Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-X-C motif) receptor 3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | PHD-finger family protein | 0.0022 | 0.0339 | 0.0339 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.2869 | 0.2295 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0063 | 0.4044 | 0.421 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.0521 | 0.0542 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0125 | 0.9605 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0021 | 0.0239 | 0.0249 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0125 | 0.9605 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0125 | 0.9605 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0125 | 0.9605 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0125 | 0.9605 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0063 | 0.4044 | 0.421 |
Brugia malayi | Bromodomain containing protein | 0.0079 | 0.5495 | 0.5132 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1449 | 0.0761 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1449 | 0.1509 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0125 | 0.9605 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.2246 | 0.2246 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0038 | 0.179 | 0.1864 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.2021 | 0.2021 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0125 | 0.9605 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0125 | 0.9605 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0019 | 0.0058 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.2869 | 0.2869 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0125 | 0.9605 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.2869 | 0.2869 |
Echinococcus granulosus | zinc finger protein | 0.0021 | 0.0239 | 0.0249 |
Schistosoma mansoni | bromodomain containing protein | 0.0067 | 0.4383 | 0.4564 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.2015 | 0.1372 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.0521 | 0.0542 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.2427 | 0.2427 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0038 | 0.179 | 0.1864 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1449 | 0.1449 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0521 | 0.0542 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0339 | 0.0353 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.5089 | 0.5089 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.2869 | 0.2295 |
Echinococcus multilocularis | zinc finger protein | 0.0021 | 0.0239 | 0.0249 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0125 | 0.9605 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3 nM | Displacement of [125I]IP10 from CXCR3 receptor expressed in PBMC | ChEMBL. | 19631529 |
IC50 (binding) | = 20 nM | Displacement of [125I]IP10 from CXCR3 receptor expressed in PBMC in presence of human plasma | ChEMBL. | 19631529 |
IC50 (functional) | = 57 nM | Antagonistic activity to CXCR3 receptor expressed in PBMC assessed as inhibition of ITAC-mediated cell migration in presence of 100% human plasma | ChEMBL. | 19631529 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.