Detailed information for compound 1071776

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 334.39 | Formula: C16H18N2O4S
  • H donors: 1 H acceptors: 3 LogP: 2.03 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)/C=C/1\SC(=O)N(C1=O)CCNC(=O)C
  • InChi: 1S/C16H18N2O4S/c1-3-22-13-6-4-12(5-7-13)10-14-15(20)18(16(21)23-14)9-8-17-11(2)19/h4-7,10H,3,8-9H2,1-2H3,(H,17,19)/b14-10-
  • InChiKey: OYUHAIFMHYISSY-UVTDQMKNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis ferritin, putative 0.0016 0.0001 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0124 0.0579 0.3876
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0091 0.0132
Brugia malayi beta-lactamase family protein 0.0296 0.1494 0.4298
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0091 0.0132
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0024 0.0024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0056 0.0212 0.0309
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0056 0.0212 0.0589
Plasmodium vivax glutathione reductase, putative 0.0046 0.0159 0.1065
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0471 0.0471
Toxoplasma gondii oxidoreductase, 2OG-Fe(II) oxygenase family protein 0.0021 0.0029 0.0197
Echinococcus granulosus tumor protein p63 0.0741 0.3869 0.563
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.0471 0.3149
Loa Loa (eye worm) hypothetical protein 0.0232 0.1154 0.3305
Loa Loa (eye worm) hypothetical protein 0.0033 0.0091 0.0238
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0248 0.1241 0.3569
Echinococcus multilocularis GPCR, family 2 0.0079 0.0335 0.0487
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.0166 0.1974
Mycobacterium tuberculosis Conserved protein 0.0296 0.1494 0.1494
Trypanosoma brucei 2OG-Fe(II) oxygenase superfamily, putative 0.0021 0.0029 0.0197
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0008 0.0012
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.011 0.0502 0.3357
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0069 0.0464
Mycobacterium tuberculosis Probable lipase LipE 0.0296 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0029 0.0069 0.0177
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.0091 0.0132
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0121 0.0559 0.0813
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0056 0.0212 0.0212
Brugia malayi RNA recognition motif domain containing protein 0.0668 0.3476 1
Onchocerca volvulus 0.0109 0.0494 0.3174
Loa Loa (eye worm) hypothetical protein 0.0296 0.1494 0.4284
Trichomonas vaginalis penicillin-binding protein, putative 0.0296 0.1494 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0084 0.0559
Toxoplasma gondii ABC1 family protein 0.0296 0.1494 1
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0016 0.0001 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0124 0.0579 0.3876
Schistosoma mansoni hypothetical protein 0.0167 0.0808 0.1176
Trypanosoma brucei hypothetical protein, conserved 0.0296 0.1494 1
Loa Loa (eye worm) hypothetical protein 0.017 0.0821 0.2345
Trichomonas vaginalis esterase, putative 0.0296 0.1494 1
Trichomonas vaginalis glucosylceramidase, putative 0.0124 0.0579 0.3876
Mycobacterium ulcerans hypothetical protein 0.0029 0.0069 0.0464
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0069 0.0464
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0102 0.0681
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0091 0.0132
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0008 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0091 0.026
Brugia malayi hypothetical protein 0.0017 0.0008 0.0023
Echinococcus granulosus prolyl 4 hydroxylase subunit alpha 1 0.0021 0.0029 0.0043
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0091 0.0132
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0533 0.0533
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0166 0.0241
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0024 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0065 0.0436
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0065
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0091 0.0132
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0168 0.0811 1
Trypanosoma brucei trypanothione reductase 0.0046 0.0159 0.1065
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0159 0.0159
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0069 0.0069
Toxoplasma gondii hypoxia- inducible factor prolyl hydroxylase (phd2), putative 0.0021 0.0029 0.0197
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0168 0.0811 0.5426
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0166 0.0241
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0166 0.0455
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0016 0.0001 0.0013
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0056 0.0212 0.0308
Mycobacterium leprae Probable lipase LipE 0.0296 0.1494 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0102 0.0681
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0335 0.0942
Schistosoma mansoni transcription factor LCR-F1 0.0121 0.0559 0.0813
Plasmodium falciparum acyl-CoA synthetase 0.0022 0.003 0.0376
Onchocerca volvulus 0.016 0.077 0.5053
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0069 0.0464
Brugia malayi hypothetical protein 0.016 0.077 0.2214
Trichomonas vaginalis glucosylceramidase, putative 0.0131 0.0615 0.4115
Loa Loa (eye worm) hypothetical protein 0.0033 0.0091 0.0238
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.011 0.0502 0.0502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0051 0.0338
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0335 0.0963
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0024 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0056 0.0212 0.0309
Entamoeba histolytica hypothetical protein 0.0121 0.0559 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.019 0.0927 0.2649
Loa Loa (eye worm) hypothetical protein 0.0296 0.1494 0.4284
Schistosoma mansoni hypothetical protein 0.0167 0.0808 0.1176
Echinococcus granulosus beta LACTamase domain containing family member 0.0296 0.1494 0.2174
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0091 0.0238
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0091 0.0238
Brugia malayi beta-lactamase 0.0296 0.1494 0.4298
Trichomonas vaginalis glucosylceramidase, putative 0.0124 0.0579 0.3876
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0296 0.1494 0.1494
Plasmodium vivax hypothetical protein, conserved 0.0296 0.1494 1
Brugia malayi MH2 domain containing protein 0.0126 0.0585 0.1683
Loa Loa (eye worm) hypothetical protein 0.0079 0.0335 0.0942
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.1154 0.168
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0008 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0064 0.0426
Trichomonas vaginalis glucosylceramidase, putative 0.0131 0.0615 0.4115
Loa Loa (eye worm) hypothetical protein 0.016 0.077 0.2196
Leishmania major hypothetical protein, unknown function 0.0021 0.0029 0.0197
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0069 0.0464
Brugia malayi prolyl 4-hydroxylase 0.0021 0.0029 0.0085
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0024 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0115 0.0768
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0335 0.0487
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0296 0.1494 1
Schistosoma mansoni cellular tumor antigen P53 0.0109 0.0494 0.0719
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0091 0.0238
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0091 0.0132
Toxoplasma gondii oxidoreductase, 2OG-Fe(II) oxygenase family protein 0.0021 0.0029 0.0197
Schistosoma mansoni aldehyde dehydrogenase 0.0056 0.0212 0.0308
Schistosoma mansoni survival motor neuron protein 0.0047 0.0168 0.0245
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0248 0.1241 0.3554
Schistosoma mansoni tar DNA-binding protein 0.0668 0.3476 0.5059
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0072 0.0892
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0065
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0668 0.3476 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0091 0.026
Schistosoma mansoni apoferritin-2 0.0016 0.0001 0.0002
Brugia malayi glutathione reductase 0.0046 0.0159 0.0458
Echinococcus multilocularis expressed protein 0.0016 0.0001 0.0002
Brugia malayi nuclear receptor NHR-88 0.0033 0.0091 0.026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0166 0.1111
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.0335 0.0487
Onchocerca volvulus Glucosylceramidase homolog 0.0124 0.0579 0.3753
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0056 0.0212 0.0309
Loa Loa (eye worm) hypothetical protein 0.0133 0.0622 0.1772
Echinococcus multilocularis beta LACTamase domain containing family member 0.0296 0.1494 0.2174
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0091 0.0132
Loa Loa (eye worm) hypothetical protein 0.0029 0.0069 0.0177
Leishmania major hypothetical protein, conserved 0.0029 0.0072 0.0484
Loa Loa (eye worm) glutathione reductase 0.0046 0.0159 0.0436
Schistosoma mansoni hypothetical protein 0.017 0.0821 0.1195
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0091 0.026
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0159 0.1065
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.0335 0.0487
Brugia malayi N-terminal motif family protein 0.0133 0.0622 0.179
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0166 0.0241
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0058 0.0224 0.1499
Echinococcus multilocularis tumor protein p63 0.0741 0.3869 0.563
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0091 0.0132
Schistosoma mansoni prolyl 4-hydroxylase alpha subunit 1 0.0021 0.0029 0.0043
Giardia lamblia GTOR 0.0047 0.0166 1
Schistosoma mansoni ferritin light chain 0.0016 0.0001 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0102 0.0681
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0008 0.0012
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0168 0.0811 0.5426
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.0296 0.1494 0.4284
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0115 0.0769
Loa Loa (eye worm) hypothetical protein 0.0029 0.0069 0.0177
Leishmania major hypothetical protein, conserved 0.0021 0.0029 0.0197
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0091 0.0132
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0471 0.0471
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0091 0.0238
Schistosoma mansoni ferritin 0.0016 0.0001 0.0002
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0056 0.0212 0.0308
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0166 0.1111
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0168 0.0811 0.5426
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0131 0.0615 0.0895
Schistosoma mansoni microtubule-associated protein tau 0.1305 0.6872 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0062
Trichomonas vaginalis glucosylceramidase, putative 0.0124 0.0579 0.3876
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0058 0.0224 0.1493
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0062
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0168 0.0811 0.118
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0072 0.0484
Schistosoma mansoni thyroid hormone receptor 0.0164 0.079 0.115
Echinococcus granulosus expressed protein 0.0016 0.0001 0.0002
Mycobacterium tuberculosis Probable hydrolase 0.0296 0.1494 0.1494
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0091 0.0132
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0072 0.0484
Trichomonas vaginalis penicillin-binding protein, putative 0.0296 0.1494 1
Trichomonas vaginalis glucosylceramidase, putative 0.0124 0.0579 0.3876
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0069 0.0069
Brugia malayi nuclear hormone receptor 0.0033 0.0091 0.026
Brugia malayi hypothetical protein 0.0019 0.0017 0.0048
Loa Loa (eye worm) TAR-binding protein 0.0668 0.3476 1
Brugia malayi TAR-binding protein 0.0668 0.3476 1
Brugia malayi Probable ClpP-like protease 0.0168 0.0811 0.2332
Trypanosoma cruzi hypothetical protein, conserved 0.0296 0.1494 1
Loa Loa (eye worm) RNA binding protein 0.0668 0.3476 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0051 0.0338
Mycobacterium ulcerans bacterioferritin BfrB 0.0016 0.0001 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0166 0.1111
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0166 0.0477
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.0166 0.1974
Schistosoma mansoni hypothetical protein 0.0047 0.0168 0.0245
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0022 0.003 0.003
Echinococcus multilocularis peptidase Clp (S14 family) 0.011 0.0502 0.0731
Loa Loa (eye worm) hypothetical protein 0.0168 0.0811 0.2314
Plasmodium falciparum glutathione reductase 0.0046 0.0159 0.1964
Onchocerca volvulus 0.0047 0.0168 0.0948
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0533 0.3565
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0166 0.1111
Entamoeba histolytica hypothetical protein 0.0121 0.0559 1
Toxoplasma gondii hypothetical protein 0.0058 0.0224 0.1499
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0091 0.0132
Trichomonas vaginalis D-aminoacylase, putative 0.0296 0.1494 1
Brugia malayi hypothetical protein 0.0029 0.0072 0.0208
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0168 0.0811 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0164 0.079 0.115
Echinococcus granulosus microtubule associated protein 2 0.1305 0.6872 1
Schistosoma mansoni hypothetical protein 0.0079 0.0335 0.0487
Onchocerca volvulus 0.0296 0.1494 1
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.1154 0.168
Schistosoma mansoni ferritin 0.0016 0.0001 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0296 0.1494 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0072 0.0484
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0091 0.0132
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0056 0.0212 0.0309
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0069 0.0199
Brugia malayi hypothetical protein 0.0232 0.1154 0.332
Echinococcus multilocularis tar DNA binding protein 0.0668 0.3476 0.5059
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0069 0.0464
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0065
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0056 0.0212 0.061
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0471 0.0471
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0927 0.6203
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0034 0.0227
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0091 0.026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0115 0.0768
Mycobacterium ulcerans lipase LipD 0.0296 0.1494 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0091 0.0132
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0008 0.0023
Leishmania major trypanothione reductase 0.0046 0.0159 0.1065
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0296 0.1494 0.1494
Schistosoma mansoni apoferritin-2 0.0016 0.0001 0.0002
Brugia malayi nuclear receptor RXR 0.0017 0.0008 0.0023
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0335 0.0963
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0168 0.0811 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0091 0.0238
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0168 0.0811 0.5426
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0058 0.0224 0.2763
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0008 0.0012
Mycobacterium tuberculosis Conserved protein 0.0296 0.1494 0.1494
Schistosoma mansoni ferritin light chain 0.0016 0.0001 0.0002
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.0091 0.0417
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0168 0.0811 0.5423
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0091 0.0132
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0056 0.0212 0.0309
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0091 0.026
Schistosoma mansoni peptidase Clp (S14 family) 0.0168 0.0811 0.118
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.019 0.0927 0.2666
Mycobacterium tuberculosis Probable reductase 0.0104 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.0033 0.0091 0.0238
Trichomonas vaginalis D-aminoacylase, putative 0.0296 0.1494 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0296 0.1494 0.4284
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0051 0.034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0051 0.034
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0159 0.0232
Schistosoma mansoni hypothetical protein 0.0121 0.0559 0.0813
Echinococcus granulosus tar DNA binding protein 0.0668 0.3476 0.5059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0051 0.034
Schistosoma mansoni coup transcription factor 0.0033 0.0091 0.0132
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0091 0.026
Plasmodium falciparum thioredoxin reductase 0.0046 0.0159 0.1964
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0296 0.1494 0.1494
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0133 0.0622 0.4049
Loa Loa (eye worm) hypothetical protein 0.0033 0.0091 0.0238
Loa Loa (eye worm) prolyl 4-hydroxylase 2 0.0021 0.0029 0.0062
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.011 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.0185
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.0033 0.0091 0.0238
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0091 0.0132
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0091 0.0238
Treponema pallidum bacterioferrin (TpF1) 0.0016 0.0001 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0102 0.0681
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.0091 0.0132
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0072 0.0892
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0533 0.0533
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0166 0.1111
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0091 0.026
Schistosoma mansoni tar DNA-binding protein 0.0668 0.3476 0.5059
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0166 0.1111
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.0585 0.1664
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0296 0.1494 0.4298
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0091 0.026
Entamoeba histolytica hypothetical protein 0.0121 0.0559 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0168 0.0811 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0091 0.0238
Brugia malayi hypothetical protein 0.0017 0.0008 0.0023
Mycobacterium ulcerans esterase/lipase LipP 0.0296 0.1494 1
Schistosoma mansoni tar DNA-binding protein 0.0668 0.3476 0.5059
Onchocerca volvulus 0.0296 0.1494 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0022 0.003 0.0204
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0927 0.6203
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0069 0.0464
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0335 0.0487
Onchocerca volvulus 0.0033 0.0091 0.0417
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0091 0.026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0102 0.0681
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0058 0.0224 0.2763
Mycobacterium leprae conserved hypothetical protein 0.0296 0.1494 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0091 0.0238
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0064 0.0426
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0115 0.0768
Echinococcus granulosus geminin 0.0167 0.0808 0.1176
Leishmania major hypothetical protein, conserved 0.0296 0.1494 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0168 0.0811 0.118
Schistosoma mansoni tar DNA-binding protein 0.0668 0.3476 0.5059
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0115 0.0769
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0078 0.0523
Onchocerca volvulus 0.0296 0.1494 1
Toxoplasma gondii tetratricopeptide repeat-containing protein 0.0021 0.0029 0.0197
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0166 0.1111
Schistosoma mansoni ferritin 0.0016 0.0001 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0927 0.6203
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0927 0.6203
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0091 0.026
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0069 0.0199
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0091 0.026
Mycobacterium ulcerans aldehyde dehydrogenase 0.0056 0.0212 0.1417
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0056 0.0212 0.0309
Schistosoma mansoni tar DNA-binding protein 0.0668 0.3476 0.5059
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0927 0.6203
Entamoeba histolytica hypothetical protein 0.0121 0.0559 1
Trypanosoma cruzi 2OG-Fe(II) oxygenase superfamily, putative 0.0021 0.0029 0.0197
Onchocerca volvulus 0.0029 0.0069 0.0272
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0091 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0102 0.0681
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0069 0.0464
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0091 0.026
Trichomonas vaginalis D-aminoacylase, putative 0.0296 0.1494 1
Loa Loa (eye worm) hypothetical protein 0.0248 0.1241 0.3554
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0051 0.034
Loa Loa (eye worm) beta-lactamase 0.0296 0.1494 0.4284
Brugia malayi Calcitonin receptor-like protein seb-1 0.0248 0.1241 0.3569
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0168 0.0811 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0065 0.0436
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0131 0.0615 0.0895
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0022 0.003 0.0204
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.0585 0.1664
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0159 0.0436
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0065 0.0436
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0069 0.0464
Mycobacterium tuberculosis Conserved protein 0.0296 0.1494 0.1494
Brugia malayi RNA binding protein 0.0668 0.3476 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0129 0.0866
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.0091 0.0417
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0022 0.003 0.0376
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0115 0.0769
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0072 0.0484
Brugia malayi steroid hormone receptor 0.0033 0.0091 0.026
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0091 0.0132
Trypanosoma cruzi 2OG-Fe(II) oxygenase superfamily, putative 0.0021 0.0029 0.0197
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0159 0.1065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0051 0.0338
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0091 0.026
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.002 0.0131
Mycobacterium ulcerans aldehyde dehydrogenase 0.0056 0.0212 0.1417
Mycobacterium tuberculosis Probable esterase LipL 0.0296 0.1494 0.1494
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0091 0.0132
Loa Loa (eye worm) hypothetical protein 0.0296 0.1494 0.4284
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0927 0.6203
Schistosoma mansoni hypothetical protein 0.0079 0.0335 0.0487
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0065
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0121 0.0559 0.0813
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.0091 0.0132
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0091 0.0132
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0069 0.0457
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0296 0.1494 0.2174
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0091 0.0132
Brugia malayi hypothetical protein 0.0121 0.0559 0.1607
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0069 0.0457
Toxoplasma gondii thioredoxin reductase 0.0046 0.0159 0.1065
Echinococcus multilocularis microtubule associated protein 2 0.1305 0.6872 1
Brugia malayi ecdysteroid receptor 0.0033 0.0091 0.026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0115 0.0768
Schistosoma mansoni hypothetical protein 0.0131 0.0615 0.0895
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.0091 0.0417
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0091 0.026
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0016 0.0001 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0069 0.0199
Loa Loa (eye worm) hypothetical protein 0.0296 0.1494 0.4284
Mycobacterium ulcerans bacterioferritin BfrA 0.0016 0.0001 0.0007
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0069 0.0464
Echinococcus granulosus FTZ F1 alpha 0.0033 0.0091 0.0132
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0533 0.0533
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0102 0.0681
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0166 0.1111
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0056 0.0212 0.0309
Trichomonas vaginalis glucosylceramidase, putative 0.0124 0.0579 0.3876
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0091 0.026
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0168 0.0811 0.5426
Schistosoma mansoni hypothetical protein 0.0079 0.0335 0.0487
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0159 0.0232
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0056 0.0212 0.1417
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0091 0.0238
Loa Loa (eye worm) hypothetical protein 0.0033 0.0091 0.0238
Mycobacterium ulcerans beta-lactamase 0.0296 0.1494 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.0091 0.0132
Echinococcus multilocularis prolyl 4 hydroxylase subunit alpha 1 0.0021 0.0029 0.0043
Loa Loa (eye worm) hypothetical protein 0.0296 0.1494 0.4284
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0069 0.0464
Schistosoma mansoni thyroid hormone receptor 0.0164 0.079 0.115
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0091 0.026
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0168 0.0484
Mycobacterium ulcerans aldehyde dehydrogenase 0.0056 0.0212 0.1417
Loa Loa (eye worm) hypothetical protein 0.0109 0.0494 0.1402
Brugia malayi beta-lactamase family protein 0.0296 0.1494 0.4298
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0091 0.0132
Echinococcus granulosus ferritin 0.0016 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0079 0.0335 0.0487
Mycobacterium tuberculosis Probable lipase LipD 0.0296 0.1494 0.1494
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0166 0.1111
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0072 0.0484
Brugia malayi Thioredoxin reductase 0.0046 0.0159 0.0458
Echinococcus granulosus GPCR family 2 0.0079 0.0335 0.0487
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0115 0.0768
Toxoplasma gondii aldehyde dehydrogenase 0.0056 0.0212 0.1417
Echinococcus multilocularis geminin 0.0167 0.0808 0.1176
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0091 0.0132
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0296 0.1494 0.2174
Loa Loa (eye worm) hypothetical protein 0.0033 0.0091 0.0238
Brugia malayi latrophilin 2 splice variant baaae 0.017 0.0821 0.2363
Echinococcus granulosus peptidase Clp S14 family 0.011 0.0502 0.0731
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0102 0.0681
Schistosoma mansoni aldehyde dehydrogenase 0.0056 0.0212 0.0308
Mycobacterium ulcerans hypothetical protein 0.0296 0.1494 1
Echinococcus multilocularis ferritin 0.0016 0.0001 0.0002
Schistosoma mansoni ferritin 0.0016 0.0001 0.0002

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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