Detailed information for compound 1071897

Basic information

Technical information
  • TDR Targets ID: 1071897
  • Name: phenyl 3-[1-[[4-(benzimidazol-1-yl)pyrimidin- 2-yl]amino]ethyl]piperidine-1-carboxylate
  • MW: 442.513 | Formula: C25H26N6O2
  • H donors: 1 H acceptors: 4 LogP: 4.67 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(C1CCCN(C1)C(=O)Oc1ccccc1)Nc1nccc(n1)n1cnc2c1cccc2
  • InChi: 1S/C25H26N6O2/c1-18(19-8-7-15-30(16-19)25(32)33-20-9-3-2-4-10-20)28-24-26-14-13-23(29-24)31-17-27-21-11-5-6-12-22(21)31/h2-6,9-14,17-19H,7-8,15-16H2,1H3,(H,26,28,29)
  • InChiKey: DHPVHQFCJDYBNK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-[1-[[4-(1-benzimidazolyl)-2-pyrimidinyl]amino]ethyl]-1-piperidinecarboxylic acid phenyl ester
  • 3-[1-[[4-(benzimidazol-1-yl)pyrimidin-2-yl]amino]ethyl]piperidine-1-carboxylic acid phenyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens LCK proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni lamin 0.0061 0.0552 0.0681
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0263 0.0325
Onchocerca volvulus 0.0061 0.0552 0.1128
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0263 0.06
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0334 0.0413
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0148
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0334 0.0334
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0291 0.0663
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0148
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0018 0.0086 0.0197
Mycobacterium leprae Probable pyruvate kinase PykA 0.0037 0.0291 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0263 0.06
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0291 0.0523
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0085 0.0194
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.0209 0.0257
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.0065 0.0148
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0263 0.0459
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0263 0.0325
Echinococcus multilocularis pyruvate kinase 0.0019 0.0095 0.0095
Echinococcus granulosus neuropeptide receptor A26 0.0517 0.5521 0.6815
Schistosoma mansoni hypothetical protein 0.0039 0.0313 0.0387
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0263 0.06
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0263 0.0263
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0106 0.1041 0.1041
Loa Loa (eye worm) hypothetical protein 0.0412 0.4381 1
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0065 0.0148
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0065 0.0065
Brugia malayi nuclear receptor NHR-88 0.0016 0.0065 0.0148
Schistosoma mansoni hypothetical protein 0.0018 0.0085 0.0105
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0334 1
Echinococcus granulosus pyruvate kinase 0.0037 0.0291 0.0359
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0085 0.0194
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.049 0.1118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0106 0.1041 0.1284
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0106 0.1041 0.1284
Onchocerca volvulus 0.0055 0.049 0.0984
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0263 0.06
Echinococcus multilocularis pyruvate kinase 0.0019 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0412 0.4381 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0263 0.06
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0261 0.2729 0.6229
Giardia lamblia Pyruvate kinase 0.0037 0.0291 0.8176
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0086 0.0086
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0086 0.0197
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0148
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0065 0.0065
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0263 0.0263
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0085 0.0105
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.1337 0.165
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0334 0.0413
Schistosoma mansoni nuclear receptor 0.0016 0.0065 0.008
Loa Loa (eye worm) hypothetical protein 0.0305 0.3207 0.732
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.051 0.1164
Onchocerca volvulus 0.0061 0.0552 0.1128
Schistosoma mansoni hypothetical protein 0.0018 0.0085 0.0105
Onchocerca volvulus 0.0034 0.0263 0.0459
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0033 0.0244 0.0556
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0086 0.0197
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0334 0.0413
Echinococcus multilocularis lamin 0.0061 0.0552 0.0552
Loa Loa (eye worm) hypothetical protein 0.0018 0.0086 0.0197
Echinococcus granulosus geminin 0.0754 0.8101 1
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0085 0.0194
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0106 0.1041 0.2375
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0263 0.06
Schistosoma mansoni pyruvate kinase 0.0037 0.0291 0.0359
Schistosoma mansoni hypothetical protein 0.0018 0.0085 0.0105
Brugia malayi Intermediate filament tail domain containing protein 0.0061 0.0552 0.126
Loa Loa (eye worm) hypothetical protein 0.0034 0.0263 0.06
Brugia malayi nuclear hormone receptor 0.0016 0.0065 0.0148
Brugia malayi nuclear receptor RXR 0.0018 0.0086 0.0197
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0106 0.1041 0.1284
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0263 0.0325
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0263 0.0263
Echinococcus granulosus GPCR family 2 0.0018 0.0085 0.0105
Loa Loa (eye worm) intermediate filament protein 0.0061 0.0552 0.126
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0065 0.008
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0263 0.06
Brugia malayi steroid hormone receptor 0.0034 0.0263 0.06
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0169 0.0385
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0263 0.0459
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0291 0.0663
Schistosoma mansoni zinc finger protein 0.0016 0.0065 0.008
Brugia malayi ecdysone receptor 0.0016 0.0065 0.0148
Chlamydia trachomatis pyruvate kinase 0.0037 0.0291 0.5
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0334 1
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.041 0.0507
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.0065 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0263 0.06
Schistosoma mansoni hypothetical protein 0.0055 0.049 0.0604
Loa Loa (eye worm) hypothetical protein 0.0061 0.0552 0.126
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0291 0.0663
Brugia malayi hypothetical protein 0.0016 0.0065 0.0148
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0263 0.0325
Schistosoma mansoni nuclear receptor 0.0016 0.0065 0.008
Brugia malayi photoreceptor-specific nuclear receptor 0.0305 0.3207 0.732
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0106 0.1041 0.1284
Loa Loa (eye worm) hypothetical protein 0.0034 0.0263 0.06
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0263 0.0459
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0148
Echinococcus multilocularis musashi 0.0061 0.0552 0.0552
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0085 0.0085
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0106 0.1041 0.2375
Onchocerca volvulus Huntingtin homolog 0.0412 0.4381 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0263 0.06
Echinococcus multilocularis pyruvate kinase 0.0019 0.0095 0.0095
Echinococcus multilocularis survival motor neuron protein 1 0.0271 0.2837 0.2837
Echinococcus granulosus neuropeptide s receptor 0.0517 0.5521 0.6815
Loa Loa (eye worm) hypothetical protein 0.0018 0.0086 0.0197
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0133 0.1337 1
Echinococcus multilocularis pyruvate kinase 0.0029 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0029 0.0209 0.0476
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0263 0.0325
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0148
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0065 0.008
Brugia malayi hypothetical protein 0.0016 0.0065 0.0148
Loa Loa (eye worm) hypothetical protein 0.0041 0.0334 0.0763
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0148
Schistosoma mansoni lamin 0.0061 0.0552 0.0681
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0086 0.0106
Brugia malayi nuclear receptor NHR-88 0.0034 0.0263 0.06
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0291 0.0523
Brugia malayi nuclear receptor NHR-67 0.0016 0.0065 0.0148
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.1337 0.165
Echinococcus granulosus pyruvate kinase 0.0019 0.0095 0.0117
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0065 0.008
Schistosoma mansoni pyruvate kinase 0.0019 0.0095 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0263 0.06
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0291 0.0523
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0334 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0313 0.0715
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0086 0.0106
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1149 0.2622
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0106 0.1041 0.1041
Brugia malayi tailless protein 0.0016 0.0065 0.0148
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0263 0.06
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.051 0.1164
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0263 0.0325
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0263 0.0325
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.0065 0.0148
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0263 0.06
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0334 1
Schistosoma mansoni coup transcription factor 0.0034 0.0263 0.0325
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0148
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0148
Echinococcus granulosus intermediate filament protein 0.0061 0.0552 0.0681
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0133 0.1337 0.1337
Loa Loa (eye worm) hypothetical protein 0.0034 0.0263 0.06
Schistosoma mansoni hypothetical protein 0.0754 0.8101 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0085 0.0085
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0148
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0065 0.008
Loa Loa (eye worm) hypothetical protein 0.0037 0.0291 0.0663
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.051 0.1164
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0106 0.1041 0.1284
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0334 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0148
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0263 0.0325
Brugia malayi hypothetical protein 0.0412 0.4381 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0334 0.0413
Echinococcus multilocularis lamin dm0 0.0061 0.0552 0.0552
Loa Loa (eye worm) hypothetical protein 0.0018 0.0086 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0263 0.06
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0334 0.0334
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0065 0.008
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0061 0.0552 0.126
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0263 0.06
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0065 0.008
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0086 0.0106
Loa Loa (eye worm) hypothetical protein 0.0018 0.0086 0.0197
Echinococcus granulosus lamin 0.0061 0.0552 0.0681
Brugia malayi nuclear receptor RXR 0.0016 0.0065 0.0148
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.1337 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0263 0.0325
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0065 0.008
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0334 1
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0263 0.0325
Brugia malayi hypothetical protein 0.0018 0.0086 0.0197
Echinococcus multilocularis tumor protein p63 0.0327 0.3455 0.3455
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0291 0.0663
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0263 0.0325
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0263 0.0263
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0263 0.06
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.0065 0.0065
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0263 0.0263
Schistosoma mansoni intermediate filament proteins 0.0061 0.0552 0.0681
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0011 0.001 0.0023
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0263 0.06
Loa Loa (eye worm) hypothetical protein 0.0018 0.0085 0.0194
Echinococcus multilocularis neuropeptide receptor A26 0.0517 0.5521 0.5521
Echinococcus granulosus survival motor neuron protein 1 0.0271 0.2837 0.3502
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.0065 0.0148
Brugia malayi intermediate filament protein 0.0061 0.0552 0.126
Brugia malayi hypothetical protein 0.0271 0.2837 0.6476
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0065 0.0148
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0148
Plasmodium falciparum pyruvate kinase 0.0037 0.0291 1
Echinococcus multilocularis geminin 0.0754 0.8101 0.8101
Echinococcus granulosus pyruvate kinase 0.0019 0.0095 0.0117
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0065 0.008
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0263 0.0263
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0065 0.0065
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0263 0.0325
Echinococcus multilocularis pyruvate kinase 0.0037 0.0291 0.0291
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0263 0.06
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0148
Echinococcus multilocularis GPCR, family 2 0.0018 0.0085 0.0085
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0065 0.008
Loa Loa (eye worm) hypothetical protein 0.0028 0.0196 0.0448
Loa Loa (eye worm) hypothetical protein 0.0271 0.2837 0.6476
Echinococcus multilocularis pyruvate kinase 0.0037 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.0034 0.0263 0.06
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0133 0.1337 0.165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0263 0.06
Loa Loa (eye worm) hypothetical protein 0.0057 0.051 0.1164
Loa Loa (eye worm) hypothetical protein 0.0048 0.041 0.0937
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0263 0.06
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0263 0.0325
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0291 0.1576
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.0065 0.0148
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0263 0.0325
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1149 0.2622
Schistosoma mansoni pyruvate kinase 0.0037 0.0291 0.0359
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0263 0.0325
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.1337 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0065 0.008
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0263 0.0325
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0065 0.008
Schistosoma mansoni hypothetical protein 0.0018 0.0085 0.0105
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0263 0.0325
Schistosoma mansoni survival motor neuron protein 0.0055 0.049 0.0604
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0263 0.0263
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0263 0.0325
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0263 0.06
Schistosoma mansoni hypothetical protein 0.0754 0.8101 1
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0313 0.0715
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0263 0.0325
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0263 0.0325
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0263 0.0325
Brugia malayi cytoplasmic intermediate filament protein 0.0033 0.0244 0.0556
Toxoplasma gondii aldehyde dehydrogenase 0.0133 0.1337 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0263 0.06
Loa Loa (eye worm) hypothetical protein 0.0034 0.0263 0.06
Loa Loa (eye worm) hypothetical protein 0.0034 0.0263 0.06
Loa Loa (eye worm) DR-78 0.0016 0.0065 0.0148
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0334 0.0763
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0065 0.0065
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0334 1
Loa Loa (eye worm) hypothetical protein 0.006 0.054 0.1232
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0334 0.0413
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.0065 0.0148
Loa Loa (eye worm) hypothetical protein 0.0034 0.0263 0.06
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0133 0.1337 1
Brugia malayi MH2 domain containing protein 0.0116 0.1149 0.2622
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0065 0.0065
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0086 0.0197
Echinococcus granulosus pyruvate kinase 0.0037 0.0291 0.0359
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.0065 0.0148
Brugia malayi nuclear hormone receptor 0.0034 0.0263 0.06
Brugia malayi ecdysteroid receptor 0.0034 0.0263 0.06
Brugia malayi conserved hypotetical protein 0.0016 0.0065 0.0148
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0334 1
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0291 1
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0291 0.0663
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0263 0.06
Loa Loa (eye worm) hypothetical protein 0.0028 0.0196 0.0448
Onchocerca volvulus 0.0048 0.041 0.08
Echinococcus multilocularis neuropeptide s receptor 0.0517 0.5521 0.5521
Brugia malayi hypothetical protein 0.0018 0.0086 0.0197
Echinococcus granulosus pyruvate kinase 0.0019 0.0095 0.0117
Echinococcus granulosus lamin dm0 0.0061 0.0552 0.0681
Echinococcus granulosus tumor protein p63 0.0327 0.3455 0.4265
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0026 0.0169 0.0385
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0334 0.0417
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0263 0.0263
Onchocerca volvulus Huntingtin homolog 0.0412 0.4381 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.1337 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0085 0.0105
Brugia malayi follicle stimulating hormone receptor 0.0261 0.2729 0.6229
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0263 0.06

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 46 nM Inhibition of Lck ChEMBL. 19674899

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.