TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 711.069 | Formula: C44H74N2O5
H donors: 1 H acceptors: 3 LogP: 10.08 Rotable bonds: 17
Rule of 5 violations (Lipinski): 2
SMILES: CCN(CCCCCCNC(=O)[C@@]12CC[C@H]([C@@H]2[C@@H]2[C@](CC1)(C)[C@]1(C)CC[C@@H]3[C@]([C@H]1CC2)(C)CC[C@@H]([C@@]3(C)COC(=O)C)OC(=O)C)C(=C)C)CC
InChi: 1S/C44H74N2O5/c1-11-46(12-2)28-16-14-13-15-27-45-39(49)44-24-19-33(30(3)4)38(44)34-17-18-36-40(7)22-21-37(51-32(6)48)41(8,29-50-31(5)47)35(40)20-23-43(36,10)42(34,9)25-26-44/h33-38H,3,11-29H2,1-2,4-10H3,(H,45,49)/t33-,34+,35+,36+,37-,38+,40-,41-,42+,43+,44-/m0/s1
InChiKey: URBHNUAIOZMJSR-ZCGFJQMFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cathepsin C	0.0472	0.1098	0.1098
Brugia malayi	Papain family cysteine protease containing protein	0.0472	0.1098	0.1098
Echinococcus multilocularis	cathepsin L cysteine protease	0.2031	0.5122	0.5122
Giardia lamblia	Cathepsin B precursor	0.0472	0.1098	0.2427
Plasmodium falciparum	cysteine proteinase falcipain 3	0.2031	0.5122	1
Trypanosoma cruzi	cysteine proteinase, putative	0.1114	0.2755	0.1862
Giardia lamblia	Cathepsin B precursor	0.1539	0.3851	1
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0085	0.0097	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0713	0.1719	0.1719
Entamoeba histolytica	cysteine protease, putative	0.0472	0.1098	0.2106
Loa Loa (eye worm)	hypothetical protein	0.0642	0.1536	0.1536
Loa Loa (eye worm)	hypothetical protein	0.0472	0.1098	0.1098
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0695	0.1672	0.4007
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0048	0.0003	0.0006
Trichomonas vaginalis	conserved hypothetical protein	0.0472	0.1098	0.2139
Brugia malayi	Probable ClpP-like protease	0.0085	0.0097	0.0097
Onchocerca volvulus		0.1389	0.3464	0.6764
Loa Loa (eye worm)	glycogen phosphorylase	0.013	0.0215	0.0215
Giardia lamblia	Cathepsin L precursor	0.0472	0.1098	0.2427
Giardia lamblia	Encystation-specific protease	0.0557	0.1316	0.3027
Plasmodium vivax	unspecified product	0.1114	0.2755	0.529
Echinococcus granulosus	cathepsin l1	0.2031	0.5122	0.5122
Schistosoma mansoni	hypothetical protein	0.0184	0.0353	0.0353
Brugia malayi	Cathepsin L-like precursor	0.2031	0.5122	0.5122
Echinococcus multilocularis	chromobox protein 1	0.008	0.0085	0.0085
Plasmodium falciparum	serine repeat antigen 8	0.0472	0.1098	0.1991
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0266	0.0564	0.0564
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.2031	0.5122	1
Loa Loa (eye worm)	cysteine protease	0.2031	0.5122	0.5122
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0713	0.1719	0.1719
Plasmodium falciparum	serine repeat antigen 4	0.0472	0.1098	0.1991
Brugia malayi	cathepsin L-like cysteine proteinase	0.0472	0.1098	0.1098
Echinococcus multilocularis	muscleblind protein 1	0.0147	0.0259	0.0259
Giardia lamblia	Hypothetical protein	0.0472	0.1098	0.2427
Brugia malayi	Papain family cysteine protease containing protein	0.1114	0.2755	0.2755
Plasmodium falciparum	serine repeat antigen 6	0.0472	0.1098	0.1991
Plasmodium falciparum	serine repeat antigen 5	0.0472	0.1098	0.1991
Entamoeba histolytica	glycogen phosphorylase, putative	0.013	0.0215	0.0375
Entamoeba histolytica	cysteine protease, putative	0.1114	0.2755	0.5357
Echinococcus granulosus	histone acetyltransferase MYST2	0.0054	0.0017	0.0017
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Echinococcus multilocularis	chromobox protein 1	0.008	0.0085	0.0085
Echinococcus granulosus	cathepsin L	0.0472	0.1098	0.1098
Entamoeba histolytica	cysteine proteinase, putative	0.1114	0.2755	0.5357
Schistosoma mansoni	cathepsin S (C01 family)	0.0472	0.1098	0.1098
Echinococcus granulosus	glycogen phosphorylase	0.013	0.0215	0.0215
Trypanosoma cruzi	cysteine peptidase, putative	0.2475	0.6268	0.5808
Giardia lamblia	Cathepsin L-like protease	0.0472	0.1098	0.2427
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0259	0.0259
Entamoeba histolytica	cysteine protease, putative	0.1114	0.2755	0.5357
Schistosoma mansoni	chromobox protein	0.008	0.0085	0.0085
Brugia malayi	Papain family cysteine protease containing protein	0.0472	0.1098	0.1098
Echinococcus multilocularis	glycogen phosphorylase	0.013	0.0215	0.0215
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2031	0.5122	1
Schistosoma mansoni	glycogen phosphorylase	0.0056	0.0024	0.0024
Brugia malayi	Muscleblind-like protein	0.0147	0.0259	0.0259
Onchocerca volvulus		0.2031	0.5122	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2031	0.5122	1
Echinococcus multilocularis	muscleblind protein	0.0147	0.0259	0.0259
Echinococcus multilocularis	cathepsin L cysteine protease	0.2031	0.5122	0.5122
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0695	0.1672	0.1672
Entamoeba histolytica	cysteine protease, putative	0.1114	0.2755	0.5357
Echinococcus multilocularis	geminin	0.0184	0.0353	0.0353
Plasmodium vivax	unspecified product	0.0642	0.1536	0.2863
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0085	0.0097	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0472	0.1098	0.1098
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0472	0.1098	0.1098
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0054	0.0017	0.0017
Echinococcus multilocularis	glycogen phosphorylase	0.013	0.0215	0.0215
Trichomonas vaginalis	conserved hypothetical protein	0.0472	0.1098	0.2139
Schistosoma mansoni	cathepsin B (C01 family)	0.0472	0.1098	0.1098
Loa Loa (eye worm)	MBCTL1	0.0054	0.0017	0.0017
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Leishmania major	cathepsin L-like protease	0.2475	0.6268	1
Loa Loa (eye worm)	hypothetical protein	0.1389	0.3464	0.3464
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0472	0.1098	0.2139
Entamoeba histolytica	cysteine proteinase 2	0.1114	0.2755	0.5357
Brugia malayi	Cathepsin L-like precursor	0.2031	0.5122	0.5122
Leishmania major	cathepsin L-like protease	0.2031	0.5122	0.5258
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.1539	0.3851	0.7517
Echinococcus granulosus	cathepsin L cysteine proteinase	0.2031	0.5122	0.5122
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.2031	0.5122	0.5122
Giardia lamblia	Cysteine protease	0.0472	0.1098	0.2427
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0085	0.0097	1
Plasmodium vivax	unspecified product	0.0472	0.1098	0.1991
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0259	0.0259
Trypanosoma cruzi	cysteine peptidase, putative	0.0642	0.1536	0.0492
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2475	0.6268	1
Onchocerca volvulus	Cathepsin L homolog	0.2031	0.5122	1
Entamoeba histolytica	cysteine proteinase, putative	0.1114	0.2755	0.5357
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0056	0.0022	0.0022
Echinococcus granulosus	geminin	0.0184	0.0353	0.0353
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0472	0.1098	0.2139
Trypanosoma cruzi	cysteine peptidase, putative	0.2031	0.5122	0.452
Giardia lamblia	Cathepsin L precursor	0.0472	0.1098	0.2427
Brugia malayi	Cathepsin L-like precursor	0.2031	0.5122	0.5122
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0085	0.0097	0.0097
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0472	0.1098	0.1098
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2475	0.6268	1
Brugia malayi	Cathepsin L-like precursor	0.2031	0.5122	0.5122
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0472	0.1098	0.1098
Echinococcus granulosus	cathepsin l1	0.1389	0.3464	0.3464
Echinococcus multilocularis	cysteine protease	0.2031	0.5122	0.5122
Entamoeba histolytica	cysteine protease, putative	0.0472	0.1098	0.2106
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.2031	0.5122	0.5122
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0695	0.1672	0.3134
Schistosoma mansoni	chromobox protein	0.008	0.0085	0.0085
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0472	0.1098	0.1991
Trichomonas vaginalis	glycogen phosphorylase, putative	0.013	0.0215	0.0415
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0472	0.1098	0.1098
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0642	0.1536	0.1536
Giardia lamblia	Cathepsin L precursor	0.0472	0.1098	0.2427
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2475	0.6268	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2031	0.5122	1
Loa Loa (eye worm)	fibroinase	0.2031	0.5122	0.5122
Entamoeba histolytica	cysteine protease, putative	0.1114	0.2755	0.5357
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0185	0.0357	0.0357
Schistosoma mansoni	cathepsin F (C01 family)	0.2031	0.5122	0.5122
Trichomonas vaginalis	glycogen phosphorylase, putative	0.013	0.0215	0.0415
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Entamoeba histolytica	cysteine protease, putative	0.1114	0.2755	0.5357
Onchocerca volvulus	Cathepsin L homolog	0.0472	0.1098	0.2143
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2475	0.6268	1
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0472	0.1098	0.2106
Loa Loa (eye worm)	hypothetical protein	0.0472	0.1098	0.1098
Loa Loa (eye worm)	hypothetical protein	0.0472	0.1098	0.1098
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0054	0.0017	0.0017
Trypanosoma cruzi	cysteine peptidase, putative	0.1114	0.2755	0.1862
Giardia lamblia	Cysteine protease	0.0472	0.1098	0.2427
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0185	0.0357	0.0357
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0472	0.1098	0.1098
Giardia lamblia	Cysteine protease	0.0472	0.1098	0.2427
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0054	0.0017	0.0017
Giardia lamblia	Cathepsin B precursor	0.0713	0.1719	0.4135
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2031	0.5122	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0472	0.1098	0.2139
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1389	0.3464	0.6762
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1114	0.2755	0.2755
Echinococcus multilocularis	Glycosyl transferase, family 35	0.013	0.0215	0.0215
Echinococcus multilocularis	cathepsin L	0.0472	0.1098	0.1098
Giardia lamblia	Cathepsin L-like protease	0.0472	0.1098	0.2427
Leishmania major	cathepsin L-like protease	0.2475	0.6268	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0472	0.1098	0.2139
Entamoeba histolytica	cysteine protease, putative	0.1114	0.2755	0.5357
Schistosoma mansoni	hypothetical protein	0.0286	0.0617	0.0617
Loa Loa (eye worm)	ctsf protein	0.2031	0.5122	0.5122
Plasmodium vivax	vivapain-1	0.1114	0.2755	0.529
Echinococcus multilocularis	cysteine protease	0.2031	0.5122	0.5122
Loa Loa (eye worm)	hypothetical protein	0.2031	0.5122	0.5122
Giardia lamblia	Cysteine protease	0.0472	0.1098	0.2427
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1539	0.3851	0.3851
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0472	0.1098	0.1098
Giardia lamblia	Cathepsin B precursor	0.0472	0.1098	0.2427
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.061	0.1454	0.2835
Loa Loa (eye worm)	cathepsin B	0.1539	0.3851	0.3851
Trypanosoma cruzi	cruzipain precursor, putative	0.0642	0.1536	0.0492
Onchocerca volvulus		0.2031	0.5122	1
Toxoplasma gondii	cathepsin CPC1	0.0695	0.1672	0.3134
Trypanosoma brucei	cysteine peptidase C (CPC)	0.1539	0.3851	0.312
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0472	0.1098	0.2427
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2031	0.5122	1
Onchocerca volvulus		0.0472	0.1098	0.2143
Chlamydia trachomatis	glycogen phosphorylase	0.013	0.0215	1
Entamoeba histolytica	cysteine protease, putative	0.0472	0.1098	0.2106
Giardia lamblia	Cathepsin L precursor	0.0472	0.1098	0.2427
Schistosoma mansoni	cathepsin F (C01 family)	0.2031	0.5122	0.5122
Onchocerca volvulus		0.2031	0.5122	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2475	0.6268	1
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0097	0.0097
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0557	0.1316	0.2424
Echinococcus granulosus	cysteine protease	0.1114	0.2755	0.2755
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0085	0.0097	0.5
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0557	0.1316	0.2424
Leishmania major	cathepsin L-like protease	0.2031	0.5122	0.5258
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0695	0.1672	0.3134
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2031	0.5122	1
Leishmania major	cathepsin L-like protease	0.2031	0.5122	0.5258
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0017	0.0017
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.2031	0.5122	0.5122
Entamoeba histolytica	cysteine proteinase, putative	0.1389	0.3464	0.6749
Onchocerca volvulus	Cathepsin F homolog	0.2031	0.5122	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2475	0.6268	1
Brugia malayi	Cathepsin L-like precursor	0.0642	0.1536	0.1536
Plasmodium vivax	serine-repeat antigen (SERA)	0.0472	0.1098	0.1991
Brugia malayi	Cathepsin L-like precursor	0.2031	0.5122	0.5122
Plasmodium falciparum	serine repeat antigen 9	0.0472	0.1098	0.1991
Trypanosoma cruzi	cysteine proteinase, putative	0.1114	0.2755	0.1862
Plasmodium falciparum	serine repeat antigen 2	0.0472	0.1098	0.1991
Entamoeba histolytica	cysteine protease, putative	0.1114	0.2755	0.5357
Plasmodium falciparum	serine repeat antigen 1	0.0472	0.1098	0.1991
Giardia lamblia	Cathepsin B precursor	0.1539	0.3851	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1114	0.2755	0.2755
Plasmodium vivax	serine-repeat antigen (SERA)	0.0472	0.1098	0.1991
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0472	0.1098	0.1991
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0472	0.1098	0.1098
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0472	0.1098	0.1991
Leishmania major	cathepsin L-like protease	0.2475	0.6268	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Brugia malayi	Heterochromatin protein 1	0.008	0.0085	0.0085
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0472	0.1098	0.1098
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2475	0.6268	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2475	0.6268	1
Onchocerca volvulus		0.2031	0.5122	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.2031	0.5122	0.5122
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0056	0.0024	1
Entamoeba histolytica	cysteine protease, putative	0.1114	0.2755	0.5357
Echinococcus granulosus	glycogen phosphorylase	0.013	0.0215	0.0215
Entamoeba histolytica	cysteine proteinase, putative	0.2031	0.5122	1
Echinococcus granulosus	chromobox protein 1	0.008	0.0085	0.0085
Brugia malayi	Cathepsin L-like precursor	0.1389	0.3464	0.3464
Giardia lamblia	Cathepsin B precursor	0.1539	0.3851	1
Loa Loa (eye worm)	hypothetical protein	0.0642	0.1536	0.1536
Entamoeba histolytica	cysteine proteinase, putative	0.1114	0.2755	0.5357
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0472	0.1098	0.1991
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.1833	0.4611	0.3946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2475	0.6268	1
Entamoeba histolytica	cysteine protease, putative	0.1114	0.2755	0.5357
Onchocerca volvulus	Glycogen phosphorylase homolog	0.013	0.0215	0.042
Plasmodium vivax	vivapain-3	0.1114	0.2755	0.529
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0472	0.1098	0.2139
Schistosoma mansoni	cathepsin s	0.0642	0.1536	0.1536
Entamoeba histolytica	cysteine protease, putative	0.0472	0.1098	0.2106
Trypanosoma cruzi	major cysteine proteinase, putative	0.0916	0.2244	0.1288
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1539	0.3851	0.3093
Brugia malayi	follicle stimulating hormone receptor	0.0266	0.0564	0.0564
Plasmodium falciparum	serine repeat antigen 7	0.0472	0.1098	0.1991
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0472	0.1098	0.1098
Brugia malayi	cathepsin F-like cysteine proteinase	0.0642	0.1536	0.1536
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2475	0.6268	1
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0695	0.1672	0.3134
Loa Loa (eye worm)	hypothetical protein	0.1389	0.3464	0.3464
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0472	0.1098	0.1991
Trichomonas vaginalis	chromobox protein, putative	0.008	0.0085	0.016
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0472	0.1098	0.1098
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0085	0.0097	1
Echinococcus granulosus	Glycosyl transferase family 35	0.013	0.0215	0.0215
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.2031	0.5122	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0472	0.1098	0.2139
Entamoeba histolytica	cysteine proteinase, putative	0.2031	0.5122	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0472	0.1098	0.2139
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1389	0.3464	0.6762
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0713	0.1719	0.3352
Entamoeba histolytica	cysteine protease, putative	0.1114	0.2755	0.5357
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0557	0.1316	0.3027
Schistosoma mansoni	glycogen phosphorylase	0.013	0.0215	0.0215
Trypanosoma cruzi	cruzipain precursor, putative	0.2475	0.6268	0.5808
Brugia malayi	Papain family cysteine protease containing protein	0.0472	0.1098	0.1098
Loa Loa (eye worm)	hypothetical protein	0.0472	0.1098	0.1098
Entamoeba histolytica	cysteine protease, putative	0.0472	0.1098	0.2106
Leishmania major	cathepsin L-like protease	0.2031	0.5122	0.5258
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0557	0.1316	0.3027
Brugia malayi	cathepsin L precursor	0.0472	0.1098	0.1098
Trypanosoma cruzi	cysteine peptidase, putative	0.2475	0.6268	0.5808
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0054	0.0017	0.0017
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0713	0.1719	0.3352
Echinococcus granulosus	cathepsin l cysteine peptidase	0.2031	0.5122	0.5122
Giardia lamblia	Cathepsin B precursor	0.0472	0.1098	0.2427
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1114	0.2755	0.2755
Schistosoma mansoni	glycogen phosphorylase	0.013	0.0215	0.0215
Loa Loa (eye worm)	heterochromatin protein 1	0.008	0.0085	0.0085
Entamoeba histolytica	cysteine protease, putative	0.0472	0.1098	0.2106
Brugia malayi	Cathepsin L-like precursor	0.1389	0.3464	0.3464
Brugia malayi	cathepsin L-like precursor	0.1389	0.3464	0.3464
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2031	0.5122	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0695	0.1672	0.3134
Leishmania major	cysteine peptidase A (CPA)	0.2031	0.5122	0.5258
Echinococcus granulosus	cathepsin L cysteine protease	0.1114	0.2755	0.2755
Entamoeba histolytica	cysteine protease, putative	0.1114	0.2755	0.5357
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Plasmodium vivax	vivapain-2	0.2031	0.5122	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0472	0.1098	0.1098
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0472	0.1098	0.2106
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.2031	0.5122	1
Toxoplasma gondii	cathepsin B	0.1539	0.3851	0.7471
Entamoeba histolytica	cysteine protease, putative	0.1114	0.2755	0.5357
Onchocerca volvulus		0.2031	0.5122	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0472	0.1098	0.2139
Echinococcus granulosus	cathepsin L	0.1114	0.2755	0.2755
Entamoeba histolytica	hypothetical protein	0.0472	0.1098	0.2106
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.1114	0.2755	0.1862
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0713	0.1719	0.1719
Brugia malayi	Cathepsin L-like cysteine proteinase	0.1389	0.3464	0.3464
Echinococcus multilocularis	cathepsin L	0.1114	0.2755	0.2755
Loa Loa (eye worm)	hypothetical protein	0.1389	0.3464	0.3464
Trichomonas vaginalis	chromobox protein, putative	0.008	0.0085	0.016
Loa Loa (eye worm)	hypothetical protein	0.0642	0.1536	0.1536
Entamoeba histolytica	cysteine protease, putative	0.2031	0.5122	1
Giardia lamblia	Cathepsin L precursor	0.0472	0.1098	0.2427
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0695	0.1672	0.3134
Brugia malayi	Cathepsin L-like precursor	0.2031	0.5122	0.5122
Brugia malayi	cathepsin F-like cysteine proteinase	0.0472	0.1098	0.1098
Brugia malayi	fibroinase precursor	0.0472	0.1098	0.1098
Loa Loa (eye worm)	hypothetical protein	0.0472	0.1098	0.1098
Echinococcus granulosus	peptidase Clp S14 family	0.0056	0.0022	0.0022
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0472	0.1098	0.2139
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.2031	0.5122	1
Schistosoma mansoni	hypothetical protein	0.0184	0.0353	0.0353
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0472	0.1098	0.1991
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0472	0.1098	0.2139
Entamoeba histolytica	cysteine proteinase, putative	0.1114	0.2755	0.5357
Giardia lamblia	Cathepsin L precursor	0.0472	0.1098	0.2427
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0054	0.0017	0.0017
Giardia lamblia	Hypothetical protein	0.0472	0.1098	0.2427
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0472	0.1098	0.2139
Entamoeba histolytica	cysteine protease, putative	0.1114	0.2755	0.5357
Plasmodium vivax	vivapain-2	0.2031	0.5122	1
Onchocerca volvulus		0.2031	0.5122	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0085	0.0097	0.5
Schistosoma mansoni	cathepsin F (C01 family)	0.1389	0.3464	0.3464
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1114	0.2755	0.5377
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2031	0.5122	1
Schistosoma mansoni	peptidase Clp (S14 family)	0.0085	0.0097	0.0097
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2031	0.5122	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.1114	0.2755	0.5357
Brugia malayi	Papain family cysteine protease containing protein	0.1114	0.2755	0.2755
Trypanosoma cruzi	cysteine peptidase, putative	0.2475	0.6268	0.5808
Plasmodium falciparum	serine repeat antigen 3	0.0472	0.1098	0.1991
Brugia malayi	Papain family cysteine protease containing protein	0.2031	0.5122	0.5122
Echinococcus granulosus	chromobox protein 1	0.008	0.0085	0.0085
Trypanosoma cruzi	cysteine protease, putative	0.1114	0.2755	0.1862
Onchocerca volvulus	Cathepsin L homolog	0.2031	0.5122	1
Brugia malayi	carbohydrate phosphorylase	0.013	0.0215	0.0215
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2031	0.5122	1
Leishmania major	cathepsin L-like protease	0.2031	0.5122	0.5258
Giardia lamblia	Cathepsin B precursor	0.0472	0.1098	0.2427
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0713	0.1719	0.3352
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0472	0.1098	0.1991
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2475	0.6268	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0713	0.1719	0.3352
Onchocerca volvulus		0.2031	0.5122	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0642	0.1536	0.1536
Plasmodium falciparum	cysteine proteinase falcipain 1	0.1114	0.2755	0.529
Toxoplasma gondii	cathepsin CPC2	0.0557	0.1316	0.2424
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0472	0.1098	0.2139
Toxoplasma gondii	cathepsin CPL	0.2031	0.5122	1
Entamoeba histolytica	glycogen phosphorylase, putative	0.013	0.0215	0.0375
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1114	0.2755	0.5377
Echinococcus granulosus	muscleblind protein	0.0147	0.0259	0.0259

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 55.6 uM	Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins	ChEMBL.	19889536

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL567250

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1071932