Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.2406 | 0.2406 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0132 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0132 | 1 | 1 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0022 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.2406 | 0.2406 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0132 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.1002 | 0.1002 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1002 | 0.1002 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0132 | 1 | 1 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0132 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.2406 | 0.2406 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1002 | 0.1002 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0132 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0132 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0022 | 0 | 0.5 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2406 | 0.2406 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0132 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Mortality inhibition (functional) | = 24 % | In vitro leishmanicidal activity of the compound against promastigotes of L. donovani at 100 microg/ml concentration | ChEMBL. | No reference |
Mortality inhibition (functional) | = 24 % | In vitro leishmanicidal activity of the compound against promastigotes of L. donovani at 100 microg/ml concentration | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.