Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0009 | 0.0241 | 0.0241 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.3791 | 0.3638 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0023 | 0.2134 | 1 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0023 | 0.2134 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3791 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.0791 | 0.0564 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.0791 | 0.0564 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0023 | 0.2134 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.5597 | 0.5597 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0023 | 0.2134 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0023 | 0.2134 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.1531 | 0.1322 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.5167 | 0.5167 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.1531 | 0.2925 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.5047 | 0.4924 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0023 | 0.2134 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.3791 | 0.3791 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0009 | 0.0241 | 0.0241 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.1531 | 0.2925 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.1531 | 0.5 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0009 | 0.0241 | 0.0241 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0009 | 0.0241 | 0.0241 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.1531 | 0.1531 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.5167 | 0.5167 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0023 | 0.2134 | 1 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0023 | 0.2134 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.1531 | 0.5 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.1531 | 0.1322 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.0791 | 0.0564 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0009 | 0.0241 | 0.0241 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.3791 | 0.3638 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.3791 | 0.3791 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.5167 | 0.5048 |
Mycobacterium leprae | conserved hypothetical protein | 0.0023 | 0.2134 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.1531 | 0.5 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0023 | 0.2134 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.4255 | 0.4114 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.5167 | 0.5048 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.5047 | 0.4924 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.5167 | 0.5048 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.0791 | 0.0564 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.2134 | 0.2666 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0791 | 0.0791 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.5167 | 0.5048 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.4652 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3791 | 1 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0023 | 0.2134 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.5167 | 0.5048 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.1531 | 0.1322 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0791 | 0.0564 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.1531 | 0.1531 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.5597 | 0.5597 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0791 | 0.0791 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.5167 | 0.5048 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.5047 | 0.4924 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3791 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.5047 | 0.4924 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0023 | 0.2134 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3791 | 1 |
Brugia malayi | hypothetical protein | 0.0035 | 0.3791 | 0.3638 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.0791 | 0.0564 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0023 | 0.2134 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.4652 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.5167 | 0.5167 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0009 | 0.0241 | 0.0241 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.1531 | 0.1322 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8181.818182 nM | Displacement of [3H]dofetilide from human recombinant ERG by Competitive binding assay | ChEMBL. | 21802950 |
Inhibition (binding) | = 55 % | Inhibition of human ERG at 10 uM | ChEMBL. | 19773164 |
Ki (binding) | = 104 nM | Displacement of [3H]N-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in HEK293 cells | ChEMBL. | 19773164 |
Ki (binding) | = 104 nM | Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assay | ChEMBL. | 21802950 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.