 0.0292 0.0533
Schistosoma mansoni hypothetical protein 0.0022 0.0087 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0341 0.0711
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Echinococcus multilocularis lamin 0.0019 0.004 0.004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0441 0.0441
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0049 0.0492 0.0492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0232 0.0485
Echinococcus granulosus jumonji domain containing protein 0.004 0.0363 0.0363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0194 0.0405
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0039 0.0039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0039 0.0039
Echinococcus multilocularis somatostatin receptor 0.0019 0.0039 0.0039
Giardia lamblia Fructose-bisphosphate aldolase 0.0206 0.2872 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0283 0.0283
Echinococcus granulosus neuropeptide receptor 0.0019 0.0039 0.0039
Schistosoma mansoni alpha-1 adrenergic receptor 0.0019 0.0039 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0168 0.0351
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0385 0.0727
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0039 0.0072
Echinococcus multilocularis chromobox protein 1 0.0069 0.0801 0.0801
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0302 0.0631
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0019 0.0039 0.0039
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0019 0.0039 0.0072
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0036 0.0292 0.0533
Echinococcus multilocularis mitogen activated protein kinase 3 0.0036 0.0292 0.0292
Trichomonas vaginalis CMGC family protein kinase 0.0036 0.0292 0.0609
Schistosoma mansoni transient receptor potential channel 0.0045 0.0437 0.0437
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0042 0.0387 0.0387
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0206 0.2872 0.5994
Onchocerca volvulus 0.0019 0.004 0.0001
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0039 0.0039
Brugia malayi hypothetical protein 0.0019 0.0039 0.0072
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0053 0.0559 0.0559
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0026 0.0144 0.0144
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0441 0.0441
Echinococcus multilocularis geminin 0.0169 0.2305 0.2305
Loa Loa (eye worm) hypothetical protein 0.0043 0.0402 0.0735
Echinococcus granulosus geminin 0.0169 0.2305 0.2305
Echinococcus granulosus chromobox protein 1 0.0069 0.0801 0.0801
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Brugia malayi hypothetical protein 0.0019 0.0039 0.0072
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0302 0.0211
Schistosoma mansoni lamin 0.0019 0.004 0.004
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0025 0.0137 0.0137
Schistosoma mansoni opsin-like receptor 0.0019 0.0039 0.0039
Echinococcus multilocularis mitogen activated protein kinase 0.0036 0.0292 0.0292
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Echinococcus multilocularis G-protein coupled receptor, putative 0.0019 0.0039 0.0039
Brugia malayi Intermediate filament tail domain containing protein 0.0019 0.004 0.0072
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0211 0.2953 0.5395
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0019 0.0039 0.0072
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0026 0.0144 0.0144
Schistosoma mansoni hypothetical protein 0.0019 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Brugia malayi hypothetical protein 0.0019 0.0039 0.0072
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0042 0.0387 0.0387
Loa Loa (eye worm) hypothetical protein 0.0048 0.0477 0.0871
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Onchocerca volvulus Alhambra homolog 0.0029 0.0191 0.0319
Leishmania major mitochondrial DNA polymerase beta 0.0211 0.2953 0.5395
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0283 0.0283
Schistosoma mansoni neuropeptide receptor 0.0019 0.0039 0.0039
Brugia malayi Dopamine receptor protein 2 0.0019 0.0039 0.0072
Schistosoma mansoni hypothetical protein 0.0019 0.0039 0.0039
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0039 0.0039
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0042 0.0387 0.0387
Brugia malayi Dopamine receptor 0.0019 0.0039 0.0072
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0659 0.1203
Brugia malayi G-protein coupled receptor 0.0019 0.0039 0.0072
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0039 0.0039
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0211 0.2953 0.5395
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0019 0.0039 0.0072
Echinococcus granulosus chromobox protein 1 0.0069 0.0801 0.0801
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.1702 0.3108
Brugia malayi putative neuropeptide receptor 0.0019 0.0039 0.0072
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.003 0.0202 0.0369
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0049 0.0492 0.1278
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0378 0.5475 1
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0039 0.0039
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0019 0.0039 0.0039
Echinococcus granulosus peptide allatostatin:somatostatin 0.0019 0.0039 0.0039
Echinococcus granulosus neuropeptide receptor A26 0.0019 0.0039 0.0039
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0039 0.0039
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0019 0.0039 0.0072
Schistosoma mansoni chromobox protein 0.0069 0.0801 0.0801
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0248 0.0518
Echinococcus granulosus intermediate filament protein 0.0019 0.004 0.004
Echinococcus multilocularis short transient receptor potential channel 6 0.0045 0.0437 0.0437
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0206 0.2872 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0019 0.004 0.0072
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0039 0.0039
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0019 0.0039 0.0039
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0026 0.0144 0.03
Echinococcus granulosus fmrfamide receptor 0.0019 0.0039 0.0039
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0039 0.0039
Echinococcus granulosus 7TM GPCR rhodopsin 0.0019 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0283 0.0517
Brugia malayi neuropeptide F receptor 0.0019 0.0039 0.0072
Loa Loa (eye worm) hypothetical protein 0.0019 0.0034 0.0063
Schistosoma mansoni adenoreceptor 0.0019 0.0039 0.0039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0039 0.0039
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.003 0.0202 0.0369
Leishmania major 0.0378 0.5475 1
Schistosoma mansoni intermediate filament proteins 0.0019 0.004 0.004
Echinococcus granulosus sex peptide receptor 0.0019 0.0039 0.0039
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0039 0.0039
Brugia malayi Heterochromatin protein 1 0.0069 0.0801 0.1464
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0302 0.0631
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.01 0.1267 0.2314
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0039 0.0039
Echinococcus multilocularis transient receptor potential ion channel A 0.0066 0.0753 0.0753
Brugia malayi putative neuropeptide receptor NPR1 0.0019 0.0039 0.0072
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0042 0.0387 0.0387
Brugia malayi AKH receptor 0.0019 0.0039 0.0072
Brugia malayi Ets-domain containing protein 0.0051 0.0525 0.0958
Schistosoma mansoni biogenic amine receptor 0.0019 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0441 0.0805
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.019 0.0396
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0049 0.0492 0.0492
Brugia malayi Bromodomain containing protein 0.0029 0.0191 0.0349
Echinococcus granulosus short transient receptor potential channel 6 0.0045 0.0437 0.0437
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0039 0.0039
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0039 0.0039
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0022 0.0087 0.0159
Brugia malayi Transient-receptor-potential like protein 0.0025 0.0137 0.025
Echinococcus granulosus tachykinin peptides receptor 99D 0.0019 0.0039 0.0039
Brugia malayi Ets-domain containing protein 0.0051 0.0525 0.0958
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0151 0.0315
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0072
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0039 0.0039
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0026 0.0144 0.0144
Schistosoma mansoni chromobox protein 0.0069 0.0801 0.0801
Loa Loa (eye worm) hypothetical protein 0.0026 0.0144 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.034 0.071
Schistosoma mansoni neuropeptide receptor 0.0019 0.0039 0.0039
Giardia lamblia GTOR 0.0049 0.0492 0.1278
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0039 0.0039
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0036 0.03 0.0549
Echinococcus granulosus tumor protein p63 0.0237 0.3334 0.3334
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0141 0.188 0.3434
Echinococcus granulosus serotonin receptor 0.0019 0.0039 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0341 0.0711
Schistosoma mansoni neuropeptide receptor 0.0019 0.0039 0.0039
Schistosoma mansoni amine GPCR 0.0019 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Loa Loa (eye worm) hypothetical protein 0.003 0.0213 0.0389
Onchocerca volvulus 0.0333 0.4792 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0211 0.2953 0.5395
Loa Loa (eye worm) pigment dispersing factor receptor c 0.007 0.0812 0.1484
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0191 0.0191
Brugia malayi follicle stimulating hormone receptor 0.0019 0.0039 0.0072
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0039 0.0039
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0026 0.0144 0.0144
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.0341 0.0623
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0441 0.0441
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0283 0.0283
Brugia malayi Dopamine receptor protein 1 0.0019 0.0039 0.0072
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0019 0.0039 0.0039
Brugia malayi intermediate filament protein 0.0019 0.004 0.0072
Brugia malayi ORL1-like opioid receptor 0.0019 0.0039 0.0072
Echinococcus granulosus dro:myosuppressin receptor 0.0019 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.005 0.0505 0.0922
Brugia malayi Melatonin receptor type 1A 0.0019 0.0039 0.0072
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0801 0.1464
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0039 0.0039
Schistosoma mansoni ets-related 0.0155 0.2099 0.2099
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0039 0.0039
Brugia malayi hypothetical protein 0.0019 0.0039 0.0072
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0039 0.0072
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0039 0.0039
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0039 0.0039
Echinococcus granulosus short transient receptor potential channel 6 0.0045 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0039 0.0039
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0019 0.0039 0.0039
Loa Loa (eye worm) fli-1 protein 0.0155 0.2099 0.3834
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0302 0.0631
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0168 0.0351
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0039 0.0072
Schistosoma mansoni amine GPCR 0.0019 0.0039 0.0039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0039 0.0039
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0049 0.0492 0.0899
Echinococcus multilocularis peregrin 0.0029 0.0191 0.0191
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0385 0.0803
Brugia malayi G protein-coupled receptor F59B2.13 0.0019 0.0039 0.0072
Echinococcus multilocularis tumor protein p63 0.0237 0.3334 0.3334
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0049 0.0492 0.0899
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0036 0.0292 0.0533
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0039 0.0341 0.0623
Mycobacterium tuberculosis Conserved hypothetical protein 0.0111 0.1438 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.003 0.0202 0.0369
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0019 0.0039 0.0039
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0378 0.5475 0.5475
Schistosoma mansoni hypothetical protein 0.0022 0.0087 0.0087
Brugia malayi hypothetical protein 0.0019 0.0039 0.0072
Schistosoma mansoni transient receptor potential channel 4 0.0068 0.0788 0.0788
Trichomonas vaginalis CMGC family protein kinase 0.0036 0.0292 0.0609
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0191 0.0191
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0039 0.0039
Schistosoma mansoni lipoxygenase 0.0039 0.0337 0.0337
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0039 0.0039
Echinococcus granulosus GA binding protein alpha chain 0.0051 0.0525 0.0525
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0019 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0029 0.0191 0.0349
Brugia malayi MH2 domain containing protein 0.0129 0.1702 0.3108
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0441 0.0441
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0022 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0029 0.0191 0.0191
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0206 0.2872 0.5994
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0019 0.0039 0.0039
Brugia malayi Latrophilin receptor protein 2 0.0022 0.0087 0.0159
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0039 0.0039
Brugia malayi G protein-coupled receptor 0.0019 0.0039 0.0072
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0039 0.0039
Schistosoma mansoni amine GPCR 0.0019 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0044 0.0413 0.0754
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0039 0.0039
Echinococcus multilocularis allatostatin A receptor 0.0019 0.0039 0.0039
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0049 0.0492 0.0899
Loa Loa (eye worm) TYRA-2 protein 0.0019 0.0039 0.0072
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0026 0.0144 0.0262
Brugia malayi PHD-finger family protein 0.0029 0.0191 0.0349
Schistosoma mansoni amine GPCR 0.0019 0.0039 0.0039
Schistosoma mansoni neuropeptide receptor 0.0019 0.0039 0.0039
Echinococcus multilocularis chromobox protein 1 0.0069 0.0801 0.0801
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Toxoplasma gondii fructose-bisphospatase I 0.0141 0.188 0.3197
Echinococcus multilocularis GPCR, family 2 0.0022 0.0087 0.0087
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0492 0.0899
Echinococcus multilocularis GA binding protein alpha chain 0.0051 0.0525 0.0525
Echinococcus granulosus GPCR family 2 0.0022 0.0087 0.0087
Toxoplasma gondii hypothetical protein 0.0034 0.0268 0.0146
Schistosoma mansoni gabp alpha 0.0051 0.0525 0.0525
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0341 0.0711
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0191 0.0191
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0039 0.0039
Echinococcus granulosus allatostatin A receptor 0.0019 0.0039 0.0039
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0019 0.0039 0.0039
Onchocerca volvulus 0.0019 0.004 0.0001
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0049 0.0492 0.0899
Echinococcus granulosus somatostatin receptor 0.0019 0.0039 0.0039
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0801 0.1672
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0019 0.0039 0.0039
Echinococcus multilocularis neuropeptide FF receptor 2 0.0019 0.0039 0.0039
Echinococcus granulosus transient receptor potential ion channel A 0.0066 0.0753 0.0753
Schistosoma mansoni growth hormone secretagogue receptor 0.0019 0.0039 0.0039
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0036 0.0292 0.0533
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0019 0.0039 0.0039
Schistosoma mansoni neuropeptide f receptor 76f 0.0019 0.0039 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0492 0.1027
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.01 0.1267 0.2314
Loa Loa (eye worm) hypothetical protein 0.0035 0.0276 0.0504
Toxoplasma gondii fructose-bisphospatase II 0.0378 0.5475 1
Echinococcus multilocularis transient receptor potential gamma protein 0.0068 0.0788 0.0788
Trypanosoma brucei protein kinase, putative 0.0036 0.0292 0.0533
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0292 0.418 0.7635
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0039 0.0039
Trichomonas vaginalis set domain proteins, putative 0.0333 0.4792 1
Schistosoma mansoni transient receptor potential channel 0.0068 0.0788 0.0788
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0292 0.0292
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Brugia malayi Serotonin receptor 0.0019 0.0039 0.0072
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0039 0.0337 0.0337
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0206 0.2872 1
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0378 0.5475 1
Giardia lamblia Kinase, CMGC MAPK 0.0036 0.0292 0.0543
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0039 0.0039
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0019 0.0039 0.0072
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0036 0.0292 0.0533
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0049 0.0492 0.1278
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0039 0.0039
Schistosoma mansoni opsin-like receptor 0.0019 0.0039 0.0039
Echinococcus granulosus orexin receptor type 2 0.0019 0.0039 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0302 0.0631
Echinococcus multilocularis neuropeptide receptor A26 0.0019 0.0039 0.0039
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0051 0.0525 0.0958
Loa Loa (eye worm) hypothetical protein 0.0022 0.0087 0.0159
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0801 0.1672
Onchocerca volvulus 0.0053 0.0559 0.1093
Loa Loa (eye worm) hypothetical protein 0.0042 0.0387 0.0706
Schistosoma mansoni opsin-like receptor 0.0019 0.0039 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0194 0.0405
Loa Loa (eye worm) hypothetical protein 0.0068 0.0788 0.1439
Schistosoma mansoni hypothetical protein 0.0019 0.0039 0.0039
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0039 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0384 0.0801
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0039 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0441 0.0441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0302 0.0631
Schistosoma mansoni hypothetical protein 0.0169 0.2305 0.2305
Brugia malayi hypothetical protein 0.0019 0.0039 0.0072
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0441 0.0805
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0039 0.0039
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0206 0.2872 0.5994
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0102 0.0186
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Trichomonas vaginalis CMGC family protein kinase 0.0036 0.0292 0.0609
Schistosoma mansoni hypothetical protein 0.0022 0.0087 0.0087
Giardia lamblia PHD finger protein 15 0.0029 0.0191 0.0173
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0039 0.0039
Echinococcus granulosus ubiquitin specific protease 41 0.0026 0.0144 0.0144
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0019 0.0039 0.0039
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0378 0.5475 0.5475
Onchocerca volvulus 0.003 0.0213 0.0365
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0441 0.0441
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0026 0.0144 0.0262
Echinococcus multilocularis lamin dm0 0.0019 0.004 0.004
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0026 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0042 0.0387 0.0371
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0302 0.0631
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0039 0.0039
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0039 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0152 0.0316
Loa Loa (eye worm) hypothetical protein 0.0019 0.0039 0.0072
Brugia malayi RE15519p 0.0019 0.0039 0.0072
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0039 0.0039
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0206 0.2872 0.5994
Brugia malayi latrophilin 2 splice variant baaae 0.0048 0.0477 0.0871
Echinococcus multilocularis short transient receptor potential channel 6 0.0045 0.0437 0.0437

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.08 uM Inhibition of human liver FBPase 1 ChEMBL. 20055427
IC50 (binding) = 0.45 uM Inhibition of rat liver FBPase 1 ChEMBL. 20055427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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