Detailed information for compound 107355

Basic information

Technical information
  • TDR Targets ID: 107355
  • Name: N-(2-dimethylaminoethyl)-4-[(E)-[[1-(3-methox yphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]hydrazi nylidene]methyl]benzenesulfonamide
  • MW: 494.569 | Formula: C23H26N8O3S
  • H donors: 2 H acceptors: 5 LogP: 2.77 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)n1ncc2c1ncnc2N/N=C/c1ccc(cc1)S(=O)(=O)NCCN(C)C
  • InChi: 1S/C23H26N8O3S/c1-30(2)12-11-28-35(32,33)20-9-7-17(8-10-20)14-26-29-22-21-15-27-31(23(21)25-16-24-22)18-5-4-6-19(13-18)34-3/h4-10,13-16,28H,11-12H2,1-3H3,(H,24,25,29)/b26-14+
  • InChiKey: MODZLDXHIYVFPM-VULFUBBASA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-dimethylaminoethyl)-4-[(E)-[[1-(3-methoxyphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]hydrazono]methyl]benzenesulfonamide
  • N-(2-dimethylaminoethyl)-4-[(E)-[[1-(3-methoxyphenyl)-4-pyrazolo[3,4-d]pyrimidinyl]hydrazono]methyl]benzenesulfonamide
  • N-(2-dimethylaminoethyl)-4-[(E)-[[1-(3-methoxyphenyl)pyrazolo[4,5-e]pyrimidin-4-yl]hydrazinylidene]methyl]benzenesulfonamide
  • N-(2-dimethylaminoethyl)-4-[(E)-[[1-(3-methoxyphenyl)pyrazolo[4,5-e]pyrimidin-4-yl]hydrazono]methyl]benzenesulfonamide
  • N-(2-dimethylaminoethyl)-4-[(E)-[[1-(3-methoxyphenyl)-4-pyrazolo[4,5-e]pyrimidinyl]hydrazono]methyl]benzenesulfonamide
  • pyrazolopyrimidine derivative 57

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi protein kinase C II. 0.0016 0.1745 0.1745
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0007 0.0051 0.5
Loa Loa (eye worm) hypothetical protein 0.0039 0.6166 0.6166
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.3255 0.3221
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.3255 0.3255
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0007 0.0051 0.5
Loa Loa (eye worm) hypothetical protein 0.0024 0.3255 0.3255
Entamoeba histolytica ATP-binding cassette protein, putative 0.0007 0.0051 0.0051
Echinococcus multilocularis serine threonine protein kinase 0.0049 0.8159 0.8149
Brugia malayi Protein kinase domain containing protein 0.0009 0.0343 0.0343
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0343 0.0343
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0009 0.0343 0.0343
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.3255 0.3255
Loa Loa (eye worm) ABC transporter 0.0007 0.0051 0.0051
Brugia malayi multidrug resistance protein 3 0.0024 0.3255 0.3255
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.3255 0.3255
Echinococcus granulosus multidrug resistance protein 1 0.0017 0.1847 0.1847
Giardia lamblia Multidrug resistance-associated protein 1 0.0007 0.0051 0.0051
Entamoeba histolytica protein kinase, putative 0.0009 0.0343 0.0343
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0016 0.1745 0.1745
Loa Loa (eye worm) hypothetical protein 0.0007 0.0051 0.0051
Echinococcus granulosus ATP binding cassette sub family B 0.0007 0.0051 0.0051
Echinococcus multilocularis multidrug resistance protein 1 0.0017 0.1847 0.1805
Loa Loa (eye worm) AGC/NDR protein kinase 0.0009 0.0343 0.0343
Trichomonas vaginalis abcb9, putative 0.0024 0.3255 0.3255
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0007 0.0051 0.5
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0343 0.0343
Loa Loa (eye worm) AGC/AKT protein kinase 0.0009 0.0343 0.0343
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0039 0.6166 0.6147
Brugia malayi ABC transporter 0.0007 0.0051 0.0051
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0058 1 1
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0007 0.0051 0.0051
Schistosoma mansoni atypical protein kinase C 0.0015 0.1504 0.1504
Plasmodium falciparum glycogen synthase kinase 3 0.0058 1 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0343 0.0343
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0058 1 1
Entamoeba histolytica P-glycoprotein-2, putative 0.0024 0.3255 0.3255
Brugia malayi ABC transporter family protein 0.0007 0.0051 0.0051
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.3255 0.3255
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0017 0.1847 0.1847
Echinococcus multilocularis protein kinase c iota type 0.0015 0.1504 0.1461
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0009 0.0343 0.0343
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0343 0.0343
Echinococcus granulosus protein kinase c epsilon type 0.0016 0.1745 0.1745
Plasmodium vivax glycogen synthase kinase 3, putative 0.0058 1 1
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0009 0.0343 0.0294
Entamoeba histolytica hypothetical protein 0.0007 0.0051 0.0051
Entamoeba histolytica ABC transporter, putative 0.0007 0.0051 0.0051
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0343 0.0343
Entamoeba histolytica protein kinase domain containing protein 0.0058 1 1
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0024 0.3255 0.3221
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.3255 0.3221
Trichomonas vaginalis taga, putative 0.0024 0.3255 0.3255
Echinococcus granulosus multidrug resistance associated protein 1 0.0007 0.0051 0.0051
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.3255 0.3255
Brugia malayi ABC transporter transmembrane region family protein 0.0007 0.0051 0.0051
Echinococcus granulosus NDR protein kinase 0.0009 0.0343 0.0343
Echinococcus granulosus Protein kinase C brain isozyme 0.0055 0.932 0.932
Giardia lamblia MRP-like ABC transporter 0.0007 0.0051 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.932 0.932
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.3255 0.3221
Giardia lamblia Multidrug resistance-associated protein 1 0.0007 0.0051 0.0051
Loa Loa (eye worm) multidrug resistance protein 3 0.0024 0.3255 0.3255
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0343 0.0343
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0058 1 1
Brugia malayi Protein kinase c protein 2 0.0047 0.7713 0.7713
Entamoeba histolytica ATP-binding cassette protein, putative 0.0007 0.0051 0.0051
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0343 0.0343
Echinococcus multilocularis serine:threonine protein kinase 38 0.0009 0.0343 0.0294
Entamoeba histolytica P-glycoprotein 6, putative 0.0007 0.0051 0.0051
Echinococcus multilocularis RNA directed DNA polymerase 0.0039 0.6166 0.6147
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.3255 0.3255
Echinococcus multilocularis protein kinase c epsilon type 0.0016 0.1745 0.1703
Trichomonas vaginalis abcb9, putative 0.0024 0.3255 0.3255
Loa Loa (eye worm) hypothetical protein 0.0007 0.0051 0.0051
Entamoeba histolytica P-glycoprotein-1 0.0024 0.3255 0.3255
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0009 0.0343 0.0343
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0024 0.3255 1
Entamoeba histolytica P-glycoprotein-2 0.0024 0.3255 0.3255
Leishmania major p-glycoprotein 0.0024 0.3255 0.3221
Loa Loa (eye worm) hypothetical protein 0.0045 0.7327 0.7327
Trypanosoma brucei rac serine-threonine kinase, putative 0.0009 0.0343 0.0294
Brugia malayi Protein kinase domain containing protein 0.0009 0.0343 0.0343
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0009 0.0343 0.0343
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0009 0.0343 0.0294
Trichomonas vaginalis ABC transporter, putative 0.0024 0.3255 0.3255
Echinococcus granulosus serine:threonine protein kinase N2 0.0009 0.0343 0.0343
Brugia malayi P-glycoprotein-like protein 0.0007 0.0051 0.0051
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0058 1 1
Toxoplasma gondii AGC kinase 0.0009 0.0343 0.0294
Echinococcus granulosus RNA directed DNA polymerase 0.0039 0.6166 0.6166
Entamoeba histolytica protein kinase, putative 0.0058 1 1
Trichomonas vaginalis ABC transporter, putative 0.0024 0.3255 0.3255
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0058 1 1
Schistosoma mansoni multidrug resistance protein 0.0007 0.0051 0.0051
Echinococcus granulosus multidrug resistance protein 1 0.0017 0.1847 0.1847
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.3204 0.3169
Giardia lamblia ABC transporter, putative 0.0007 0.0051 0.0051
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.3255 0.3255
Loa Loa (eye worm) hypothetical protein 0.0024 0.3255 0.3255
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.3255 0.3255
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0007 0.0051 0.5
Brugia malayi p70 ribosomal S6 kinase beta 0.0009 0.0343 0.0343
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.3255 0.3255
Schistosoma mansoni multidrug resistance protein 0.0007 0.0051 0.0051
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0343 0.0343
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0007 0.0051 0.0051
Trichomonas vaginalis CMGC family protein kinase 0.0058 1 1
Entamoeba histolytica P-glycoprotein-5 0.0024 0.3255 0.3255
Brugia malayi ABC transporter family protein 0.0007 0.0051 0.0051
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.3255 0.3255
Echinococcus multilocularis serine:threonine protein kinase N2 0.0009 0.0343 0.0294
Schistosoma mansoni smdr1 0.0007 0.0051 0.0051
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0007 0.0051 0.5
Schistosoma mansoni multidrug resistance protein 0.0007 0.0051 0.0051
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0058 1 1
Giardia lamblia Kinase, CMGC GSK 0.0058 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.3255 0.3255
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0058 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0007 0.0051 0.0051
Schistosoma mansoni multidrug resistance protein 0.0024 0.3255 0.3255
Echinococcus multilocularis multidrug resistance protein 1 0.0024 0.3255 0.3221
Plasmodium falciparum multidrug resistance protein 1 0.0024 0.3255 0.3221
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0024 0.3255 0.5
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.3255 0.3255
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.3255 0.3255
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0024 0.3255 0.3255
Entamoeba histolytica P-glycoprotein-2 0.0024 0.3255 0.3255
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.3255 0.3255
Brugia malayi ABC transporter transmembrane region family protein 0.0007 0.0051 0.0051
Entamoeba histolytica ATP-binding cassette protein, putative 0.0007 0.0051 0.0051
Entamoeba histolytica protein kinase, putative 0.0009 0.0343 0.0343
Giardia lamblia Kinase, CMGC GSK 0.0058 1 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.3255 0.3255
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0041 0.6552 0.6552
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0343 0.0343
Entamoeba histolytica protein kinase, putative 0.0009 0.0343 0.0343
Loa Loa (eye worm) AGC/PKN protein kinase 0.0009 0.0343 0.0343
Schistosoma mansoni multidrug resistance protein 0.0007 0.0051 0.0051
Trichomonas vaginalis ABC transporter, putative 0.0024 0.3255 0.3255
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.1745 0.1745
Brugia malayi Hr1 repeat family protein 0.0009 0.0343 0.0343
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.3255 0.3255
Schistosoma mansoni multidrug resistance protein 0.0007 0.0051 0.0051
Echinococcus multilocularis multidrug resistance protein 1 0.0024 0.3255 0.3221
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0007 0.0051 0.5
Echinococcus multilocularis serine:threonine protein kinase N2 0.0009 0.0343 0.0294
Loa Loa (eye worm) hypothetical protein 0.0024 0.3204 0.3204
Brugia malayi multidrug resistance related protein 1 0.0007 0.0051 0.0051
Brugia malayi Protein kinase domain containing protein 0.0009 0.0343 0.0343
Entamoeba histolytica protein kinase, putative 0.0009 0.0343 0.0343
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0024 0.3255 0.3255
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.3255 0.3221
Schistosoma mansoni serine/threonine kinase 0.0009 0.0343 0.0343
Schistosoma mansoni multidrug resistance protein 0.0024 0.3255 0.3255
Plasmodium vivax multidrug resistance protein 1, putative 0.0024 0.3255 0.3221
Entamoeba histolytica P-glycoprotein 5, putative 0.0024 0.3255 0.3255
Entamoeba histolytica P-glycoprotein 6, putative 0.0007 0.0051 0.0051
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0007 0.0051 0.5
Trichomonas vaginalis ABC transporter, putative 0.0024 0.3255 0.3255
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0009 0.0343 0.0343
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.3255 0.3255
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0343 0.0343
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0024 0.3255 0.3221
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.3255 0.3255
Entamoeba histolytica P-glyco protein 6, putative 0.0024 0.3255 0.3255
Trichomonas vaginalis CMGC family protein kinase 0.0058 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.3255 0.3255
Brugia malayi hypothetical protein 0.0007 0.0051 0.0051
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0343 0.0343
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.3255 0.3255
Loa Loa (eye worm) ABC transporter 0.0007 0.0051 0.0051
Brugia malayi ABC transporter family protein 0.0024 0.3255 0.3255
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0343 0.0343
Trichomonas vaginalis abcb9, putative 0.0024 0.3255 0.3255
Entamoeba histolytica protein kinase domain containing protein 0.0058 1 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0058 1 1
Entamoeba histolytica multidrug resistance protein, putative 0.0007 0.0051 0.0051
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0007 0.0051 0.5
Echinococcus multilocularis protein kinase shaggy 0.0058 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.3255 0.3255
Schistosoma mansoni multidrug resistance protein 0.0024 0.3255 0.3255
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.3255 0.3255
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0009 0.0343 0.0294
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.3255 0.3255
Loa Loa (eye worm) ABC transporter 0.0007 0.0051 0.0051
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0009 0.0343 0.0343
Entamoeba histolytica ATP-binding cassette protein, putative 0.0007 0.0051 0.0051
Trypanosoma brucei protein kinase, putative 0.0058 1 1
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0007 0.0051 0.5
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0024 0.3204 0.3204
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0343 0.0343
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.3255 0.3255
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0343 0.0343
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.3255 0.3255
Echinococcus granulosus protein kinase c iota type 0.0015 0.1504 0.1504
Echinococcus granulosus ATP binding cassette sub family B 0.0007 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0007 0.0051 0.0051
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0008 0.0199 0.0199
Echinococcus granulosus protein kinase C gamma type 0.0049 0.8159 0.8159
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.932 0.932
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.3255 0.3255
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0024 0.3255 0.3255
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0007 0.0051 0.0051
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.3255 0.3255
Brugia malayi ABC transporter family protein 0.0007 0.0051 0.0051
Echinococcus granulosus protein kinase shaggy 0.0058 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.3255 0.3221
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0009 0.0343 0.0343
Schistosoma mansoni smdr2 0.0024 0.3255 0.3255
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0055 0.932 0.9316
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.3255 0.3221
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0343 0.0343
Onchocerca volvulus 0.0058 1 1
Echinococcus granulosus multidrug resistance associated protein 7 0.0007 0.0051 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0343 0.0343

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 8 Ability of the compound to inhibit 50% glycogen synthase kinase-3 beta of recombinant human, expressed as log of concentration ChEMBL. 15080992
Log IC50 (binding) = 8 Ability of the compound to inhibit 50% glycogen synthase kinase-3 beta of recombinant human, expressed as log of concentration ChEMBL. 15080992

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.