Detailed information for compound 107413

Basic information

Technical information
  • TDR Targets ID: 107413
  • Name: 4-methoxy-N-[2-[(1-pyridin-4-ylpiperidin-4-yl )carbamoylamino]phenyl]benzamide
  • MW: 445.514 | Formula: C25H27N5O3
  • H donors: 3 H acceptors: 3 LogP: 3.04 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(=O)Nc1ccccc1NC(=O)NC1CCN(CC1)c1ccncc1
  • InChi: 1S/C25H27N5O3/c1-33-21-8-6-18(7-9-21)24(31)28-22-4-2-3-5-23(22)29-25(32)27-19-12-16-30(17-13-19)20-10-14-26-15-11-20/h2-11,14-15,19H,12-13,16-17H2,1H3,(H,28,31)(H2,27,29,32)
  • InChiKey: HCXVSBKPPFGNDA-UHFFFAOYSA-N  

Network

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Synonyms

  • 4-methoxy-N-[2-[[1-(4-pyridyl)-4-piperidyl]carbamoylamino]phenyl]benzamide
  • 4-methoxy-N-[2-[[oxo-[[1-(4-pyridyl)-4-piperidinyl]amino]methyl]amino]phenyl]benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0035 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0234 0.0679
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0052 0.0319 0.0299
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0425 0.0943
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0371 0.1281
Onchocerca volvulus 0.015 0.1084 0.3172
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0448 0.0996
Schistosoma mansoni single-minded 0.02 0.1477 0.331
Trichomonas vaginalis C-MYB, putative 0.002 0.0068 0.0214
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Brugia malayi isocitrate dehydrogenase 0.0016 0.0035 0.0052
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0301 0.0983
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0153 0.0432
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.002 0.0068 0.0095
Trypanosoma brucei trypanothione reductase 0.004 0.0225 0.0892
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.2235 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0234 0.0529
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0052 0.0319 0.1347
Mycobacterium ulcerans thioesterase 0.0023 0.0093 0.0073
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0184 0.0257
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0064 0.0178
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0064 0.0131
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.002 0.0045
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0035 0.0054
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0052 0.0319 0.1347
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0035 0.009
Schistosoma mansoni nuclear receptor 0.0019 0.0064 0.0131
Loa Loa (eye worm) fatty acid synthase 0.0027 0.0127 0.0351
Brugia malayi Pre-SET motif family protein 0.0032 0.0164 0.0504
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.012 0.0436
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.2235 1
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.007 0.0098
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0159
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1289 1 1
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0225 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0184 0.0527
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0064 0.0131
Toxoplasma gondii type I fatty acid synthase, putative 0.0027 0.0123 0.0375
Brugia malayi nuclear receptor RXR 0.0019 0.0064 0.0153
Loa Loa (eye worm) hypothetical protein 0.0044 0.0257 0.0751
Mycobacterium ulcerans hypothetical protein 0.0162 0.1176 0.1158
Plasmodium falciparum glutathione reductase 0.004 0.0225 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0035 0.0726
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.1638 0.4976
Leishmania major hypothetical protein, conserved 0.0035 0.0184 0.0714
Onchocerca volvulus Dual oxidase homolog 0.0025 0.0111 0.0148
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0184 0.0257
Plasmodium vivax SET domain protein, putative 0.0032 0.0164 0.7027
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0184 0.0402
Echinococcus granulosus GPCR family 2 0.0016 0.0035 0.009
Brugia malayi nuclear hormone receptor 0.0041 0.0234 0.0749
Schistosoma mansoni coup transcription factor 0.0041 0.0234 0.0514
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0068 0.0214
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0064 0.0178
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0234 0.0514
Loa Loa (eye worm) hypothetical protein 0.0022 0.0082 0.0214
Onchocerca volvulus 0.0026 0.0115 0.016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0159
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0082 0.0233
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0064 0.0153
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0234 0.0514
Loa Loa (eye worm) hypothetical protein 0.005 0.0301 0.0884
Loa Loa (eye worm) animal heme peroxidase 0.0025 0.0111 0.0304
Trichomonas vaginalis adenylate cyclase, putative 0.0052 0.0319 0.1347
Mycobacterium ulcerans polyketide synthase Pks13 0.0039 0.0217 0.0197
Echinococcus granulosus aryl hydrocarbon receptor 0.0432 0.3293 1
Onchocerca volvulus 0.003 0.0149 0.0266
Brugia malayi Peroxidasin 0.0025 0.0111 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0234 0.0749
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0159
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0027 0.0123 0.0172
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0307 0.2312 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.1047 0.1463
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0448 0.1866
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0364 0.2756 0.2741
Brugia malayi hypothetical protein 0.0025 0.0111 0.0319
Schistosoma mansoni cpg binding protein 0.003 0.0149 0.0324
Brugia malayi Cytochrome P450 family protein 0.002 0.0069 0.0172
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.005 0.0304 0.0996
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0064 0.0178
Trichomonas vaginalis MYB72, putative 0.002 0.0068 0.0214
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0164 0.0357
Loa Loa (eye worm) animal heme peroxidase 0.0025 0.0111 0.0304
Loa Loa (eye worm) hypothetical protein 0.0302 0.2276 0.6931
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0026 0.0115 0.0161
Giardia lamblia Fructose-bisphosphate aldolase 0.0297 0.2235 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0184 0.0544
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0068 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0319 0.1347
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0234 0.0749
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0184 0.0164
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0448 0.1335
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0064 0.0131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0234 0.0679
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0035 0.0065
Echinococcus multilocularis peroxidasin 0.0025 0.0111 0.0322
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0064 0.0178
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.025 0.1
Mycobacterium tuberculosis Probable thioesterase TesA 0.0023 0.0093 0.013
Onchocerca volvulus Peroxidasin homolog 0.0025 0.0111 0.0148
Brugia malayi nuclear receptor NHR-67 0.0019 0.0064 0.0153
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0027 0.0123 0.0172
Schistosoma mansoni hypothetical protein 0.017 0.1242 0.2782
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0016 0.0036 0.005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0234 0.0749
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0027 0.0123 0.0123
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0035 0.009
Loa Loa (eye worm) hypothetical protein 0.0035 0.0184 0.0527
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0064 0.0153
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0109 0.0089
Brugia malayi MH2 domain containing protein 0.0118 0.0833 0.285
Mycobacterium ulcerans polyketide synthase 0.0025 0.0109 0.0089
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0184 0.0544
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0035 0.009
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0164 0.0482
Brugia malayi tailless protein 0.0019 0.0064 0.0153
Brugia malayi hypothetical protein 0.0022 0.0082 0.0217
Schistosoma mansoni hypothetical protein 0.0016 0.0035 0.0066
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0026 0.0115 0.0316
Treponema pallidum fructose-bisphosphate aldolase 0.0297 0.2235 0.2219
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0027 0.0123 0.0172
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0234 0.0679
Mycobacterium ulcerans lipase LipD 0.0035 0.0184 0.0164
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0225 0.0892
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0064 0.0153
Brugia malayi Blistered cuticle protein 3 0.0025 0.0111 0.0319
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Loa Loa (eye worm) CYP4Cod1 0.002 0.0069 0.0175
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0064 0.0178
Brugia malayi nuclear receptor NHR-88 0.0019 0.0064 0.0153
Loa Loa (eye worm) hypothetical protein 0.0041 0.0234 0.0679
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0069 0.0214
Brugia malayi hypothetical protein 0.0017 0.0047 0.0092
Onchocerca volvulus Fatty acid synthase homolog 0.005 0.0304 0.0748
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0069 0.0214
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0159
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0234 0.0679
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.0109 0.0104
Mycobacterium ulcerans polyketide synthase 0.0027 0.0123 0.0103
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.1651 0.2307
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0234 0.0749
Schistosoma mansoni hypothetical protein 0.0016 0.0035 0.0066
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0091 0.0625 0.0874
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0035 0.0065
Schistosoma mansoni nuclear receptor 0.0019 0.0064 0.0131
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0068 0.0214
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0109 0.0089
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0234 0.0514
Loa Loa (eye worm) hypothetical protein 0.0035 0.0184 0.0527
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0323 0.1322
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Schistosoma mansoni cpg binding protein 0.0032 0.0163 0.0354
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0035 0.0065
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.0109 0.0104
Onchocerca volvulus 0.0048 0.0291 0.0706
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0123 0.0103
Mycobacterium tuberculosis Probable reductase 0.0091 0.0625 0.0874
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0234 0.0749
Echinococcus granulosus cpg binding protein 0.0032 0.0163 0.0479
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.025 0.1
Brugia malayi hypothetical protein 0.0022 0.0082 0.0217
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0234 0.0695
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0052 0.0319 0.1302
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.012 0.0436
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.2235 1
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0234 0.0695
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0027 0.0123 0.0172
Loa Loa (eye worm) hypothetical protein 0.0032 0.0164 0.0465
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0091 0.0625 0.0828
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0052 0.0319 0.1302
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0035 0.009
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0234 0.0695
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0234 0.0695
Brugia malayi ecdysteroid receptor 0.0041 0.0234 0.0749
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0184 0.0257
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0005
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0229 0.068
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0052 0.0319 0.1302
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0064 0.0153
Onchocerca volvulus 0.043 0.3279 1
Onchocerca volvulus 0.0041 0.0234 0.0529
Echinococcus granulosus peroxidasin 0.0025 0.0111 0.0322
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0149 0.042
Onchocerca volvulus 0.0035 0.0184 0.0374
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0109 0.0153
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0035 0.0051
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0229 0.068
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0222 0.066
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Schistosoma mansoni zinc finger protein 0.0019 0.0064 0.0131
Trichomonas vaginalis pc-MYB2, putative 0.002 0.0068 0.0214
Leishmania major trypanothione reductase 0.004 0.0225 0.0892
Echinococcus multilocularis cpg binding protein 0.0032 0.0163 0.0479
Mycobacterium leprae Possible regulatory protein 0.0052 0.0319 0.0397
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0234 0.0695
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0164 0.0357
Schistosoma mansoni hypothetical protein 0.0016 0.0035 0.0066
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0091 0.0625 0.0874
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0184 0.0208
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0234 0.0749
Toxoplasma gondii ABC1 family protein 0.0035 0.0184 0.0599
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0068 0.0214
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0109 0.0089
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0833 0.2513
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0234 0.0695
Trichomonas vaginalis pc-MYB2, putative 0.002 0.0068 0.0214
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0184 0.0402
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0052 0.0319 0.1302
Onchocerca volvulus Peroxidase homolog 0.0025 0.0111 0.0148
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0234 0.0679
Plasmodium vivax glutathione reductase, putative 0.004 0.0225 1
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0926 0.7156 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0234 0.0679
Brugia malayi hypothetical protein 0.0019 0.0064 0.0153
Brugia malayi PAS domain containing protein 0.02 0.1477 0.5108
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0234 0.0514
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0069 0.0175
Schistosoma mansoni peroxidasin 0.0025 0.0111 0.0238
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0067 0.0044
Loa Loa (eye worm) hypothetical protein 0.0378 0.2872 0.8755
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.1047 0.142
Loa Loa (eye worm) animal heme peroxidase 0.0025 0.0111 0.0304
Loa Loa (eye worm) hypothetical protein 0.0041 0.0234 0.0679
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0082 0.0233
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0064 0.0178
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.2235 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1048 0.4484
Loa Loa (eye worm) hypothetical protein 0.0034 0.0178 0.0507
Loa Loa (eye worm) hypothetical protein 0.0041 0.0234 0.0679
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0164 0.0357
Loa Loa (eye worm) hypothetical protein 0.0049 0.0298 0.0874
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.2235 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0159
Brugia malayi ecdysone receptor 0.0019 0.0064 0.0153
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0064 0.0178
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0301 0.0983
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0234 0.0749
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0115 0.0333
Echinococcus multilocularis geminin 0.017 0.1242 0.3762
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.2235 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0091 0.0625 0.0874
Mycobacterium ulcerans thioesterase TesA 0.0023 0.0093 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0319 0.1347
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0225 0.0651
Onchocerca volvulus 0.0049 0.0298 0.0727
Brugia malayi Cytochrome P450 family protein 0.0031 0.0153 0.0466
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0378 0.2872 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0035 0.009
Trichomonas vaginalis C-MYB, putative 0.002 0.0068 0.0214
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0082 0.0217
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0109 0.0089
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.2312 1
Brugia malayi Pre-SET motif family protein 0.0221 0.1638 0.5671
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0035 0.0052
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0022 0.0006
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.1047 0.1029
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0234 0.0695
Echinococcus granulosus tumor protein p63 0.0337 0.2547 0.7732
Loa Loa (eye worm) DR-78 0.0019 0.0064 0.0159
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0234 0.0695
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0184 0.0164
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0035 0.009
Echinococcus multilocularis GPCR, family 2 0.0016 0.0035 0.009
Loa Loa (eye worm) hypothetical protein 0.0041 0.0234 0.0679
Brugia malayi beta-lactamase family protein 0.0035 0.0184 0.0574
Trichomonas vaginalis MYB3r3, putative 0.002 0.0068 0.0214
Brugia malayi beta-lactamase 0.0035 0.0184 0.0574
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0068 0.0217
Loa Loa (eye worm) hypothetical protein 0.0035 0.0184 0.0527
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.012 0.0436
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0234 0.0749
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.1048 0.4484
Mycobacterium leprae Probable lipase LipE 0.0035 0.0184 0.0208
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0364 0.2756 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0052 0.0319 0.1302
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0035 0.0067
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0448 0.15
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0064 0.0159
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0035 0.0049
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0234 0.0695
Leishmania major mitochondrial DNA polymerase beta 0.0307 0.2312 1
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0364 0.2756 0.382
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0064 0.0153
Trichomonas vaginalis set domain proteins, putative 0.0251 0.1875 0.8376
Brugia malayi nuclear hormone receptor 0.0019 0.0064 0.0153
Trypanosoma brucei cytochrome P450, putative 0.002 0.0069 0.0214
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.012 0.4894
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.012 0.4894
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0234 0.0529
Echinococcus granulosus single minded 2 0.0148 0.107 0.324
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1048 0.4484
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0234 0.0679
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0184 0.0714
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0067 0.0047
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0082 0.0172
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.025 0.1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0052 0.0319 0.1302
Loa Loa (eye worm) hypothetical protein 0.0035 0.0184 0.0527
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0364 0.2756 0.2741
Giardia lamblia Myb 1-like protein 0.002 0.0068 0.0217
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0064 0.0178
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1289 1 1
Onchocerca volvulus 0.0025 0.0111 0.0148
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0448 0.1347
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0159
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.002 0.0034
Trichomonas vaginalis MYB, putative 0.002 0.0068 0.0217
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0064 0.0178
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0068 0.0217
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0064 0.0178
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0064 0.0178
Toxoplasma gondii hypothetical protein 0.0049 0.0299 0.1019
Mycobacterium tuberculosis Conserved protein 0.0035 0.0184 0.0257
Brugia malayi conserved hypotetical protein 0.0019 0.0064 0.0153
Loa Loa (eye worm) hypothetical protein 0.0052 0.0319 0.0939
Plasmodium falciparum thioredoxin reductase 0.004 0.0225 1
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0184 0.0714
Echinococcus granulosus transcription factor Dp 1 0.004 0.0222 0.066
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.015 0.0439
Leishmania major hypothetical protein, conserved 0.0027 0.012 0.0436
Brugia malayi steroid hormone receptor 0.0041 0.0234 0.0749
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0035 0.0071
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0101 0.0705 0.094
Onchocerca volvulus 0.0302 0.2276 0.6881
Leishmania major protein kinase, putative 0.0052 0.0319 0.1302
Mycobacterium leprae Polyketide synthase Pks13 0.0039 0.0217 0.0255
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0069 0.0049
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0035 0.007
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0164 0.0482
Onchocerca volvulus Peroxidasin homolog 0.0025 0.0111 0.0148
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0123 0.0172
Brugia malayi bHLH-PAS transcription factor 0.0148 0.107 0.3682
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0234 0.0749
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0184 0.0739
Mycobacterium tuberculosis Conserved protein 0.0035 0.0184 0.0257
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.0109 0.0153
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0068 0.0214
Mycobacterium ulcerans polyketide synthase Pks9 0.0016 0.0036 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0319 0.1347
Mycobacterium tuberculosis Probable oxidoreductase 0.0101 0.0705 0.0985
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0926 0.7156 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0234 0.0695
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0027 0.0123 0.0103
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0064 0.0178
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.012 0.4894
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0234 0.0749
Brugia malayi hypothetical protein 0.0027 0.012 0.0351
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0234 0.0514
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0184 0.0574
Loa Loa (eye worm) hypothetical protein 0.043 0.3279 1
Echinococcus multilocularis tumor protein p63 0.0337 0.2547 0.7732
Leishmania major protein kinase, putative 0.0052 0.0319 0.1302
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.012 0.0366
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0052 0.0319 0.1347
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0164 0.0357
Schistosoma mansoni cpg binding protein 0.0032 0.0163 0.0354
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0067 0.0047
Onchocerca volvulus 0.0025 0.0111 0.0148
Brugia malayi Pax transcription factor protein 2 0.024 0.1789 0.6201
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0184 0.0257
Schistosoma mansoni peroxidasin 0.0025 0.0111 0.0238
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0833 0.2513
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0234 0.0514
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0164 0.0525
Mycobacterium ulcerans hypothetical protein 0.0035 0.0184 0.0164
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0101 0.0705 0.0985
Brugia malayi Animal haem peroxidase family protein 0.0025 0.0111 0.0319
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0184 0.0739
Echinococcus granulosus geminin 0.017 0.1242 0.3762
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0234 0.0695
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0164 0.0482
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0054 0.0332 0.098
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0448 0.1347
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.2312 1
Schistosoma mansoni hypothetical protein 0.0034 0.0178 0.0388
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.007
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.0109 0.0153
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0082 0.0214
Toxoplasma gondii type I fatty acid synthase, putative 0.002 0.0067 0.017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0159
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0035 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0234 0.0679
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Loa Loa (eye worm) hypothetical protein 0.0041 0.0234 0.0679
Brugia malayi Thioredoxin reductase 0.004 0.0225 0.0717
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0184 0.0739
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0234 0.0514
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0184 0.0714
Toxoplasma gondii thioredoxin reductase 0.004 0.0225 0.0747
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.002 0.0045
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.2235 1
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0039 0.0217 0.0303
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0448 0.1866
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0064 0.0159
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0234 0.0514
Brugia malayi Animal haem peroxidase family protein 0.0025 0.0111 0.0319
Brugia malayi nuclear receptor NHR-88 0.0041 0.0234 0.0749
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0016 0.0036 0.0015
Brugia malayi Animal haem peroxidase family protein 0.0025 0.0111 0.0319
Onchocerca volvulus 0.0251 0.1875 0.5634
Loa Loa (eye worm) beta-lactamase 0.0035 0.0184 0.0527
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0234 0.0695
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0234 0.0695
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0234 0.0695
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0184 0.0257
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0052 0.0319 0.1347
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0035 0.009
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.002 0.0068 0.0175
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0064 0.0131
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0234 0.0514
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0069 0.0175
Loa Loa (eye worm) glutathione reductase 0.004 0.0225 0.0651
Schistosoma mansoni hypothetical protein 0.017 0.1242 0.2782
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0018 0.0053 0.012
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0064 0.0153
Loa Loa (eye worm) hypothetical protein 0.0041 0.0234 0.0679
Brugia malayi Animal haem peroxidase family protein 0.0025 0.0111 0.0319
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.2235 1
Onchocerca volvulus 0.0025 0.0111 0.0148
Loa Loa (eye worm) hypothetical protein 0.038 0.2886 0.8796
Loa Loa (eye worm) hypothetical protein 0.0022 0.0082 0.0214
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0052 0.0319 0.1347
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0234 0.0695
Echinococcus multilocularis transfer RNA-Lys 0.0148 0.107 0.324
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0184 0.0257
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0159
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.2235 1
Trichomonas vaginalis guanylate cyclase, putative 0.0052 0.0319 0.1347
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0101 0.0705 0.0985
Onchocerca volvulus 0.0035 0.0184 0.0374
Loa Loa (eye worm) hypothetical protein 0.0022 0.0082 0.0214
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0234 0.0749
Onchocerca volvulus 0.024 0.1789 0.5365
Loa Loa (eye worm) animal heme peroxidase 0.0025 0.0111 0.0304
Loa Loa (eye worm) hypothetical protein 0.0022 0.0082 0.0214
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0234 0.0749
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.2235 1
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0082 0.0217
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0023 0.0093 0.0081
Trichomonas vaginalis guanylate cyclase, putative 0.0052 0.0319 0.1347
Brugia malayi hypothetical protein 0.0019 0.0064 0.0153
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0064 0.0159
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0178 0.0552
Loa Loa (eye worm) hypothetical protein 0.0027 0.012 0.0331
Loa Loa (eye worm) hypothetical protein 0.0035 0.0184 0.0527
Echinococcus multilocularis aryl hydrocarbon receptor 0.0432 0.3293 1
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0054 0.0332 0.0994
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0035 0.009
Trichomonas vaginalis esterase, putative 0.0035 0.0184 0.0739
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0234 0.0695
Brugia malayi CXXC zinc finger family protein 0.003 0.0149 0.0452
Onchocerca volvulus 0.0035 0.0184 0.0374
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0035 0.0051
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0159
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0035 0.009
Brugia malayi nuclear receptor RXR 0.0022 0.0082 0.0217
Brugia malayi glutathione reductase 0.004 0.0225 0.0717
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0091 0.0625 0.0874
Loa Loa (eye worm) pax transcription factor protein 2 0.024 0.1789 0.5438
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0159
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0225 0.0314
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0448 0.1755
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0234 0.0749
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0035 0.0726
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0234 0.0679
Mycobacterium ulcerans beta-lactamase 0.0035 0.0184 0.0164
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0234 0.0695
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0298 0.0657
Loa Loa (eye worm) blistered cuticle protein 3 0.0025 0.0111 0.0304
Onchocerca volvulus Peroxidase homolog 0.0025 0.0111 0.0148
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0184 0.0739
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1289 1 1
Brugia malayi Cytochrome P450 family protein 0.002 0.0069 0.0172
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0304
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0234 0.0529
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0234 0.0749
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0052 0.0319 0.1302
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0234 0.0514
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0159
Schistosoma mansoni hypothetical protein 0.0016 0.0035 0.0066
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0184 0.0739
Schistosoma mansoni aryl hydrocarbon receptor 0.058 0.4451 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0082 0.0214
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0184 0.0257
Brugia malayi hypothetical protein 0.0052 0.0319 0.1046
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0064 0.0131
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0035 0.0065
Onchocerca volvulus 0.0032 0.0164 0.0311
Mycobacterium tuberculosis Probable dehydrogenase 0.0091 0.0625 0.0874
Brugia malayi Animal haem peroxidase family protein 0.0025 0.0111 0.0319
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0448 0.1866
Onchocerca volvulus Chorion peroxidase homolog 0.0025 0.0111 0.0148
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0159
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0014 0.002 0.0028
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0082 0.0172
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0234 0.0514
Brugia malayi beta-lactamase family protein 0.0035 0.0184 0.0574
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0035 0.0054
Mycobacterium ulcerans putative regulatory protein 0.0148 0.107 0.1052
Loa Loa (eye worm) hypothetical protein 0.0041 0.0234 0.0679
Mycobacterium leprae Probable polyketide synthase Pks1 0.0027 0.0123 0.0123
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0184 0.8014
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0234 0.0749
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0301 0.0884
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0068 0.0214
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0448 0.1866
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0027 0.0123 0.0123
Mycobacterium tuberculosis Conserved protein 0.0035 0.0184 0.0257
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.025 0.1
Leishmania major cytochrome p450-like protein 0.002 0.0069 0.0214
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0234 0.0695
Mycobacterium tuberculosis Conserved hypothetical protein 0.0162 0.1176 0.1644
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0184 0.0527
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.0109 0.0312
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0054 0.0332 0.0994
Brugia malayi hypothetical protein 0.0302 0.2276 0.7911
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0234 0.0514
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0234 0.0749
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0159
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0039 0.0217 0.0303

Activities

Activity type Activity value Assay description Source Reference
K ass (binding) = 12000000 l M-1 Binding affinity for human Coagulation factor X ChEMBL. 10841787
K ass (binding) = 12000000 l M-1 Binding affinity for human Coagulation factor X ChEMBL. 10841787
PT (functional) = 2.4 uM Prothrombin time activity, concentration required to double the time of clot formation in the prothrombin time assay ChEMBL. 10841787

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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