Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | thymidylate synthetase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0584 | 0.6436 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0753 | 1 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0584 | 0.6436 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0753 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0753 | 1 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0753 | 1 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0753 | 1 | 1 |
Onchocerca volvulus | 0.0753 | 1 | 1 | |
Echinococcus multilocularis | serotonin transporter | 0.0753 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0584 | 0.6436 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0584 | 0.6436 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0753 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0584 | 0.6436 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0584 | 0.6436 | 0.6436 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0584 | 0.6436 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0753 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0278 | 0 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0753 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0753 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0753 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0584 | 0.6436 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0584 | 0.6436 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0584 | 0.6436 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 63 uM | In vitro cytotoxicity against mock infected MT-4 cells. | ChEMBL. | 10377217 |
CC50 (functional) | = 63 uM | In vitro cytotoxicity against mock infected MT-4 cells. | ChEMBL. | 10377217 |
IF (binding) | = 0.12 | Inhibition factor for Cryptococcus Thymidylate synthase at 27 uM. | ChEMBL. | 10377217 |
IF (binding) | = 0.129 | Inhibition factor for Lactobacillus casei Thymidylate synthase at 27 uM. | ChEMBL. | 10377217 |
IF (binding) | = 0.488 | Inhibition factor for Pneumocystis carinii Thymidylate synthase at 27 uM. | ChEMBL. | 10377217 |
IF (binding) | = 1 | Inhibition factor for Human Thymidylate synthase at 27 uM. | ChEMBL. | 10377217 |
IF (binding) | = 0.12 | Inhibition factor for Cryptococcus Thymidylate synthase at 27 uM. | ChEMBL. | 10377217 |
IF (binding) | = 0.129 | Inhibition factor for Lactobacillus casei Thymidylate synthase at 27 uM. | ChEMBL. | 10377217 |
IF (binding) | = 0.488 | Inhibition factor for Pneumocystis carinii Thymidylate synthase at 27 uM. | ChEMBL. | 10377217 |
IF (binding) | = 1 | Inhibition factor for Human Thymidylate synthase at 27 uM. | ChEMBL. | 10377217 |
Ki (binding) | = 0.73 uM | In vitro inhibition of Lactobacillus casei Thymidylate synthase. | ChEMBL. | 10377217 |
Ki (binding) | = 0.73 uM | In vitro inhibition of Lactobacillus casei Thymidylate synthase. | ChEMBL. | 10377217 |
MGC (functional) | = 1.6 uM | In vitro minimum concentration for germicidal effect on Streptococcus. | ChEMBL. | 10377217 |
MGC (functional) | = 3 uM | In vitro evaluation of the compound for minimum germicidal effect on Stapylococcus aureus was determined | ChEMBL. | 10377217 |
MIC (functional) | = 1.6 uM | In vitro inhibition of Streptococcus growth. | ChEMBL. | 10377217 |
MIC (functional) | = 3 uM | In vitro inhibition of Stapylococcus aureus growth. | ChEMBL. | 10377217 |
MIC (functional) | > 9.37 uM | In vitro inhibition of Cryptococcus neoformans growth. | ChEMBL. | 10377217 |
MIC (functional) | > 9.37000000000001 uM | In vitro inhibition of Cryptococcus neoformans growth. | ChEMBL. | 10377217 |
SI (functional) | = 39.4 | Ratio of cytotoxic concentration to that of minimum inhibitory concentration against Steptococcus (CC50/MIC50). | ChEMBL. | 10377217 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.