Detailed information for compound 1073851

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 292.332 | Formula: C18H16N2O2
  • H donors: 0 H acceptors: 2 LogP: 3.81 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(=O)n1nc(cc1C)c1ccccc1
  • InChi: 1S/C18H16N2O2/c1-13-12-17(14-6-4-3-5-7-14)19-20(13)18(21)15-8-10-16(22-2)11-9-15/h3-12H,1-2H3
  • InChiKey: CYZXQEDINWGQTK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0027 0.0252 0.0383
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0197 0.036
Brugia malayi G-protein alpha subunit 0.0008 0.0029 0.0054
Loa Loa (eye worm) hypothetical protein 0.0008 0.0029 0.0054
Plasmodium falciparum DNA repair protein REV1, putative 0.0063 0.0695 0.7891
Trypanosoma cruzi DNA polymerase kappa, putative 0.0203 0.2402 0.6457
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0665 0.1329
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.04 0.063
Echinococcus granulosus MAM 0.0017 0.014 0.0242
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0197 0.0174
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0844 0.1373
Trypanosoma cruzi DNA polymerase kappa, putative 0.0203 0.2402 0.6457
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.04 0.0378
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0053 0.0102
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0053 0.0031
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0023 0.0102
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0844 0.1373
Echinococcus granulosus dna polymerase kappa 0.0203 0.2402 0.4924
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.04 0.1584
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0053 0.0064
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0844 0.1426
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0008 0.0029 0.0054
Onchocerca volvulus 0.0016 0.0125 0.0171
Brugia malayi Muscle positioning protein 4 0.0016 0.0125 0.0237
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0008 0.0029 0.0054
Loa Loa (eye worm) hypothetical protein 0.001 0.0053 0.0102
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0224 0.0337
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0197 0.0472
Loa Loa (eye worm) acetyltransferase 0.0156 0.1838 0.349
Loa Loa (eye worm) hypothetical protein 0.0078 0.0875 0.1662
Onchocerca volvulus 0.0016 0.0125 0.0171
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.0229 0.5
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0844 1
Schistosoma mansoni hypothetical protein 0.0035 0.0352 0.0775
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0023 0.0043
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0844 0.2228
Loa Loa (eye worm) hypothetical protein 0.003 0.0293 0.0557
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0844 0.2228
Onchocerca volvulus 0.0008 0.0029 0.001
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0053 0.0102
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0193 0.2288 0.2271
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0415 0.1064
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0053 0.0102
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0352 0.0682
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0053 0.0102
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0197 0.0972
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0844 0.1699
Plasmodium vivax SET domain protein, putative 0.0063 0.0693 0.7914
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0415 0.1648
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0252 0.0622
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.2288 0.5323
Toxoplasma gondii ABC1 family protein 0.0075 0.0844 0.421
Loa Loa (eye worm) hypothetical protein 0.0075 0.0844 0.1602
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0008 0.0029 0.001
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0008 0.0029 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0415 0.0656
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0437 0.5267 1
Trypanosoma brucei DNA polymerase eta, putative 0.031 0.3708 1
Trypanosoma brucei DNA polymerase IV, putative 0.0203 0.2402 0.6457
Echinococcus multilocularis snurportin 1 0.032 0.3833 0.3819
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.0695 0.1826
Loa Loa (eye worm) hypothetical protein 0.004 0.0415 0.0788
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0053 0.0073
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.04 0.0759
Onchocerca volvulus 0.0008 0.0029 0.001
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0197 0.0373
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0053 0.0102
Loa Loa (eye worm) hypothetical protein 0.0075 0.0844 0.1602
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0053 0.0102
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0008 0.0029 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0203 0.2402 0.6457
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0023 0.0102
Toxoplasma gondii ImpB/MucB/SamB family protein 0.017 0.2001 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0693 0.1575
Plasmodium vivax importin-beta 2, putative 0.003 0.0293 0.3332
Leishmania major importin beta-1 subunit, putative 0.0024 0.0224 0.0546
Trypanosoma brucei DNA polymerase IV, putative 0.0203 0.2402 0.6457
Schistosoma mansoni coup transcription factor 0.001 0.0053 0.0073
Schistosoma mansoni DNA polymerase eta 0.031 0.3708 0.8659
Loa Loa (eye worm) hypothetical protein 0.0063 0.0693 0.1316
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0027 0.0252 0.1248
Trichomonas vaginalis dullard protein, putative 0.0027 0.0252 0.0383
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0197 0.0472
Brugia malayi steroid hormone receptor 0.001 0.0053 0.0102
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0063 0.0695 0.3468
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.04 0.078
Trichomonas vaginalis DNA polymerase eta, putative 0.0203 0.2402 0.3978
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0271 0.0249
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0053 0.0102
Onchocerca volvulus 0.0088 0.1 0.1633
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0053 0.0102
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0415 0.0393
Trypanosoma brucei DNA polymerase kappa, putative 0.0203 0.2402 0.6457
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0008 0.0029 0.0013
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0053 0.0052
Plasmodium falciparum importin beta, putative 0.003 0.0293 0.3173
Loa Loa (eye worm) hypothetical protein 0.0075 0.0844 0.1602
Loa Loa (eye worm) hypothetical protein 0.0017 0.014 0.0265
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0442 0.1764
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0053 0.0031
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0415 0.0812
Mycobacterium ulcerans DNA polymerase IV 0.0203 0.2402 1
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0271 0.3074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0053 0.0102
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0027 0.0252 0.0383
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0027 0.0252 0.0478
Trypanosoma brucei DNA damage repair protein, putative 0.0063 0.0695 0.1826
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0023 0.0043
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0271 0.1042
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0008 0.0029 0.0014
Mycobacterium tuberculosis Conserved protein 0.0075 0.0844 0.1426
Brugia malayi RNA, U transporter 1 0.0085 0.0968 0.1837
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0053 0.0031
Trichomonas vaginalis dullard protein, putative 0.0027 0.0252 0.0383
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0008 0.0029 0.0006
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.04 0.1584
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0053 0.0031
Brugia malayi beta-lactamase family protein 0.0075 0.0844 0.1602
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0844 0.1426
Brugia malayi hypothetical protein 0.0017 0.014 0.0265
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.04 0.1023
Mycobacterium leprae Probable lipase LipE 0.0075 0.0844 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0844 0.2829
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0008 0.0029 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0203 0.2402 0.6457
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0008 0.0029 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0695 0.1826
Mycobacterium tuberculosis Conserved hypothetical protein 0.0203 0.2402 0.4131
Trypanosoma brucei unspecified product 0.014 0.1634 0.4373
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0229 0.2419
Schistosoma mansoni GTP-binding protein alpha subunit 0.0008 0.0029 0.0014
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0008 0.0029 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0844 0.1373
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0027 0.0252 0.0963
Loa Loa (eye worm) hypothetical protein 0.001 0.0053 0.0102
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0027 0.0252 0.0474
Echinococcus granulosus geminin 0.0356 0.4279 0.8806
Trypanosoma brucei DNA polymerase kappa, putative 0.0203 0.2402 0.6457
Entamoeba histolytica deoxycytidyl transferase, putative 0.0203 0.2402 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0193 0.2288 0.4687
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.04 0.455
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0053 0.0031
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0053 0.0031
Trichomonas vaginalis esterase, putative 0.0075 0.0844 0.1373
Trypanosoma brucei unspecified product 0.014 0.1634 0.4373
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.04 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0053 0.0073
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0271 0.1042
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0229 0.056
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0489 0.0965
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0197 0.2225
Schistosoma mansoni GTP-binding protein alpha subunit 0.0008 0.0029 0.0014
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0008 0.0029 0.0014
Loa Loa (eye worm) hypothetical protein 0.0075 0.0844 0.1602
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0442 0.1764
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0027 0.0252 0.0383
Plasmodium vivax DNA repair protein REV1, putative 0.0063 0.0695 0.794
Trypanosoma brucei chrX additional, unordered contigs 0.0063 0.0695 0.1826
Loa Loa (eye worm) hypothetical protein 0.0017 0.014 0.0265
Leishmania major hypothetical protein, conserved 0.0078 0.0875 0.2314
Echinococcus multilocularis geminin 0.0356 0.4279 0.4266
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0053 0.0102
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0197 0.0472
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0008 0.0029 0.0054
Loa Loa (eye worm) hypothetical protein 0.0008 0.0029 0.0054
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0415 0.1064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0053 0.0102
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0027 0.0252 0.0538
Brugia malayi Flap endonuclease-1 0.0028 0.0271 0.0514
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0053 0.0102
Mycobacterium ulcerans hypothetical protein 0.0063 0.0695 0.2147
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.04 0.442
Loa Loa (eye worm) hypothetical protein 0.0016 0.0125 0.0237
Schistosoma mansoni ran 0.0022 0.0197 0.0409
Schistosoma mansoni ap endonuclease 0.0039 0.04 0.0886
Brugia malayi SEA domain containing protein 0.0016 0.0125 0.0237
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0053 0.0073
Schistosoma mansoni thyroid hormone receptor 0.001 0.0053 0.0073
Trypanosoma cruzi DNA polymerase kappa, putative 0.0203 0.2402 0.6457
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0023 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0053 0.0102
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0352 0.0331
Leishmania major DNA polymerase eta, putative 0.017 0.2001 0.5369
Schistosoma mansoni hypothetical protein 0.0017 0.014 0.0275
Brugia malayi ImpB/MucB/SamB family protein 0.0203 0.2402 0.4561
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0008 0.0029 0.0054
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0224 0.0337
Loa Loa (eye worm) hypothetical protein 0.001 0.0053 0.0102
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0224 0.0337
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0844 0.1426
Loa Loa (eye worm) G protein alpha subunit 3 0.0008 0.0029 0.0054
Echinococcus granulosus dna polymerase eta 0.031 0.3708 0.7625
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0008 0.0029 0.0054
Schistosoma mansoni flap endonuclease-1 0.0025 0.0238 0.0505
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0844 0.1426
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0415 0.0656
Schistosoma mansoni hypothetical protein 0.032 0.3833 0.8953
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0008 0.0029 0.0014
Mycobacterium ulcerans hypothetical protein 0.0075 0.0844 0.2829
Onchocerca volvulus 0.0498 0.6005 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0203 0.2402 0.6457
Toxoplasma gondii exonuclease III APE 0.0039 0.04 0.1987
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.0875 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0415 0.0922
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0023 0.0043
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0053 0.0102
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0053 0.0064
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0008 0.0029 0.0054
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0053 0.0031
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0043
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0008 0.0029 0.001
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0008 0.0023 0.0001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0053 0.0031
Brugia malayi ImpB/MucB/SamB family protein 0.031 0.3708 0.704
Echinococcus multilocularis importin subunit beta 1 0.003 0.0293 0.0271
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0053 0.0102
Trypanosoma brucei DNA polymerase kappa, putative 0.014 0.1634 0.4373
Schistosoma mansoni ran 0.0022 0.0197 0.0409
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0489 0.2436
Brugia malayi beta-lactamase 0.0075 0.0844 0.1602
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0415 0.1064
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0008 0.0023 0.0233
Schistosoma mansoni terminal deoxycytidyl transferase 0.0203 0.2402 0.5591
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0053 0.0064
Brugia malayi nuclear hormone receptor 0.001 0.0053 0.0102
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0193 0.2288 0.4344
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0293 0.1455
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.04 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0248 0.047
Onchocerca volvulus 0.0016 0.0125 0.0171
Mycobacterium ulcerans DNA polymerase IV 0.0203 0.2402 1
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0844 0.1426
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0008 0.0029 0.0014
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0043
Onchocerca volvulus 0.0075 0.0844 0.1373
Loa Loa (eye worm) beta-lactamase 0.0075 0.0844 0.1602
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0023 0.0043
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0415 0.0393
Echinococcus multilocularis dna polymerase eta 0.031 0.3708 0.3694
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0053 0.0073
Loa Loa (eye worm) hypothetical protein 0.001 0.0053 0.0102
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0008 0.0029 0.0006
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0023 0.0043
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0229 0.0358
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0053 0.0102
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0053 0.0052
Loa Loa (eye worm) hypothetical protein 0.0017 0.014 0.0265
Echinococcus granulosus importin subunit beta 1 0.003 0.0293 0.056
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0415 0.0812
Trichomonas vaginalis set domain proteins, putative 0.0498 0.6005 1
Onchocerca volvulus 0.0075 0.0844 0.1373
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0271 0.0673
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0293 0.0734
Loa Loa (eye worm) TK/ALK protein kinase 0.0017 0.014 0.0265
Trypanosoma cruzi DNA polymerase eta, putative 0.031 0.3708 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0844 0.0823
Brugia malayi CCR4 0.0008 0.0023 0.0043
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0229 0.1134
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0197 0.204
Loa Loa (eye worm) hypothetical protein 0.0075 0.0844 0.1602
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0489 0.078
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0229 0.5472
Loa Loa (eye worm) hypothetical protein 0.0008 0.0029 0.0054
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0271 0.0415
Plasmodium vivax exodeoxyribonuclease III, putative 0.0008 0.0023 0.0233
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0844 0.2829
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0844 0.1929
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0008 0.0029 0.0054
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0203 0.2402 0.2385
Loa Loa (eye worm) hypothetical protein 0.0063 0.0695 0.132
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.04 0.0654
Echinococcus multilocularis 0.0027 0.0252 0.023
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0197 0.0373
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0023 0.0102
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0008 0.0023 0.0233
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0008 0.0023 0.0043
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0053 0.0073
Plasmodium falciparum flap endonuclease 1 0.0028 0.0271 0.2909
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0489 0.2436
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0203 0.2402 0.4561
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0023 0.0102
Leishmania major DNA polymerase kappa, putative 0.0063 0.0695 0.1826
Brugia malayi beta-lactamase family protein 0.0075 0.0844 0.1602
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0053 0.0073
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0156 0.1838 0.4266
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0229 0.056
Loa Loa (eye worm) hypothetical protein 0.001 0.0053 0.0102
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0193 0.2288 0.4344
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0271 0.0673
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0008 0.0029 0.0013
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0844 0.1602
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0693 0.1387
Entamoeba histolytica Ran family GTPase 0.0022 0.0197 0.0731
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0008 0.0029 0.0013
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0008 0.0029 0.0014
Echinococcus multilocularis L aminoadipate semialdehyde 0.0088 0.1 0.0979
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0193 0.2288 0.2271
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0027 0.0252 0.2858
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0088 0.1 0.1898
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0844 0.1426
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0027 0.0252 0.2688
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0844 0.1929
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0844 0.9639
Loa Loa (eye worm) hypothetical protein 0.001 0.0053 0.0102
Entamoeba histolytica hypothetical protein 0.0024 0.0224 0.0846
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0203 0.2402 0.5591
Leishmania major hypothetical protein, conserved 0.0075 0.0844 0.2228
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.04 0.1023
Schistosoma mansoni importin beta-1 0.003 0.0293 0.0636
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0008 0.0029 0.0006
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0203 0.2402 0.4131
Trypanosoma cruzi DNA polymerase kappa, putative 0.0203 0.2402 0.6457
Mycobacterium tuberculosis Conserved protein 0.0075 0.0844 0.1426
Loa Loa (eye worm) hypothetical protein 0.0027 0.0252 0.0478
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0053 0.0102
Trypanosoma brucei DNA polymerase kappa, putative 0.014 0.1634 0.4373
Loa Loa (eye worm) DOMON domain-containing protein 0.0016 0.0125 0.0237
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0008 0.0029 0.0014
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0875 1
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0008 0.0029 0.0054
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0053 0.0073
Echinococcus multilocularis MAM 0.0017 0.014 0.0117
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0008 0.0029 0.001
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0479 0.5783 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0063 0.0695 0.1826
Onchocerca volvulus 0.0075 0.0844 0.1373
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0008 0.0029 0.001
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0693 0.3456
Trypanosoma cruzi DNA polymerase eta, putative 0.017 0.2001 0.5369
Brugia malayi Pre-SET motif family protein 0.0063 0.0693 0.1316
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0053 0.0102
Plasmodium vivax hypothetical protein, conserved 0.0008 0.0023 0.0233
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0489 0.5578
Trypanosoma brucei DNA damage repair protein, putative 0.0063 0.0695 0.1826
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0053 0.0102
Trypanosoma brucei hypothetical protein, conserved 0.0063 0.0695 0.1826
Leishmania major DNA damage repair protein, putative 0.0063 0.0695 0.1826
Entamoeba histolytica hypothetical protein 0.0025 0.0229 0.0867
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0442 0.4924
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0197 0.0731
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0053 0.0064
Trichomonas vaginalis ran, putative 0.0022 0.0197 0.0291
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.032 0.3833 0.7278
Trypanosoma brucei DNA polymerase kappa, putative 0.0203 0.2402 0.6457
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0415 0.1064
Echinococcus granulosus FTZ F1 alpha 0.0403 0.4856 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.04 0.0785
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0156 0.1838 0.182
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0844 0.1602
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0415 0.0922
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0008 0.0029 0.001
Schistosoma mansoni nuclear hormone receptor 0.001 0.0053 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0203 0.2402 0.6457
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0693 0.0672
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.04 0.1023
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0008 0.0029 0.0054
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0008 0.0029 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0203 0.2402 0.6457
Echinococcus granulosus snurportin 1 0.032 0.3833 0.7884
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0023 0.0043
Trypanosoma cruzi DNA damage repair protein, putative 0.0063 0.0695 0.1826
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0415 0.1648
Echinococcus granulosus histone acetyltransferase KAT2B 0.0152 0.1785 0.3646
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.0695 0.1826
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0063 0.0695 0.3468
Echinococcus granulosus expressed protein 0.0008 0.0029 0.0013
Leishmania major hypothetical protein, conserved 0.0027 0.0252 0.0622
Brugia malayi Protein kinase domain containing protein 0.0017 0.014 0.0265
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0875 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0875 0.2314
Mycobacterium tuberculosis Conserved protein 0.0075 0.0844 0.1426
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0008 0.0029 0.0013
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0229 0.2595
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0043
Onchocerca volvulus 0.0008 0.0029 0.001
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0271 0.0673
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0023 0.0043
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0693 0.1575
Schistosoma mansoni thyroid hormone receptor 0.001 0.0053 0.0073
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0027 0.0252 0.0622
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0023 0.0043
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0043
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0008 0.0029 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0695 0.1826
Onchocerca volvulus 0.0017 0.014 0.0195
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.2288 0.5323
Trypanosoma brucei hypothetical protein, conserved 0.0063 0.0695 0.1826
Trypanosoma brucei DNA polymerase kappa, putative 0.014 0.1634 0.4373
Loa Loa (eye worm) hypothetical protein 0.0008 0.0029 0.0054
Loa Loa (eye worm) hypothetical protein 0.0075 0.0844 0.1602
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0053 0.0073
Onchocerca volvulus 0.0016 0.0125 0.0171
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0023 0.0102
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0088 0.1 0.2295
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0844 0.1426
Entamoeba histolytica G protein alpha subunit, putative 0.0008 0.0029 0.0025
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0693 0.1575
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0008 0.0029 0.0054
Echinococcus multilocularis expressed protein 0.0008 0.0029 0.0006
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0415 0.0393
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0271 0.1343
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0053 0.0102
Giardia lamblia DINP protein human, muc B family 0.0203 0.2402 1
Mycobacterium ulcerans lipase LipD 0.0075 0.0844 0.2829
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0271 0.0514
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0008 0.0029 0.001
Leishmania major DNA polymerase kappa, putative 0.0203 0.2402 0.6457
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.04 0.063
Loa Loa (eye worm) hypothetical protein 0.001 0.0053 0.0102
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0224 0.0546
Brugia malayi hypothetical protein 0.0078 0.0875 0.1662
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0023 0.0043
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0008 0.0029 0.0014
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0008 0.0029 0.0014
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0293 0.0734
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0053 0.0102
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0875 0.2314
Leishmania major GTP-binding protein, putative 0.0022 0.0197 0.0472
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.04 0.1023
Brugia malayi Pre-SET motif family protein 0.0437 0.5267 1
Echinococcus granulosus CTD small phosphatase protein like 0.0027 0.0252 0.0474
Loa Loa (eye worm) hypothetical protein 0.0088 0.1 0.1898
Brugia malayi nuclear receptor NHR-88 0.001 0.0053 0.0102
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0203 0.2402 0.3978
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0193 0.2288 0.4687
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.0875 0.4368
Trichomonas vaginalis dullard protein, putative 0.0027 0.0252 0.0383
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0008 0.0029 0.0013
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0027 0.0252 0.0538
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0844 0.1373
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0053 0.0073
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0203 0.2402 0.6457
Schistosoma mansoni hypothetical protein 0.0017 0.014 0.0275
Brugia malayi ecdysteroid receptor 0.001 0.0053 0.0102
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0008 0.0029 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0203 0.2402 0.6457
Onchocerca volvulus 0.0017 0.014 0.0195
Schistosoma mansoni hypothetical protein 0.0026 0.0248 0.0529
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0053 0.0102
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0053 0.0031
Trypanosoma brucei DNA polymerase IV, putative 0.0203 0.2402 0.6457
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.04 0.0759
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0415 0.0788
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0023 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0053 0.0102
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0027 0.0252 0.2858
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0844 0.1373
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0203 0.2402 0.4924
Onchocerca volvulus 0.0063 0.0693 0.1121
Loa Loa (eye worm) hypothetical protein 0.0016 0.0125 0.0237
Trypanosoma brucei unspecified product 0.0203 0.2402 0.6457
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0027 0.0252 0.0963
Loa Loa (eye worm) hypothetical protein 0.001 0.0053 0.0102
Schistosoma mansoni ap endonuclease 0.0039 0.04 0.0886
Brugia malayi hypothetical protein 0.0008 0.0029 0.0054
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0053 0.0064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0193 0.2288 0.5323
Brugia malayi acetyltransferase, GNAT family protein 0.0156 0.1838 0.349
Schistosoma mansoni hypothetical protein 0.0356 0.4279 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0489 0.078
Schistosoma mansoni hypothetical protein 0.0016 0.0125 0.024
Echinococcus granulosus flap endonuclease 1 0.0028 0.0271 0.0513
Echinococcus granulosus L aminoadipate semialdehyde 0.0088 0.1 0.2021
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0008 0.0029 0.001
Giardia lamblia DNA damage repair protein 0.0063 0.0695 0.2827
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0053 0.0102
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0415 0.0812
Onchocerca volvulus 0.0016 0.0125 0.0171
Schistosoma mansoni DNA polymerase IV / kappa 0.0063 0.0695 0.1581
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0229 0.1134
Trypanosoma brucei DNA polymerase kappa, putative 0.0203 0.2402 0.6457
Brugia malayi polk-prov protein 0.0063 0.0695 0.132
Echinococcus multilocularis dna polymerase kappa 0.0203 0.2402 0.2385
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0023 0.0043
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0008 0.0023 0.0043
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0027 0.0252 0.023
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0053 0.0064
Loa Loa (eye worm) hypothetical protein 0.031 0.3708 0.704
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0008 0.0023 0.0102
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0023 0.0043
Schistosoma mansoni hypothetical protein 0.0356 0.4279 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0053 0.0064
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0415 0.0656
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0693 0.0672
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.0875 0.2314
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0053 0.0064
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0008 0.0029 0.0014
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0027 0.0252 0.0383
Brugia malayi Importin beta-1 subunit 0.003 0.0293 0.0557
Onchocerca volvulus 0.001 0.0053 0.0052
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0053 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0693 0.1575
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0008 0.0023 0.0043
Mycobacterium ulcerans beta-lactamase 0.0075 0.0844 0.2829
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0844 0.2228
Loa Loa (eye worm) hypothetical protein 0.0008 0.0029 0.0054
Leishmania major DNA polymerase eta, putative 0.031 0.3708 1
Brugia malayi hypothetical protein 0.005 0.0539 0.1024

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 5.1 umol/Kg Antinociceptive activity in po dosed mouse assessed as inhibition of acetic acid-induced abdominal constrictions ChEMBL. 19646868
Inhibition (functional) = 50 % Antinociceptive activity in mouse assessed as inhibition of acetic acid-induced abdominal constrictions at 100 umol/kg, po relative to untreated control ChEMBL. 19646868

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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