Detailed information for compound 1072479

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 480.644 | Formula: C22H32N4O4S2
  • H donors: 4 H acceptors: 4 LogP: 1.2 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)CCCCCNC(=O)[C@@H]1CC2(CN1C(=O)[C@H](Cc1ccccc1)N)SCCS2
  • InChi: 1S/C22H32N4O4S2/c23-17(13-16-7-3-1-4-8-16)21(29)26-15-22(31-11-12-32-22)14-18(26)20(28)24-10-6-2-5-9-19(27)25-30/h1,3-4,7-8,17-18,30H,2,5-6,9-15,23H2,(H,24,28)(H,25,27)/t17-,18-/m0/s1
  • InChiKey: XFXNOERGJPXACU-ROUUACIJSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0405 0.0396
Echinococcus granulosus tubulin alpha chain 0.0774 0.7514 0.7512
Leishmania major alpha tubulin 0.0774 0.7514 0.7514
Onchocerca volvulus 0.002 0.0105 0.0259
Echinococcus granulosus tubulin delta chain 0.0265 0.2509 0.2502
Echinococcus granulosus peptidase Clp S14 family 0.0032 0.0221 0.0211
Leishmania major 4-coumarate:coa ligase-like protein 0.0013 0.0037 0.0037
Plasmodium falciparum alpha tubulin 1 0.0774 0.7514 0.7513
Trypanosoma brucei alpha tubulin 0.0774 0.7514 0.7514
Echinococcus granulosus dna polymerase kappa 0.0012 0.0028 0.0018
Echinococcus granulosus zinc finger protein 0.0014 0.0048 0.0038
Trypanosoma brucei epsilon tubulin 0.063 0.6104 0.6104
Schistosoma mansoni cytochrome P450 0.0021 0.0113 0.0113
Echinococcus multilocularis tubulin alpha chain 0.0774 0.7514 0.7512
Giardia lamblia Epsilon tubulin 0.0318 0.3029 0.3022
Schistosoma mansoni tubulin subunit alpha 0.0774 0.7514 0.7514
Echinococcus multilocularis neuropeptide s receptor 0.0266 0.2525 0.2517
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0461 0.4439 0.4434
Loa Loa (eye worm) tubulin alpha 2 0.0509 0.491 0.4908
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0036
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0117 0.0108
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0014 0.0039 0.0036
Loa Loa (eye worm) hypothetical protein 0.002 0.0105 0.0101
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0023 0.0127 0.0118
Onchocerca volvulus Bile acid receptor homolog 0.0014 0.0039 0.0037
Echinococcus multilocularis zinc finger protein 0.0014 0.0048 0.0038
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0017 0.0071 0.0246
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0036
Echinococcus multilocularis cpg binding protein 0.0041 0.031 0.03
Echinococcus granulosus Tubulin alpha 1 chain 0.0774 0.7514 0.7512
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0405 0.0396
Loa Loa (eye worm) hypothetical protein 0.002 0.01 0.0097
Plasmodium vivax delta tubulin, putative 0.0265 0.2509 0.2507
Leishmania major DNA polymerase kappa, putative 0.0012 0.0028 0.0028
Trichomonas vaginalis tubulin, putative 0.0318 0.3037 0.303
Brugia malayi Plexin repeat family protein 0.0012 0.0028 0.0019
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0021 0.0113 0.0438
Leishmania major GTP-binding protein, putative 0.0015 0.0049 0.0049
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0021 0.0113 0.0438
Schistosoma mansoni eyes absent homolog 0.0089 0.0783 0.0783
Toxoplasma gondii hypothetical protein 0.0017 0.0071 0.0061
Trypanosoma cruzi zeta tubulin, putative 0.0818 0.7954 0.7954
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0014 0.0039 0.003
Loa Loa (eye worm) hypothetical protein 0.0034 0.0243 0.0239
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0015 0.0049 0.0039
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0038 0.0282 0.0273
Brugia malayi tubulin alpha-2 chain 0.0774 0.7514 0.7512
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0049 0.0386 0.1527
Toxoplasma gondii alpha tubulin TUBA1 0.0774 0.7514 0.7512
Mycobacterium ulcerans DNA polymerase IV 0.0012 0.0028 0.0096
Echinococcus granulosus tubulin alpha 1C chain 0.0774 0.7514 0.7512
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0016 0.0064 0.0054
Schistosoma mansoni cpg binding protein 0.0041 0.031 0.031
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0013 0.0037 0.0132
Loa Loa (eye worm) RNA binding protein 0.0044 0.0335 0.0331
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0021 0.0113 0.0438
Loa Loa (eye worm) hypothetical protein 0.0111 0.1001 0.0998
Trypanosoma brucei importin beta-1 subunit, putative 0.002 0.01 0.01
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0014 0.0039 0.003
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0049 0.0386 0.1506
Giardia lamblia Alpha-tubulin 0.0774 0.7514 0.7512
Brugia malayi Cytochrome P450 family protein 0.0059 0.0486 0.0477
Schistosoma mansoni ap endonuclease 0.0011 0.001 0.001
Loa Loa (eye worm) steroid hormone receptor 0.0014 0.0039 0.0036
Leishmania major cytochrome p450-like protein 0.0021 0.0113 0.0113
Brugia malayi CXXC zinc finger family protein 0.0038 0.0277 0.0267
Loa Loa (eye worm) tubulin gamma chain 0.0631 0.6112 0.6111
Echinococcus granulosus ecdysone induced protein 78C 0.0014 0.0039 0.003
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0021 0.0113 0.0438
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0021 0.0113 0.0438
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0015 0.0049 0.0039
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0011 0.001 0.0006
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0405 0.0405
Echinococcus multilocularis tubulin epsilon chain 0.063 0.6104 0.61
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.002 0.0105 0.0101
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0509 0.491 0.4908
Schistosoma mansoni tar DNA-binding protein 0.0044 0.0335 0.0335
Loa Loa (eye worm) hypothetical protein 0.002 0.0105 0.0101
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0014 0.0039 0.003
Brugia malayi nuclear receptor NHR-88 0.0014 0.0039 0.003
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0014 0.0039 0.0039
Brugia malayi MAP kinase sur-1 0.0051 0.0405 0.0396
Plasmodium falciparum tubulin delta chain, putative 0.0265 0.2509 0.2507
Echinococcus granulosus tubulin alpha chain 0.0774 0.7514 0.7512
Schistosoma mansoni RAR-like nuclear receptor 0.0014 0.0039 0.0039
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0038 0.0282 0.0273
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0039 0.0285 0.1122
Schistosoma mansoni alpha tubulin 0.0774 0.7514 0.7514
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0021 0.0113 0.0438
Brugia malayi Probable ClpP-like protease 0.0049 0.0386 0.0377
Trichomonas vaginalis tubulin beta chain, putative 0.0774 0.7514 0.7512
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0021 0.0113 0.0438
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0021 0.0113 0.0438
Plasmodium vivax aspartyl proteinase, putative 0.0038 0.0282 0.0279
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0021 0.0113 0.0438
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0036 0.0255 0.1002
Mycobacterium tuberculosis Probable esterase LipL 0.002 0.0105 0.0404
Giardia lamblia DINP protein human, muc B family 0.0012 0.0028 0.0018
Brugia malayi Muscleblind-like protein 0.0307 0.2925 0.2918
Brugia malayi Tubulin alpha-2 chain 0.0774 0.7514 0.7512
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0014 0.0039 0.003
Onchocerca volvulus Protein ultraspiracle homolog 0.0014 0.0039 0.0037
Plasmodium vivax tubulin alpha chain, putative 0.0774 0.7514 0.7513
Echinococcus multilocularis Tubulin alpha 1 chain 0.0774 0.7514 0.7512
Leishmania major alpha tubulin 0.0774 0.7514 0.7514
Echinococcus multilocularis Tubulin alpha 1 chain 0.0774 0.7514 0.7512
Trichomonas vaginalis penicillin-binding protein, putative 0.002 0.0105 0.0095
Echinococcus multilocularis thyroid hormone receptor alpha 0.0014 0.0039 0.003
Brugia malayi AMP-binding enzyme family protein 0.0013 0.0037 0.0027
Loa Loa (eye worm) PHD-finger family protein 0.0013 0.0033 0.0029
Schistosoma mansoni plexin 0.0012 0.0028 0.0028
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0405 0.0396
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0013 0.0037 0.0132
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0028 0.0028
Schistosoma mansoni thyroid hormone receptor 0.0014 0.0039 0.0039
Schistosoma mansoni methyl-cpg binding protein mbd 0.0011 0.0011 0.0011
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0015 0.0049 0.0039
Brugia malayi AMP-binding enzyme family protein 0.0013 0.0037 0.0027
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0014 0.0039 0.003
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0034 0.0243 0.0727
Brugia malayi cytochrome P450 0.0021 0.0113 0.0104
Schistosoma mansoni tubulin subunit epsilon 0.063 0.6104 0.6104
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0049 0.0386 0.0377
Trichomonas vaginalis tubulin beta chain, putative 0.0313 0.2981 0.2974
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0027 0.0167 0.0157
Trypanosoma brucei alpha tubulin 0.0774 0.7514 0.7514
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0021 0.0113 0.0438
Schistosoma mansoni bromodomain containing protein 0.0042 0.0318 0.0318
Mycobacterium tuberculosis Cell division protein FtsZ 0.0265 0.2509 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0032 0.0221 0.0866
Trypanosoma brucei epsilon tubulin 0.063 0.6104 0.6104
Schistosoma mansoni hypothetical protein 0.0212 0.1986 0.1986
Echinococcus granulosus cpg binding protein 0.0041 0.031 0.03
Echinococcus granulosus beta LACTamase domain containing family member 0.002 0.0105 0.0095
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0015 0.0049 0.0049
Loa Loa (eye worm) bromodomain containing protein 0.0011 0.0015 0.0011
Echinococcus granulosus Tubulin alpha 1 chain 0.0774 0.7514 0.7512
Loa Loa (eye worm) cytochrome P450 0.0021 0.0113 0.011
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0014 0.0039 0.003
Trypanosoma brucei importin beta-1 subunit, putative 0.002 0.01 0.01
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0037 0.0132
Echinococcus granulosus snurportin 1 0.0212 0.1986 0.1978
Mycobacterium tuberculosis Conserved protein 0.002 0.0105 0.0404
Echinococcus granulosus GTP binding nuclear protein Ran 0.0015 0.0049 0.0039
Brugia malayi ecdysteroid receptor 0.0014 0.0039 0.003
Loa Loa (eye worm) hypothetical protein 0.0029 0.019 0.0187
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0014 0.0039 0.003
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0013 0.0037 0.0132
Echinococcus granulosus FTZ F1 alpha 0.0014 0.0039 0.003
Brugia malayi mbt repeat family protein 0.0034 0.0243 0.0233
Mycobacterium leprae putative cytochrome p450 0.0021 0.0113 0.0309
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0105 0.0105
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0021 0.0113 0.0113
Schistosoma mansoni DNA polymerase eta 0.0012 0.0028 0.0028
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0016 0.0066 0.0066
Schistosoma mansoni tar DNA-binding protein 0.0044 0.0335 0.0335
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0021 0.0113 0.0438
Loa Loa (eye worm) hypothetical protein 0.0024 0.0143 0.0139
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0049 0.0386 0.1527
Giardia lamblia Delta tubulin 0.0265 0.2509 0.2502
Mycobacterium tuberculosis Conserved protein 0.002 0.0105 0.0404
Loa Loa (eye worm) hypothetical protein 0.002 0.0105 0.0101
Loa Loa (eye worm) tubulin beta chain 0.0265 0.2509 0.2507
Trichomonas vaginalis tubulin epsilon chain, putative 0.0265 0.2509 0.2502
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0117 0.0108
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0021 0.0113 0.0438
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0028 0.0028
Echinococcus granulosus SAM and MBT domain containing protein 0.0034 0.0243 0.0233
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0405 0.0396
Plasmodium falciparum tubulin epsilon chain, putative 0.063 0.6104 0.6103
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0021 0.0113 0.0438
Plasmodium vivax plasmepsin IV, putative 0.0038 0.0282 0.0279
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0044 0.0335 0.0331
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0049 0.0386 0.1414
Schistosoma mansoni tubulin subunit alpha 0.0774 0.7514 0.7514
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0014 0.0039 0.0036
Brugia malayi Steroid receptor seven-up type 2 0.0014 0.0039 0.003
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0015 0.0049 0.0045
Echinococcus granulosus tubulin alpha 3 chain 0.0774 0.7514 0.7512
Plasmodium vivax tubulin alpha chain, putative 0.0774 0.7514 0.7513
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0282 0.0282
Mycobacterium tuberculosis Conserved hypothetical protein 0.0012 0.0028 0.0096
Schistosoma mansoni biogenic amine (5HT) receptor 0.0405 0.3888 0.3888
Trichomonas vaginalis tubulin, putative 0.0313 0.2981 0.2974
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0025
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0021 0.0113 0.0438
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.002 0.0105 0.0101
Onchocerca volvulus 0.002 0.0105 0.0259
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0405 0.0396
Echinococcus multilocularis peroxisome assembly protein 26 0.0774 0.7514 0.7512
Brugia malayi Tubulin beta chain 0.0265 0.2509 0.2502
Trypanosoma brucei alpha tubulin 0.0774 0.7514 0.7514
Loa Loa (eye worm) alpha-tubulin 0.0774 0.7514 0.7513
Schistosoma mansoni cathepsin D (A01 family) 0.0113 0.1017 0.1017
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0023 0.0127 0.0118
Brugia malayi photoreceptor-specific nuclear receptor 0.0014 0.0039 0.003
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.0285 0.0285
Schistosoma mansoni terminal deoxycytidyl transferase 0.0012 0.0028 0.0028
Echinococcus granulosus cytochrome P450 2K1 0.0021 0.0113 0.0104
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0036
Trichomonas vaginalis D-aminoacylase, putative 0.002 0.0105 0.0095
Trypanosoma cruzi tubulin delta chain 0.0596 0.5766 0.5766
Schistosoma mansoni tubulin subunit alpha 0.0774 0.7514 0.7514
Loa Loa (eye worm) tubulin alpha-3 chain 0.0461 0.4439 0.4437
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0038 0.0282 0.0273
Trypanosoma brucei squalene synthase, putative 0.0114 0.1026 0.1026
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0015 0.0049 0.0049
Mycobacterium leprae Conserved hypothetical protein 0.0021 0.0113 0.0309
Mycobacterium ulcerans lipase LipD 0.002 0.0105 0.0404
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0021 0.0113 0.0438
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0088 0.0775 0.0766
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0021 0.0113 0.0438
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0021 0.0113 0.0438
Echinococcus multilocularis tubulin alpha chain 0.0774 0.7514 0.7512
Mycobacterium tuberculosis Probable lipase LipD 0.002 0.0105 0.0404
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0021 0.0113 0.0438
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0049 0.0386 0.0383
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0405 0.0396
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0014 0.0039 0.003
Leishmania major alpha tubulin 0.0774 0.7514 0.7514
Mycobacterium ulcerans aldehyde dehydrogenase 0.0088 0.0775 0.3079
Echinococcus granulosus tubulin alpha chain 0.0774 0.7514 0.7512
Trichomonas vaginalis D-aminoacylase, putative 0.002 0.0105 0.0095
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0021 0.0113 0.0438
Schistosoma mansoni zinc finger protein 0.0014 0.0048 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0028 0.0028
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0017 0.0071 0.0068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0014 0.0039 0.0036
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0088 0.0775 0.0766
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0027 0.0167 0.0157
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0212 0.1986 0.1983
Leishmania major alpha tubulin 0.0774 0.7514 0.7514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0015 0.0049 0.0039
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0113 0.1012 0.1003
Schistosoma mansoni ran 0.0015 0.0049 0.0049
Trypanosoma brucei cytochrome P450, putative 0.0039 0.0285 0.0285
Trypanosoma cruzi DNA polymerase kappa, putative 0.0012 0.0028 0.0028
Leishmania major DNA polymerase eta, putative 0.0012 0.0028 0.0028
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0015 0.0049 0.0049
Trypanosoma cruzi phytoene synthase, putative 0.0036 0.0255 0.0255
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0038 0.0282 0.0279
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0036 0.0255 0.0766
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0028 0.0028
Mycobacterium tuberculosis Probable conserved lipoprotein 0.002 0.0105 0.0404
Entamoeba histolytica acyl-CoA synthetase, putative 0.0013 0.0037 0.0027
Echinococcus granulosus methyl CpG binding domain protein 2 0.0011 0.0011 0.0001
Leishmania major hypothetical protein, conserved 0.0036 0.0255 0.0255
Echinococcus multilocularis serotonin receptor 0.0072 0.0612 0.0603
Brugia malayi ImpB/MucB/SamB family protein 0.0012 0.0028 0.0018
Schistosoma mansoni retinoic acid receptor RXR 0.0014 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0307 0.2925 0.2922
Trichomonas vaginalis importin beta-1, putative 0.0016 0.0064 0.0054
Echinococcus granulosus microtubule associated protein 2 0.0388 0.3723 0.3717
Trichomonas vaginalis ran, putative 0.0015 0.0049 0.0039
Schistosoma mansoni hypothetical protein 0.0013 0.0033 0.0033
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0049 0.0386 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0014 0.0039 0.003
Brugia malayi Tubulin alpha chain 0.0774 0.7514 0.7512
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0405 0.0396
Echinococcus multilocularis serotonin receptor 0.0072 0.0612 0.0603
Loa Loa (eye worm) plexin A 0.0015 0.0051 0.0047
Leishmania major gamma-tubulin 0.0631 0.6112 0.6112
Loa Loa (eye worm) hypothetical protein 0.0084 0.0731 0.0727
Echinococcus granulosus polycomb protein SCMH1 0.0034 0.0243 0.0233
Brugia malayi nuclear hormone receptor 0.0014 0.0039 0.003
Mycobacterium leprae conserved hypothetical protein 0.002 0.0105 0.0275
Loa Loa (eye worm) hypothetical protein 0.0026 0.0157 0.0154
Brugia malayi steroid hormone receptor 0.0014 0.0039 0.003
Mycobacterium ulcerans DNA polymerase IV 0.0012 0.0028 0.0096
Echinococcus multilocularis tubulin alpha chain 0.0774 0.7514 0.7512
Onchocerca volvulus 0.0111 0.1001 0.3295
Echinococcus multilocularis histone acetyltransferase MYST2 0.0039 0.029 0.028
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0049 0.0386 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0012 0.0019 0.0009
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0012 0.0028 0.0028
Trypanosoma brucei alpha tubulin 0.0774 0.7514 0.7514
Loa Loa (eye worm) tubulin alpha-2 chain 0.0774 0.7514 0.7513
Trichomonas vaginalis tubulin gamma chain, putative 0.063 0.6104 0.61
Leishmania major alpha tubulin 0.0774 0.7514 0.7514
Echinococcus multilocularis muscleblind protein 0.0307 0.2925 0.2918
Loa Loa (eye worm) hypothetical protein 0.0027 0.0167 0.0163
Entamoeba histolytica tubulin alpha chain, putative 0.0774 0.7514 0.7512
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0084 0.0731 0.0722
Brugia malayi ImpB/MucB/SamB family protein 0.0012 0.0028 0.0018
Trypanosoma cruzi DNA polymerase kappa, putative 0.0012 0.0028 0.0028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0113 0.1012 0.1012
Echinococcus multilocularis hypothetical protein 0.0774 0.7514 0.7512
Echinococcus granulosus biogenic amine 5HT receptor 0.0405 0.3888 0.3882
Toxoplasma gondii aldehyde dehydrogenase 0.0088 0.0775 0.0766
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0021 0.0113 0.0438
Plasmodium falciparum importin beta, putative 0.002 0.01 0.0097
Trichomonas vaginalis tubulin gamma chain, putative 0.0265 0.2509 0.2502
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0021 0.0113 0.0438
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0021 0.0113 0.0438
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.0285 0.0285
Brugia malayi beta-lactamase 0.002 0.0105 0.0095
Brugia malayi Cytochrome P450 family protein 0.0039 0.0285 0.0275
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0146 0.1345 0.1345
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0011 0.001 0.0006
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0405 0.0396
Echinococcus multilocularis muscleblind protein 1 0.0307 0.2925 0.2918
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0265 0.2509 1
Trypanosoma cruzi tubulin delta chain 0.0596 0.5766 0.5766
Mycobacterium ulcerans phytoene synthase, CrtB 0.0036 0.0255 0.1002
Schistosoma mansoni sex comb on midleg homolog 0.0034 0.0243 0.0243
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0113 0.1012 0.1003
Giardia lamblia Alpha-tubulin 0.0774 0.7514 0.7512
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0017 0.0071 0.0139
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0405 0.0402
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0021 0.0113 0.0113
Loa Loa (eye worm) mbt repeat family protein 0.0034 0.0243 0.0239
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0405 0.0405
Echinococcus multilocularis beta LACTamase domain containing family member 0.002 0.0105 0.0095
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0049 0.0386 0.0377
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0014 0.0039 0.003
Loa Loa (eye worm) hypothetical protein 0.0089 0.0783 0.078
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0318 0.3029 0.3022
Trypanosoma brucei PAB1-binding protein , putative 0.0048 0.0377 0.0377
Plasmodium falciparum ataxin-2 like protein, putative 0.0048 0.0377 0.0374
Echinococcus granulosus dna polymerase eta 0.0012 0.0028 0.0018
Schistosoma mansoni alpha tubulin 0.0774 0.7514 0.7514
Leishmania major alpha tubulin 0.0774 0.7514 0.7514
Trypanosoma brucei DNA polymerase eta, putative 0.0012 0.0028 0.0028
Onchocerca volvulus 0.0014 0.0039 0.0037
Plasmodium falciparum plasmepsin VI 0.0038 0.0282 0.0279
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0028 0.0028
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0012 0.0028 0.0018
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0039 0.029 0.028
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0113 0.1012 0.1003
Loa Loa (eye worm) hypothetical protein 0.0461 0.4439 0.4437
Loa Loa (eye worm) hypothetical protein 0.0036 0.0255 0.0251
Brugia malayi tubulin alpha chain - mouse 0.0774 0.7514 0.7512
Brugia malayi Cytochrome P450 family protein 0.0021 0.0113 0.0104
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0021 0.0113 0.0438
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0313 0.2981 0.2974
Loa Loa (eye worm) hypothetical protein 0.0044 0.0342 0.0339
Trichomonas vaginalis D-aminoacylase, putative 0.002 0.0105 0.0095
Trypanosoma cruzi DNA polymerase eta, putative 0.0012 0.0028 0.0028
Mycobacterium ulcerans esterase/lipase LipP 0.002 0.0105 0.0404
Trichomonas vaginalis DNA polymerase eta, putative 0.0012 0.0028 0.0018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0014 0.0039 0.003
Schistosoma mansoni methyl-cpg binding protein mbd 0.0011 0.0011 0.0011
Mycobacterium ulcerans beta-lactamase 0.002 0.0105 0.0404
Trypanosoma brucei unspecified product 0.0012 0.0028 0.0028
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0021 0.0113 0.0438
Trypanosoma cruzi tubulin gamma chain 0.0631 0.6112 0.6112
Mycobacterium tuberculosis Probable hydrolase 0.002 0.0105 0.0404
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0021 0.0113 0.0438
Trypanosoma cruzi zeta tubulin, putative 0.0818 0.7954 0.7954
Loa Loa (eye worm) hypothetical protein 0.0039 0.029 0.0286
Loa Loa (eye worm) hypothetical protein 0.0774 0.7514 0.7513
Trichomonas vaginalis tubulin beta chain, putative 0.0774 0.7514 0.7512
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0265 0.2509 0.2502
Echinococcus granulosus plexin a4 0.0015 0.0051 0.0041
Echinococcus multilocularis plexin a4 0.0015 0.0051 0.0041
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.002 0.0011
Schistosoma mansoni alpha tubulin 0.0774 0.7514 0.7514
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0405 0.3888 0.3882
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0113 0.0113
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0021 0.0113 0.0438
Schistosoma mansoni cpg binding protein 0.0041 0.031 0.031
Trypanosoma cruzi importin beta-1 subunit, putative 0.0016 0.0064 0.0064
Leishmania major 4-coumarate:coa ligase-like protein 0.0013 0.0037 0.0037
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0014 0.0039 0.003
Leishmania major cytochrome p450-like protein 0.0021 0.0113 0.0113
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0021 0.0113 0.0438
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0049 0.0386 0.0377
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0036
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0013 0.0037 0.0132
Echinococcus multilocularis microtubule associated protein 2 0.0388 0.3723 0.3717
Schistosoma mansoni hypothetical protein 0.0057 0.0469 0.0469
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0113 0.1012 0.1012
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0113 0.1012 0.1009
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.002 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0014 0.0039 0.0036
Toxoplasma gondii HEAT repeat-containing protein 0.002 0.01 0.0091
Brugia malayi RNA, U transporter 1 0.0056 0.046 0.045
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0021 0.0113 0.0438
Echinococcus multilocularis GPCR, family 2 0.0027 0.0167 0.0157
Brugia malayi Cytochrome P450 family protein 0.0039 0.0285 0.0275
Brugia malayi hypothetical protein 0.0031 0.021 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0265 0.2509 0.2502
Loa Loa (eye worm) hypothetical protein 0.0072 0.0612 0.0609
Schistosoma mansoni coup transcription factor 0.0014 0.0039 0.0039
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0014 0.0039 0.0039
Schistosoma mansoni myelin transcription factor 1 myt1 0.0039 0.029 0.029
Mycobacterium leprae cell division protein FtsZ 0.0265 0.2509 1
Brugia malayi alpha-tubulin 0.0774 0.7514 0.7512
Schistosoma mansoni cathepsin D (A01 family) 0.0113 0.1017 0.1017
Trichomonas vaginalis conserved hypothetical protein 0.0265 0.2509 0.2502
Trypanosoma brucei RNA helicase, putative 0.0146 0.1345 0.1345
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0014 0.0039 0.0037
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0016 0.0064 0.0054
Loa Loa (eye worm) hypothetical protein 0.0013 0.0037 0.0033
Trichomonas vaginalis tubulin alpha chain, putative 0.0313 0.2981 0.2974
Echinococcus granulosus muscleblind protein 0.0307 0.2925 0.2918
Loa Loa (eye worm) hypothetical protein 0.0072 0.0612 0.0609
Brugia malayi Bromodomain containing protein 0.0049 0.039 0.0381
Echinococcus multilocularis tubulin gamma 1 chain 0.0631 0.6112 0.6108
Echinococcus multilocularis SAM and MBT domain containing protein 0.0034 0.0243 0.0233
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0039 0.003
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0021 0.0113 0.0438
Echinococcus granulosus neuropeptide s receptor 0.0266 0.2525 0.2517
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.002 0.0105 0.0404
Echinococcus multilocularis tubulin subunit TubB 0.0774 0.7514 0.7512
Schistosoma mansoni thyroid hormone receptor 0.0014 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0089 0.0783 0.078
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0014 0.0039 0.0036
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0021 0.0113 0.0438
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0015 0.0049 0.0045
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0011 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0027 0.0167 0.0167
Entamoeba histolytica acyl-CoA synthetase, putative 0.0013 0.0037 0.0027
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0036
Echinococcus multilocularis tubulin delta chain 0.0265 0.2509 0.2502
Leishmania major zeta tubulin, putative 0.0818 0.7954 0.7954
Mycobacterium ulcerans cell division protein FtsZ 0.0265 0.2509 1
Schistosoma mansoni hypothetical protein 0.0027 0.0167 0.0167
Echinococcus granulosus tubulin epsilon chain 0.063 0.6104 0.61
Schistosoma mansoni aldehyde dehydrogenase 0.0088 0.0775 0.0775
Loa Loa (eye worm) MBCTL1 0.0039 0.029 0.0286
Trypanosoma brucei DNA polymerase IV, putative 0.0012 0.0028 0.0028
Trypanosoma cruzi alpha tubulin, putative 0.0774 0.7514 0.7514
Brugia malayi TAR-binding protein 0.0044 0.0335 0.0325
Entamoeba histolytica tubulin alpha-1 chain 0.0774 0.7514 0.7512
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0039 0.003
Giardia lamblia Gamma tubulin 0.0631 0.6112 0.6108
Trypanosoma brucei epsilon tubulin 0.0577 0.5585 0.5585
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0011 0.001 0.0025
Onchocerca volvulus 0.0013 0.0037 0.0028
Leishmania major 4-coumarate:coa ligase-like protein 0.0013 0.0037 0.0037
Echinococcus granulosus biogenic amine 5HT receptor 0.0072 0.0612 0.0603
Schistosoma mansoni tar DNA-binding protein 0.0044 0.0335 0.0335
Echinococcus granulosus tubulin gamma 1 chain 0.0631 0.6112 0.6108
Entamoeba histolytica hypothetical protein 0.0016 0.0064 0.0054
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0011 0.0011 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0028 0.0028
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0021 0.0113 0.0438
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0015 0.0049 0.0045
Echinococcus granulosus GPCR family 2 0.0027 0.0167 0.0157
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0596 0.5766 0.5762
Leishmania major hypothetical protein, conserved 0.0048 0.0377 0.0377
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0011 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0038 0.0282 0.0279
Brugia malayi hypothetical protein 0.0048 0.0377 0.0368
Trypanosoma cruzi PAB1-binding protein , putative 0.0048 0.0377 0.0377
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0405 0.0405
Brugia malayi Latrophilin receptor protein 2 0.0027 0.0167 0.0157
Trypanosoma cruzi squalene synthase, putative 0.0114 0.1026 0.1026
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0014 0.0039 0.003
Echinococcus multilocularis tubulin alpha 3 chain 0.0774 0.7514 0.7512
Schistosoma mansoni biogenic amine (5HT) receptor 0.0072 0.0612 0.0612
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0405 0.0405
Echinococcus multilocularis 0.0021 0.0113 0.0104
Loa Loa (eye worm) hypothetical protein 0.0057 0.0469 0.0466
Schistosoma mansoni hypothetical protein 0.0036 0.0255 0.0255
Trypanosoma cruzi epsilon tubulin, putative 0.063 0.6104 0.6104
Plasmodium falciparum plasmepsin IV 0.0038 0.0282 0.0279
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0012 0.0028 0.0018
Loa Loa (eye worm) hypothetical protein 0.0307 0.2925 0.2922
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0039 0.003
Loa Loa (eye worm) histone methyltransferase 0.0012 0.002 0.0017
Plasmodium vivax hypothetical protein, conserved 0.002 0.0105 0.0101
Brugia malayi Importin beta-1 subunit 0.002 0.01 0.0091
Loa Loa (eye worm) tubulin alpha chain 0.0774 0.7514 0.7513
Loa Loa (eye worm) CYP4Cod1 0.0039 0.0285 0.0281
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0039 0.003
Echinococcus granulosus tubulin alpha 3 chain 0.0774 0.7514 0.7512
Echinococcus granulosus peroxisome assembly protein 26 0.0774 0.7514 0.7512
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0012 0.0019 0.0019
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0027 0.0167 0.0157
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0774 0.7514 0.7512
Echinococcus granulosus dnaJ subfamily B 0.0256 0.242 0.2412
Loa Loa (eye worm) beta-lactamase 0.002 0.0105 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0014 0.0039 0.003
Echinococcus granulosus importin subunit beta 1 0.002 0.01 0.0091
Trichomonas vaginalis esterase, putative 0.002 0.0105 0.0095
Echinococcus granulosus fetal alzheimer antigen falz 0.0016 0.0066 0.0056
Trichomonas vaginalis tubulin alpha chain, putative 0.0577 0.5585 0.558
Toxoplasma gondii histone lysine methyltransferase SET1 0.0073 0.0623 0.0614
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0034 0.0243 0.0243
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0088 0.0775 0.3079
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0015
Echinococcus multilocularis tubulin alpha 3 chain 0.0774 0.7514 0.7512
Echinococcus multilocularis neuropeptide receptor A26 0.0266 0.2525 0.2517
Loa Loa (eye worm) tubulin alpha chain 0.0774 0.7514 0.7513
Schistosoma mansoni hypothetical protein 0.0419 0.4022 0.4022
Leishmania major delta tubulin, putative 0.0596 0.5766 0.5766
Schistosoma mansoni hypothetical protein 0.0256 0.242 0.242
Trypanosoma cruzi DNA polymerase kappa, putative 0.0012 0.0028 0.0028
Schistosoma mansoni aldehyde dehydrogenase 0.0088 0.0775 0.0775
Echinococcus multilocularis importin subunit beta 1 0.002 0.01 0.0091
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0113 0.1012 0.1012
Toxoplasma gondii cytochrome p450 superfamily protein 0.0021 0.0113 0.0104
Mycobacterium leprae Probable lipase LipE 0.002 0.0105 0.0275
Plasmodium falciparum plasmepsin II 0.0038 0.0282 0.0279
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0014 0.0039 0.003
Loa Loa (eye worm) alpha-tubulin 0.0774 0.7514 0.7513
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0012 0.0019 0.0019
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0021 0.0113 0.0438
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0036
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0405 0.0405
Trichomonas vaginalis tubulin epsilon chain, putative 0.0774 0.7514 0.7512
Brugia malayi beta-lactamase family protein 0.002 0.0105 0.0095
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0021 0.0113 0.0438
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0455 0.4382 0.4376
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0039 0.003
Echinococcus multilocularis tubulin alpha chain 0.0774 0.7514 0.7512
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0027 0.0167 0.0157
Plasmodium vivax tubulin gamma chain, putative 0.0631 0.6112 0.6111
Onchocerca volvulus 0.0313 0.2981 1
Echinococcus granulosus alpha tubulin 0.0774 0.7514 0.7512
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0014 0.0039 0.003
Brugia malayi beta-lactamase family protein 0.002 0.0105 0.0095
Mycobacterium tuberculosis Conserved protein 0.002 0.0105 0.0404
Schistosoma mansoni tubulin subunit alpha 0.0265 0.2509 0.2509
Echinococcus granulosus geminin 0.0419 0.4022 0.4016
Brugia malayi Calcitonin receptor-like protein seb-1 0.0084 0.0731 0.0722
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.002 0.0105 0.0105
Leishmania major alpha tubulin 0.0774 0.7514 0.7514
Loa Loa (eye worm) TAR-binding protein 0.0044 0.0335 0.0331
Echinococcus multilocularis tar DNA binding protein 0.0044 0.0335 0.0325
Leishmania major epsilon tubulin, putative 0.063 0.6104 0.6104
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0031 0.0021
Echinococcus multilocularis dna polymerase eta 0.0012 0.0028 0.0018
Trichomonas vaginalis tubulin alpha chain, putative 0.0313 0.2981 0.2974
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0084 0.0731 0.0727
Trypanosoma brucei alpha tubulin, putative 0.0313 0.2981 0.2981
Plasmodium vivax ataxin-2 like protein, putative 0.0048 0.0377 0.0374
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0295 0.0286
Plasmodium falciparum ataxin-2 like protein, putative 0.0048 0.0377 0.0374
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0113 0.1012 0.1003
Toxoplasma gondii alpha-tubulin I, putative 0.0774 0.7514 0.7512
Echinococcus granulosus histone lysine methyltransferase setb 0.0012 0.0019 0.0009
Echinococcus multilocularis tubulin alpha chain 0.0774 0.7514 0.7512
Echinococcus granulosus tubulin alpha chain 0.0774 0.7514 0.7512
Trichomonas vaginalis tubulin beta chain, putative 0.0774 0.7514 0.7512
Loa Loa (eye worm) hypothetical protein 0.0013 0.0037 0.0033
Onchocerca volvulus 0.0038 0.0277 0.0841
Schistosoma mansoni mixed-lineage leukemia protein mll 0.008 0.0693 0.0693
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0137 0.1256 0.1247
Echinococcus multilocularis dnaJ subfamily B 0.0256 0.242 0.2412
Schistosoma mansoni tubulin subunit delta 0.0265 0.2509 0.2509
Loa Loa (eye worm) hypothetical protein 0.0509 0.491 0.4908
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0405 0.0396
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0039 0.029 0.028
Toxoplasma gondii tubulin, putative 0.0053 0.0425 0.0416
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0014 0.0039 0.003
Echinococcus multilocularis FTZ F1 alpha 0.0014 0.0039 0.003
Leishmania major alpha tubulin 0.0774 0.7514 0.7514
Leishmania major importin beta-1 subunit, putative 0.0016 0.0064 0.0064
Trypanosoma brucei beta tubulin 0.0577 0.5585 0.5585
Trypanosoma brucei tubulin gamma chain 0.0631 0.6112 0.6112
Brugia malayi PHD-finger family protein 0.0018 0.0081 0.0071
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0028 0.0028
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0021 0.0113 0.0438
Echinococcus granulosus tar DNA binding protein 0.0044 0.0335 0.0325
Schistosoma mansoni peptidase Clp (S14 family) 0.0049 0.0386 0.0386
Toxoplasma gondii ABC1 family protein 0.002 0.0105 0.0095
Loa Loa (eye worm) CXXC zinc finger family protein 0.0038 0.0277 0.0273
Brugia malayi AMP-binding enzyme family protein 0.0013 0.0037 0.0027
Brugia malayi Tubulin beta chain 0.0313 0.2981 0.2974
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0295 0.0286
Echinococcus multilocularis polycomb protein SCMH1 0.0034 0.0243 0.0233
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0012 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0021 0.0113 0.0113
Treponema pallidum cell division protein FtsZ 0.0265 0.2509 1
Brugia malayi Tubulin gamma chain 0.0631 0.6112 0.6108
Trypanosoma brucei zeta tubulin 0.0818 0.7954 0.7954
Leishmania major alpha tubulin 0.0774 0.7514 0.7514
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0014 0.0039 0.003
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0012 0.0028 0.0018
Onchocerca volvulus 0.002 0.0105 0.0259
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0129 0.1178 0.4687
Brugia malayi hypothetical protein 0.0111 0.1001 0.0992
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0014 0.0039 0.003
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0049 0.0386 0.0383
Loa Loa (eye worm) tubulin alpha 2 0.0509 0.491 0.4908
Echinococcus multilocularis snurportin 1 0.0212 0.1986 0.1978
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0105 0.0105
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.002 0.0105 0.0105
Brugia malayi RNA recognition motif domain containing protein 0.0044 0.0335 0.0325
Schistosoma mansoni hypothetical protein 0.0022 0.0117 0.0117
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0021 0.0113 0.0438
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0021 0.0113 0.0438
Echinococcus multilocularis peptidase Clp (S14 family) 0.0032 0.0221 0.0211
Leishmania major hypothetical protein, conserved 0.002 0.0105 0.0105
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0014 0.0039 0.0039
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0049 0.0386 0.0377
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0405 0.0405
Schistosoma mansoni hypothetical protein 0.0211 0.1977 0.1977
Trypanosoma cruzi DNA polymerase kappa, putative 0.0012 0.0028 0.0028
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0113 0.0113
Trypanosoma brucei protein kinase, putative 0.0051 0.0405 0.0405
Echinococcus multilocularis Tubulin alpha 1 chain 0.0774 0.7514 0.7512
Trichomonas vaginalis tubulin beta chain, putative 0.0774 0.7514 0.7512
Loa Loa (eye worm) hypothetical protein 0.0017 0.0077 0.0074
Plasmodium falciparum tubulin gamma chain 0.0631 0.6112 0.6111
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0037 0.0132
Echinococcus granulosus tubulin alpha chain 0.0774 0.7514 0.7512
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0011 0.001 0.001
Plasmodium falciparum alpha tubulin 2 0.0774 0.7514 0.7513
Leishmania major squalene synthase, putative 0.0114 0.1026 0.1026
Echinococcus multilocularis Squalene phytoene synthase 0.0036 0.0255 0.0245
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0037 0.0132
Entamoeba histolytica acyl-coA synthetase, putative 0.0013 0.0037 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0014 0.0039 0.0036
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.002 0.0105 0.0404
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0014 0.0039 0.0036
Brugia malayi latrophilin 2 splice variant baaae 0.0057 0.0469 0.046
Brugia malayi hypothetical protein 0.0089 0.0783 0.0774
Echinococcus multilocularis tubulin alpha 0.0577 0.5585 0.558
Echinococcus granulosus tubulin alpha 0.0577 0.5585 0.558
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.0037 0.0132
Trypanosoma cruzi PAB1-binding protein , putative 0.0048 0.0377 0.0377
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0011 0.001 0.0025
Loa Loa (eye worm) hypothetical protein 0.002 0.0105 0.0101
Mycobacterium ulcerans hypothetical protein 0.0013 0.0037 0.0132
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.0039 0.0039
Brugia malayi Cell division protein ftsZ 0.0265 0.2509 0.2502
Leishmania major alpha tubulin 0.0774 0.7514 0.7514
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0038 0.0282 0.0273
Brugia malayi Tubulin alpha-2 chain 0.0774 0.7514 0.7512
Plasmodium vivax importin-beta 2, putative 0.002 0.01 0.0097
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0486 0.0483
Mycobacterium ulcerans hypothetical protein 0.002 0.0105 0.0404
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0016 0.0066 0.0056
Echinococcus multilocularis tubulin alpha 1C chain 0.0774 0.7514 0.7512
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0014 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.002 0.0105 0.0101
Brugia malayi RNA binding protein 0.0044 0.0335 0.0325
Trichomonas vaginalis tubulin gamma chain, putative 0.0631 0.6112 0.6108
Trichomonas vaginalis tubulin alpha chain, putative 0.0313 0.2981 0.2974
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0036
Echinococcus granulosus Squalene phytoene synthase 0.0036 0.0255 0.0245
Schistosoma mansoni tubulin subunit beta 0.0265 0.2509 0.2509
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0405 0.0396
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0012 0.0028 0.0096
Schistosoma mansoni microtubule-associated protein tau 0.0388 0.3723 0.3723
Trichomonas vaginalis tubulin epsilon chain, putative 0.0774 0.7514 0.7512
Schistosoma mansoni hypothetical protein 0.0027 0.0167 0.0167
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0014 0.0039 0.0039
Leishmania major cytochrome p450-like protein 0.0039 0.0285 0.0285
Schistosoma mansoni cpg binding protein 0.0038 0.0277 0.0277
Entamoeba histolytica tubulin gamma chain 0.0631 0.6112 0.6108
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0021 0.0113 0.0438
Echinococcus granulosus tubulin subunit TubB 0.0774 0.7514 0.7512
Echinococcus granulosus histone acetyltransferase MYST2 0.0039 0.029 0.028
Echinococcus granulosus Tubulin alpha 1 chain 0.0774 0.7514 0.7512
Leishmania major alpha tubulin 0.0774 0.7514 0.7514
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0014 0.0039 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0028 0.0028
Trypanosoma cruzi epsilon tubulin, putative 0.063 0.6104 0.6104
Loa Loa (eye worm) hypothetical protein 0.0013 0.0037 0.0033
Plasmodium falciparum plasmepsin I 0.0038 0.0282 0.0279
Schistosoma mansoni hypothetical protein 0.0027 0.0167 0.0167
Leishmania major alpha tubulin 0.0774 0.7514 0.7514
Schistosoma mansoni ap endonuclease 0.0011 0.001 0.001
Trichomonas vaginalis tubulin beta chain, putative 0.0774 0.7514 0.7512
Trypanosoma brucei DNA polymerase IV, putative 0.0012 0.0028 0.0028
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0039 0.029 0.028
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0021 0.0113 0.0113
Brugia malayi plexin A 0.0015 0.0051 0.0041
Trypanosoma cruzi squalene synthase, putative 0.0114 0.1026 0.1026
Entamoeba histolytica deoxycytidyl transferase, putative 0.0012 0.0028 0.0018
Toxoplasma gondii aspartyl protease ASP1 0.0038 0.0282 0.0273
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0021 0.0113 0.0438
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0021 0.0113 0.0438
Loa Loa (eye worm) hypothetical protein 0.0049 0.0386 0.0383
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0032 0.0221 0.0866
Schistosoma mansoni sex comb on midleg homolog 0.0034 0.0243 0.0243
Trichomonas vaginalis tubulin beta chain, putative 0.0774 0.7514 0.7512
Trypanosoma brucei DNA polymerase IV, putative 0.0012 0.0028 0.0028
Mycobacterium ulcerans aldehyde dehydrogenase 0.0088 0.0775 0.3079
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0013 0.0037 0.0132
Entamoeba histolytica Ran family GTPase 0.0015 0.0049 0.0039
Mycobacterium tuberculosis Probable lipase LipE 0.002 0.0105 0.0404
Trypanosoma brucei tubulin delta chain 0.0596 0.5766 0.5766
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0049 0.0386 0.1506
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0017 0.0071 0.0068
Echinococcus granulosus tubulin alpha 1C chain 0.0774 0.7514 0.7512
Echinococcus multilocularis dna polymerase kappa 0.0012 0.0028 0.0018
Trichomonas vaginalis penicillin-binding protein, putative 0.002 0.0105 0.0095
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0137 0.1256 0.1247
Trichomonas vaginalis tubulin, putative 0.0313 0.2981 0.2974
Echinococcus multilocularis tubulin alpha 1C chain 0.0774 0.7514 0.7512
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0028 0.0028
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0405 0.0405
Mycobacterium ulcerans aldehyde dehydrogenase 0.0088 0.0775 0.3079
Schistosoma mansoni tar DNA-binding protein 0.0044 0.0335 0.0335
Schistosoma mansoni importin beta-1 0.002 0.01 0.01
Plasmodium vivax tubulin epsilon chain, putative 0.063 0.6104 0.6103
Brugia malayi Bromodomain containing protein 0.0024 0.0142 0.0132
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0011 0.001 0.001
Brugia malayi mbt repeat family protein 0.0034 0.0243 0.0233
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0577 0.5585 0.558
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0012 0.0028 0.0024
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0032 0.0221 0.0744
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0285 0.0281
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0014 0.0039 0.003
Onchocerca volvulus 0.0034 0.0243 0.0727
Schistosoma mansoni hypothetical protein 0.0419 0.4022 0.4022
Echinococcus granulosus neuropeptide receptor A26 0.0266 0.2525 0.2517
Echinococcus multilocularis ecdysone induced protein 78C 0.0014 0.0039 0.003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0027 0.0167 0.0163
Schistosoma mansoni steroid hormone receptor ad4bp 0.0014 0.0039 0.0039
Schistosoma mansoni ran 0.0015 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0048 0.0377 0.0374
Trypanosoma brucei zeta tubulin, putative 0.0818 0.7954 0.7954
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0021 0.0113 0.0438
Toxoplasma gondii LsmAD domain-containing protein 0.0048 0.0377 0.0368
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0509 0.491 0.4905
Schistosoma mansoni tar DNA-binding protein 0.0044 0.0335 0.0335
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0405 0.0405
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0014 0.0039 0.003
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.002 0.0105 0.0095
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0285 0.0281
Loa Loa (eye worm) tubulin alpha 2 0.0196 0.1835 0.1832
Brugia malayi Tubulin alpha chain 0.0265 0.2509 0.2502
Loa Loa (eye worm) hypothetical protein 0.0012 0.0028 0.0024
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0027 0.0167 0.0157
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0113 0.1012 0.1003
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0011 0.001 0.001
Echinococcus multilocularis geminin 0.0419 0.4022 0.4016
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.002 0.0105 0.0404
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0088 0.0775 0.0775
Schistosoma mansoni tubulin subunit gamma 0.0631 0.6112 0.6112
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0105 0.0105

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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