Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0271 | 0.0675 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0343 | 0.4011 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0163 | 0.1813 | 0.4124 |
Onchocerca volvulus | 0.0037 | 0.0271 | 0.0294 | |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0343 | 0.4011 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0294 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0294 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0271 | 0.0675 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0157 | 0.0392 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.0271 | 0.0675 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0236 | 0.2707 | 0.6513 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0343 | 0.4011 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0157 | 0.0392 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0271 | 0.0675 |
Onchocerca volvulus | 0.0037 | 0.0271 | 0.0294 | |
Echinococcus granulosus | geminin | 0.0166 | 0.1842 | 0.4371 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.0157 | 0.0392 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.0294 | 0.0139 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0163 | 0.1813 | 0.4124 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0343 | 0.4011 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0294 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.0294 | 0.0355 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0294 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0343 | 0.4011 | 0.3915 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.0271 | 0.0675 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0294 | 0.0733 |
Onchocerca volvulus | 0.0037 | 0.0271 | 0.0294 | |
Onchocerca volvulus | 0.0343 | 0.4011 | 1 | |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0271 | 0.0675 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0271 | 0.0675 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0163 | 0.1813 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.0271 | 0.0675 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.0157 | 0.0392 |
Mycobacterium ulcerans | thymidylate synthase | 0.0343 | 0.4011 | 1 |
Brugia malayi | hypothetical protein | 0.0163 | 0.1813 | 0.452 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0294 | 0.0355 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0343 | 0.4011 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.1842 | 0.4371 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0343 | 0.4011 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0343 | 0.4011 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0343 | 0.4011 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0271 | 0.0675 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0271 | 0.0675 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.0271 | 0.0294 |
Brugia malayi | thymidylate synthase | 0.0343 | 0.4011 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0151 | 0.0377 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.1842 | 0.4371 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0271 | 0.0294 |
Echinococcus multilocularis | geminin | 0.0166 | 0.1842 | 0.1711 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0343 | 0.4011 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0271 | 0.0294 |
Brugia malayi | beta-lactamase | 0.0037 | 0.0271 | 0.0675 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.0271 | 0.0115 |
Echinococcus granulosus | thymidylate synthase | 0.0343 | 0.4011 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.0294 | 0.0355 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0343 | 0.4011 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0157 | 0.0392 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0271 | 0.0675 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.