Detailed information for compound 107332

Basic information

Technical information
  • TDR Targets ID: 107332
  • Name: (2R)-3-(4-hydroxyphenyl)-2-(phenylmethoxycarb onylamino)propanoic acid
  • MW: 315.321 | Formula: C17H17NO5
  • H donors: 3 H acceptors: 4 LogP: 2.67 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N[C@@H](C(=O)O)Cc1ccc(cc1)O)OCc1ccccc1
  • InChi: 1S/C17H17NO5/c19-14-8-6-12(7-9-14)10-15(16(20)21)18-17(22)23-11-13-4-2-1-3-5-13/h1-9,15,19H,10-11H2,(H,18,22)(H,20,21)/t15-/m1/s1
  • InChiKey: MCRMUCXATQAAMN-OAHLLOKOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R)-2-(benzyloxycarbonylamino)-3-(4-hydroxyphenyl)propanoic acid
  • (2R)-2-(benzyloxycarbonylamino)-3-(4-hydroxyphenyl)propionic acid
  • (2R)-3-(4-hydroxyphenyl)-2-[[oxo-(phenylmethoxy)methyl]amino]propanoic acid
  • UPCMLD00WV-86
  • BB_NC-1968
  • UPCMLD00WV-86:002
  • 97285_FLUKA
  • Z-D-Tyr-OH
  • Z-D-tyrosine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0627 0.0603 1
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1298 0.1278 0.3169
Plasmodium vivax subtilisin-like protease 2, putative 0.0287 0.0261 0.4114
Echinococcus multilocularis epidermal growth factor receptor 0.0202 0.0176 0.0235
Echinococcus granulosus integrin alpha ps 0.0898 0.0876 0.1186
Trichomonas vaginalis conserved hypothetical protein 0.0287 0.0261 0.0644
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0091 0.0064 0.0769
Loa Loa (eye worm) transcriptional regulator 0.0049 0.0022 0.002
Loa Loa (eye worm) hypothetical protein 0.007 0.0043 0.0041
Giardia lamblia Tenascin precursor 0.0212 0.0186 0.0757
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0287 0.0261 0.0644
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0287 0.0261 0.0644
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0035 0.0009 0.0009
Echinococcus granulosus chromatin regulatory protein sir2 0.0331 0.0305 0.0411
Echinococcus granulosus nmda type glutamate receptor 0.0126 0.01 0.0132
Toxoplasma gondii subtilisin SUB11 0.0287 0.0261 0.4308
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0014 0.0169
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.012 0.0093 0.0091
Trichomonas vaginalis hypothetical protein 0.0212 0.0186 0.0457
Trichomonas vaginalis conserved hypothetical protein 0.1298 0.1278 0.3169
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0287 0.0261 0.0644
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0331 0.0305 0.4937
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0084 0.0058 0.0058
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.007 0.0043 0.0367
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0288 0.0263 0.0354
Loa Loa (eye worm) hypothetical protein 0.1532 0.1514 0.1512
Echinococcus granulosus lysine specific histone demethylase 1A 0.0344 0.0319 0.043
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0581 0.0557 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4032 0.4027 1
Schistosoma mansoni integrin beta subunit 0.5826 0.5831 0.8802
Loa Loa (eye worm) hypothetical protein 0.0405 0.038 0.0378
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0049 0.0022 0.0081
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0287 0.0261 0.0644
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0627 0.0603 0.0908
Schistosoma mansoni integrin alpha 0.1643 0.1625 0.245
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0049 0.0022 0.0394
Schistosoma mansoni tyrosine kinase 0.0202 0.0176 0.0262
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0331 0.0305 0.0753
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0126 0.01 0.0148
Toxoplasma gondii type I fatty acid synthase, putative 0.009 0.0063 0.1017
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0212 0.0186 0.0457
Echinococcus granulosus lysine specific histone demethylase 1A 0.007 0.0043 0.0056
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0287 0.0261 0.0644
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.007 0.0043 0.0683
Loa Loa (eye worm) apoptosis regulator protein 0.0063 0.0036 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0287 0.0261 0.0644
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0627 0.0603 0.0816
Mycobacterium ulcerans Sir2-like regulatory protein 0.0049 0.0022 0.0394
Loa Loa (eye worm) integrin beta-2 0.9973 1 1
Echinococcus granulosus protein will die slowly 0.0067 0.004 0.0051
Mycobacterium ulcerans oxidoreductase 0.007 0.0043 0.0777
Trichomonas vaginalis conserved hypothetical protein 0.1298 0.1278 0.3169
Schistosoma mansoni hypothetical protein 0.0031 0.0005 0.0004
Schistosoma mansoni protein kinase 0.0137 0.0111 0.0164
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.025 0.0224 0.0222
Loa Loa (eye worm) endoprotease bli-4 0.6615 0.6624 0.6623
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0014 0.003
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.009 0.0063 0.1137
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1584 0.1566 0.3885
Echinococcus multilocularis c Jun NH2 terminal kinase 0.025 0.0224 0.0301
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0298 0.0272 0.4475
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0049 0.0022 0.0027
Toxoplasma gondii subtilisin SUB9 0.0287 0.0261 0.4308
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0014 0.0169
Giardia lamblia Tenascin-X 0.0212 0.0186 0.0757
Plasmodium vivax plasmepsin V, putative 0.0127 0.0101 0.1361
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.007 0.0043 0.0367
Plasmodium vivax hypothetical protein, conserved 0.007 0.0043 0.0367
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0084 0.0058 0.1039
Mycobacterium ulcerans thioesterase TesA 0.0073 0.0046 0.083
Entamoeba histolytica PH domain containing protein kinase, putative 0.007 0.0043 0.1348
Echinococcus multilocularis nmda type glutamate receptor 0.0126 0.01 0.0132
Plasmodium falciparum plasmepsin V 0.0127 0.0101 0.1361
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0008 0.0057
Brugia malayi polk-prov protein 0.0031 0.0004 0.0004
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0027 0.0001 0.0011
Loa Loa (eye worm) glutamate receptor 2 0.0035 0.0009 0.0006
Brugia malayi Subtilase family protein 0.0287 0.0261 0.0261
Toxoplasma gondii prolyl endopeptidase 0.0126 0.01 0.1628
Echinococcus granulosus fibrillin 1 0.0213 0.0187 0.0251
Schistosoma mansoni glutamate receptor kainate 0.0035 0.0009 0.001
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0035 0.0009 0.0009
Toxoplasma gondii histone lysine-specific demethylase 0.007 0.0043 0.0683
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.007 0.0043 0.0367
Schistosoma mansoni glutamate receptor kainate 0.0035 0.0009 0.001
Schistosoma mansoni hypothetical protein 0.0068 0.0041 0.0059
Echinococcus multilocularis integrin alpha ps 0.0898 0.0876 0.1186
Loa Loa (eye worm) hypothetical protein 0.05 0.0476 0.0474
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0331 0.0305 0.0753
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0581 0.0557 1
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0331 0.0305 0.5023
Loa Loa (eye worm) hypothetical protein 0.0046 0.0019 0.0017
Mycobacterium tuberculosis Probable transcriptional regulatory protein NrdR 0.0046 0.0019 0.0345
Echinococcus granulosus c-Jun N-terminal kinases 0.025 0.0224 0.0301
Trichomonas vaginalis conserved hypothetical protein 0.1298 0.1278 0.3169
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.0059 0.0085
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0055 0.0028 0.0494
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1584 0.1566 0.3885
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0063 0.0036 0.0052
Loa Loa (eye worm) glutamate receptor 1 0.0035 0.0009 0.0006
Schistosoma mansoni dihydroceramide desaturase 0.012 0.0093 0.0137
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0055 0.0028 0.0504
Loa Loa (eye worm) hypothetical protein 0.0212 0.0186 0.0184
Brugia malayi proprotein convertase 2 0.4168 0.4163 0.4163
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0287 0.0261 0.0644
Mycobacterium ulcerans thioesterase 0.0073 0.0046 0.083
Echinococcus multilocularis fibrillin 1 0.0213 0.0187 0.0251
Brugia malayi angiogenesis inhibito 0.0169 0.0142 0.0142
Onchocerca volvulus Prolyl endopeptidase homolog 0.0126 0.01 0.2256
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0054 0.0027 0.0033
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0049 0.0022 0.0027
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0627 0.0603 1
Echinococcus granulosus integrin beta 2 0.7358 0.7372 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.007 0.0043 0.0489
Trichomonas vaginalis hypothetical protein 0.1298 0.1278 0.3169
Schistosoma mansoni chromatin regulatory protein sir2 0.0331 0.0305 0.0458
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0344 0.0319 0.043
Loa Loa (eye worm) hypothetical protein 0.012 0.0093 0.0091
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0085 0.0059 0.0057
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.007 0.0043 0.0777
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0082 0.0055 0.0053
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4032 0.4027 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0337 0.0312 0.042
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0049 0.0022 0.0293
Loa Loa (eye worm) hypothetical protein 0.0144 0.0118 0.0116
Echinococcus granulosus neuroendocrine convertase 2 0.4168 0.4163 0.5647
Trypanosoma brucei SIR2-like protein 4, putative 0.0049 0.0022 0.0293
Trypanosoma brucei unspecified product 0.0035 0.0008 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.1298 0.1278 0.3169
Brugia malayi Reprolysin 0.0169 0.0143 0.0143
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0126 0.01 0.1344
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0126 0.01 0.0132
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1584 0.1566 0.3885
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0627 0.0603 0.0603
Schistosoma mansoni hypothetical protein 0.0067 0.004 0.0057
Echinococcus granulosus dna polymerase kappa 0.0041 0.0014 0.0017
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0035 0.0009 0.0009
Onchocerca volvulus 0.0287 0.0261 0.728
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.4032 0.4027 0.5461
Loa Loa (eye worm) hypothetical protein 0.0031 0.0005 0.0002
Plasmodium vivax subtilisin-like protease 1 0.0287 0.0261 0.4114
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0035 0.0009 0.0153
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0014 0.0169
Giardia lamblia Tenascin-like 0.0212 0.0186 0.0757
Trypanosoma cruzi subtilisin peptidase 0.0287 0.0261 0.4189
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0084 0.0058 0.1039
Loa Loa (eye worm) hypothetical protein 0.0287 0.0261 0.0259
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0049 0.0022 0.0127
Plasmodium vivax protoporphyrinogen oxidase, putative 0.007 0.0043 0.0367
Mycobacterium leprae Possible secreted protease 0.0287 0.0261 0.4683
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0287 0.0261 0.0644
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0581 0.0557 0.1379
Schistosoma mansoni chromatin regulatory protein sir2 0.0049 0.0022 0.003
Toxoplasma gondii type I fatty acid synthase, putative 0.0062 0.0036 0.0555
Echinococcus granulosus serine:threonine protein kinase N2 0.007 0.0043 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.1298 0.1278 0.3169
Echinococcus multilocularis Furin 1 0.1584 0.1566 0.2122
Brugia malayi ADAMTS-like protease 0.0169 0.0142 0.0142
Mycobacterium tuberculosis Probable peptidase 0.005 0.0024 0.0422
Schistosoma mansoni chromatin regulatory protein sir2 0.0049 0.0022 0.003
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0057 0.003 0.0462
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0014 0.0169
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1584 0.1566 0.3885
Leishmania major oligopeptidase b 0.005 0.0024 0.0027
Echinococcus multilocularis glutamate receptor 2 0.0054 0.0027 0.0033
Mycobacterium ulcerans dehydrogenase 0.007 0.0043 0.0777
Schistosoma mansoni chromatin regulatory protein sir2 0.0331 0.0305 0.0458
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0085 0.0058 0.1045
Loa Loa (eye worm) hypothetical protein 0.1245 0.1224 0.1222
Schistosoma mansoni glutamate receptor NMDA 0.0298 0.0273 0.0409
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0022 0.0049
Entamoeba histolytica hypothetical protein, conserved 0.0049 0.0022 0.0651
Loa Loa (eye worm) hypothetical protein 0.6615 0.6624 0.6623
Echinococcus multilocularis fibrillin 2 0.0212 0.0186 0.025
Echinococcus granulosus furin 0.6615 0.6624 0.8986
Onchocerca volvulus 0.0082 0.0055 0.0854
Echinococcus multilocularis 0.007 0.0043 0.0056
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0091 0.0064 0.1152
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.005 0.0024 0.0153
Echinococcus multilocularis NMDA receptor 0.0035 0.0009 0.0009
Echinococcus granulosus adam 17 protease 0.012 0.0093 0.0123
Loa Loa (eye worm) hypothetical protein 0.0373 0.0348 0.0346
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0014 0.0169
Echinococcus multilocularis integrin alpha 3 0.121 0.119 0.1611
Loa Loa (eye worm) hypothetical protein 0.007 0.0043 0.0041
Schistosoma mansoni amine oxidase 0.007 0.0043 0.0062
Brugia malayi Integrin alpha pat-2 precursor 0.1643 0.1625 0.1625
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0287 0.0261 0.4688
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0331 0.0305 0.0411
Giardia lamblia High cysteine membrane protein Group 2 0.2447 0.2434 1
Trypanosoma cruzi prolyl endopeptidase 0.0126 0.01 0.1454
Loa Loa (eye worm) hypothetical protein 0.0812 0.079 0.0787
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0049 0.0022 0.0027
Schistosoma mansoni glutamate receptor AMPA 0.0035 0.0009 0.001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0005 0.0002
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0014 0.0017
Echinococcus multilocularis neuroendocrine convertase 2 0.4168 0.4163 0.5647
Trichomonas vaginalis conserved hypothetical protein 0.0287 0.0261 0.0644
Brugia malayi Will die slowly protein 0.0067 0.004 0.004
Brugia malayi EGF-like domain containing protein 0.0212 0.0186 0.0186
Trypanosoma brucei prolyl oligopeptidase, putative 0.005 0.0024 0.0319
Trypanosoma cruzi UDP-galactopyranose mutase 0.007 0.0043 0.0489
Loa Loa (eye worm) hypothetical protein 0.0169 0.0142 0.014
Brugia malayi endoprotease bli-4 precursor 0.6615 0.6624 0.6624
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0627 0.0603 1
Trypanosoma cruzi oligopeptidase b 0.005 0.0024 0.0153
Schistosoma mansoni glutamate receptor kainate 0.0035 0.0009 0.001
Toxoplasma gondii histone deacetylase SIR2-like 0.0049 0.0022 0.0328
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0287 0.0261 0.4688
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0035 0.0009 0.0009
Mycobacterium leprae Probable polyketide synthase Pks1 0.009 0.0063 0.1128
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0063 0.0036 0.0649
Echinococcus multilocularis protoporphyrinogen oxidase 0.007 0.0043 0.0056
Schistosoma mansoni site-1 peptidase (S08 family) 0.0287 0.0261 0.0391
Brugia malayi Glutamate receptor 2 precursor 0.0035 0.0009 0.0009
Plasmodium falciparum protoporphyrinogen oxidase 0.007 0.0043 0.0367
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0035 0.0009 0.0009
Echinococcus multilocularis glutamate receptor 2 0.0035 0.0009 0.0009
Trypanosoma brucei subtilisin peptidase 0.0287 0.0261 0.4287
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0049 0.0022 0.0027
Loa Loa (eye worm) hypothetical protein 0.1145 0.1124 0.1122
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0287 0.0261 0.0644
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1298 0.1278 0.3169
Trichomonas vaginalis conserved hypothetical protein 0.1298 0.1278 0.3169
Echinococcus multilocularis adam 0.0589 0.0565 0.0764
Loa Loa (eye worm) hypothetical protein 0.0089 0.0062 0.006
Chlamydia trachomatis protoporphyrinogen oxidase 0.007 0.0043 0.0412
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0287 0.0261 0.4683
Echinococcus multilocularis chromatin regulatory protein sir2 0.0331 0.0305 0.0411
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0073 0.0071
Loa Loa (eye worm) TK/EGFR protein kinase 0.0202 0.0176 0.0173
Brugia malayi transcriptional regulator, Sir2 family protein 0.0331 0.0305 0.0305
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.005 0.0024 0.0422
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0287 0.0261 0.0644
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0581 0.0557 0.5
Loa Loa (eye worm) subtilase 0.0287 0.0261 0.0259
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0128 0.0101 0.182
Brugia malayi AMP-binding enzyme family protein 0.0082 0.0055 0.0055
Brugia malayi neuroendocrine convertase 1 precursor 0.4168 0.4163 0.4163
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0627 0.0603 0.0816
Echinococcus multilocularis serine:threonine protein kinase N2 0.0078 0.0051 0.0067
Loa Loa (eye worm) hypothetical protein 0.0099 0.0073 0.007
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0627 0.0603 1
Loa Loa (eye worm) integrin alpha pat-2 0.2322 0.2308 0.2306
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0627 0.0603 1
Schistosoma mansoni hypothetical protein 0.0031 0.0005 0.0004
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.009 0.0063 0.1137
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0298 0.0273 0.0368
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0331 0.0305 1
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.009 0.0063 0.1137
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0287 0.0261 0.4688
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0627 0.0603 1
Onchocerca volvulus 0.0152 0.0126 0.3066
Loa Loa (eye worm) hypothetical protein 0.0344 0.0319 0.0317
Toxoplasma gondii subtilisin SUB2 0.0287 0.0261 0.4308
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.012 0.0093 0.0123
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0287 0.0261 0.4688
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0287 0.0261 0.0644
Brugia malayi EGF-like domain containing protein 0.0212 0.0186 0.0186
Onchocerca volvulus 0.0212 0.0186 0.494
Loa Loa (eye worm) hypothetical protein 0.0212 0.0186 0.0184
Schistosoma mansoni site-1 peptidase (S08 family) 0.0287 0.0261 0.0391
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0791 0.0769 0.104
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0022 0.0049
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.005 0.0023 0.0412
Toxoplasma gondii subtilisin SUB8 0.0287 0.0261 0.4308
Loa Loa (eye worm) hypothetical protein 0.2583 0.257 0.2569
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0287 0.0261 0.0644
Brugia malayi transcriptional regulator, Sir2 family protein 0.0049 0.0022 0.0022
Mycobacterium tuberculosis Possible oxidoreductase 0.007 0.0043 0.0777
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0405 0.038 0.038
Plasmodium vivax subtilisin-like serine protease, putative 0.0287 0.0261 0.4114
Giardia lamblia Tenascin-37 0.0212 0.0186 0.0757
Giardia lamblia Neurogenic locus notch-like protein 0.0212 0.0186 0.0757
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0084 0.0058 0.103
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0287 0.0261 0.0351
Schistosoma mansoni hypothetical protein 0.0031 0.0005 0.0004
Schistosoma mansoni hypothetical protein 0.0035 0.0009 0.001
Brugia malayi transcriptional regulator, Sir2 family protein 0.0049 0.0022 0.0022
Toxoplasma gondii histone deacetylase SIR2 0.0049 0.0022 0.0328
Schistosoma mansoni chromatin regulatory protein sir2 0.0049 0.0022 0.003
Brugia malayi EGF-like domain containing protein 0.0212 0.0186 0.0186
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0063 0.0036 0.0046
Echinococcus multilocularis protein kinase c epsilon type 0.0085 0.0059 0.0077
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0287 0.0261 0.0644
Toxoplasma gondii subtilisin SUB4 0.0287 0.0261 0.4308
Schistosoma mansoni hypothetical protein 0.0063 0.0036 0.0052
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.007 0.0043 0.0062
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.007 0.0043 0.0777
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0049 0.0022 0.0027
Schistosoma mansoni furin-1 (S08 family) 0.287 0.2859 0.4314
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0014 0.0169
Loa Loa (eye worm) hypothetical protein 0.0031 0.0004 0.0002
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0377 0.0352 0.0528
Plasmodium falciparum subtilisin-like protease 2 0.0287 0.0261 0.4114
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0287 0.0261 0.4683
Trypanosoma brucei oligopeptidase b 0.005 0.0024 0.0319
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0014 0.0169
Trichomonas vaginalis WD repeat domain, putative 0.0067 0.004 0.0094
Schistosoma mansoni amine oxidase 0.007 0.0043 0.0062
Echinococcus granulosus glutamate NMDA receptor subunit 0.0298 0.0273 0.0368
Brugia malayi ADAM-TS Spacer 1 family protein 0.0169 0.0142 0.0142
Loa Loa (eye worm) acyl carrier protein 0.004 0.0013 0.0011
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0344 0.0319 0.0479
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0287 0.0261 0.0644
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0178 0.0152 0.2338
Loa Loa (eye worm) hypothetical protein 0.0288 0.0263 0.0261
Mycobacterium leprae conserved hypothetical protein 0.0046 0.0019 0.0335
Loa Loa (eye worm) hypothetical protein 0.0212 0.0186 0.0184
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0005 0.0005
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0298 0.0272 0.4381
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0067 0.0041 0.073
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0331 0.0305 0.4937
Toxoplasma gondii subtilisin SUB10 0.0287 0.0261 0.4308
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0287 0.0261 0.4688
Brugia malayi Stress-activated protein kinase jnk-1 0.025 0.0224 0.0224
Giardia lamblia Furin precursor putative serine protease 0.1298 0.1278 0.5245
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0287 0.0261 0.0644
Onchocerca volvulus 0.0067 0.004 0.0378
Schistosoma mansoni protein kinase 0.0137 0.0111 0.0164
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0049 0.0022 0.0027
Schistosoma mansoni hypothetical protein 0.0031 0.0005 0.0004
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0581 0.0557 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0084 0.0058 0.1039
Trichomonas vaginalis conserved hypothetical protein 0.1298 0.1278 0.3169
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0014 0.026
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0288 0.0263 0.0354
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.012 0.0093 0.0093
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0022 0.0049
Loa Loa (eye worm) hypothetical protein 0.008 0.0053 0.0051
Schistosoma mansoni ATP-binding cassette transporter 0.0038 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0344 0.0319 0.0317
Echinococcus multilocularis prolyl endopeptidase 0.0126 0.01 0.0133
Mycobacterium tuberculosis Polyketide synthase Pks12 0.009 0.0063 0.1137
Toxoplasma gondii subtilisin SUB1 0.0287 0.0261 0.4308
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0126 0.01 0.0148
Loa Loa (eye worm) kelch domain-containing protein family protein 0.1544 0.1525 0.1523
Trichomonas vaginalis conserved hypothetical protein 0.1298 0.1278 0.3169
Mycobacterium leprae Polyketide synthase Pks13 0.0128 0.0101 0.1811
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0073 0.0073
Brugia malayi EGF-like domain containing protein 0.0212 0.0186 0.0186
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0287 0.0261 0.0391
Echinococcus multilocularis integrin beta 2 0.7358 0.7372 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1584 0.1566 0.3885
Brugia malayi prolyl oligopeptidase family protein 0.0126 0.01 0.01
Echinococcus granulosus integrin alpha 3 0.121 0.119 0.1611
Echinococcus granulosus GPCR family 2 0.0031 0.0005 0.0003
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0054 0.0027 0.0033
Echinococcus granulosus integrin alpha ps 0.0398 0.0373 0.0503
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0022 0.0049
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0022 0.0049
Mycobacterium ulcerans fatty acid synthase Fas 0.0027 0.0001 0.0011
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0014 0.026
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.009 0.0063 0.1128
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0231 0.0206 0.0307
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0073 0.0046 0.0821
Schistosoma mansoni integrin alpha-ps 0.05 0.0476 0.0715
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0063 0.0036 0.0036
Mycobacterium tuberculosis Conserved hypothetical protein 0.007 0.0043 0.0777
Loa Loa (eye worm) transcriptional regulator 0.0049 0.0022 0.002
Echinococcus multilocularis integrin alpha ps 0.0398 0.0373 0.0503
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0287 0.0261 0.0644
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0049 0.0022 0.0651
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0049 0.0022 0.0127
Schistosoma mansoni apoptosis regulator bax 0.0063 0.0036 0.0052
Mycobacterium ulcerans Type I modular polyketide synthase 0.0084 0.0058 0.1039
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0022 0.0049
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0287 0.0261 0.0644
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0014 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0014 0.0169
Schistosoma mansoni integrin alpha-ps 0.0831 0.0808 0.1217
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0054 0.0027 0.0033
Mycobacterium ulcerans Type I modular polyketide synthase 0.0084 0.0058 0.1039
Echinococcus multilocularis 0.5317 0.5319 0.7215
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0005 0.0005
Echinococcus granulosus protein kinase c epsilon type 0.0085 0.0059 0.0077
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.008 0.0053 0.0077
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.6615 0.6624 1
Schistosoma mansoni hypothetical protein 0.0063 0.0036 0.0052
Loa Loa (eye worm) hypothetical protein 0.003 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0212 0.0186 0.0184
Loa Loa (eye worm) hypothetical protein 0.0466 0.0441 0.0439
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0005 0.0003
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0005 0.0003
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0287 0.0261 0.4688
Echinococcus granulosus prolyl endopeptidase 0.0126 0.01 0.0133
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0014 0.0169
Echinococcus granulosus disintegrin and metalloproteinase 0.012 0.0093 0.0123
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0627 0.0603 1
Toxoplasma gondii subtilisin SUB12 0.0287 0.0261 0.4308
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0287 0.0261 0.0644
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0298 0.0272 0.4381
Echinococcus granulosus glutamate receptor subunit protein glur 0.0035 0.0009 0.0009
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.005 0.0024 0.0422
Brugia malayi Integrin alpha cytoplasmic region family protein 0.1145 0.1124 0.1124
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0287 0.0261 0.0351
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0044 0.0017 0.0252
Schistosoma mansoni chromatin regulatory protein sir2 0.0331 0.0305 0.0458
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1273 0.1253 0.1889
Schistosoma mansoni hypothetical protein 0.1298 0.1278 0.1926
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0287 0.0261 0.0261
Mycobacterium ulcerans monoamine oxidase 0.007 0.0043 0.0777
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0288 0.0263 0.0394
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0091 0.0064 0.1152
Mycobacterium ulcerans transcriptional regulator NrdR 0.0046 0.0019 0.0345
Brugia malayi SWIRM domain containing protein 0.0373 0.0348 0.0348
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1584 0.1566 0.3885
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0128 0.0101 0.182
Giardia lamblia High cysteine protein 0.0212 0.0186 0.0757
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.005 0.0024 0.0319
Loa Loa (eye worm) reprolysin 0.0288 0.0263 0.0261
Echinococcus multilocularis integrin alpha ps 0.0831 0.0808 0.1093
Mycobacterium ulcerans NAD-dependent deacetylase 0.0049 0.0022 0.0394
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0627 0.0603 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0014 0.0169
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0287 0.0261 0.4688
Brugia malayi Furin-like cysteine rich region family protein 0.0202 0.0176 0.0176
Onchocerca volvulus Fatty acid synthase homolog 0.0158 0.0132 0.3236
Schistosoma mansoni protein kinase 0.0137 0.0111 0.0164
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0791 0.0769 0.104
Leishmania major UDP-galactopyranose mutase 0.007 0.0043 0.0367
Schistosoma mansoni serine/threonine protein kinase 0.025 0.0224 0.0335
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.005 0.0024 0.0027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0287 0.0261 0.0644
Trichomonas vaginalis conserved hypothetical protein 0.1298 0.1278 0.3169
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0287 0.0261 0.0644
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0137 0.0111 0.0147
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0287 0.0261 0.0644
Brugia malayi Glutamate receptor 1 precursor 0.0035 0.0009 0.0009
Giardia lamblia Sirtuin type 2 0.0049 0.0022 0.0081
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1298 0.1278 0.3169
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.009 0.0063 0.1128
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0067 0.0041 0.0721
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0049 0.0022 0.0651
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0287 0.0261 0.4189
Loa Loa (eye worm) hypothetical protein 0.0126 0.01 0.0098
Giardia lamblia Transcriptional regulator, Sir2 family 0.0049 0.0022 0.0081
Loa Loa (eye worm) angiogenesis inhibito 0.008 0.0053 0.0051
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0288 0.0263 0.0394
Mycobacterium ulcerans polyketide synthase 0.0084 0.0058 0.1039
Brugia malayi celfurPC protein 0.5317 0.5319 0.5319
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.005 0.0024 0.0153
Schistosoma mansoni hypothetical protein 0.0063 0.0036 0.0052
Echinococcus multilocularis GPCR, family 2 0.0031 0.0005 0.0003
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0035 0.0009 0.0009
Schistosoma mansoni glutamate receptor NMDA 0.0054 0.0027 0.0037
Toxoplasma gondii aspartyl protease ASP5 0.0116 0.009 0.1455
Plasmodium vivax hypothetical protein, conserved 0.007 0.0043 0.0367
Giardia lamblia Neurogenic locus Notch protein precursor 0.0212 0.0186 0.0757
Mycobacterium tuberculosis Probable thioesterase TesA 0.0073 0.0046 0.083
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.007 0.0043 0.0767
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.009 0.0063 0.1137
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0082 0.0055 0.099
Loa Loa (eye worm) hypothetical protein 0.0169 0.0142 0.014
Toxoplasma gondii subtilisin SUB7 0.0287 0.0261 0.4308
Echinococcus multilocularis membrane bound transcription factor site 1 0.0287 0.0261 0.0351
Brugia malayi SWIRM domain containing protein 0.0029 0.0002 0.0002
Chlamydia trachomatis glutamine binding protein 0.0091 0.0064 0.0769
Brugia malayi hypothetical protein 0.1532 0.1514 0.1514
Brugia malayi metalloprotease 0.008 0.0053 0.0053
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.4032 0.4027 0.5461
Echinococcus granulosus epidermal growth factor receptor 0.0202 0.0176 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.0287 0.0261 0.0644
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0287 0.0261 0.0644
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0022 0.0049
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0287 0.0261 0.0261
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0337 0.0312 0.042
Schistosoma mansoni glutamate receptor AMPA 0.0035 0.0009 0.001
Echinococcus multilocularis protein jagged 2 0.0212 0.0186 0.025
Echinococcus granulosus glutamate receptor 2 0.0054 0.0027 0.0033
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0287 0.0261 0.0644
Brugia malayi protein kinase C II. 0.0085 0.0059 0.0059
Brugia malayi amine oxidase, flavin-containing family protein 0.0099 0.0073 0.0073
Plasmodium falciparum subtilisin-like protease 1 0.0287 0.0261 0.4114
Plasmodium falciparum subtilisin-like protease 3 0.0287 0.0261 0.4114
Loa Loa (eye worm) sirtuin 4 0.0049 0.0022 0.002
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0054 0.0027 0.0033
Echinococcus granulosus Furin 1 0.1584 0.1566 0.2122
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0084 0.0058 0.1039
Trichomonas vaginalis conserved hypothetical protein 0.0287 0.0261 0.0644
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0063 0.0036 0.0046
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0137 0.0111 0.0147
Giardia lamblia Hypothetical protein 0.0331 0.0305 0.1246
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0084 0.0058 0.1039
Toxoplasma gondii subtilisin SUB6 0.0287 0.0261 0.4308
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0054 0.0027 0.0033
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0084 0.0058 0.103
Loa Loa (eye worm) hypothetical protein 0.0063 0.0036 0.0034
Leishmania major silent information regulator 2, putative 0.0331 0.0305 0.4872
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0287 0.0261 0.0644
Schistosoma mansoni hypothetical protein 0.0398 0.0373 0.056
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1584 0.1566 0.2361
Leishmania major subtilisin-like serine peptidase 0.0287 0.0261 0.4114
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0027 0 0.0003
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0287 0.0261 0.0391
Trypanosoma brucei prolyl endopeptidase 0.0126 0.01 0.1598
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.005 0.0024 0.0412
Brugia malayi hypothetical protein 0.007 0.0043 0.0043
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0069 0.0042 0.0751
Mycobacterium ulcerans polyketide synthase 0.009 0.0063 0.1137
Loa Loa (eye worm) hypothetical protein 0.0068 0.0041 0.0039
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0041 0.0041
Brugia malayi hypothetical protein 0.0377 0.0352 0.0352
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0054 0.0027 0.0033
Echinococcus multilocularis disintegrin and metalloproteinase 0.012 0.0093 0.0123
Giardia lamblia High cysteine protein 0.0212 0.0186 0.0757
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.012 0.0093 0.0123
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0113 0.0087 0.1558
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0022 0.0049
Echinococcus granulosus adam 0.0589 0.0565 0.0764
Loa Loa (eye worm) WD40 repeat protein 0.0067 0.004 0.0038
Loa Loa (eye worm) hypothetical protein 0.0068 0.0041 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.1298 0.1278 0.3169
Loa Loa (eye worm) fatty acid synthase 0.0086 0.006 0.0058
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0022 0.0049
Toxoplasma gondii hypothetical protein 0.0212 0.0186 0.306
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0331 0.0305 0.0411
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0067 0.0041 0.073
Loa Loa (eye worm) proprotein convertase 2 0.1584 0.1566 0.1564
Trichomonas vaginalis conserved hypothetical protein 0.1298 0.1278 0.3169
Brugia malayi NAD-dependent deacetylase SIRT1 0.0049 0.0022 0.0022
Mycobacterium ulcerans polyketide synthase Pks13 0.0128 0.0101 0.182
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0627 0.0603 0.0601
Echinococcus granulosus fibrillin 2 0.0212 0.0186 0.025
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0331 0.0305 1
Onchocerca volvulus 0.0373 0.0348 1
Brugia malayi Kelch motif family protein 0.1544 0.1525 0.1525
Loa Loa (eye worm) transcriptional regulator 0.0331 0.0305 0.0303
Mycobacterium ulcerans polyketide synthase Pks9 0.0055 0.0028 0.0504
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0163 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0049 0.0022 0.002
Echinococcus multilocularis protein will die slowly 0.0067 0.004 0.0051
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0054 0.0027 0.0033
Trypanosoma cruzi oligopeptidase b 0.005 0.0024 0.0153
Loa Loa (eye worm) metalloprotease 0.008 0.0053 0.0051
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0209 0.0183 0.3284
Schistosoma mansoni chromatin regulatory protein sir2 0.0049 0.0022 0.003
Toxoplasma gondii subtilisin SUB5 0.0287 0.0261 0.4308
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0287 0.0261 0.0644
Echinococcus granulosus membrane bound transcription factor site 1 0.0287 0.0261 0.0351
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0085 0.0058 0.1045
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0054 0.0027 0.0033
Giardia lamblia hypothetical protein 0.0212 0.0186 0.0757
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0014 0.0169
Brugia malayi Disintegrin family protein 0.012 0.0093 0.0093
Mycobacterium ulcerans protoporphyrinogen oxidase 0.007 0.0043 0.0777

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 432 uM In vitro inhibition of recombinant stromelysin catalytic domain. ChEMBL. 8289198
IC50 (binding) = 432 uM In vitro inhibition of recombinant stromelysin catalytic domain. ChEMBL. 8289198
IC50 (binding) = 450 uM Inhibition of recombinant full length stromelysin (FLS). ChEMBL. 8289198
IC50 (binding) = 450 uM Inhibition of recombinant full length stromelysin (FLS). ChEMBL. 8289198
Ki (binding) = 356 uM Inhibition of recombinant stromelysin catalytic domain (SCD) ChEMBL. 8289198
Ki (binding) = 356 uM Inhibition of recombinant stromelysin catalytic domain (SCD) ChEMBL. 8289198
Ki (binding) = 377 uM Inhibition of recombinant full length stromelysin (FLS) ChEMBL. 8289198
Ki (binding) = 377 uM Inhibition of recombinant full length stromelysin (FLS) ChEMBL. 8289198

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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