Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | uM | In vitro inhibition of human platelet aggregation induced by collagen (at a concentration of 3 ug/mL); In active at 50 microM concentration | ChEMBL. | 11514149 |
IC50 (functional) | uM | In vitro inhibition of human platelet aggregation induced by thromboxane mimetic U-46,619 (at a concentration of 0.3 microM concentration | ChEMBL. | 11514149 |
IC50 (functional) | 0 uM | In vitro inhibition of human platelet aggregation induced by collagen (at a concentration of 3 ug/mL); In active at 50 microM concentration | ChEMBL. | 11514149 |
IC50 (functional) | 0 uM | In vitro inhibition of human platelet aggregation induced by thromboxane mimetic U-46,619 (at a concentration of 0.3 microM concentration | ChEMBL. | 11514149 |
IC50 (functional) | = 0.16 uM | In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM) | ChEMBL. | 11514149 |
IC50 (functional) | = 0.16 uM | In vitro inhibition of human platelet aggregation induced by SFLLRN-NH2 (at a concentration of 2 uM) | ChEMBL. | 11514149 |
IC50 (functional) | = 0.34 uM | In vitro inhibition of human platelet aggregation induced by alpha-thrombin (at a concentration of 0.15 nM) | ChEMBL. | 11514149 |
IC50 (functional) | = 0.34 uM | In vitro inhibition of human platelet aggregation induced by alpha-thrombin (at a concentration of 0.15 nM) | ChEMBL. | 11514149 |
IC50 (binding) | = 0.44 uM | In vitro displacement of [3H]-S-(p-F-Phe)-homoarginine-K Y-NH2 (at a concentration of 10 microM) from thrombin receptor (PAR-1) on the membranes of CHRF-288-11 cells | ChEMBL. | 11514149 |
IC50 (binding) | = 0.44 uM | In vitro displacement of [3H]-S-(p-F-Phe)-homoarginine-K Y-NH2 (at a concentration of 10 microM) from thrombin receptor (PAR-1) on the membranes of CHRF-288-11 cells | ChEMBL. | 11514149 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.