Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 2 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 2 | 617 aa | 638 aa | 32.5 % |
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 4 | 630 aa | 574 aa | 31.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0126 | 0.6304 | 0.6304 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.6304 | 0.6304 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.1853 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0126 | 0.6304 | 0.6304 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.6304 | 0.6304 |
Loa Loa (eye worm) | RNA binding protein | 0.0126 | 0.6304 | 0.6304 |
Echinococcus multilocularis | tar DNA binding protein | 0.0126 | 0.6304 | 0.6304 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.6304 | 0.6304 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.1853 | 0.1853 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.1611 | 0.1611 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.6304 | 0.6304 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0454 | 0.0454 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.1853 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.1853 | 0.1853 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.1853 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.1853 | 0.1853 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.1853 | 0.1853 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1611 | 0.1611 |
Brugia malayi | TAR-binding protein | 0.0126 | 0.6304 | 0.6304 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0454 | 0.0454 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.6304 | 0.6304 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0126 | 0.6304 | 0.6304 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.1853 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.1853 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0454 | 0.0454 |
Brugia malayi | RNA binding protein | 0.0126 | 0.6304 | 0.6304 |
Echinococcus granulosus | tar DNA binding protein | 0.0126 | 0.6304 | 0.6304 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.1611 | 0.1611 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.1853 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.1611 | 0.1611 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7 nM | Inhibition of human NET expressed in MDCK-Net6 cells | ChEMBL. | 19713106 |
IC50 (binding) | = 175 nM | Inhibition of human SERT expressed in JAR cells | ChEMBL. | 19713106 |
Inhibition (binding) | = 8 % | Displacement of [3H]WIN-35428 from human DAT expressed in CHO cells | ChEMBL. | 19713106 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.