Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cysteine protease | 0.0117 | 0.562 | 0.5415 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0098 | 0.3702 | 0.3702 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0117 | 0.562 | 0.562 |
Loa Loa (eye worm) | fibroinase | 0.0117 | 0.562 | 0.5415 |
Leishmania major | cathepsin L-like protease | 0.0117 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0117 | 0.562 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.008 | 0.1788 | 0.1788 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0098 | 0.3702 | 0.6588 |
Entamoeba histolytica | cysteine proteinase, putative | 0.008 | 0.1788 | 0.3182 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0098 | 0.3702 | 0.6588 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0117 | 0.562 | 1 |
Onchocerca volvulus | 0.0117 | 0.562 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0117 | 0.562 | 1 |
Echinococcus granulosus | cathepsin b | 0.016 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0117 | 0.562 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0117 | 0.562 | 0.562 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0098 | 0.3702 | 0.5 |
Leishmania major | cysteine peptidase A (CPA) | 0.0117 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0117 | 0.562 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0117 | 0.562 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0098 | 0.3702 | 0.3702 |
Leishmania major | cathepsin L-like protease | 0.0117 | 0.562 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.016 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.008 | 0.1788 | 0.1788 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0117 | 0.562 | 1 |
Onchocerca volvulus | 0.0117 | 0.562 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0117 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0117 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.008 | 0.1788 | 0.3182 |
Echinococcus granulosus | cathepsin b | 0.016 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0117 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0117 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0117 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0117 | 0.562 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0117 | 0.562 | 0.562 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0117 | 0.562 | 0.562 |
Leishmania major | cathepsin L-like protease | 0.0117 | 0.562 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.3702 | 0.3408 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0117 | 0.562 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0117 | 0.562 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0117 | 0.562 | 0.562 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0117 | 0.562 | 1 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0098 | 0.3702 | 0.6588 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0117 | 0.562 | 1 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0098 | 0.3702 | 0.6588 |
Plasmodium vivax | RNA helicase-1, putative | 0.0098 | 0.3702 | 0.6588 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0117 | 0.562 | 0.562 |
Brugia malayi | Cathepsin L-like precursor | 0.008 | 0.1788 | 0.1788 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0117 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0117 | 0.562 | 1 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0098 | 0.3702 | 0.5 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0098 | 0.3702 | 0.3702 |
Echinococcus multilocularis | cathepsin b | 0.016 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0117 | 0.562 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0117 | 0.562 | 0.562 |
Onchocerca volvulus | Cathepsin F homolog | 0.0117 | 0.562 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0098 | 0.3702 | 0.6294 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.1788 | 0.1405 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0098 | 0.3702 | 0.6294 |
Brugia malayi | Cathepsin L-like precursor | 0.008 | 0.1788 | 0.1788 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0098 | 0.3702 | 0.3702 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0098 | 0.3702 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0117 | 0.562 | 1 |
Leishmania major | cathepsin L-like protease | 0.0117 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0117 | 0.562 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0117 | 0.562 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0117 | 0.562 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.008 | 0.1788 | 0.1788 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.008 | 0.1788 | 0.3182 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.1788 | 0.1405 |
Onchocerca volvulus | 0.0117 | 0.562 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0117 | 0.562 | 0.562 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.562 | 0.5415 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0098 | 0.3702 | 0.4996 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0098 | 0.3702 | 0.6588 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0117 | 0.562 | 1 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0098 | 0.3702 | 0.6588 |
Onchocerca volvulus | Cathepsin L homolog | 0.0117 | 0.562 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0117 | 0.562 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0117 | 0.562 | 0.562 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0117 | 0.562 | 0.5415 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0117 | 0.562 | 0.562 |
Brugia malayi | Cathepsin L-like precursor | 0.0117 | 0.562 | 0.562 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.016 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0117 | 0.562 | 0.562 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0117 | 0.562 | 0.562 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0098 | 0.3702 | 0.3702 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0117 | 0.562 | 1 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0098 | 0.3702 | 0.3702 |
Brugia malayi | cathepsin L-like precursor | 0.008 | 0.1788 | 0.1788 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0117 | 0.562 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0117 | 0.562 | 0.5415 |
Loa Loa (eye worm) | hypothetical protein | 0.016 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0117 | 0.562 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0117 | 0.562 | 0.562 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0117 | 0.562 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.016 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0117 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0117 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0117 | 0.562 | 1 |
Leishmania major | cathepsin L-like protease | 0.0117 | 0.562 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0117 | 0.562 | 0.562 |
Onchocerca volvulus | 0.0117 | 0.562 | 1 | |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0067 | 0.0446 | 0.0446 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0117 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0117 | 0.562 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.008 | 0.1788 | 0.1788 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0098 | 0.3702 | 0.3702 |
Loa Loa (eye worm) | ctsf protein | 0.0117 | 0.562 | 0.5415 |
Brugia malayi | Cathepsin L-like precursor | 0.0117 | 0.562 | 0.562 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0098 | 0.3702 | 0.3702 |
Brugia malayi | Cathepsin L-like precursor | 0.0117 | 0.562 | 0.562 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.1788 | 0.1405 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0067 | 0.0446 | 0.0794 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0117 | 0.562 | 1 |
Leishmania major | cathepsin L-like protease | 0.0117 | 0.562 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0117 | 0.562 | 0.562 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0117 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0117 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0117 | 0.562 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0098 | 0.3702 | 0.6294 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0067 | 0.0446 | 0.0446 |
Onchocerca volvulus | 0.0117 | 0.562 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0117 | 0.562 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0117 | 0.562 | 0.562 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0117 | 0.562 | 1 |
Onchocerca volvulus | 0.0117 | 0.562 | 1 | |
Echinococcus multilocularis | cathepsin b | 0.016 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.016 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0117 | 0.562 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0117 | 0.562 | 0.562 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0117 | 0.562 | 0.562 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0117 | 0.562 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0117 | 0.562 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0117 | 0.562 | 0.562 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0117 | 0.562 | 1 |
Leishmania major | cathepsin L-like protease | 0.0117 | 0.562 | 1 |
Onchocerca volvulus | 0.0117 | 0.562 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0067 | 0.0446 | 0.0794 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.016 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0117 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0117 | 0.562 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0098 | 0.3702 | 0.3702 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0117 | 0.562 | 0.562 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0 mM | Ki value was evaluated for the inhibition of porcine pancreatic elastase; No data | ChEMBL. | 3844034 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.