TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 339.388 | Formula: C19H21N3O3
H donors: 1 H acceptors: 0 LogP: 3.19 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: N/N=C(\c1ccc(c(c1OC)OC)OC)/c1ccc2c(c1)ccn2C
InChi: 1S/C19H21N3O3/c1-22-10-9-12-11-13(5-7-15(12)22)17(21-20)14-6-8-16(23-2)19(25-4)18(14)24-3/h5-11H,20H2,1-4H3/b21-17-
InChiKey: BBQPMJJPQDCYSX-FXBPSFAMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.052	0.2055
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0025	0.0057	0.0082
Onchocerca volvulus		0.003	0.0114	0.0165
Brugia malayi	RNA binding protein	0.0405	0.3711	1
Schistosoma mansoni	tar DNA-binding protein	0.0405	0.3711	0.5288
Schistosoma mansoni	smad1 5 8 and	0.0025	0.0057	0.0082
Loa Loa (eye worm)	Smad1	0.0025	0.0057	0.0054
Entamoeba histolytica	hypothetical protein	0.0152	0.1279	1
Brugia malayi	Bromodomain containing protein	0.0086	0.0643	0.1607
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0047	0.0274	0.0274
Brugia malayi	intermediate filament protein	0.0027	0.0079	0.0064
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0066	0.0452	0.0452
Loa Loa (eye worm)	acetyltransferase	0.0154	0.1301	0.3438
Loa Loa (eye worm)	hypothetical protein	0.0073	0.052	0.1313
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0069	0.0482	0.0482
Trypanosoma brucei	hypothetical protein, conserved	0.0073	0.052	1
Trichomonas vaginalis	chromobox protein, putative	0.0069	0.0487	0.19
Loa Loa (eye worm)	hypothetical protein	0.0073	0.052	0.1313
Brugia malayi	beta-lactamase	0.0073	0.052	0.127
Echinococcus multilocularis	chromobox protein 1	0.0069	0.0487	0.0487
Echinococcus granulosus	lamin	0.0027	0.0079	0.0079
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0121	0.0121
Brugia malayi	MH2 domain containing protein	0.0361	0.3285	0.8833
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0047	0.0274	0.4704
Plasmodium vivax	hypothetical protein, conserved	0.0073	0.052	1
Onchocerca volvulus	Huntingtin homolog	0.0122	0.0992	0.4308
Echinococcus granulosus	histone lysine methyltransferase setb	0.005	0.03	0.03
Schistosoma mansoni	hypothetical protein	0.0049	0.0288	0.0411
Echinococcus granulosus	intermediate filament protein	0.0027	0.0079	0.0079
Loa Loa (eye worm)	bromodomain containing protein	0.0023	0.0042	0.0012
Schistosoma mansoni	cellular tumor antigen P53	0.0155	0.1311	0.1868
Trichomonas vaginalis	esterase, putative	0.0073	0.052	0.2055
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0047	0.0274	0.4704
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0121	0.0172
Brugia malayi	hypothetical protein	0.0122	0.0992	0.2562
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0154	0.1301	0.1301
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0042	0.0223	0.0679
Brugia malayi	beta-lactamase family protein	0.0073	0.052	0.127
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.005	0.03	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0284	0.067
Brugia malayi	Pre-SET motif family protein	0.0031	0.0121	0.0179
Brugia malayi	Heterochromatin protein 1	0.0069	0.0487	0.1181
Schistosoma mansoni	smad1 5 8 and	0.0025	0.0057	0.0082
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0066	0.0452	0.224
Entamoeba histolytica	hypothetical protein	0.0152	0.1279	1
Schistosoma mansoni	smad	0.0025	0.0057	0.0082
Brugia malayi	beta-lactamase family protein	0.0073	0.052	0.127
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0055	0.0049
Brugia malayi	hypothetical protein	0.0146	0.1225	0.3199
Loa Loa (eye worm)	RNA binding protein	0.0405	0.3711	1
Schistosoma mansoni	hypothetical protein	0.0023	0.0038	0.0053
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0039	0.0198	0.0198
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0069	0.0482	0.0482
Brugia malayi	MH2 domain containing protein	0.0025	0.0057	0.0005
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0039	0.0195	0.0545
Brugia malayi	TAR-binding protein	0.0405	0.3711	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0361	0.3285	0.8839
Echinococcus granulosus	chromobox protein 1	0.0069	0.0487	0.0487
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0049	0.0288	0.0288
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0133	0.1094	0.1094
Echinococcus granulosus	mothers against decapentaplegic 5	0.0025	0.0057	0.0057
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.0452	0.8542
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0079	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0073	0.052	0.1313
Brugia malayi	Bromodomain containing protein	0.0046	0.0258	0.0555
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0992	0.2598
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0066	0.0452	0.0644
Echinococcus multilocularis	musashi	0.0027	0.0079	0.0079
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0025	0.0057	0.0057
Schistosoma mansoni	tar DNA-binding protein	0.0405	0.3711	0.5288
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0405	0.3711	1
Brugia malayi	acetyltransferase, GNAT family protein	0.0154	0.1301	0.3406
Mycobacterium ulcerans	lipase LipD	0.0073	0.052	0.5
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0079	0.0113
Onchocerca volvulus		0.0073	0.052	0.208
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0143	0.1196	0.1196
Schistosoma mansoni	microtubule-associated protein tau	0.075	0.7018	1
Schistosoma mansoni	chromobox protein	0.0069	0.0487	0.0694
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.005	0.03	0.0427
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0025	0.0057	0.0057
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0066	0.0452	0.1129
Brugia malayi	chromobox protein homolog 3	0.0039	0.0195	0.038
Echinococcus multilocularis	microtubule associated protein 2	0.075	0.7018	0.7018
Trichomonas vaginalis	chromobox protein, putative	0.0069	0.0487	0.19
Mycobacterium ulcerans	esterase/lipase LipP	0.0073	0.052	0.5
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0043	0.023	0.0328
Echinococcus granulosus	transcription factor Dp 1	0.0038	0.0186	0.0186
Mycobacterium ulcerans	hypothetical protein	0.0073	0.052	0.5
Brugia malayi	MH2 domain containing protein	0.0025	0.0057	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0288	0.0683
Schistosoma mansoni	bromodomain containing protein	0.0073	0.052	0.0741
Schistosoma mansoni	zinc finger protein	0.0025	0.0062	0.0088
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.005	0.03	0.03
Brugia malayi	hypothetical protein	0.0269	0.2407	0.6434
Brugia malayi	Smad1	0.0025	0.0057	0.0005
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0039	0.0198	0.0198
Echinococcus multilocularis	survival motor neuron protein 1	0.0269	0.2407	0.2407
Mycobacterium leprae	Probable lipase LipE	0.0073	0.052	0.5
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0049	0.0288	0.0288
Loa Loa (eye worm)	beta-lactamase	0.0073	0.052	0.1313
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0073	0.052	0.127
Schistosoma mansoni	lamin	0.0027	0.0079	0.0113
Echinococcus granulosus	microtubule associated protein 2	0.075	0.7018	0.7018
Onchocerca volvulus	Huntingtin homolog	0.0122	0.0992	0.4308
Trichomonas vaginalis	set domain proteins, putative	0.0248	0.2198	1
Loa Loa (eye worm)	hypothetical protein	0.0155	0.1311	0.3467
Echinococcus granulosus	lamin dm0	0.0027	0.0079	0.0079
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0073	0.052	0.1313
Brugia malayi	RNA recognition motif domain containing protein	0.0405	0.3711	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0074	0.01
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.011	0.011
Schistosoma mansoni	hypothetical protein	0.0152	0.1279	0.1823
Echinococcus granulosus	GPCR family 2	0.0049	0.0288	0.0288
Echinococcus granulosus	smad	0.0025	0.0057	0.0057
Echinococcus multilocularis	zinc finger protein	0.0025	0.0062	0.0062
Brugia malayi	MH1 domain containing protein	0.0025	0.0057	0.0005
Plasmodium falciparum	histone acetyltransferase GCN5	0.0041	0.0213	1
Echinococcus granulosus	Smad4	0.0025	0.0057	0.0057
Schistosoma mansoni	hypothetical protein	0.0133	0.1094	0.1559
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0049	0.0288	0.0288
Echinococcus granulosus	fetal alzheimer antigen falz	0.0025	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0562	0.1429
Onchocerca volvulus		0.0043	0.023	0.0712
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0079	0.0113
Entamoeba histolytica	hypothetical protein	0.0152	0.1279	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0147	0.1235	0.1235
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0049	0.0288	0.0288
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0025	0.0057	0.0057
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0133	0.1094	0.1094
Brugia malayi	latrophilin 2 splice variant baaae	0.0105	0.0831	0.212
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0223	0.065
Schistosoma mansoni	survival motor neuron protein	0.0055	0.0349	0.0497
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0073	0.052	0.0741
Echinococcus multilocularis	lamin	0.0027	0.0079	0.0079
Brugia malayi	Latrophilin receptor protein 2	0.0049	0.0288	0.0637
Echinococcus granulosus	tar DNA binding protein	0.0405	0.3711	0.3711
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0154	0.1301	0.1853
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0154	0.1298	0.343
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0195	0.0516
Loa Loa (eye worm)	hypothetical protein	0.0073	0.052	0.1313
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.0452	0.8542
Echinococcus granulosus	survival motor neuron protein 1	0.0269	0.2407	0.2407
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0154	0.1298	0.3398
Loa Loa (eye worm)	hypothetical protein	0.003	0.0114	0.0208
Toxoplasma gondii	ABC1 family protein	0.0073	0.052	1
Brugia malayi	PHD-finger family protein	0.0031	0.0118	0.0171
Loa Loa (eye worm)	TAR-binding protein	0.0405	0.3711	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0079	0.0064
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0047	0.0274	0.0891
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0079	0.0113
Echinococcus granulosus	zinc finger protein	0.0025	0.0062	0.0062
Schistosoma mansoni	hypothetical protein	0.0049	0.0288	0.0411
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0465	0.4284	1
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0047	0.0274	0.0891
Onchocerca volvulus		0.0073	0.052	0.208
Echinococcus granulosus	beta LACTamase domain containing family member	0.0073	0.052	0.052
Schistosoma mansoni	tar DNA-binding protein	0.0405	0.3711	0.5288
Echinococcus multilocularis	Smad4	0.0025	0.0057	0.0057
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0049	0.0288	0.0683
Schistosoma mansoni	lamin	0.0027	0.0079	0.0113
Onchocerca volvulus		0.0146	0.1225	0.5406
Schistosoma mansoni	chromobox protein	0.0069	0.0487	0.0694
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0049	0.0288	0.0637
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0073	0.052	0.5
Echinococcus multilocularis	transcription factor Dp 1	0.0038	0.0186	0.0186
Schistosoma mansoni	thyroid hormone receptor	0.0143	0.1196	0.1705
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0992	0.2598
Trichomonas vaginalis	penicillin-binding protein, putative	0.0073	0.052	0.2055
Plasmodium vivax	SET domain protein, putative	0.0031	0.0121	0.1409
Loa Loa (eye worm)	hypothetical protein	0.0269	0.2407	0.6451
Trichomonas vaginalis	penicillin-binding protein, putative	0.0073	0.052	0.2055
Schistosoma mansoni	hypothetical protein	0.0105	0.0831	0.1183
Schistosoma mansoni	hypothetical protein	0.0049	0.0288	0.0411
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0073	0.052	0.052
Brugia malayi	Pre-SET motif family protein	0.0218	0.191	0.5073
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0066	0.0452	0.0452
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.052	0.2055
Echinococcus multilocularis	smad	0.0025	0.0057	0.0057
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.0452	0.8542
Entamoeba histolytica	hypothetical protein	0.0152	0.1279	1
Brugia malayi	hypothetical protein	0.0152	0.1279	0.3347
Mycobacterium leprae	conserved hypothetical protein	0.0073	0.052	0.5
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0055	0.0349	0.0802
Leishmania major	hypothetical protein, conserved	0.0073	0.052	1
Brugia malayi	MH1 domain containing protein	0.0025	0.0057	0.0005
Schistosoma mansoni	Smad4	0.0025	0.0057	0.0082
Schistosoma mansoni	smad1 5 8 and	0.0025	0.0057	0.0082
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0121	0.1409
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0152	0.1279	0.1279
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0154	0.1298	0.3398
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0223	0.0506
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0066	0.0452	0.1085
Onchocerca volvulus		0.0055	0.0349	0.1273
Loa Loa (eye worm)	heterochromatin protein 1	0.0069	0.0487	0.1224
Loa Loa (eye worm)	hypothetical protein	0.005	0.03	0.0713
Mycobacterium ulcerans	beta-lactamase	0.0073	0.052	0.5
Schistosoma mansoni	transcription factor LCR-F1	0.0152	0.1279	0.1823
Echinococcus granulosus	chromobox protein 1	0.0069	0.0487	0.0487
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0047	0.0274	0.4704
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.052	1
Echinococcus multilocularis	GPCR, family 2	0.0049	0.0288	0.0288
Loa Loa (eye worm)	MH2 domain-containing protein	0.0025	0.0057	0.0054
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0025	0.0058	0.0082
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0025	0.0058	0.0058
Schistosoma mansoni	tar DNA-binding protein	0.0405	0.3711	0.5288
Onchocerca volvulus		0.0073	0.052	0.208
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0831	0.2159
Onchocerca volvulus		0.0248	0.2198	1
Schistosoma mansoni	hypothetical protein	0.0055	0.0349	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0073	0.052	0.1313
Schistosoma mansoni	tar DNA-binding protein	0.0405	0.3711	0.5288
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0152	0.1279	0.1279
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1225	0.3232
Onchocerca volvulus		0.0155	0.1311	0.5814
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0218	0.191	0.5097
Giardia lamblia	Histone acetyltransferase GCN5	0.0041	0.0213	0.5
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0066	0.0452	0.8542
Trichomonas vaginalis	D-aminoacylase, putative	0.0073	0.052	0.2055
Loa Loa (eye worm)	MH1 domain-containing protein	0.0025	0.0057	0.0054
Echinococcus multilocularis	chromobox protein 1	0.0069	0.0487	0.0487
Echinococcus multilocularis	tar DNA binding protein	0.0405	0.3711	0.3711
Schistosoma mansoni	hypothetical protein	0.0049	0.0288	0.0411
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0223	0.065
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1298	0.343
Echinococcus multilocularis	lamin dm0	0.0027	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0195	0.0427
Trypanosoma cruzi	hypothetical protein, conserved	0.0073	0.052	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0304	0.0725
Loa Loa (eye worm)	hypothetical protein	0.0073	0.052	0.1313
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0195	0.0516
Schistosoma mansoni	thyroid hormone receptor	0.0143	0.1196	0.1705
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0073	0.052	0.0741
Loa Loa (eye worm)	transcription factor SMAD2	0.0361	0.3285	0.8839

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 2 microM	Cytotoxicity against human HeLa cells after 72 hrs by XTT assay	ChEMBL.	19939521
IC50 (functional)	= 2 microM	Cytotoxicity against human HL60 cells after 72 hrs by XTT assay	ChEMBL.	19939521
IC50 (functional)	= 2 microM	Cytotoxicity against human HT-29 cells after 72 hrs by XTT assay	ChEMBL.	19939521
IC50 (functional)	> 10 microM	Cytotoxicity against human A549 cells after 72 hrs by XTT assay	ChEMBL.	19939521

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	19939521

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL574226

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1072801