Detailed information for compound 107413

Basic information

Technical information
  • TDR Targets ID: 107413
  • Name: 4-methoxy-N-[2-[(1-pyridin-4-ylpiperidin-4-yl )carbamoylamino]phenyl]benzamide
  • MW: 445.514 | Formula: C25H27N5O3
  • H donors: 3 H acceptors: 3 LogP: 3.04 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(=O)Nc1ccccc1NC(=O)NC1CCN(CC1)c1ccncc1
  • InChi: 1S/C25H27N5O3/c1-33-21-8-6-18(7-9-21)24(31)28-22-4-2-3-5-23(22)29-25(32)27-19-12-16-30(17-13-19)20-10-14-26-15-11-20/h2-11,14-15,19H,12-13,16-17H2,1H3,(H,28,31)(H2,27,29,32)
  • InChiKey: HCXVSBKPPFGNDA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-methoxy-N-[2-[[1-(4-pyridyl)-4-piperidyl]carbamoylamino]phenyl]benzamide
  • 4-methoxy-N-[2-[[oxo-[[1-(4-pyridyl)-4-piperidinyl]amino]methyl]amino]phenyl]benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0035 0.009
Schistosoma mansoni cpg binding protein 0.0032 0.0163 0.0354
Schistosoma mansoni peroxidasin 0.0025 0.0111 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0319 0.1347
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.025 0.1
Echinococcus multilocularis peroxidasin 0.0025 0.0111 0.0322
Onchocerca volvulus 0.0026 0.0115 0.016
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0091 0.0625 0.0874
Echinococcus granulosus aryl hydrocarbon receptor 0.0432 0.3293 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.2235 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0035 0.0051
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.012 0.0436
Onchocerca volvulus 0.0302 0.2276 0.6881
Leishmania major mitochondrial DNA polymerase beta 0.0307 0.2312 1
Echinococcus granulosus single minded 2 0.0148 0.107 0.324
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0052 0.0319 0.1302
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0234 0.0514
Brugia malayi hypothetical protein 0.0019 0.0064 0.0153
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.007
Mycobacterium tuberculosis Probable dehydrogenase 0.0091 0.0625 0.0874
Brugia malayi hypothetical protein 0.0022 0.0082 0.0217
Loa Loa (eye worm) DR-78 0.0019 0.0064 0.0159
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0234 0.0679
Brugia malayi nuclear hormone receptor 0.0041 0.0234 0.0749
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1048 0.4484
Leishmania major protein kinase, putative 0.0052 0.0319 0.1302
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.2235 1
Brugia malayi Blistered cuticle protein 3 0.0025 0.0111 0.0319
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0234 0.0514
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0234 0.0679
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0101 0.0705 0.094
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0068 0.0217
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0068 0.0214
Mycobacterium leprae Probable lipase LipE 0.0035 0.0184 0.0208
Leishmania major trypanothione reductase 0.004 0.0225 0.0892
Loa Loa (eye worm) blistered cuticle protein 3 0.0025 0.0111 0.0304
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0184 0.0257
Loa Loa (eye worm) animal heme peroxidase 0.0025 0.0111 0.0304
Mycobacterium ulcerans beta-lactamase 0.0035 0.0184 0.0164
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0159
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0184 0.8014
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0052 0.0319 0.1302
Trichomonas vaginalis guanylate cyclase, putative 0.0052 0.0319 0.1347
Loa Loa (eye worm) hypothetical protein 0.0022 0.0082 0.0214
Loa Loa (eye worm) beta-lactamase 0.0035 0.0184 0.0527
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1289 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0069 0.0175
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0068 0.0214
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0052 0.0319 0.1347
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0035 0.0052
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0184 0.0739
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0234 0.0679
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.025 0.1
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1289 1 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0091 0.0625 0.0874
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Mycobacterium tuberculosis Probable oxidoreductase 0.0101 0.0705 0.0985
Giardia lamblia Myb 1-like protein 0.002 0.0068 0.0217
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.025 0.1
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0222 0.066
Brugia malayi MH2 domain containing protein 0.0118 0.0833 0.285
Trichomonas vaginalis MYB3r3, putative 0.002 0.0068 0.0214
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0234 0.0695
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0159
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0064 0.0178
Loa Loa (eye worm) hypothetical protein 0.0302 0.2276 0.6931
Brugia malayi nuclear hormone receptor 0.0019 0.0064 0.0153
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0068 0.0214
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0027 0.0123 0.0123
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0082 0.0172
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0039 0.0217 0.0303
Onchocerca volvulus 0.003 0.0149 0.0266
Brugia malayi hypothetical protein 0.0017 0.0047 0.0092
Loa Loa (eye worm) CYP4Cod1 0.002 0.0069 0.0175
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0234 0.0695
Onchocerca volvulus 0.0035 0.0184 0.0374
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0371 0.1281
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0448 0.0996
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0027 0.0123 0.0172
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0225 0.0892
Brugia malayi beta-lactamase family protein 0.0035 0.0184 0.0574
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0064 0.0178
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0234 0.0514
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.025 0.1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0184 0.0257
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0123 0.0172
Mycobacterium leprae Polyketide synthase Pks13 0.0039 0.0217 0.0255
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0184 0.0739
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0064 0.0153
Schistosoma mansoni hypothetical protein 0.017 0.1242 0.2782
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.0109 0.0153
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.2312 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0234 0.0695
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0035 0.009
Brugia malayi Cytochrome P450 family protein 0.002 0.0069 0.0172
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0035 0.0065
Mycobacterium ulcerans hypothetical protein 0.0162 0.1176 0.1158
Onchocerca volvulus 0.0048 0.0291 0.0706
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0109 0.0153
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0035 0.0065
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.0109 0.0153
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0234 0.0695
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0184 0.0257
Loa Loa (eye worm) hypothetical protein 0.0044 0.0257 0.0751
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0234 0.0749
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0234 0.0695
Brugia malayi ecdysteroid receptor 0.0041 0.0234 0.0749
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0159
Trichomonas vaginalis set domain proteins, putative 0.0251 0.1875 0.8376
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0234 0.0514
Leishmania major hypothetical protein, conserved 0.0035 0.0184 0.0714
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0016 0.0036 0.005
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0364 0.2756 0.2741
Loa Loa (eye worm) hypothetical protein 0.0041 0.0234 0.0679
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0052 0.0319 0.1302
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0064 0.0131
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0039 0.0217 0.0303
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0448 0.1866
Loa Loa (eye worm) hypothetical protein 0.005 0.0301 0.0884
Schistosoma mansoni hypothetical protein 0.0016 0.0035 0.0066
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.1047 0.142
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0184 0.0714
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.012 0.0366
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0184 0.0527
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0448 0.1347
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0064 0.0153
Plasmodium falciparum thioredoxin reductase 0.004 0.0225 1
Toxoplasma gondii type I fatty acid synthase, putative 0.0027 0.0123 0.0375
Onchocerca volvulus 0.0032 0.0164 0.0311
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.1651 0.2307
Loa Loa (eye worm) hypothetical protein 0.0022 0.0082 0.0214
Brugia malayi nuclear receptor NHR-88 0.0041 0.0234 0.0749
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0026 0.0115 0.0316
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0164 0.0482
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0109 0.0089
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0052 0.0319 0.1302
Giardia lamblia Fructose-bisphosphate aldolase 0.0297 0.2235 1
Brugia malayi Animal haem peroxidase family protein 0.0025 0.0111 0.0319
Loa Loa (eye worm) hypothetical protein 0.0022 0.0082 0.0214
Loa Loa (eye worm) hypothetical protein 0.0378 0.2872 0.8755
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0069 0.0214
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Loa Loa (eye worm) hypothetical protein 0.0041 0.0234 0.0679
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0064 0.0159
Brugia malayi hypothetical protein 0.0019 0.0064 0.0153
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0052 0.0319 0.1347
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0101 0.0705 0.0985
Brugia malayi Animal haem peroxidase family protein 0.0025 0.0111 0.0319
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0082 0.0214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.2235 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0234 0.0695
Mycobacterium tuberculosis Conserved protein 0.0035 0.0184 0.0257
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0082 0.0217
Brugia malayi hypothetical protein 0.0025 0.0111 0.0319
Onchocerca volvulus Peroxidase homolog 0.0025 0.0111 0.0148
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0184 0.0257
Echinococcus granulosus tumor protein p63 0.0337 0.2547 0.7732
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0234 0.0695
Schistosoma mansoni cpg binding protein 0.0032 0.0163 0.0354
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0184 0.0739
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.0109 0.0312
Loa Loa (eye worm) hypothetical protein 0.038 0.2886 0.8796
Loa Loa (eye worm) hypothetical protein 0.043 0.3279 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0035 0.009
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0184 0.0714
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.002 0.0068 0.0095
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0068 0.0214
Mycobacterium tuberculosis Probable reductase 0.0091 0.0625 0.0874
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0035 0.0726
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0184 0.0402
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0064 0.0178
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0082 0.0233
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0926 0.7156 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0052 0.0319 0.1347
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0064 0.0178
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0149 0.042
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Schistosoma mansoni zinc finger protein 0.0019 0.0064 0.0131
Brugia malayi PAS domain containing protein 0.02 0.1477 0.5108
Trichomonas vaginalis MYB72, putative 0.002 0.0068 0.0214
Schistosoma mansoni hypothetical protein 0.0016 0.0035 0.0066
Trichomonas vaginalis C-MYB, putative 0.002 0.0068 0.0214
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0035 0.0065
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0833 0.2513
Onchocerca volvulus 0.0035 0.0184 0.0374
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0301 0.0983
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0184 0.0208
Brugia malayi Animal haem peroxidase family protein 0.0025 0.0111 0.0319
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0054 0.0332 0.0994
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0234 0.0679
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0064 0.0178
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0109 0.0089
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0234 0.0695
Toxoplasma gondii ABC1 family protein 0.0035 0.0184 0.0599
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0234 0.0679
Brugia malayi Animal haem peroxidase family protein 0.0025 0.0111 0.0319
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0101 0.0705 0.0985
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0184 0.0574
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0234 0.0514
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0319 0.1347
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0234 0.0514
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0234 0.0695
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0035 0.009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.2235 1
Brugia malayi nuclear receptor NHR-88 0.0019 0.0064 0.0153
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0234 0.0695
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0035 0.0054
Trichomonas vaginalis C-MYB, putative 0.002 0.0068 0.0214
Mycobacterium ulcerans thioesterase 0.0023 0.0093 0.0073
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.2312 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0069 0.0049
Mycobacterium ulcerans polyketide synthase 0.0027 0.0123 0.0103
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0184 0.0257
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0448 0.1335
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0159
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1289 1 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0052 0.0319 0.1302
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0027 0.0123 0.0103
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0035 0.0071
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0035 0.009
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.012 0.0436
Loa Loa (eye worm) hypothetical protein 0.0035 0.0184 0.0527
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0052 0.0319 0.1347
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0159
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0364 0.2756 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.002 0.0034
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0164 0.0357
Mycobacterium leprae Possible regulatory protein 0.0052 0.0319 0.0397
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0069 0.0175
Mycobacterium ulcerans polyketide synthase 0.0025 0.0109 0.0089
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.012 0.4894
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0091 0.0625 0.0874
Brugia malayi Thioredoxin reductase 0.004 0.0225 0.0717
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0115 0.0333
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.0109 0.0104
Schistosoma mansoni cpg binding protein 0.003 0.0149 0.0324
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0184 0.0402
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0064 0.0178
Onchocerca volvulus Peroxidasin homolog 0.0025 0.0111 0.0148
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0027 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0035 0.0184 0.0527
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0035 0.0051
Loa Loa (eye worm) hypothetical protein 0.0034 0.0178 0.0507
Mycobacterium tuberculosis Conserved protein 0.0035 0.0184 0.0257
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0234 0.0679
Onchocerca volvulus Dual oxidase homolog 0.0025 0.0111 0.0148
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0159
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0234 0.0749
Schistosoma mansoni peroxidasin 0.0025 0.0111 0.0238
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0448 0.1866
Mycobacterium ulcerans thioesterase TesA 0.0023 0.0093 0.0073
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0054 0.0332 0.0994
Echinococcus granulosus GPCR family 2 0.0016 0.0035 0.009
Onchocerca volvulus Peroxidase homolog 0.0025 0.0111 0.0148
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0301 0.0983
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0035 0.009
Brugia malayi Pre-SET motif family protein 0.0032 0.0164 0.0504
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0234 0.0695
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0064 0.0153
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0234 0.0695
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0064 0.0178
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0926 0.7156 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0184 0.0544
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0164 0.0357
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0234 0.0749
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0178 0.0552
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0035 0.0054
Loa Loa (eye worm) hypothetical protein 0.0052 0.0319 0.0939
Onchocerca volvulus 0.0025 0.0111 0.0148
Loa Loa (eye worm) hypothetical protein 0.0035 0.0184 0.0527
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0022 0.0006
Loa Loa (eye worm) hypothetical protein 0.0032 0.0164 0.0465
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0234 0.0529
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0234 0.0749
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.2235 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0234 0.0679
Schistosoma mansoni nuclear receptor 0.0019 0.0064 0.0131
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0164 0.0482
Brugia malayi bHLH-PAS transcription factor 0.0148 0.107 0.3682
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0159
Brugia malayi glutathione reductase 0.004 0.0225 0.0717
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.012 0.4894
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0052 0.0319 0.0299
Trichomonas vaginalis pc-MYB2, putative 0.002 0.0068 0.0214
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.1638 0.4976
Loa Loa (eye worm) hypothetical protein 0.0041 0.0234 0.0679
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0448 0.1866
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0035 0.0065
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.002 0.0045
Echinococcus multilocularis aryl hydrocarbon receptor 0.0432 0.3293 1
Plasmodium falciparum glutathione reductase 0.004 0.0225 1
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.007 0.0098
Treponema pallidum fructose-bisphosphate aldolase 0.0297 0.2235 0.2219
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0319 0.1347
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0005
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0026 0.0115 0.0161
Leishmania major cytochrome p450-like protein 0.002 0.0069 0.0214
Onchocerca volvulus 0.0041 0.0234 0.0529
Brugia malayi beta-lactamase 0.0035 0.0184 0.0574
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0064 0.0178
Schistosoma mansoni hypothetical protein 0.0016 0.0035 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0234 0.0749
Onchocerca volvulus 0.024 0.1789 0.5365
Onchocerca volvulus 0.0035 0.0184 0.0374
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0229 0.068
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0298 0.0657
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0067 0.0044
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0064 0.0131
Brugia malayi Peroxidasin 0.0025 0.0111 0.0319
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0164 0.0482
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.2235 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0159
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0035 0.0049
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0064 0.0178
Trichomonas vaginalis esterase, putative 0.0035 0.0184 0.0739
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0234 0.0749
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0184 0.0544
Loa Loa (eye worm) animal heme peroxidase 0.0025 0.0111 0.0304
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0023 0.0093 0.0081
Mycobacterium tuberculosis Conserved protein 0.0035 0.0184 0.0257
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0035 0.0065
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0035 0.009
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0052 0.0319 0.1302
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.002 0.0068 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0234 0.0749
Schistosoma mansoni aryl hydrocarbon receptor 0.058 0.4451 1
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0234 0.0695
Loa Loa (eye worm) hypothetical protein 0.0022 0.0082 0.0214
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0035 0.009
Echinococcus multilocularis geminin 0.017 0.1242 0.3762
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0225 1
Onchocerca volvulus 0.0025 0.0111 0.0148
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0054 0.0332 0.098
Loa Loa (eye worm) hypothetical protein 0.0041 0.0234 0.0679
Schistosoma mansoni hypothetical protein 0.0034 0.0178 0.0388
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0109 0.0089
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0068 0.0217
Brugia malayi Cytochrome P450 family protein 0.002 0.0069 0.0172
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.1047 0.1029
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0035 0.009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0159
Brugia malayi hypothetical protein 0.0022 0.0082 0.0217
Toxoplasma gondii thioredoxin reductase 0.004 0.0225 0.0747
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0364 0.2756 0.382
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0035 0.0726
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0229 0.068
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0234 0.0695
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1048 0.4484
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0064 0.0153
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0323 0.1322
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0064 0.0178
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0234 0.0529
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0234 0.0514
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0027 0.0123 0.0172
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0307 0.2312 1
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0234 0.0514
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.2235 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0164 0.0357
Brugia malayi conserved hypotetical protein 0.0019 0.0064 0.0153
Onchocerca volvulus 0.0251 0.1875 0.5634
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.2235 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0052 0.0319 0.1302
Plasmodium vivax SET domain protein, putative 0.0032 0.0164 0.7027
Echinococcus granulosus peroxidasin 0.0025 0.0111 0.0322
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0225 0.0651
Trichomonas vaginalis pc-MYB2, putative 0.002 0.0068 0.0214
Mycobacterium ulcerans lipase LipD 0.0035 0.0184 0.0164
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.1047 0.1463
Loa Loa (eye worm) hypothetical protein 0.0049 0.0298 0.0874
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0184 0.0257
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0064 0.0131
Brugia malayi tailless protein 0.0019 0.0064 0.0153
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0184 0.0739
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0234 0.0749
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0184 0.0164
Onchocerca volvulus Chorion peroxidase homolog 0.0025 0.0111 0.0148
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0064 0.0178
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0035 0.009
Onchocerca volvulus Fatty acid synthase homolog 0.005 0.0304 0.0748
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0184 0.0714
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0234 0.0695
Loa Loa (eye worm) hypothetical protein 0.0027 0.012 0.0331
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0082 0.0217
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0082 0.0233
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0064 0.0159
Trichomonas vaginalis MYB, putative 0.002 0.0068 0.0217
Leishmania major protein kinase, putative 0.0052 0.0319 0.1302
Brugia malayi steroid hormone receptor 0.0041 0.0234 0.0749
Echinococcus multilocularis GPCR, family 2 0.0016 0.0035 0.009
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0027 0.0123 0.0172
Toxoplasma gondii hypothetical protein 0.0049 0.0299 0.1019
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.012 0.0436
Leishmania major hypothetical protein, conserved 0.0027 0.012 0.0436
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.002 0.0045
Loa Loa (eye worm) hypothetical protein 0.0035 0.0184 0.0527
Brugia malayi Pax transcription factor protein 2 0.024 0.1789 0.6201
Trypanosoma brucei trypanothione reductase 0.004 0.0225 0.0892
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.1048 0.4484
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0234 0.0749
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Schistosoma mansoni hypothetical protein 0.0016 0.0035 0.0066
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.2235 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0425 0.0943
Brugia malayi hypothetical protein 0.0052 0.0319 0.1046
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0234 0.0695
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0448 0.1347
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0153 0.0432
Mycobacterium ulcerans putative regulatory protein 0.0148 0.107 0.1052
Loa Loa (eye worm) hypothetical protein 0.0035 0.0184 0.0527
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0234 0.0695
Schistosoma mansoni nuclear receptor 0.0019 0.0064 0.0131
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0016 0.0036 0.0015
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0082 0.0172
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0159
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0234 0.0695
Brugia malayi nuclear receptor RXR 0.0022 0.0082 0.0217
Brugia malayi nuclear receptor NHR-67 0.0019 0.0064 0.0153
Brugia malayi beta-lactamase family protein 0.0035 0.0184 0.0574
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.012 0.4894
Mycobacterium tuberculosis Conserved hypothetical protein 0.0162 0.1176 0.1644
Loa Loa (eye worm) hypothetical protein 0.0041 0.0234 0.0679
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0234 0.0679
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0234 0.0749
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0225 0.0314
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.005 0.0304 0.0996
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0064 0.0159
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.0109 0.0104
Brugia malayi CXXC zinc finger family protein 0.003 0.0149 0.0452
Loa Loa (eye worm) glutathione reductase 0.004 0.0225 0.0651
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0234 0.0749
Trichomonas vaginalis guanylate cyclase, putative 0.0052 0.0319 0.1347
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0068 0.0214
Brugia malayi nuclear receptor RXR 0.0019 0.0064 0.0153
Loa Loa (eye worm) hypothetical protein 0.0022 0.0082 0.0214
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0234 0.0749
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0067 0.0047
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0448 0.1755
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0064 0.0178
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0301 0.0884
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0164 0.0525
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0018 0.0053 0.012
Brugia malayi hypothetical protein 0.0302 0.2276 0.7911
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0159
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0067 0.0047
Mycobacterium tuberculosis Probable thioesterase TesA 0.0023 0.0093 0.013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.2235 1
Onchocerca volvulus 0.0025 0.0111 0.0148
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0159
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0234 0.0514
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0234 0.0679
Echinococcus granulosus cpg binding protein 0.0032 0.0163 0.0479
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0052 0.0319 0.1347
Echinococcus multilocularis tumor protein p63 0.0337 0.2547 0.7732
Loa Loa (eye worm) animal heme peroxidase 0.0025 0.0111 0.0304
Plasmodium vivax glutathione reductase, putative 0.004 0.0225 1
Onchocerca volvulus 0.043 0.3279 1
Loa Loa (eye worm) pax transcription factor protein 2 0.024 0.1789 0.5438
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0234 0.0749
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0123 0.0103
Echinococcus granulosus geminin 0.017 0.1242 0.3762
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0064 0.0131
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0064 0.0153
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0364 0.2756 0.2741
Schistosoma mansoni coup transcription factor 0.0041 0.0234 0.0514
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0069 0.0214
Brugia malayi Pre-SET motif family protein 0.0221 0.1638 0.5671
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0448 0.1866
Schistosoma mansoni hypothetical protein 0.017 0.1242 0.2782
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0234 0.0749
Mycobacterium leprae Probable polyketide synthase Pks1 0.0027 0.0123 0.0123
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.015 0.0439
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0184 0.0164
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0234 0.0529
Trichomonas vaginalis adenylate cyclase, putative 0.0052 0.0319 0.1347
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0091 0.0625 0.0874
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0378 0.2872 1
Brugia malayi hypothetical protein 0.0027 0.012 0.0351
Echinococcus multilocularis cpg binding protein 0.0032 0.0163 0.0479
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0159
Loa Loa (eye worm) hypothetical protein 0.0041 0.0234 0.0679
Mycobacterium ulcerans polyketide synthase Pks9 0.0016 0.0036 0.0015
Brugia malayi Animal haem peroxidase family protein 0.0025 0.0111 0.0319
Loa Loa (eye worm) animal heme peroxidase 0.0025 0.0111 0.0304
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0448 0.15
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0035 0.0067
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0064 0.0153
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0164 0.0357
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0027 0.0123 0.0172
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0014 0.002 0.0028
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0109 0.0089
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0091 0.0625 0.0828
Echinococcus multilocularis transfer RNA-Lys 0.0148 0.107 0.324
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0068 0.0214
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0184 0.0739
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0833 0.2513
Mycobacterium ulcerans hypothetical protein 0.0035 0.0184 0.0164
Loa Loa (eye worm) hypothetical protein 0.0035 0.0184 0.0527
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0064 0.0131
Onchocerca volvulus Peroxidasin homolog 0.0025 0.0111 0.0148
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0234 0.0749
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0184 0.0257
Toxoplasma gondii type I fatty acid synthase, putative 0.002 0.0067 0.017
Echinococcus granulosus transcription factor Dp 1 0.004 0.0222 0.066
Onchocerca volvulus 0.0049 0.0298 0.0727
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0035 0.007
Trypanosoma brucei cytochrome P450, putative 0.002 0.0069 0.0214
Loa Loa (eye worm) fatty acid synthase 0.0027 0.0127 0.0351
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0234 0.0514
Schistosoma mansoni single-minded 0.02 0.1477 0.331
Brugia malayi Cytochrome P450 family protein 0.0031 0.0153 0.0466
Brugia malayi ecdysone receptor 0.0019 0.0064 0.0153
Loa Loa (eye worm) hypothetical protein 0.0041 0.0234 0.0679
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0234 0.0514
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0234 0.0749
Onchocerca volvulus 0.015 0.1084 0.3172
Brugia malayi isocitrate dehydrogenase 0.0016 0.0035 0.0052
Mycobacterium ulcerans polyketide synthase Pks13 0.0039 0.0217 0.0197
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0234 0.0514

Activities

Activity type Activity value Assay description Source Reference
K ass (binding) = 12000000 l M-1 Binding affinity for human Coagulation factor X ChEMBL. 10841787
K ass (binding) = 12000000 l M-1 Binding affinity for human Coagulation factor X ChEMBL. 10841787
PT (functional) = 2.4 uM Prothrombin time activity, concentration required to double the time of clot formation in the prothrombin time assay ChEMBL. 10841787

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.