Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tolloid-like 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0105 | 0.0471 | 0.2023 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) | 0.0172 | 0.0848 | 0.0766 |
Trichomonas vaginalis | NADH-ubiquinone oxidoreductase flavoprotein, putative | 0.0172 | 0.0848 | 1 |
Brugia malayi | hypoxia-induced factor 1 | 0.0326 | 0.1727 | 0.9006 |
Brugia malayi | hypothetical protein | 0.0081 | 0.0333 | 0.0114 |
Trypanosoma cruzi | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0172 | 0.0848 | 1 |
Loa Loa (eye worm) | NADH-ubiquinone oxidoreductase 51 kDa subunit | 0.0172 | 0.0848 | 0.4503 |
Mycobacterium ulcerans | putative regulatory protein | 0.0078 | 0.0315 | 0.0228 |
Onchocerca volvulus | 0.0081 | 0.0333 | 0.8316 | |
Brugia malayi | NADH dehydrogenase subunit 1 | 0.0081 | 0.0333 | 0.0114 |
Echinococcus granulosus | single minded 2 | 0.0078 | 0.0315 | 0.1847 |
Onchocerca volvulus | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog | 0.0092 | 0.0395 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0175 | 0.0929 |
Echinococcus granulosus | NADH dehydrogenase ubiquinone flavoprotein 1 | 0.0172 | 0.0848 | 0.5266 |
Brugia malayi | NADH dehydrogenase subunit 1, identical | 0.0081 | 0.0333 | 0.0114 |
Mycobacterium ulcerans | NADH dehydrogenase I subunit F | 0.0172 | 0.0848 | 0.0766 |
Loa Loa (eye worm) | AStacin protease | 0.0035 | 0.0069 | 0.0367 |
Leishmania major | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0172 | 0.0848 | 1 |
Onchocerca volvulus | 0.0078 | 0.0315 | 0.783 | |
Echinococcus multilocularis | transfer RNA-Lys | 0.0078 | 0.0315 | 0.3508 |
Brugia malayi | NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor | 0.0172 | 0.0848 | 0.34 |
Mycobacterium tuberculosis | Possible formate hydrogenlyase HycD (FHL) | 0.0081 | 0.0333 | 0.0246 |
Schistosoma mansoni | hypothetical protein | 0.0301 | 0.1586 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0353 | 0.1883 | 1 |
Loa Loa (eye worm) | NADH dehydrogenase subunit 1 | 0.0081 | 0.0333 | 0.1767 |
Mycobacterium tuberculosis | Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. | 0.1778 | 1 | 1 |
Trypanosoma cruzi | NADH-ubiquinone oxidoreductase, mitochondrial, putative | 0.0172 | 0.0848 | 1 |
Wolbachia endosymbiont of Brugia malayi | NADH dehydrogenase subunit H | 0.0301 | 0.1586 | 1 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0056 | 0.0188 | 0.196 |
Brugia malayi | PAS domain containing protein | 0.0105 | 0.0471 | 0.0994 |
Mycobacterium ulcerans | NADH dehydrogenase subunit H | 0.0301 | 0.1586 | 0.1511 |
Schistosoma mansoni | single-minded | 0.0105 | 0.0471 | 0.2023 |
Trypanosoma brucei | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | 0.0172 | 0.0848 | 0.5 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0056 | 0.0188 | 0.0997 |
Trichomonas vaginalis | NADH-ubiquinone oxidoreductase flavoprotein, putative | 0.0172 | 0.0848 | 1 |
Chlamydia trachomatis | two component regulatory system sensor histidine kinase | 0.0027 | 0.0027 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) | 0.0301 | 0.1586 | 0.1511 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0326 | 0.1727 | 0.9172 |
Brugia malayi | hypothetical protein | 0.0353 | 0.1883 | 1 |
Echinococcus granulosus | Tolloid protein 1 | 0.0056 | 0.0188 | 0.1032 |
Loa Loa (eye worm) | aryl Hydrocarbon receptor Associated protein family member | 0.0027 | 0.0027 | 0.0142 |
Mycobacterium ulcerans | formate hydrogenlyase HycD | 0.0081 | 0.0333 | 0.0246 |
Echinococcus multilocularis | NADH dehydrogenase (ubiquinone) flavoprotein 1 | 0.0172 | 0.0848 | 1 |
Mycobacterium ulcerans | proteasome PrcA | 0.1778 | 1 | 1 |
Trypanosoma brucei | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative | 0.0172 | 0.0848 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0027 | 0.0142 |
Treponema pallidum | nitrogen fixation protein (rnfC) | 0.0038 | 0.0089 | 0.5 |
Echinococcus granulosus | NADH dehydrogenase subunit 1 | 0.0301 | 0.1586 | 1 |
Schistosoma mansoni | NADH dehydrogenase subunit 1 | 0.0081 | 0.0333 | 0.1036 |
Onchocerca volvulus | 0.0081 | 0.0333 | 0.8316 | |
Schistosoma mansoni | NADH-ubiquinone oxidoreductase | 0.0172 | 0.0848 | 0.4721 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 28 nM | In vitro inhibitory activity against procollagen C-terminal proteinase (PCP) in HT-1080 cells using synthetic peptide as substrate | ChEMBL. | 12798313 |
Ki (binding) | = 28 nM | In vitro inhibitory activity against procollagen C-terminal proteinase (PCP) in HT-1080 cells using synthetic peptide as substrate | ChEMBL. | 12798313 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.