Detailed information for compound 1073338

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 503.484 | Formula: C22H26FN7O6
  • H donors: 1 H acceptors: 6 LogP: 0.82 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(=O)NC[C@@H]1OC(=O)N(C1)c1ccc(c(c1)F)N1CCN(CC1)C(=O)Cn1c(C)ncc1[N+](=O)[O-]
  • InChi: 1S/C22H26FN7O6/c1-14-24-11-20(30(34)35)28(14)13-21(32)27-7-5-26(6-8-27)19-4-3-16(9-18(19)23)29-12-17(36-22(29)33)10-25-15(2)31/h3-4,9,11,17H,5-8,10,12-13H2,1-2H3,(H,25,31)/t17-/m0/s1
  • InChiKey: GUFMQTOGXJHFDH-KRWDZBQOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0057 0.0206
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.0888 0.2434
Loa Loa (eye worm) latrophilin receptor protein 2 0.01 0.093 0.2549
Schistosoma mansoni hypothetical protein 0.0333 0.3648 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.003 0.0394
Echinococcus granulosus peregrin 0.003 0.0109 0.03
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0228 0.0825
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0103 0.137
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0149 0.1496 0.1496
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.01 0.093 0.2549
Trypanosoma brucei polo-like protein kinase 0.0097 0.0888 1
Schistosoma mansoni tar DNA-binding protein 0.0262 0.2815 0.7717
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0005 0.006
Brugia malayi Pre-SET motif family protein 0.0226 0.2399 0.6946
Leishmania major DNA polymerase kappa, putative 0.0021 0.0005 0.006
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.003 0.0334
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0005 0.0036
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0228 0.303
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0005 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0005 0.006
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0109 0.03
Brugia malayi TAR-binding protein 0.0262 0.2815 0.8152
Schistosoma mansoni hypothetical protein 0.0044 0.0276 0.0756
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0085 0.0753 1
Trichomonas vaginalis set domain proteins, putative 0.0257 0.2763 1
Schistosoma mansoni kinase 0.0049 0.0334 0.0916
Echinococcus granulosus GPCR family 2 0.01 0.093 0.2549
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.1522 0.4171
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0005 0.006
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0005 0.006
Schistosoma mansoni ran 0.0023 0.003 0.0081
Entamoeba histolytica hypothetical protein 0.0149 0.1496 1
Echinococcus granulosus expressed conserved protein 0.01 0.0929 0.2547
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.0753 1
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0888 0.3214
Echinococcus granulosus tar DNA binding protein 0.0262 0.2815 0.7717
Entamoeba histolytica hypothetical protein 0.0149 0.1496 1
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0005 0.0071
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0103 0.137
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0228 0.0228
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0228 0.303
Brugia malayi RNA, U transporter 1 0.0089 0.0797 0.2308
Loa Loa (eye worm) hypothetical protein 0.0316 0.3454 0.9466
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0228 0.2568
Schistosoma mansoni hypothetical protein 0.003 0.0109 0.03
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0126 0.0345
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.003 0.0334
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0085 0.0753 0.0753
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0228 0.2568
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.003 0.0334
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0085 0.0753 1
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0319 0.1155
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.0888 0.5936
Echinococcus granulosus dna polymerase kappa 0.0021 0.0005 0.0015
Echinococcus granulosus peptidase Clp S14 family 0.0056 0.0411 0.1127
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0888 1
Brugia malayi CHE-14 protein 0.0046 0.0295 0.0855
Schistosoma mansoni hypothetical protein 0.01 0.093 0.2549
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.014 0.0384
Brugia malayi Niemann-Pick C1 protein precursor 0.0107 0.1005 0.2909
Schistosoma mansoni peptidase Clp (S14 family) 0.0085 0.0753 0.2063
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0005 0.006
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0226 0.2399 0.6575
Plasmodium falciparum phd finger protein, putative 0.003 0.0109 0.1452
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.003 0.0086
Echinococcus granulosus Niemann Pick C1 protein 0.0107 0.1005 0.2754
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.0888 0.2571
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0005 0.0015
Loa Loa (eye worm) inositol-1 0.004 0.0228 0.0625
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0005 0.006
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0005 0.0071
Plasmodium vivax SET domain protein, putative 0.0032 0.014 0.186
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0005 0.006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0151 0.1522 0.1522
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0109 0.1452
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0109 0.03
Entamoeba histolytica Ran family GTPase 0.0023 0.003 0.0198
Toxoplasma gondii hypothetical protein 0.0029 0.0103 0.137
Schistosoma mansoni tar DNA-binding protein 0.0262 0.2815 0.7717
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0316 0.3454 1
Giardia lamblia PHD finger protein 15 0.003 0.0109 0.1231
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0182 0.0182
Loa Loa (eye worm) TAR-binding protein 0.0262 0.2815 0.7717
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0149 0.1496 0.41
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0295 0.0809
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0228 0.2568
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.01 0.093 0.2549
Schistosoma mansoni tar DNA-binding protein 0.0262 0.2815 0.7717
Onchocerca volvulus 0.0032 0.014 0.0115
Brugia malayi hypothetical protein 0.0149 0.1496 0.4332
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.01 0.093 0.2692
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0182 0.05
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0005 0.006
Brugia malayi Probable ClpP-like protease 0.0085 0.0753 0.2179
Schistosoma mansoni hypothetical protein 0.01 0.093 0.2549
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0085 0.0753 1
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0005 0.006
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.09 0.2468
Giardia lamblia Kinase, PLK 0.0097 0.0888 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0056 0.0411 0.0411
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0228 0.0625
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0109 0.0109
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0005 0.006
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.01 0.093 0.2549
Leishmania major importin beta-1 subunit, putative 0.0025 0.0057 0.0641
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0245 0.0245
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0005 0.006
Schistosoma mansoni hypothetical protein 0.0044 0.0276 0.0756
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0182 0.05
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0151 0.1522 0.1522
Schistosoma mansoni importin beta-1 0.0031 0.0126 0.0345
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.003 0.0081
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0005 0.0016
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0056 0.0411 0.4744
Echinococcus multilocularis protein dispatched 1 0.0052 0.0371 0.0371
Schistosoma mansoni transcription factor LCR-F1 0.0149 0.1496 0.41
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0005 0.013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.1522 0.4171
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0005 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0295 0.1068
Echinococcus multilocularis tar DNA binding protein 0.0262 0.2815 0.2815
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0316 0.3454 0.9466
Schistosoma mansoni hypothetical protein 0.01 0.093 0.2549
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0005 0.006
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0182 0.05
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0108 0.1024 0.2807
Schistosoma mansoni inositol monophosphatase 0.004 0.0228 0.0625
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0057 0.0641
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0245 0.0673
Schistosoma mansoni tar DNA-binding protein 0.0262 0.2815 0.7717
Plasmodium vivax importin-beta 2, putative 0.0031 0.0126 0.1671
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.0753 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0005 0.006
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0228 0.303
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0888 0.3214
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.014 0.014
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0057 0.0206
Brugia malayi latrophilin 2 splice variant baaae 0.0216 0.2285 0.6618
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.014 0.0384
Entamoeba histolytica hypothetical protein 0.0025 0.0057 0.038
Echinococcus multilocularis dna polymerase eta 0.0021 0.0005 0.0005
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0056 0.0411 1
Entamoeba histolytica hypothetical protein 0.0149 0.1496 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0107 0.1005 0.1005
Leishmania major GTP-binding protein, putative 0.0023 0.003 0.0334
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0179 0.4357
Schistosoma mansoni DNA polymerase eta 0.0021 0.0005 0.0015
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.0888 0.2934
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0888 0.3214
Brugia malayi RNA recognition motif domain containing protein 0.0262 0.2815 0.8152
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0126 0.1671
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0057 0.0206
Loa Loa (eye worm) hypothetical protein 0.01 0.093 0.2549
Entamoeba histolytica hypothetical protein 0.0149 0.1496 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.01 0.093 0.093
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0085 0.0753 0.2063
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0005 0.006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0015
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.0888 0.2434
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0005 0.006
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0888 0.3214
Trichomonas vaginalis ran, putative 0.0023 0.003 0.0107
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0333 0.3648 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0107 0.1005 0.6717
Loa Loa (eye worm) hypothetical protein 0.0046 0.0295 0.0809
Echinococcus multilocularis Niemann Pick C1 protein 0.0152 0.1538 0.1538
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0005 0.0015
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0888 0.3214
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0228 0.1524
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0126 0.1416
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.014 0.0384
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.01 0.093 0.093
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0005 0.006
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.014 0.186
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0151 0.1522 0.4171
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.003 0.0081
Loa Loa (eye worm) hypothetical protein 0.0085 0.0753 0.2063
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0005 0.0015
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0228 0.0825
Schistosoma mansoni hypothetical protein 0.0149 0.1496 0.41
Echinococcus multilocularis peregrin 0.003 0.0109 0.0109
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0005 0.0015
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0888 0.3214
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0085 0.0753 1
Brugia malayi Inositol-1 0.004 0.0228 0.066
Loa Loa (eye worm) hypothetical protein 0.0216 0.2285 0.6264
Brugia malayi RNA binding protein 0.0262 0.2815 0.8152
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0182 0.05
Brugia malayi Bromodomain containing protein 0.003 0.0109 0.0317
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.0888 0.0888
Schistosoma mansoni ran 0.0023 0.003 0.0081
Onchocerca volvulus 0.0257 0.2763 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0179 0.1171
Loa Loa (eye worm) hypothetical protein 0.0107 0.1005 0.2754
Brugia malayi PHD-finger family protein 0.003 0.0109 0.0317
Brugia malayi Calcitonin receptor-like protein seb-1 0.0316 0.3454 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.003 0.0334
Brugia malayi jmjC domain containing protein 0.0098 0.09 0.2607
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0228 0.2568
Plasmodium vivax hypothetical protein, conserved 0.003 0.0109 0.1452
Loa Loa (eye worm) hypothetical protein 0.003 0.0109 0.03
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0262 0.2815 0.7717
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.0753 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0479 0.1314
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0888 1
Brugia malayi jmjC domain containing protein 0.0036 0.0182 0.0528
Schistosoma mansoni inositol monophosphatase 0.004 0.0228 0.0625
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0005 0.0005
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0888 0.3214
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.0753 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.003 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0005 0.006
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0151 0.1522 0.4171
Echinococcus multilocularis protein patched 0.0046 0.0295 0.0295
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0151 0.1522 0.4171
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0295 0.0295
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0319 0.1155
Echinococcus granulosus Niemann Pick C1 protein 0.0152 0.1538 0.4216
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0005 0.0019
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.0888 1
Echinococcus multilocularis expressed conserved protein 0.01 0.0929 0.0929
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0888 0.2434
Schistosoma mansoni patched 1 0.0046 0.0295 0.0809
Plasmodium falciparum importin beta, putative 0.0031 0.0126 0.1671
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.014 0.0384
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0126 0.0126
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0109 0.03
Echinococcus granulosus snurportin 1 0.0333 0.3648 1
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0295 0.0809
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.014 0.0384
Loa Loa (eye worm) hypothetical protein 0.0031 0.0126 0.0345
Echinococcus multilocularis GPCR, family 2 0.01 0.093 0.093
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.014 0.014
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.0753 0.5
Schistosoma mansoni hypothetical protein 0.0216 0.2285 0.6264
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0126 0.1416
Giardia lamblia DINP protein human, muc B family 0.0021 0.0005 0.006
Echinococcus granulosus importin subunit beta 1 0.0031 0.0126 0.0345
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.003 0.0394
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0005 0.0016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0151 0.1522 0.4171
Brugia malayi Pre-SET motif family protein 0.0032 0.014 0.0405
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0056 0.0411 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.014 0.0384
Trypanosoma brucei unspecified product 0.0021 0.0005 0.006
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0666 0.1826
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.09 0.09
Brugia malayi Latrophilin receptor protein 2 0.01 0.093 0.2692
Schistosoma mansoni hypothetical protein 0.0044 0.0276 0.0756
Loa Loa (eye worm) RNA binding protein 0.0262 0.2815 0.7717
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0109 0.1452
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0295 0.0809
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0151 0.1522 0.4407
Loa Loa (eye worm) hypothetical protein 0.0051 0.0358 0.098
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.0753 1
Leishmania major DNA polymerase eta, putative 0.0021 0.0005 0.006
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.003 0.0394
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0005 0.006
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0228 0.0825
Schistosoma mansoni hypothetical protein 0.0044 0.0276 0.0756
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0085 0.0753 1
Brugia malayi Importin beta-1 subunit 0.0031 0.0126 0.0364
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0005 0.006
Schistosoma mansoni tar DNA-binding protein 0.0262 0.2815 0.7717
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0005 0.006
Echinococcus multilocularis snurportin 1 0.0333 0.3648 0.3648
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0103 0.137
Echinococcus granulosus dna polymerase eta 0.0021 0.0005 0.0015
Loa Loa (eye worm) hypothetical protein 0.0056 0.0415 0.1138

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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