Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0017 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.0021 | 0.0015 | 0.0014 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0329 | 0.5521 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0068 | 0.0344 | 0.1042 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0107 | 0.032 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0103 | 0.0595 | 1 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.003 | 0.0079 | 0.045 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.003 | 0.0079 | 0.1318 |
Brugia malayi | Importin beta-1 subunit | 0.0029 | 0.0072 | 0.0215 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0109 | 0.0638 | 0.0637 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0039 | 0.014 | 0.0139 |
Brugia malayi | AMP-binding enzyme family protein | 0.003 | 0.0079 | 0.0237 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.003 | 0.0079 | 0.1318 |
Schistosoma mansoni | ran | 0.0022 | 0.0017 | 0.0016 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.003 | 0.0079 | 0.1318 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0094 | 0.0529 | 0.0528 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0053 | 0.024 | 0.5569 |
Echinococcus granulosus | lamin | 0.0081 | 0.044 | 0.0439 |
Schistosoma mansoni | inositol monophosphatase | 0.008 | 0.0429 | 0.0428 |
Echinococcus granulosus | tumor protein p63 | 0.0746 | 0.5144 | 0.5143 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0965 | 0.6687 | 0.6686 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0037 | 0.0127 | 0.0721 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0052 | 0.0232 | 0.0231 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0066 | 0.0329 | 0.5521 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0024 | 0.0033 | 0.0032 |
Trichomonas vaginalis | importin beta-1, putative | 0.0024 | 0.0033 | 0.0183 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0044 | 0.0173 | 0.052 |
Mycobacterium ulcerans | long-chain-acyl-CoA synthetase | 0.003 | 0.0079 | 0.1318 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0037 | 0.0127 | 0.0383 |
Brugia malayi | jmjC domain containing protein | 0.006 | 0.029 | 0.0876 |
Brugia malayi | Bromodomain containing protein | 0.0041 | 0.0158 | 0.0474 |
Plasmodium falciparum | acetyl-CoA synthetase, putative | 0.003 | 0.0079 | 0.1913 |
Echinococcus granulosus | geminin | 0.0351 | 0.2347 | 0.2346 |
Entamoeba histolytica | Ran family GTPase | 0.0022 | 0.0017 | 0.0249 |
Schistosoma mansoni | intermediate filament proteins | 0.0081 | 0.044 | 0.0439 |
Mycobacterium ulcerans | hypothetical protein | 0.0103 | 0.0595 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0068 | 0.0344 | 0.0343 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.003 | 0.0079 | 0.1828 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0077 | 0.0411 | 0.6893 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtF | 0.003 | 0.0079 | 0.1318 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0052 | 0.0232 | 0.0231 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.003 | 0.0079 | 0.1318 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.008 | 0.0429 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.008 | 0.0429 | 0.0428 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0101 | 0.0304 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0073 | 0.0381 | 0.6392 |
Schistosoma mansoni | alpha glucosidase | 0.0037 | 0.0127 | 0.0125 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.008 | 0.0429 | 0.0428 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.008 | 0.0429 | 0.721 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0071 | 0.037 | 0.564 |
Onchocerca volvulus | 0.0109 | 0.0638 | 0.336 | |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0233 | 0.1513 | 0.4579 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.003 | 0.0079 | 0.1318 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.003 | 0.0079 | 0.1318 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0112 | 0.0658 | 0.0657 |
Toxoplasma gondii | propionate-CoA ligase | 0.003 | 0.0079 | 0.1828 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0167 | 0.1044 | 0.3158 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.003 | 0.0079 | 0.0078 |
Brugia malayi | hypothetical protein | 0.0112 | 0.0658 | 0.1987 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0344 | 0.1042 |
Mycobacterium tuberculosis | PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.005 | 0.0817 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0094 | 0.0529 | 0.0528 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0073 | 0.0381 | 0.6392 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.008 | 0.0429 | 0.2462 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0037 | 0.0127 | 0.038 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0344 | 0.0343 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0037 | 0.0127 | 0.0721 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.003 | 0.0079 | 0.1318 |
Brugia malayi | MH2 domain containing protein | 0.0136 | 0.0828 | 0.2504 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0053 | 0.024 | 0.5826 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0066 | 0.0329 | 0.0328 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0112 | 0.0658 | 0.0657 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0062 | 0.0305 | 0.0304 |
Loa Loa (eye worm) | RNA binding protein | 0.0408 | 0.275 | 0.832 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0103 | 0.0595 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0062 | 0.0305 | 0.092 |
Brugia malayi | AMP-binding enzyme family protein | 0.0103 | 0.0595 | 0.1798 |
Schistosoma mansoni | zinc finger protein | 0.0021 | 0.0015 | 0.0014 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0066 | 0.0329 | 0.5521 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0344 | 0.0343 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0037 | 0.0127 | 0.0721 |
Echinococcus granulosus | snurportin 1 | 0.0312 | 0.2075 | 0.2074 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0094 | 0.0529 | 0.0528 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0081 | 0.044 | 0.1328 |
Leishmania major | acetyl-CoA synthetase, putative | 0.003 | 0.0079 | 0.1318 |
Brugia malayi | Pre-SET motif family protein | 0.0233 | 0.1513 | 0.4577 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0132 | 0.0399 |
Entamoeba histolytica | long-chain-fatty-acid--CoA ligase, putative | 0.003 | 0.0079 | 0.1193 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0024 | 0.0033 | 0.0743 |
Brugia malayi | RNA, U transporter 1 | 0.0083 | 0.0454 | 0.137 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.003 | 0.0079 | 0.1318 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0052 | 0.0232 | 0.0231 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.003 | 0.0079 | 0.0237 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.0658 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.003 | 0.0079 | 0.0237 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.024 | 0.5569 |
Loa Loa (eye worm) | oxidoreductase | 0.003 | 0.0079 | 0.024 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.006 | 0.029 | 0.0289 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0329 | 0.5521 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0176 | 0.0533 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0344 | 0.0343 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.008 | 0.0429 | 0.6525 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0037 | 0.0127 | 0.2112 |
Echinococcus granulosus | zinc finger protein | 0.0021 | 0.0015 | 0.0014 |
Trypanosoma brucei | glucosidase, putative | 0.0037 | 0.0127 | 0.2929 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0077 | 0.0411 | 0.5 |
Echinococcus multilocularis | lamin | 0.0081 | 0.044 | 0.0439 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0065 | 0.0321 | 0.032 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0037 | 0.0127 | 0.0125 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0094 | 0.0529 | 0.0528 |
Brugia malayi | Bromodomain containing protein | 0.0081 | 0.0438 | 0.1323 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0101 | 0.01 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.0033 | 0.0485 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0103 | 0.0595 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0065 | 0.0321 | 0.032 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0103 | 0.0595 | 1 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0965 | 0.6687 | 0.6686 |
Leishmania major | hypothetical protein, conserved | 0.0053 | 0.024 | 0.4016 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0103 | 0.0595 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.008 | 0.0429 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0073 | 0.0381 | 0.6392 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0214 | 0.138 | 0.4175 |
Schistosoma mansoni | alpha-glucosidase | 0.0143 | 0.0879 | 0.0879 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0101 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0429 | 0.1299 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0022 | 0.0017 | 0.0381 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0037 | 0.0127 | 0.0721 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0077 | 0.0411 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0033 | 0.0183 |
Schistosoma mansoni | hypothetical protein | 0.0312 | 0.2075 | 0.2074 |
Leishmania major | long-chain-fatty-acid-CoA ligase, putative | 0.003 | 0.0079 | 0.1318 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.003 | 0.0079 | 0.0237 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0146 | 0.0901 | 0.2724 |
Echinococcus multilocularis | musashi | 0.0081 | 0.044 | 0.0439 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0079 | 0.024 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.006 | 0.029 | 0.0289 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0001 | 0.5 |
Brugia malayi | PHD-finger family protein | 0.0027 | 0.0055 | 0.0164 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.0037 | 0.0036 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0044 | 0.0173 | 0.0523 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.003 | 0.0079 | 0.1318 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0062 | 0.0305 | 0.0304 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0127 | 0.0721 |
Echinococcus multilocularis | lamin dm0 | 0.0081 | 0.044 | 0.0439 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0638 | 0.1929 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0094 | 0.0529 | 0.0528 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.003 | 0.0079 | 0.1318 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0136 | 0.0828 | 0.2506 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0066 | 0.0329 | 0.0328 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0037 | 0.0127 | 0.1911 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0405 | 0.1227 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0214 | 0.138 | 0.4175 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0127 | 0.2929 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0022 | 0.0017 | 0.0381 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0037 | 0.0127 | 0.0125 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.0072 | 0.1733 |
Schistosoma mansoni | hypothetical protein | 0.0351 | 0.2347 | 0.2346 |
Mycobacterium ulcerans | peptide synthetase Nrp (peptide synthase) | 0.003 | 0.0079 | 0.1318 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0073 | 0.0381 | 0.6392 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0022 | 0.0017 | 0.0399 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.0658 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0112 | 0.0658 | 0.0657 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0232 | 0.0701 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0094 | 0.0529 | 0.0528 |
Echinococcus multilocularis | geminin | 0.0351 | 0.2347 | 0.2346 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0037 | 0.0127 | 0.1911 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0101 | 0.2451 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.003 | 0.0079 | 0.1828 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0158 | 0.0479 |
Schistosoma mansoni | tar DNA-binding protein | 0.0408 | 0.275 | 0.2749 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.024 | 0.5826 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.0658 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.008 | 0.0429 | 0.2462 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0094 | 0.0529 | 0.1598 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0053 | 0.024 | 0.5569 |
Brugia malayi | Inositol-1 | 0.008 | 0.0429 | 0.1296 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0411 | 0.1242 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0094 | 0.0529 | 0.0528 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.003 | 0.0079 | 0.1318 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0103 | 0.0595 | 0.9049 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0103 | 0.0595 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.003 | 0.0079 | 0.1318 |
Onchocerca volvulus | 0.0081 | 0.044 | 0.2169 | |
Mycobacterium ulcerans | acetyl-CoA synthetase | 0.003 | 0.0079 | 0.1318 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0071 | 0.037 | 0.6215 |
Mycobacterium ulcerans | phenyloxazoline synthase MbtB | 0.003 | 0.0079 | 0.1318 |
Schistosoma mansoni | jumonji domain containing protein | 0.006 | 0.029 | 0.0289 |
Echinococcus multilocularis | tar DNA binding protein | 0.0408 | 0.275 | 0.2749 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0127 | 0.0721 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0103 | 0.0595 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0081 | 0.044 | 0.133 |
Echinococcus granulosus | tar DNA binding protein | 0.0408 | 0.275 | 0.2749 |
Loa Loa (eye worm) | inositol-1 | 0.008 | 0.0429 | 0.1299 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0062 | 0.0305 | 0.0304 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0017 | 0.0049 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0023 | 0.0022 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0408 | 0.275 | 0.832 |
Brugia malayi | follicle stimulating hormone receptor | 0.0486 | 0.3305 | 1 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.003 | 0.0079 | 0.1318 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0052 | 0.0232 | 0.0231 |
Trichomonas vaginalis | ran, putative | 0.0022 | 0.0017 | 0.0094 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.024 | 0.5569 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0103 | 0.0595 | 1 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0037 | 0.0127 | 0.2929 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0068 | 0.0344 | 0.0343 |
Schistosoma mansoni | hypothetical protein | 0.0351 | 0.2347 | 0.2346 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0411 | 0.1242 |
Trichomonas vaginalis | set domain proteins, putative | 0.0265 | 0.1741 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0595 | 0.1801 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0191 | 0.0578 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0068 | 0.0344 | 0.1039 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtE | 0.003 | 0.0079 | 0.1318 |
Schistosoma mansoni | lamin | 0.0081 | 0.044 | 0.0439 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0127 | 0.0721 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0001 | 0.0003 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.003 | 0.0079 | 0.0078 |
Leishmania major | importin beta-1 subunit, putative | 0.0024 | 0.0033 | 0.0536 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0022 | 0.0017 | 0.0381 |
Schistosoma mansoni | tar DNA-binding protein | 0.0408 | 0.275 | 0.2749 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0167 | 0.1044 | 0.1043 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.003 | 0.0079 | 0.1318 |
Schistosoma mansoni | tar DNA-binding protein | 0.0408 | 0.275 | 0.2749 |
Onchocerca volvulus | 0.0103 | 0.0595 | 0.3104 | |
Schistosoma mansoni | inositol monophosphatase | 0.008 | 0.0429 | 0.0428 |
Brugia malayi | RNA binding protein | 0.0408 | 0.275 | 0.832 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.003 | 0.0079 | 0.024 |
Loa Loa (eye worm) | TAR-binding protein | 0.0408 | 0.275 | 0.832 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.003 | 0.0079 | 0.1828 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0103 | 0.0595 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0312 | 0.2075 | 0.6279 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0965 | 0.6687 | 0.6686 |
Brugia malayi | TAR-binding protein | 0.0408 | 0.275 | 0.832 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0101 | 0.01 |
Brugia malayi | AMP-binding enzyme family protein | 0.0103 | 0.0595 | 0.1798 |
Schistosoma mansoni | ran | 0.0022 | 0.0017 | 0.0016 |
Echinococcus multilocularis | tumor protein p63 | 0.0746 | 0.5144 | 0.5143 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0167 | 0.1044 | 0.3156 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.0658 | 1 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0022 | 0.0017 | 0.0016 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.008 | 0.0429 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0127 | 0.2929 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.0037 | 0.0036 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0068 | 0.0344 | 0.0343 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0167 | 0.1044 | 0.1043 |
Echinococcus granulosus | GPCR family 2 | 0.0068 | 0.0344 | 0.0343 |
Brugia malayi | AMP-binding enzyme family protein | 0.0103 | 0.0595 | 0.1798 |
Schistosoma mansoni | tar DNA-binding protein | 0.0408 | 0.275 | 0.2749 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0132 | 0.0399 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0142 | 0.0431 |
Mycobacterium ulcerans | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase | 0.003 | 0.0079 | 0.1318 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0072 | 0.0218 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0022 | 0.0017 | 0.0381 |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.0072 | 0.0071 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.003 | 0.0079 | 0.1828 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0039 | 0.014 | 0.0139 |
Brugia malayi | intermediate filament protein | 0.0081 | 0.044 | 0.1328 |
Echinococcus multilocularis | snurportin 1 | 0.0312 | 0.2075 | 0.2074 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0103 | 0.0595 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0595 | 0.1801 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0136 | 0.0828 | 0.2506 |
Onchocerca volvulus | 0.0033 | 0.0101 | 0.0133 | |
Leishmania major | acetyl-CoA synthetase, putative | 0.003 | 0.0079 | 0.1318 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.0072 | 0.1657 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.024 | 0.5826 |
Brugia malayi | AMP-binding enzyme family protein | 0.003 | 0.0079 | 0.0237 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0103 | 0.0595 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0037 | 0.0036 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0167 | 0.1044 | 0.1043 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0127 | 0.0721 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0411 | 0.1242 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0022 | 0.0017 | 0.0016 |
Echinococcus granulosus | lamin dm0 | 0.0081 | 0.044 | 0.0439 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0066 | 0.0329 | 0.5521 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.003 | 0.0079 | 0.1318 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0077 | 0.0411 | 0.6893 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0022 | 0.0023 | 0.0069 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0093 | 0.0092 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0103 | 0.0595 | 0.9049 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0411 | 0.1242 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.0101 | 0.2343 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0037 | 0.0127 | 0.0721 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.003 | 0.0079 | 0.1828 |
Schistosoma mansoni | alpha-glucosidase | 0.0143 | 0.0879 | 0.0879 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.003 | 0.0079 | 0.1828 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0039 | 0.0142 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0079 | 0.024 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.0072 | 0.0071 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.024 | 0.0725 |
Echinococcus multilocularis | GPCR, family 2 | 0.0068 | 0.0344 | 0.0343 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0214 | 0.138 | 0.4177 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0486 | 0.3305 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.008 | 0.0429 | 0.2462 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.003 | 0.0079 | 0.1318 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.0658 | 0.0657 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0066 | 0.0329 | 0.7657 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0344 | 0.0343 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0081 | 0.044 | 0.133 |
Schistosoma mansoni | lamin | 0.0081 | 0.044 | 0.0439 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.003 | 0.0079 | 0.1828 |
Onchocerca volvulus | 0.0096 | 0.0547 | 0.2812 | |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0094 | 0.0529 | 0.1601 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.044 | 0.133 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.003 | 0.0079 | 0.1318 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.003 | 0.0079 | 0.024 |
Plasmodium vivax | acetyl-CoA synthetase, putative | 0.003 | 0.0079 | 0.1913 |
Leishmania major | GTP-binding protein, putative | 0.0022 | 0.0017 | 0.0275 |
Schistosoma mansoni | tar DNA-binding protein | 0.0408 | 0.275 | 0.2749 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.003 | 0.0079 | 0.1318 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0408 | 0.275 | 0.832 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.003 | 0.0079 | 0.1828 |
Schistosoma mansoni | bromodomain containing protein | 0.0068 | 0.0349 | 0.0348 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0595 | 0.1801 |
Brugia malayi | AMP-binding enzyme family protein | 0.003 | 0.0079 | 0.0237 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.0329 | 0.0328 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0103 | 0.0595 | 1 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.0072 | 0.1733 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0103 | 0.0595 | 1 |
Mycobacterium ulcerans | O-succinylbenzoic acid--CoA ligase | 0.003 | 0.0079 | 0.1318 |
Onchocerca volvulus | 0.0081 | 0.044 | 0.2169 | |
Schistosoma mansoni | acetyl-CoA synthetase | 0.003 | 0.0079 | 0.0078 |
Schistosoma mansoni | hypothetical protein | 0.0146 | 0.0901 | 0.09 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.003 | 0.0079 | 0.1318 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0103 | 0.0595 | 0.9049 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0103 | 0.0595 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0081 | 0.044 | 0.0439 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0062 | 0.0305 | 0.0923 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0033 | 0.0183 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0066 | 0.0329 | 0.0328 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.008 | 0.0429 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0039 | 0.0142 | 0.0141 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.0901 | 0.2726 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.006 | 0.029 | 0.0289 |
Echinococcus granulosus | neuropeptide s receptor | 0.0965 | 0.6687 | 0.6686 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0072 | 0.1657 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.003 | 0.0079 | 0.045 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0072 | 0.1657 |
Brugia malayi | hypothetical protein | 0.0053 | 0.024 | 0.0722 |
Onchocerca volvulus | 0.0265 | 0.1741 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0033 | 0.0032 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0077 | 0.0411 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.008 | 0.0429 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0068 | 0.0344 | 0.1039 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0017 | 0.0399 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0024 | 0.0033 | 0.0032 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0022 | 0.0017 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.138 | 0.4177 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.008 | 0.0429 | 0.721 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.003 | 0.0079 | 0.1318 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0411 | 0.1242 |
Schistosoma mansoni | importin beta-1 | 0.0029 | 0.0072 | 0.0071 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0068 | 0.0344 | 0.0343 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 68 % | Cytotoxicity against human NCI-H460 cells at 20 ug/ml after 48 hrs by SRB assay | ChEMBL. | 19926361 |
Activity (functional) | = 90 % | Cytotoxicity against human NCI-H460 cells at 4 ug/ml after 48 hrs by SRB assay | ChEMBL. | 19926361 |
Activity (functional) | = 92 % | Cytotoxicity against human MCF7 cells at 20 ug/ml after 48 hrs by SRB assay | ChEMBL. | 19926361 |
Activity (functional) | = 98 % | Cytotoxicity against human SF268 cells at 20 ug/ml after 48 hrs by SRB assay | ChEMBL. | 19926361 |
Activity (functional) | = 98 % | Cytotoxicity against human SF268 cells at 4 ug/ml after 48 hrs by SRB assay | ChEMBL. | 19926361 |
Activity (functional) | = 102 % | Cytotoxicity against human MCF7 cells at 4 ug/ml after 48 hrs by SRB assay | ChEMBL. | 19926361 |
Inhibition (functional) | = 99 % | Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 at <0.2 ug/ml by microplate Alamar blue assay | ChEMBL. | 19926361 |
MIC (functional) | < 0.2 microg/ml | Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 by microplate Alamar blue assay | ChEMBL. | 19926361 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.