Detailed information for compound 107522

Basic information

Technical information
  • TDR Targets ID: 107522
  • Name: methyl 2-(imidazole-1-carbonylamino)acetate
  • MW: 183.165 | Formula: C7H9N3O3
  • H donors: 1 H acceptors: 3 LogP: -0.36 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)CNC(=O)n1cncc1
  • InChi: 1S/C7H9N3O3/c1-13-6(11)4-9-7(12)10-3-2-8-5-10/h2-3,5H,4H2,1H3,(H,9,12)
  • InChiKey: NFIMTWGTNSFCTF-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-[[1-imidazolyl(oxo)methyl]amino]acetic acid methyl ester
  • methyl 2-(imidazol-1-ylcarbonylamino)ethanoate
  • 2-(imidazole-1-carbonylamino)acetic acid methyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0041 0.0302
Brugia malayi hypothetical protein 0.001 0.0002 0.0015
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0078 0.0326
Echinococcus multilocularis neural cadherin 0.0017 0.0049 0.0203
Loa Loa (eye worm) hypothetical protein 0.0021 0.0078 0.0559
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.013 0.0552
Loa Loa (eye worm) Notch2 0.0017 0.0049 0.0348
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0078 0.0573
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0024 0.0093
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0078 0.0559
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0078 0.0573
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0142 0.043
Schistosoma mansoni peroxidasin 0.0051 0.0289 0.1236
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0251 0.1073
Schistosoma mansoni coup transcription factor 0.0021 0.0078 0.0326
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0078 0.0326
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0078 0.0326
Brugia malayi hypothetical protein 0.0011 0.001 0.0075
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0106 0.4894
Echinococcus granulosus delta-like protein 1 0.0017 0.0049 0.0203
Echinococcus multilocularis peroxidasin 0.0051 0.0289 0.1236
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0348
Brugia malayi hypothetical protein 0.001 0.0002 0.0015
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.0049 0.0203
Loa Loa (eye worm) hypothetical protein 0.0051 0.0289 0.2122
Schistosoma mansoni hypothetical protein 0.0011 0.0011 0.004
Brugia malayi EGF-like domain containing protein 0.0017 0.0049 0.0362
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0251 0.1073
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0774 0.5704
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.0049 0.0203
Onchocerca volvulus 0.0051 0.0289 0.1854
Schistosoma mansoni hypothetical protein 0.0017 0.0049 0.0203
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0078 0.0573
Schistosoma mansoni slit 0.0017 0.0049 0.0203
Loa Loa (eye worm) glutathione reductase 0.0037 0.0192 0.1403
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0348
Onchocerca volvulus 0.0028 0.013 0.0826
Echinococcus multilocularis notch 0.0017 0.0049 0.0203
Brugia malayi tailless protein 0.001 0.0002 0.0015
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0078 0.0326
Brugia malayi hypothetical protein 0.0016 0.0045 0.0334
Schistosoma mansoni notch 0.0017 0.0049 0.0203
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0357 0.1526
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.001 0.0035
Trichomonas vaginalis pc-MYB2, putative 0.0029 0.0137 0.0742
Brugia malayi notch-like transmembrane receptor 0.0017 0.0049 0.0362
Loa Loa (eye worm) hypothetical protein 0.0021 0.0078 0.0559
Brugia malayi EGF-like domain containing protein 0.0017 0.0049 0.0362
Giardia lamblia Myb 1-like protein 0.0029 0.0138 1
Brugia malayi nuclear receptor RXR 0.0011 0.001 0.0075
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0011 0.004
Brugia malayi hypothetical protein 0.0011 0.001 0.0075
Schistosoma mansoni hypothetical protein 0.0017 0.0049 0.0203
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0289 0.2134
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0348
Onchocerca volvulus 0.0017 0.0049 0.0304
Loa Loa (eye worm) hypothetical protein 0.0051 0.0289 0.2122
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.001 0.0035
Giardia lamblia High cysteine protein 0.0017 0.0049 0.2222
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0078 0.0326
Loa Loa (eye worm) animal heme peroxidase 0.0051 0.0289 0.2122
Loa Loa (eye worm) animal heme peroxidase 0.0051 0.0289 0.2122
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0029 0.0137 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0041 0.0168
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0078 0.0559
Echinococcus granulosus notch 0.0017 0.0049 0.0203
Brugia malayi EGF-like domain containing protein 0.0017 0.0049 0.0362
Brugia malayi nuclear receptor NHR-88 0.001 0.0002 0.0015
Brugia malayi EGF-like domain containing protein 0.0017 0.0049 0.0362
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0137 0.0742
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.0049 0.0203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0078 0.0559
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0041 0.0168
Echinococcus multilocularis GPCR, family 2 0.0015 0.0041 0.0168
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.0588 0.079
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.0588 0.079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0078 0.0559
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0348
Loa Loa (eye worm) hypothetical protein 0.003 0.0142 0.1034
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0348
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0348
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0195 0.0832
Onchocerca volvulus 0.0161 0.1047 0.6744
Schistosoma mansoni cpg binding protein 0.003 0.0141 0.0599
Echinococcus granulosus neural cadherin 0.0017 0.0049 0.0203
Onchocerca volvulus 0.003 0.0142 0.0903
Schistosoma mansoni hypothetical protein 0.0345 0.2327 1
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0078 0.0559
Onchocerca volvulus Neurogenic locus notch homolog 0.0017 0.0049 0.0304
Schistosoma mansoni notch 0.0017 0.0049 0.0203
Echinococcus granulosus protein jagged 1 0.0017 0.0049 0.0203
Onchocerca volvulus Putative cubilin 0.0017 0.0049 0.0304
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0002 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0078 0.0559
Schistosoma mansoni hypothetical protein 0.0015 0.0041 0.0168
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0078 0.0326
Echinococcus multilocularis cpg binding protein 0.003 0.0141 0.0599
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.041 0.2772 0.2755
Loa Loa (eye worm) hypothetical protein 0.0021 0.0078 0.0559
Trichomonas vaginalis MYB72, putative 0.0029 0.0137 0.0742
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0142 0.0602
Loa Loa (eye worm) hypothetical protein 0.0021 0.0078 0.0559
Loa Loa (eye worm) hypothetical protein 0.0051 0.0289 0.2122
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0049 0.0362
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0024 0.0093
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0774 0.5704
Brugia malayi hypothetical protein 0.0051 0.0289 0.2134
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1044 0.7162 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0251 0.1073
Brugia malayi Pre-SET motif family protein 0.0205 0.1356 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0348
Loa Loa (eye worm) hypothetical protein 0.0051 0.0289 0.2122
Schistosoma mansoni notch 0.0017 0.0049 0.0203
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0142 0.0602
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0348
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0078 0.0326
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0078 0.0573
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0137 0.0742
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0029 0.0137 0.5
Onchocerca volvulus Peroxidase homolog 0.0051 0.0289 0.1854
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0348
Brugia malayi EGF-like domain containing protein 0.0017 0.0049 0.0362
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0078 0.0559
Plasmodium falciparum glutathione reductase 0.0037 0.0192 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0078 0.0573
Schistosoma mansoni notch 0.0017 0.0049 0.0203
Schistosoma mansoni hypothetical protein 0.0017 0.0049 0.0203
Onchocerca volvulus 0.0017 0.0049 0.0304
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.001 0.0035
Echinococcus granulosus slit 2 protein 0.0017 0.0049 0.0203
Onchocerca volvulus 0.0021 0.0078 0.0488
Loa Loa (eye worm) hypothetical protein 0.0051 0.0289 0.2122
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.0588 0.079
Loa Loa (eye worm) hypothetical protein 0.0051 0.0289 0.2122
Leishmania major hypothetical protein, conserved 0.0025 0.0106 0.4894
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0078 0.0573
Brugia malayi steroid hormone receptor 0.0021 0.0078 0.0573
Schistosoma mansoni hypothetical protein 0.0017 0.0049 0.0203
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.006
Echinococcus granulosus protein jagged 2 0.0017 0.0049 0.0203
Trichomonas vaginalis set domain proteins, putative 0.0234 0.1552 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0078 0.0559
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0142 0.0602
Brugia malayi Nuclear hormone receptor E75 0.001 0.0002 0.0015
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0078 0.0488
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0522 0.0698
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0348
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0041 0.0288
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1454 1 1
Echinococcus multilocularis protein jagged 1 0.0017 0.0049 0.0203
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.001 0.0035
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0251 0.1073
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1454 1 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0192 0.0236
Echinococcus granulosus neurogenic locus protein delta 0.0017 0.0049 0.0203
Schistosoma mansoni hypothetical protein 0.0017 0.0049 0.0203
Echinococcus granulosus protein jagged 2 0.0017 0.0049 0.0203
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0289 0.2134
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0078 0.0326
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0348
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0348
Loa Loa (eye worm) hypothetical protein 0.0051 0.0289 0.2122
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0078 0.0573
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0142 0.0602
Plasmodium vivax glutathione reductase, putative 0.0037 0.0192 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0348
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0078 0.0326
Onchocerca volvulus Peroxidasin homolog 0.0051 0.0289 0.1854
Loa Loa (eye worm) blistered cuticle protein 3 0.0051 0.0289 0.2122
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.0049 0.0203
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0195 0.0832
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0251 0.1854
Loa Loa (eye worm) hypothetical protein 0.0025 0.0106 0.0769
Onchocerca volvulus 0.0051 0.0289 0.1854
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0017 0.0049 0.0304
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.001 0.0075
Loa Loa (eye worm) hypothetical protein 0.0051 0.0289 0.2122
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0137 0.0742
Echinococcus granulosus cpg binding protein 0.003 0.0141 0.0599
Brugia malayi EGF-like domain containing protein 0.0017 0.0049 0.0362
Trypanosoma brucei trypanothione reductase 0.0037 0.0192 1
Echinococcus granulosus neurogenic locus notch protein 4 0.0017 0.0049 0.0203
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0348
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0017 0.0049 0.0362
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0078 0.0573
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0137 0.0742
Loa Loa (eye worm) hypothetical protein 0.0021 0.0078 0.0559
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0078 0.0326
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0348
Loa Loa (eye worm) hypothetical protein 0.0051 0.0289 0.2122
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0078 0.0326
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.1356 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0165 0.1201
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0029 0.0137 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0251 0.1073
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0106 0.4894
Brugia malayi GCC2 and GCC3 family protein 0.0017 0.0049 0.0362
Loa Loa (eye worm) hypothetical protein 0.0051 0.0289 0.2122
Onchocerca volvulus Slit protein homolog 0.0017 0.0049 0.0304
Echinococcus multilocularis protein jagged 2 0.0017 0.0049 0.0203
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0348
Loa Loa (eye worm) hypothetical protein 0.0051 0.0289 0.2122
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0078 0.0326
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0251 0.1073
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.006
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0192 1
Onchocerca volvulus 0.0234 0.1552 1
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0078 0.0573
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0106 0.4894
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.0588 0.0099
Loa Loa (eye worm) hypothetical protein 0.0021 0.0078 0.0559
Brugia malayi hypothetical protein 0.0161 0.1047 0.7723
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0078 0.0326
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0078 0.0326
Echinococcus multilocularis neurogenic locus notch protein 4 0.0017 0.0049 0.0203
Brugia malayi ecdysteroid receptor 0.0021 0.0078 0.0573
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0078 0.0326
Schistosoma mansoni hypothetical protein 0.0015 0.0041 0.0168
Brugia malayi nuclear receptor NHR-88 0.0021 0.0078 0.0573
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0289 0.2134
Schistosoma mansoni cpg binding protein 0.003 0.0141 0.0599
Echinococcus multilocularis protein jagged 1 0.0017 0.0049 0.0203
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0142 0.0602
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0348
Loa Loa (eye worm) hypothetical protein 0.0161 0.1047 0.772
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0078 0.0573
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.041 0.2772 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0251 0.1073
Loa Loa (eye worm) hypothetical protein 0.0015 0.0041 0.0288
Schistosoma mansoni hypothetical protein 0.0017 0.0049 0.0203
Echinococcus granulosus peroxidasin 0.0051 0.0289 0.1236
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.006
Trichomonas vaginalis C-MYB, putative 0.0029 0.0137 0.0742
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.0049 0.0203
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0106 0.4894
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0049 0.0362
Schistosoma mansoni hypothetical protein 0.0345 0.2327 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0078 0.0326
Schistosoma mansoni hypothetical protein 0.0033 0.0165 0.0699
Trichomonas vaginalis MYB3r3, putative 0.0029 0.0137 0.0742
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0029 0.0138 0.0416
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0078 0.0326
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0137 0.0742
Loa Loa (eye worm) notch protein 0.0017 0.0049 0.0348
Brugia malayi conserved hypotetical protein 0.001 0.0002 0.0015
Brugia malayi ecdysone receptor 0.001 0.0002 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0078 0.0573
Brugia malayi MH2 domain containing protein 0.0121 0.0774 0.5711
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0017 0.0049 0.0203
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.001 0.0075
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1454 1 1
Brugia malayi Nuclear hormone receptor E75 0.001 0.0002 0.0015
Onchocerca volvulus Dual oxidase homolog 0.0051 0.0289 0.1854
Brugia malayi Delta serrate ligand family protein 0.0017 0.0049 0.0362
Schistosoma mansoni cell polarity protein 0.0017 0.0049 0.0203
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0078 0.0326
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0271 0.2
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0002 0.0012
Mycobacterium tuberculosis Probable reductase 0.0085 0.0522 0.0698
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0078 0.0326
Trichomonas vaginalis MYB, putative 0.0029 0.0138 0.0748
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0348
Brugia malayi Peroxidasin 0.0051 0.0289 0.2134
Plasmodium vivax SET domain protein, putative 0.003 0.0142 0.7027
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0078 0.0326
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0251 0.1842
Onchocerca volvulus Peroxidase homolog 0.0051 0.0289 0.1854
Brugia malayi nuclear receptor RXR 0.001 0.0002 0.0015
Loa Loa (eye worm) hypothetical protein 0.0049 0.0271 0.1988
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0289 0.2134
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0078 0.0326
Brugia malayi nuclear hormone receptor 0.0021 0.0078 0.0573
Echinococcus multilocularis slit 2 protein 0.0017 0.0049 0.0203
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0041 0.0168
Leishmania major trypanothione reductase 0.0037 0.0192 1
Onchocerca volvulus Chorion peroxidase homolog 0.0051 0.0289 0.1854
Schistosoma mansoni laminin gamma-3 chain 0.0017 0.0049 0.0203
Toxoplasma gondii EGF family domain-containing protein 0.0017 0.0049 0.0092
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0078 0.0326
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0041 0.0302
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0078 0.0488
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1044 0.7162 1
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.041 0.2772 0.2755
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0142 0.0602
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0024 0.0175
Schistosoma mansoni septate junction protein 0.0017 0.0049 0.0203
Echinococcus granulosus geminin 0.0345 0.2327 1
Onchocerca volvulus 0.0051 0.0289 0.1854
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0192 0.1403
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0106 0.03
Brugia malayi hypothetical protein 0.0025 0.0106 0.0782
Schistosoma mansoni peroxidasin 0.0051 0.0289 0.1236
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0024 0.0093
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0002 0.0015
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0522 0.0698
Onchocerca volvulus 0.0017 0.0049 0.0304
Loa Loa (eye worm) hypothetical protein 0.0051 0.0289 0.2122
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.006
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0106 0.4894
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0348
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0078 0.0326
Brugia malayi EGF-like domain containing protein 0.0017 0.0049 0.0362
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0002 0.0002
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0522 0.0698
Loa Loa (eye worm) animal heme peroxidase 0.0051 0.0289 0.2122
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0078 0.0326
Loa Loa (eye worm) histone methyltransferase 0.001 0.0002 0.0003
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0078 0.0326
Echinococcus multilocularis fibropellin Ia 0.0017 0.0049 0.0203
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0289 0.2134
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0192 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0137 0.0742
Schistosoma mansoni hypothetical protein 0.0017 0.0049 0.0203
Loa Loa (eye worm) hypothetical protein 0.0021 0.0078 0.0559
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0078 0.0326
Schistosoma mansoni cpg binding protein 0.0028 0.013 0.0551
Brugia malayi Cadherin domain containing protein 0.0017 0.0049 0.0362
Loa Loa (eye worm) hypothetical protein 0.0051 0.0289 0.2122
Plasmodium falciparum thioredoxin reductase 0.0037 0.0192 1
Schistosoma mansoni hypothetical protein 0.0015 0.0041 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0078 0.0573
Onchocerca volvulus 0.0017 0.0049 0.0304
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.0049 0.0203
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0002 0.0015
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0522 0.0698
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0271 0.1988
Echinococcus granulosus protein jagged 1 0.0017 0.0049 0.0203
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0078 0.0573
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0312 0.1051
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0078 0.0326
Brugia malayi Thioredoxin reductase 0.0037 0.0192 0.1416
Loa Loa (eye worm) hypothetical protein 0.0021 0.0078 0.0559
Loa Loa (eye worm) hypothetical protein 0.0051 0.0289 0.2122
Echinococcus multilocularis fat cadherin tumor suppressor 0.0017 0.0049 0.0203
Echinococcus granulosus fibropellin Ia 0.0017 0.0049 0.0203
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0142 0.0602
Schistosoma mansoni notch 0.0017 0.0049 0.0203
Loa Loa (eye worm) animal heme peroxidase 0.0051 0.0289 0.2122
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0138 0.0748
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0106 0.4894
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0522 0.0698
Brugia malayi glutathione reductase 0.0037 0.0192 0.1416
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.006
Echinococcus multilocularis geminin 0.0345 0.2327 1
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.041 0.2772 0.3388
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0078 0.0326
Brugia malayi nuclear hormone receptor 0.001 0.0002 0.0015
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0078 0.0326
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0165 0.1214
Brugia malayi CXXC zinc finger family protein 0.0028 0.013 0.0959
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0078 0.0573
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.013 0.0945
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0002 0.0002
Brugia malayi Cadherin domain containing protein 0.0017 0.0049 0.0362
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0348
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0011 0.004
Brugia malayi nuclear receptor NHR-67 0.001 0.0002 0.0015
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0041 0.0168
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0271 0.2
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0029 0.0137 0.5
Echinococcus granulosus GPCR family 2 0.0015 0.0041 0.0168
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0348
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0348
Trichomonas vaginalis pc-MYB2, putative 0.0029 0.0137 0.0742
Trichomonas vaginalis C-MYB, putative 0.0029 0.0137 0.0742
Brugia malayi Blistered cuticle protein 3 0.0051 0.0289 0.2134
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0078 0.0573
Schistosoma mansoni hypothetical protein 0.0015 0.0041 0.0168
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0078 0.0488
Brugia malayi Muscle positioning protein 4 0.0017 0.0049 0.0362
Toxoplasma gondii thioredoxin reductase 0.0037 0.0192 0.0612
Onchocerca volvulus Peroxidasin homolog 0.0051 0.0289 0.1854
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.001 0.006
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0049 0.0362
Brugia malayi Pre-SET motif family protein 0.003 0.0142 0.1047
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0029 0.0137 0.5
Schistosoma mansoni notch 0.0017 0.0049 0.0203
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0078 0.0573
Onchocerca volvulus 0.0017 0.0049 0.0304
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0002 0.0015
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0078 0.0326
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0029 0.0138 0.0748

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0 mM Ki value was evaluated for the inhibition of porcine pancreatic elastase; Inactive ChEMBL. 3844034

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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