Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.1712 | 0.2714 |
Echinococcus granulosus | zinc finger protein | 0.0022 | 0.0248 | 0.0191 |
Onchocerca volvulus | Huntingtin homolog | 0.0136 | 0.8051 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0471 | 0.1043 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0066 | 0.3263 | 0.3223 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.0671 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1838 | 0.179 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.1712 | 0.2714 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.1477 | 0.1427 |
Brugia malayi | PHD-finger family protein | 0.0027 | 0.0649 | 0.0649 |
Echinococcus multilocularis | chromobox protein 1 | 0.0077 | 0.4012 | 0.3976 |
Schistosoma mansoni | zinc finger protein | 0.0022 | 0.0248 | 0.0479 |
Echinococcus multilocularis | zinc finger protein | 0.0022 | 0.0248 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0671 | 0.0616 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0046 | 0.1934 | 0.1229 |
Schistosoma mansoni | chromobox protein | 0.0077 | 0.4012 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0077 | 0.4012 | 0.3976 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0671 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.4091 | 0.4056 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0328 | 0.0271 |
Trichomonas vaginalis | chromobox protein, putative | 0.0046 | 0.1934 | 0.3419 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1078 | 0.1025 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0043 | 0.1712 | 0.0909 |
Brugia malayi | hypothetical protein | 0.0136 | 0.8051 | 0.8051 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0328 | 0.068 |
Brugia malayi | chromobox protein homolog 3 | 0.0043 | 0.1712 | 0.1712 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1981 | 0.1934 |
Trichomonas vaginalis | chromobox protein, putative | 0.0077 | 0.4012 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1712 | 0.1663 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.1655 | 0.1655 |
Onchocerca volvulus | Huntingtin homolog | 0.0136 | 0.8051 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0077 | 0.4012 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0082 | 0.4412 | 0.4412 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.8051 | 0.8039 |
Schistosoma mansoni | bromodomain containing protein | 0.007 | 0.3532 | 0.8785 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0019 | 0.0105 | 0.0046 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.8051 | 0.8039 |
Trichomonas vaginalis | chromobox protein, putative | 0.0046 | 0.1934 | 0.3419 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.166 | 0.1611 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0671 | 0.0671 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0471 | 0.0415 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0671 | 0.5 |
Echinococcus granulosus | chromobox protein 1 | 0.0077 | 0.4012 | 0.3976 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0671 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.0671 | 0.5 |
Brugia malayi | Heterochromatin protein 1 | 0.0077 | 0.4012 | 0.4012 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.1477 | 0.1427 |
Schistosoma mansoni | chromobox protein | 0.0077 | 0.4012 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0077 | 0.4012 | 0.3976 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0671 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0066 | 0.3263 | 0.3223 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0671 | 0.5 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0471 | 0.0415 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0671 | 0.5 |
Echinococcus granulosus | chromobox protein 1 | 0.0077 | 0.4012 | 0.3976 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 274 umol/Kg | Anticonvulsant activity in ip dosed albino mouse assessed as absence of hind limb tonic extension after 0.5 hrs by MES test | ChEMBL. | 19853976 |
TD50 (ADMET) | = 355 umol/Kg | Neurotoxicity in ip dosed albino mouse during 1 min by rotarod test | ChEMBL. | 19853976 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.