Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purinergic receptor P2Y, G-protein coupled, 12 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1912 | 0.1912 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.1912 | 0.1912 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.3128 | 0.3128 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.1303 | 0.1303 |
Trichomonas vaginalis | CAMK family protein kinase | 0.005 | 0.1982 | 0.3756 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.01 | 0.5278 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.01 | 0.5278 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.1303 | 0.247 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.1912 | 0.1912 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.01 | 0.5278 | 1 |
Brugia malayi | Inositol-1 | 0.0039 | 0.1303 | 0.247 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.1303 | 0.247 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.1912 | 0.3623 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.5278 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.01 | 0.5278 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.01 | 0.5278 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0039 | 0.1303 | 0.1303 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.3128 | 0.5927 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.1912 | 0.1912 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.5278 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.01 | 0.5278 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.1912 | 0.1912 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.5278 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1912 | 0.1912 |
Schistosoma mansoni | kinase | 0.0051 | 0.2068 | 0.2068 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.3128 | 0.5927 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.3128 | 0.5927 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.3128 | 0.5927 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0035 | 0.1036 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0039 | 0.1303 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.1303 | 0.247 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0039 | 0.1303 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0035 | 0.1036 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3128 | 0.3128 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3128 | 0.3128 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.1303 | 0.247 |
Giardia lamblia | Kinase, PLK | 0.01 | 0.5278 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.1303 | 0.1303 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.01 | 0.5278 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.01 | 0.5278 | 0.5278 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0039 | 0.1303 | 0.1303 |
Brugia malayi | RNA binding protein | 0.0067 | 0.3128 | 0.5927 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.1912 | 0.3623 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0039 | 0.1303 | 0.247 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3128 | 0.3128 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.3128 | 0.3128 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1912 | 0.1912 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3128 | 0.3128 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.5278 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3128 | 0.3128 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.3128 | 0.5927 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.5278 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.01 | 0.5278 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0039 | 0.1303 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.5278 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.005 | 0.1982 | 0.3756 |
Loa Loa (eye worm) | inositol-1 | 0.0039 | 0.1303 | 0.247 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0039 | 0.1303 | 0.247 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.1303 | 0.247 |
Schistosoma mansoni | serine/threonine protein kinase | 0.01 | 0.5278 | 0.5278 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.01 | 0.5278 | 0.5278 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.5278 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.1303 | 0.247 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Binding affinity at human recombinant P2Y12 receptor expressed in CHO cells by radioligand binding assay in presence of 0.4% human serum albumin | ChEMBL. | 19796941 | |
IC50 (functional) | > 10 uM | Antagonist activity at P2Y12 receptor in human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation by light transmission aggregometry | ChEMBL. | 19796941 |
Ki (binding) | = 70 nM | Binding affinity at human recombinant P2Y12 receptor expressed in CHO cells by radioligand binding assay | ChEMBL. | 19796941 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.