Detailed information for compound 1071648

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 595.69 | Formula: C30H41N7O6
  • H donors: 5 H acceptors: 4 LogP: -2.91 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@H]([C@@H]([C@H]2O)OCc2ccccn2)N)[C@@H]([C@H]([C@@H]1OCc1ccccn1)OCc1ccccn1)N
  • InChi: 1S/C30H41N7O6/c31-14-23-28(40-16-19-8-2-5-11-36-19)29(41-17-20-9-3-6-12-37-20)24(34)30(42-23)43-27-22(33)13-21(32)26(25(27)38)39-15-18-7-1-4-10-35-18/h1-12,21-30,38H,13-17,31-34H2/t21-,22+,23-,24-,25-,26+,27-,28-,29-,30-/m1/s1
  • InChiKey: SSYXODQQGHPWTP-YKFWBMAGSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) MBCTL1 0.0056 0.1389 0.1496
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.135 0.1347
Echinococcus multilocularis phosphoglycerate kinase 1 0.0174 0.5072 0.5072
Echinococcus multilocularis citrate lyase subunit beta protein 0.0025 0.0441 0.0441
Schistosoma mansoni hypothetical protein 0.0016 0.0164 0.0164
Schistosoma mansoni DNA polymerase eta 0.008 0.2159 0.2159
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0031 0.0637 0.0923
Trichomonas vaginalis DNA polymerase eta, putative 0.0081 0.2195 0.2391
Loa Loa (eye worm) hypothetical protein 0.008 0.2159 0.2437
Entamoeba histolytica deoxycytidyl transferase, putative 0.0054 0.1349 0.2263
Schistosoma mansoni hypothetical protein 0.003 0.0589 0.0589
Schistosoma mansoni phd finger protein 0.0013 0.0078 0.0078
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0589 0.0589
Brugia malayi ImpB/MucB/SamB family protein 0.008 0.2159 0.2585
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0164 0.0164
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0952 0.0952
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0064 0.1648 0.2344
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.1017 0.0936
Chlamydia trachomatis phosphoglycerate kinase 0.0174 0.5072 0.5
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.1389 0.1662
Giardia lamblia Phosphoglycerate kinase 0.0174 0.5072 1
Trypanosoma cruzi metacaspase, putative 0.0054 0.135 0.1865
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.135 0.1347
Mycobacterium ulcerans glutaminase 0.028 0.8351 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.026 0.0152
Loa Loa (eye worm) hypothetical protein 0.0054 0.135 0.1448
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.135 0.1347
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.2195 0.322
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.1761 0.1761
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.135 0.1347
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0025 0.0441 0.0312
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0054 0.135 0.1616
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.135 0.1347
Trypanosoma cruzi small ubiquitin protein, putative 0.0053 0.132 0.1817
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.1179 0.1179
Schistosoma mansoni caspase-3 (C14 family) 0.0129 0.3661 0.3661
Onchocerca volvulus Cell death protein 3 homolog 0.0054 0.135 0.1581
Toxoplasma gondii small ubiquitin family modifier, putative 0.0053 0.132 0.232
Brugia malayi glutaminase DH11.1 0.028 0.8351 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.2195 0.322
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.1031 0.1355
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0258 0.0258
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0053 0.132 0.132
Toxoplasma gondii exonuclease III APE 0.0019 0.026 0.0152
Loa Loa (eye worm) hypothetical protein 0.0185 0.54 0.6396
Trypanosoma cruzi hypothetical protein, conserved 0.0218 0.6424 1
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0174 0.5072 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.1247 0.1323
Trypanosoma brucei DNA polymerase IV, putative 0.0081 0.2195 0.322
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.135 0.1347
Loa Loa (eye worm) hypothetical protein 0.0054 0.135 0.1448
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0174 0.5072 0.5947
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.1017 0.1701
Brugia malayi hypothetical protein 0.0033 0.0686 0.0821
Leishmania major metacaspase, putative 0.0054 0.135 0.1865
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.135 0.1347
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0433 0.0395
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0258 0.0146
Brugia malayi Phosphoglycerate kinase 0.0064 0.1648 0.1973
Echinococcus multilocularis caspase 3 0.0074 0.1974 0.1974
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.1761 0.3118
Schistosoma mansoni hypothetical protein 0.0016 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.003 0.0589 0.0519
Brugia malayi Bloom's syndrome protein homolog 0.0046 0.1104 0.1321
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0041 0.0929 0.152
Plasmodium falciparum small ubiquitin-related modifier 0.0053 0.132 0.232
Leishmania major phosphoglycerate kinase C, glycosomal 0.0174 0.5072 0.7832
Mycobacterium ulcerans hypothetical protein 0.0025 0.0441 0.0312
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0174 0.5072 1
Trypanosoma cruzi metacaspase, putative 0.0054 0.135 0.1865
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0064 0.1648 0.2344
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.1389 0.1389
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0877 0.0877
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0258 0.0146
Loa Loa (eye worm) hypothetical protein 0.0174 0.5072 0.5995
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0784 0.0784
Schistosoma mansoni hypothetical protein 0.0301 0.9 0.9
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.1179 0.1179
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1559 0.2201
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.026 0.0311
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0904 0.147
Trypanosoma brucei unspecified product 0.0037 0.0826 0.1026
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0441 0.0409
Plasmodium falciparum metacaspase-like protein 0.0054 0.135 0.2382
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.135 0.1347
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0441 0.0312
Trypanosoma cruzi small ubiquitin protein, putative 0.0053 0.132 0.1817
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0064 0.1648 0.2344
Schistosoma mansoni ap endonuclease 0.0019 0.026 0.026
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.135 0.1347
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0174 0.5072 0.5
Giardia lamblia DINP protein human, muc B family 0.0061 0.1559 0.281
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.132 0.131
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0034 0.0704 0.0704
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0174 0.5072 0.7832
Giardia lamblia Sentrin 0.0053 0.132 0.232
Echinococcus granulosus ubiquitin 0.0033 0.0686 0.0686
Loa Loa (eye worm) hypothetical protein 0.0044 0.1031 0.1059
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0258 0.0258
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.2195 0.322
Echinococcus multilocularis dna polymerase kappa 0.0081 0.2195 0.2195
Echinococcus granulosus citrate lyase subunit beta protein 0.0025 0.0441 0.0441
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.135 0.1347
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0024 0.0396 0.0429
Brugia malayi Cell death protein 3 precursor 0.0054 0.135 0.1616
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0784 0.0784
Trypanosoma brucei phosphoglycerate kinase, putative 0.0064 0.1648 0.2344
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.1179 0.1179
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.4269 0.4269
Leishmania major DNA polymerase kappa, putative 0.0061 0.1559 0.2201
Brugia malayi Bromodomain containing protein 0.0033 0.0702 0.084
Echinococcus multilocularis GPCR, family 2 0.0016 0.0164 0.0164
Echinococcus granulosus caspase 0.0129 0.3661 0.3661
Trichomonas vaginalis DNA helicase recq, putative 0.0046 0.1104 0.1042
Treponema pallidum phosphoglycerate kinase 0.0174 0.5072 1
Plasmodium vivax hypothetical protein, conserved 0.003 0.0589 0.0825
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0054 0.135 0.2382
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0164 0.0164
Trypanosoma brucei hypothetical protein, conserved 0.0218 0.6424 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.2195 0.322
Echinococcus multilocularis Small ubiquitin modifier 2 0.0053 0.132 0.132
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.1179 0.1179
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.2195 0.322
Plasmodium vivax hypothetical protein, conserved 0.0054 0.135 0.2382
Trypanosoma brucei unspecified product 0.0037 0.0826 0.1026
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0164 0.0196
Leishmania major DNA polymerase eta, putative 0.008 0.2159 0.3163
Mycobacterium ulcerans hypothetical protein 0.0025 0.0441 0.0312
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0054 0.135 0.2382
Trypanosoma brucei metacaspase MCA3 0.0054 0.135 0.1865
Loa Loa (eye worm) hypothetical protein 0.0141 0.4044 0.4739
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.1179 0.1225
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0164 0.0196
Schistosoma mansoni glutaminase 0.028 0.8351 0.8351
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0174 0.5072 0.7832
Echinococcus multilocularis caspase 0.0129 0.3661 0.3661
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0626 0.0899
Giardia lamblia PHD finger protein 15 0.003 0.0589 0.0825
Echinococcus granulosus caspase 3 0.0074 0.1974 0.1974
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.135 0.1347
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.1179 0.1179
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0054 0.1349 0.1349
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.1761 0.2524
Brugia malayi N-terminal motif family protein 0.0185 0.54 0.6467
Entamoeba histolytica ubiquitin like protein 0.0053 0.132 0.2202
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0904 0.1339
Echinococcus multilocularis caspase 8 0.0054 0.135 0.135
Schistosoma mansoni caspase-7 (C14 family) 0.0054 0.135 0.135
Mycobacterium ulcerans DNA polymerase IV 0.0081 0.2195 0.246
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.026 0.0118
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0746 0.0893
Brugia malayi PHD-finger family protein 0.003 0.0589 0.0705
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.135 0.1347
Echinococcus granulosus dna polymerase kappa 0.0081 0.2195 0.2195
Trypanosoma brucei Metacaspase-4 0.0054 0.135 0.1865
Schistosoma mansoni terminal deoxycytidyl transferase 0.0054 0.1349 0.1349
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.0051 0.1251 0.1328
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.1761 0.1761
Trypanosoma brucei DNA polymerase eta, putative 0.008 0.2159 0.3163
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0258 0.0308
Trypanosoma cruzi metacaspase, putative 0.0054 0.135 0.1865
Brugia malayi polk-prov protein 0.0044 0.1031 0.1235
Plasmodium vivax phosphoglycerate kinase, putative 0.0174 0.5072 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.1761 0.2108
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0433 0.0213
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0784 0.0758
Mycobacterium tuberculosis Conserved hypothetical protein 0.0054 0.1349 0.2263
Brugia malayi Phosphoglycerate kinase 0.0174 0.5072 0.6073
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0258 0.0258
Trypanosoma brucei unspecified product 0.0075 0.1985 0.2884
Echinococcus granulosus peregrin 0.0043 0.1005 0.1005
Loa Loa (eye worm) glutaminase 0.028 0.8351 1
Loa Loa (eye worm) RecQ helicase 0.0046 0.1104 0.1148
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.2195 0.322
Schistosoma mansoni hypothetical protein 0.0173 0.5034 0.5034
Loa Loa (eye worm) hypothetical protein 0.0033 0.0686 0.0638
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.1761 0.1761
Echinococcus granulosus dna polymerase eta 0.008 0.2159 0.2159
Schistosoma mansoni SET domain protein 0.0034 0.0704 0.0704
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0034 0.0704 0.0704
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0129 0.3661 0.3661
Loa Loa (eye worm) hypothetical protein 0.0019 0.0258 0.0114
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0433 0.0395
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0174 0.5072 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.1389 0.1389
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.026 0.0119
Trypanosoma brucei metacaspase 0.0054 0.135 0.1865
Trypanosoma cruzi metacaspase, putative 0.0054 0.135 0.1865
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0081 0.2195 0.2391
Onchocerca volvulus 0.0033 0.0686 0.0201
Echinococcus granulosus bloom syndrome protein 0.0046 0.1104 0.1104
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.026 0.026
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.1179 0.1179
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0054 0.135 0.2382
Trypanosoma brucei phosphoglycerate kinase 0.0174 0.5072 0.7832
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.1247 0.1323
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0196 0.5758 0.5758
Entamoeba histolytica phosphoglycerate kinase, putative 0.0174 0.5072 1
Loa Loa (eye worm) glutaminase 2 0.028 0.8351 1
Mycobacterium ulcerans DNA polymerase IV 0.0081 0.2195 0.246
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0877 0.0877
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0025 0.0441 0.0376
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.135 0.1347
Brugia malayi jmjC domain containing protein 0.0098 0.2697 0.323
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0064 0.1648 0.2344
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0589 0.0589
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.135 0.1347
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0185 0.54 1
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0589 0.0519
Plasmodium falciparum phosphoglycerate kinase 0.0174 0.5072 1
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0129 0.3661 0.3661
Trichomonas vaginalis DNA helicase recq1, putative 0.0046 0.1104 0.1042
Brugia malayi jmjC domain containing protein 0.0036 0.0784 0.0939
Trypanosoma cruzi DNA polymerase eta, putative 0.008 0.2159 0.3163
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.026 0.026
Trypanosoma brucei metacaspase MCA2 0.0054 0.135 0.1865
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.026 0.0119
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0064 0.1648 0.2344
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0996 0.1298
Mycobacterium ulcerans phosphoglycerate kinase 0.0174 0.5072 0.5984
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.1247 0.1493
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0174 0.5072 0.5947
Leishmania major small ubiquitin protein, putative 0.0053 0.132 0.1817
Trypanosoma brucei small ubiquitin-related modifier 0.0053 0.132 0.1817
Trichomonas vaginalis ubiquitin, putative 0.0033 0.0686 0.0526
Echinococcus multilocularis ubiquitin 0.0033 0.0686 0.0686
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.135 0.1347
Echinococcus granulosus GPCR family 2 0.0016 0.0164 0.0164
Schistosoma mansoni hypothetical protein 0.0035 0.0746 0.0746
Entamoeba histolytica hypothetical protein 0.0033 0.0686 0.0884
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0258 0.0114
Echinococcus granulosus Small ubiquitin modifier 2 0.0053 0.132 0.132
Trypanosoma brucei phosphoglycerate kinase 0.0174 0.5072 0.7832
Plasmodium vivax metacaspase 1, putative 0.0054 0.135 0.2382
Schistosoma mansoni ap endonuclease 0.0019 0.026 0.026
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.1017 0.1701
Echinococcus granulosus phosphoglycerate kinase 1 0.0174 0.5072 0.5072
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.1036 0.1362
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.026 0.0152
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.1389 0.1389
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.1576 0.1725
Schistosoma mansoni DNA polymerase IV / kappa 0.0017 0.0186 0.0186
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.1389 0.1389
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.1036 0.1362
Echinococcus granulosus histone acetyltransferase KAT2B 0.0144 0.414 0.414
Schistosoma mansoni hypothetical protein 0.0016 0.0164 0.0164
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0433 0.0395
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0441 0.0409
Echinococcus multilocularis peregrin 0.0043 0.1005 0.1005
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.1761 0.2524
Schistosoma mansoni jumonji domain containing protein 0.0078 0.2074 0.2074
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.2195 0.322
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.026 0.0119
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0164 0.0164
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.2195 0.322
Onchocerca volvulus 0.0049 0.1179 0.1225
Trypanosoma cruzi metacaspase 5, putative 0.0054 0.135 0.1865
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0904 0.147
Echinococcus granulosus caspase 2 0.0054 0.135 0.135
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0054 0.1349 0.1349
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0061 0.1559 0.2699
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.1247 0.1493
Leishmania major DNA polymerase eta, putative 0.0043 0.0996 0.1298
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.026 0.0152
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0258 0.0146
Brugia malayi mbt repeat family protein 0.0049 0.1179 0.1411
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.026 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.1031 0.1355
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0589 0.0825
Trypanosoma cruzi metacaspase 5, putative 0.0054 0.135 0.1865
Loa Loa (eye worm) hypothetical protein 0.0035 0.0746 0.0711
Leishmania major phosphoglycerate kinase B, cytosolic 0.0174 0.5072 0.7832
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0996 0.1657
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0164 0.0164
Mycobacterium tuberculosis Conserved protein 0.0025 0.0441 0.0376
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0025 0.0441 0.0224
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0258 0.0308
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.2195 0.322
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0174 0.5072 1
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0054 0.135 0.135
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0196 0.5758 0.5758
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.1179 0.1239
Trypanosoma brucei phosphoglycerate kinase 0.0064 0.1648 0.2344
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.1389 0.1389
Entamoeba histolytica recQ family helicase, putative 0.0025 0.0433 0.0358
Schistosoma mansoni phosphoglycerate kinase 0.0174 0.5072 0.5072
Loa Loa (eye worm) hypothetical protein 0.0049 0.1179 0.1239
Trypanosoma brucei DNA polymerase IV, putative 0.0075 0.1985 0.2884
Trichomonas vaginalis glutaminase, putative 0.028 0.8351 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.1017 0.1701
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.2697 0.2697
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.2195 0.322
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0258 0.0258
Schistosoma mansoni phosphoglycerate kinase 0.0174 0.5072 0.5072
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0952 0.0952
Echinococcus multilocularis caspase 2 0.0054 0.135 0.135
Brugia malayi mbt repeat family protein 0.0049 0.1179 0.1411
Brugia malayi Ubiquitin-like protein SMT3 0.0053 0.132 0.158
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.2195 0.322
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.4269 0.4269
Echinococcus multilocularis dna polymerase eta 0.008 0.2159 0.2159
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0589 0.0825
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0784 0.0784
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0061 0.1559 0.2201
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.1761 0.2524
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.1017 0.0936
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.026 0.0091
Plasmodium falciparum metacaspase 1 0.0054 0.135 0.2382
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0064 0.1648 0.2344
Echinococcus multilocularis bloom syndrome protein 0.0046 0.1104 0.1104
Loa Loa (eye worm) hypothetical protein 0.0056 0.1389 0.1496
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.1349 0.1615
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.2697 0.2697
Schistosoma mansoni caspase-7 (C14 family) 0.0129 0.3661 0.3661
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0441 0.0312
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.2195 0.322
Echinococcus granulosus caspase 8 0.0054 0.135 0.135
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.4269 0.5112
Trypanosoma cruzi hypothetical protein, conserved 0.0218 0.6424 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0589 0.0589
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0686 0.0526
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.1036 0.1362
Schistosoma mansoni blooms syndrome DNA helicase 0.0037 0.0801 0.0801
Loa Loa (eye worm) acetyltransferase 0.0148 0.4269 0.5014
Trypanosoma brucei DNA polymerase IV, putative 0.0081 0.2195 0.322
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.1017 0.1017
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.2195 0.322
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.1761 0.2524
Plasmodium vivax small ubiquitin-related modifier, putative 0.0053 0.132 0.232
Plasmodium falciparum phd finger protein, putative 0.003 0.0589 0.0825
Trypanosoma brucei metacaspase 5, putative 0.0054 0.135 0.1865
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0441 0.0409
Schistosoma mansoni DNA helicase recq5 0.0019 0.0258 0.0258
Loa Loa (eye worm) SMO-1 protein 0.0053 0.132 0.1412
Schistosoma mansoni DNA helicase recq1 0.0019 0.0258 0.0258
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.1179 0.1179
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0258 0.0146
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0054 0.1349 0.1349
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0054 0.1349 0.1448
Leishmania major hypothetical protein, conserved 0.0218 0.6424 1
Schistosoma mansoni hypothetical protein 0.0016 0.0164 0.0164
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.1761 0.195

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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