Detailed information for compound 107543

Basic information

Technical information
  • TDR Targets ID: 107543
  • Name: 3-[(4-tert-butylbenzoyl)amino]-4-[(3-carbamim idoylbenzoyl)amino]benzoic acid
  • MW: 458.509 | Formula: C26H26N4O4
  • H donors: 4 H acceptors: 4 LogP: 3.76 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)C(C)(C)C)Nc1cc(ccc1NC(=O)c1cccc(c1)C(=N)N)C(=O)O
  • InChi: 1S/C26H26N4O4/c1-26(2,3)19-10-7-15(8-11-19)23(31)30-21-14-18(25(33)34)9-12-20(21)29-24(32)17-6-4-5-16(13-17)22(27)28/h4-14H,1-3H3,(H3,27,28)(H,29,32)(H,30,31)(H,33,34)
  • InChiKey: YFZYXSAJNCPPFM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[[(4-tert-butylphenyl)-oxomethyl]amino]-4-[[(3-carbamimidoylphenyl)-oxomethyl]amino]benzoic acid
  • 3-[(4-tert-butylphenyl)carbonylamino]-4-[(3-carbamimidoylphenyl)carbonylamino]benzoic acid
  • 4-[(3-amidinobenzoyl)amino]-3-[(4-tert-butylbenzoyl)amino]benzoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0275 0.0588
Entamoeba histolytica ;Alias 0.0026 0.011 0.0228
Echinococcus multilocularis Regulator of G protein signaling 20 0.0042 0.0275 0.0275
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0027 0.0031
Onchocerca volvulus 0.0019 0.0035 0.0121
Loa Loa (eye worm) hypothetical protein 0.0034 0.019 0.019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0289 0.2909 0.2909
Schistosoma mansoni thyroid hormone receptor 0.0034 0.019 0.019
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0019 0.0035 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0275 0.0588
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0026 0.011 0.0228
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0026 0.011 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0035 0.0035
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0445 0.4574 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0027 0.0047
Entamoeba histolytica hypothetical protein 0.0042 0.0275 0.0588
Entamoeba histolytica PH domain containing protein kinase, putative 0.0074 0.0615 0.1334
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.019 0.019
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0954 1 1
Echinococcus granulosus sex peptide receptor 0.0019 0.0035 0.0035
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.002 0.002
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0026 0.011 0.011
Echinococcus granulosus Diacylglycerol kinase theta 0.0047 0.033 0.033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0035 0.0035
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0075 0.0105
Plasmodium falciparum esterase, putative 0.0445 0.4574 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0445 0.4574 1
Toxoplasma gondii hypothetical protein 0.0026 0.011 0.1966
Onchocerca volvulus 0.0016 0.0006 0.002
Mycobacterium ulcerans amidase 0.0115 0.1057 0.2289
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0035 0.0035
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0026 0.011 0.1966
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.011 0.0228
Plasmodium vivax PST-A protein 0.0026 0.011 0.0228
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.1283 0.1283
Schistosoma mansoni z-protein (S1r protein) 0.0042 0.0275 0.0275
Entamoeba histolytica hypothetical protein 0.0035 0.0202 0.0429
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0035 0.0035
Echinococcus multilocularis axis inhibition protein axin 0.0042 0.0275 0.0275
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0026 0.011 0.0228
Brugia malayi diacylglycerol kinase 0.0047 0.033 0.033
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0536 0.0536
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0075 0.0136
Plasmodium vivax hypothetical protein, conserved 0.0026 0.011 0.0228
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0043 0.029 0.029
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0035 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.011 0.0228
Mycobacterium ulcerans amidase 0.0115 0.1057 0.2289
Entamoeba histolytica protein kinase, putative 0.0066 0.0536 0.1161
Schistosoma mansoni opsin-like receptor 0.0019 0.0035 0.0035
Toxoplasma gondii hypothetical protein 0.0026 0.011 0.1966
Brugia malayi ShTK domain containing protein 0.0106 0.0955 0.0955
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0536 0.1161
Trypanosoma cruzi monoglyceride lipase, putative 0.0445 0.4574 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.019 0.019
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.019 0.019
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0085 0.0741 0.0741
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Echinococcus granulosus beta-adrenergic receptor kinase 0.0043 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Leishmania major hypothetical protein, conserved 0.0026 0.011 0.0228
Toxoplasma gondii phospholipase 0.0026 0.011 0.1966
Echinococcus multilocularis regulator of G protein signaling 3 0.0042 0.0275 0.0275
Echinococcus multilocularis serotonin receptor 0.0019 0.0035 0.0035
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0035 0.0035
Onchocerca volvulus 0.0016 0.0006 0.002
Brugia malayi Serotonin receptor 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0034 0.019 0.019
Echinococcus granulosus expressed protein 0.0811 0.8475 0.8475
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.019 0.019
Brugia malayi Protein kinase domain containing protein 0.0048 0.0345 0.0345
Echinococcus granulosus tachykinin peptides receptor 99D 0.0019 0.0035 0.0035
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0066 0.0536 0.0536
Brugia malayi hypothetical protein 0.0018 0.002 0.002
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0498 0.1078
Schistosoma mansoni myosin xvIII 0.0019 0.0035 0.0035
Echinococcus multilocularis cysteine protease 0.0016 0.0006 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0035 0.0035
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0006 0.0006
Schistosoma mansoni tyrosinase precursor 0.0106 0.0955 0.0955
Trypanosoma cruzi serine peptidase, putative 0.0026 0.011 0.0228
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0536 0.1161
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0035 0.0035
Brugia malayi Hr1 repeat family protein 0.0066 0.0536 0.0536
Onchocerca volvulus 0.0016 0.0006 0.002
Schistosoma mansoni rac gtpase activating protein 0.0047 0.033 0.033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0498 0.1036
Echinococcus multilocularis neuropeptide receptor A26 0.0019 0.0035 0.0035
Plasmodium vivax alpha/beta hydrolase, putative 0.0026 0.011 0.0228
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0954 1 1
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0035 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.019 0.019
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0075 0.0136
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0048 0.0345 0.0345
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0026 0.011 1
Echinococcus multilocularis protein patched 0.0041 0.0267 0.0267
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0267 0.0267
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0115 0.1057 0.2306
Echinococcus multilocularis serine threonine protein kinase 0.0234 0.2322 0.2322
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0075 0.0075
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0445 0.4574 1
Schistosoma mansoni opsin-like receptor 0.0019 0.0035 0.0035
Echinococcus granulosus regulator of G protein signaling 7 0.0042 0.0275 0.0275
Brugia malayi G-protein coupled receptor 0.0019 0.0035 0.0035
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0035 0.0035
Brugia malayi Dopamine receptor protein 2 0.0019 0.0035 0.0035
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0026 0.011 0.0228
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.019 0.019
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0035 0.0035
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0006 0.0006
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0013 0.0017
Schistosoma mansoni axis inhibition protein axin 0.0042 0.0275 0.0275
Brugia malayi hypothetical protein 0.0019 0.0035 0.0035
Brugia malayi hypothetical protein 0.0019 0.0035 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0275 0.0588
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.011 0.0228
Onchocerca volvulus 0.0229 0.2275 0.7822
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0192 0.1874 0.1874
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0275 0.0275
Brugia malayi hypothetical protein 0.0019 0.0035 0.0035
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0047 0.033 0.033
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0026 0.011 0.0228
Echinococcus multilocularis neuropeptide s receptor 0.0019 0.0035 0.0035
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0445 0.4574 1
Mycobacterium ulcerans peptide amidase, GatA 0.0115 0.1057 0.2289
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0536 0.0536
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.011 0.0228
Echinococcus granulosus neuropeptide receptor A26 0.0019 0.0035 0.0035
Plasmodium vivax lysophospholipase, putative 0.0026 0.011 0.0228
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0035 0.0035
Echinococcus multilocularis expressed protein 0.0811 0.8475 0.8475
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0035 0.0035
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0139 0.0139
Echinococcus granulosus G protein coupled receptor 139 0.0019 0.0035 0.0035
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0006 0.0006
Brugia malayi Serotonin receptor 0.0019 0.0035 0.0035
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0019 0.0035 0.0035
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0019 0.0035 0.0035
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0536 0.1161
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0139 0.0139
Trypanosoma cruzi amidase, putative 0.0115 0.1057 0.2302
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.002 0.002
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0445 0.4574 1
Toxoplasma gondii phospholipase/carboxylesterase 0.0026 0.011 0.1966
Schistosoma mansoni hypothetical protein 0.0039 0.0251 0.0251
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0019 0.0035 0.0121
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0075 0.0075
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0267 0.0267
Schistosoma mansoni biogenic amine receptor 0.0019 0.0035 0.0035
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0075 0.0594
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0075 0.0152
Schistosoma mansoni hypothetical protein 0.0164 0.1579 0.1579
Loa Loa (eye worm) hypothetical protein 0.0289 0.2909 0.2909
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0035 0.0035
Brugia malayi Pleckstrin Homology Domain 0.0047 0.033 0.033
Mycobacterium ulcerans lysophospholipase 0.0445 0.4574 1
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0536 0.0536
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0075 0.0152
Brugia malayi MGC79044 protein 0.0026 0.011 0.011
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0075 0.0157
Onchocerca volvulus 0.0106 0.0955 0.3284
Brugia malayi ORL1-like opioid receptor 0.0019 0.0035 0.0035
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0026 0.011 0.1966
Schistosoma mansoni neuropeptide receptor 0.0019 0.0035 0.0035
Plasmodium vivax PST-A protein 0.0026 0.011 0.0228
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0208 0.2046 0.2046
Brugia malayi hypothetical protein 0.0019 0.0035 0.0035
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0075 0.0465
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0035 0.0035
Onchocerca volvulus 0.0019 0.0035 0.0121
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.1283 0.1283
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0785 0.8199 0.8199
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0075 0.0136
Loa Loa (eye worm) hypothetical protein 0.0026 0.011 0.011
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.002 0.002
Echinococcus multilocularis beta adrenergic receptor kinase 0.0043 0.029 0.029
Echinococcus granulosus allatostatin A receptor 0.0019 0.0035 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0275 0.0588
Schistosoma mansoni thyroid hormone receptor 0.0034 0.019 0.019
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0484 0.0484
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0536 0.1161
Brugia malayi protein kinase C II. 0.0192 0.1874 0.1874
Schistosoma mansoni protein kinase C 0.0053 0.0398 0.0398
Brugia malayi CHE-14 protein 0.0041 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0026 0.011 0.0228
Echinococcus granulosus Regulator of G protein signaling 20 0.0042 0.0275 0.0275
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0484 0.0484
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Onchocerca volvulus 0.0019 0.0035 0.0121
Toxoplasma gondii diacylglycerol kinase, putative 0.0047 0.033 0.6103
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0006 0.0006
Onchocerca volvulus 0.0019 0.0035 0.0121
Schistosoma mansoni fatty-acid amide hydrolase 0.0115 0.1057 0.1057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0006
Onchocerca volvulus 0.0029 0.0139 0.0477
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0498 0.1036
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0047 0.033 0.033
Echinococcus granulosus axis inhibition protein axin 0.0042 0.0275 0.0275
Brugia malayi GnHR receptor homolog 0.0019 0.0035 0.0035
Brugia malayi bZIP transcription factor family protein 0.0088 0.0767 0.0767
Loa Loa (eye worm) hypothetical protein 0.0053 0.0398 0.0398
Schistosoma mansoni biogenic amine receptor 0.0019 0.0035 0.0035
Onchocerca volvulus 0.0019 0.0035 0.0121
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0169 0.1631 0.1631
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0498 0.1036
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0139 0.0139
Brugia malayi Tachykinin-like peptides receptor 99D 0.0019 0.0035 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0498 0.1036
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0445 0.4574 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0019 0.0035 0.0121
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Leishmania major cathepsin L-like protease 0.0063 0.0498 0.1078
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.019 0.019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0035 0.0035
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.019 0.019
Brugia malayi hypothetical protein 0.0019 0.0035 0.0035
Brugia malayi Pre-SET motif family protein 0.0029 0.0139 0.0139
Chlamydia trachomatis hydrolase 0.0026 0.011 0.0927
Schistosoma mansoni neuropeptide receptor 0.0019 0.0035 0.0035
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0161 0.1547 0.1547
Mycobacterium ulcerans hypothetical protein 0.0445 0.4574 1
Onchocerca volvulus 0.0047 0.033 0.1133
Loa Loa (eye worm) hypothetical protein 0.0042 0.0275 0.0275
Plasmodium falciparum lysophospholipase, putative 0.0445 0.4574 1
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.002 0.002
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0275 0.0275
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0498 0.1036
Entamoeba histolytica hypothetical protein 0.0023 0.0075 0.0152
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0041 0.0267 0.0267
Brugia malayi small heat shock protein 0.0605 0.6271 0.6271
Plasmodium vivax lysophospholipase, putative 0.0026 0.011 0.0228
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0498 0.1036
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0075 0.0136
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0115 0.1057 0.1057
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0019 0.0035 0.0035
Brugia malayi RhoGAP domain containing protein 0.0047 0.033 0.033
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0019 0.0035 0.0035
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.019 0.019
Echinococcus multilocularis protein kinase c iota type 0.0113 0.1035 0.1035
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.019 0.019
Plasmodium vivax alpha/beta hydrolase, putative 0.0026 0.011 0.0228
Plasmodium falciparum prodrug activation and resistance esterase 0.0026 0.011 0.0228
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0026 0.011 0.0228
Trypanosoma cruzi amidase, putative 0.0115 0.1057 0.2302
Loa Loa (eye worm) hypothetical protein 0.0047 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0023 0.0075 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0275 0.0588
Echinococcus granulosus somatostatin receptor 0.0019 0.0035 0.0035
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0275 0.0275
Brugia malayi nuclear receptor NHR-88 0.0034 0.019 0.019
Brugia malayi hypothetical protein 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Echinococcus granulosus axis inhibition protein axin 0.0042 0.0275 0.0275
Onchocerca volvulus 0.0019 0.0035 0.0121
Echinococcus granulosus g protein coupled receptor 0.0019 0.0035 0.0035
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0355 0.3614 0.3614
Brugia malayi Dopamine receptor 0.0019 0.0035 0.0035
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0035 0.0035
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0026 0.011 0.0228
Echinococcus multilocularis allatostatin A receptor 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.002
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0026 0.011 0.0228
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0035 0.0035
Brugia malayi nuclear receptor RXR 0.0018 0.002 0.002
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0026 0.011 0.011
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.002 0.002
Schistosoma mansoni amine GPCR 0.0019 0.0035 0.0035
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0035 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.019 0.019
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0006 0.0006
Echinococcus granulosus protein kinase c eta type 0.0047 0.033 0.033
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0035 0.0035
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0035 0.0035
Brugia malayi PXA domain containing protein 0.0042 0.0275 0.0275
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0066 0.0536 0.0536
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0498 0.1036
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0139 0.0139
Schistosoma mansoni coup transcription factor 0.0034 0.019 0.019
Echinococcus granulosus 7tm_1 domain containing protein 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0536 0.0536
Onchocerca volvulus 0.0289 0.2909 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0035 0.0035
Echinococcus granulosus neuropeptide FF receptor 2 0.0019 0.0035 0.0035
Loa Loa (eye worm) RNA binding protein 0.0061 0.0484 0.0484
Echinococcus granulosus fatty acid amide hydrolase 1 0.0115 0.1057 0.1057
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0035 0.0035
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0026 0.011 0.011
Brugia malayi G protein-coupled receptor 0.0019 0.0035 0.0035
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0066 0.0536 0.0536
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0019 0.0035 0.0035
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0066 0.0536 0.0536
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0066 0.0536 0.0536
Loa Loa (eye worm) hypothetical protein 0.0047 0.033 0.033
Plasmodium falciparum alpha/beta hydrolase, putative 0.0026 0.011 0.0228
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0075 0.0152
Echinococcus granulosus RNA directed DNA polymerase 0.0161 0.1547 0.1547
Loa Loa (eye worm) hypothetical protein 0.0034 0.019 0.019
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.019 0.019
Brugia malayi Protein C20orf22 0.0026 0.011 0.011
Trypanosoma cruzi serine peptidase, putative 0.0026 0.011 0.0228
Brugia malayi PXA domain containing protein 0.0042 0.0275 0.0275
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0075 0.0152
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0042 0.0275 0.0275
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0027 0.0047
Echinococcus multilocularis regulator of G protein signaling 3 0.0042 0.0275 0.0275
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.019 0.019
Schistosoma mansoni diacylglycerol kinase theta 0.0047 0.033 0.033
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.019 0.019
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0536 0.1161
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.019 0.019
Plasmodium falciparum esterase, putative 0.0026 0.011 0.0228
Loa Loa (eye worm) hypothetical protein 0.0954 1 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Onchocerca volvulus 0.0034 0.019 0.0652
Loa Loa (eye worm) hypothetical protein 0.0047 0.033 0.033
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.019 0.019
Onchocerca volvulus 0.0069 0.0566 0.1946
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0275 0.0275
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0026 0.011 0.0228
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0075 0.0136
Brugia malayi C1-like domain containing protein 0.0048 0.0345 0.0345
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.2271 0.2271
Leishmania major cathepsin L-like protease 0.0063 0.0498 0.1078
Loa Loa (eye worm) raf kinase 0.0047 0.033 0.033
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.019 0.019
Schistosoma mansoni neuropeptide f receptor 76f 0.0019 0.0035 0.0035
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.019 0.019
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.019 0.019
Toxoplasma gondii hypothetical protein 0.0026 0.011 0.1966
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0006 0.002
Brugia malayi MGC83647 protein 0.0026 0.011 0.011
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0035 0.0035
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0035 0.0035
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0035 0.0035
Onchocerca volvulus 0.0047 0.033 0.1133
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0019 0.0035 0.0035
Echinococcus multilocularis cysteine protease 0.0016 0.0006 0.0006
Plasmodium falciparum epoxide hydrolase 2 0.0026 0.011 0.0228
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0106 0.0955 0.0955
Echinococcus multilocularis protein dispatched 1 0.0047 0.0328 0.0328
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0026 0.011 0.0228
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.0847 0.0847
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Plasmodium falciparum BEM46-like protein, putative 0.0026 0.011 0.0228
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0075 0.0465
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Brugia malayi regulator of G-protein signaling rgs-7 0.0042 0.0275 0.0275
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0047 0.033 0.033
Mycobacterium ulcerans hydrolase 0.0026 0.011 0.0212
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0139 0.0139
Echinococcus multilocularis Diacylglycerol kinase theta 0.0047 0.033 0.033
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0048 0.0345 0.0345
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0035 0.0035
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0484 0.0484
Echinococcus granulosus alpha 1A adrenergic receptor 0.0019 0.0035 0.0035
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0075 0.0075
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0013 0.0022
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0075 0.0152
Brugia malayi hypothetical protein 0.0019 0.0035 0.0035
Onchocerca volvulus 0.0016 0.0006 0.002
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0019 0.0035 0.0035
Toxoplasma gondii hypothetical protein 0.0026 0.011 0.1966
Brugia malayi Amidase family protein 0.0115 0.1057 0.1057
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0019 0.0035 0.0035
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0035 0.0035
Schistosoma mansoni unc-13 (munc13) 0.0053 0.0398 0.0398
Brugia malayi Protein kinase domain containing protein 0.0066 0.0536 0.0536
Echinococcus granulosus g-protein coupled receptor 0.0019 0.0035 0.0035
Echinococcus granulosus abhydrolase domain containing 3 0.0026 0.011 0.011
Brugia malayi AKH receptor 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Schistosoma mansoni ap endonuclease 0.0018 0.0027 0.0027
Echinococcus granulosus NDR protein kinase 0.0066 0.0536 0.0536
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.019 0.019
Loa Loa (eye worm) melatonin receptor type 1A 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0082 0.0701 0.0701
Echinococcus granulosus neuropeptide receptor 0.0019 0.0035 0.0035
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.029 0.029
Schistosoma mansoni patched 1 0.0041 0.0267 0.0267
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0006 0.0006
Echinococcus multilocularis g-protein coupled receptor 0.0019 0.0035 0.0035
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0536 0.1161
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.002 0.002
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0075 0.0136
Loa Loa (eye worm) hypothetical protein 0.0026 0.011 0.011
Toxoplasma gondii AGC kinase 0.0066 0.0536 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0075 0.0136
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0498 0.1078
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Echinococcus multilocularis orexin receptor type 2 0.0019 0.0035 0.0035
Brugia malayi hypothetical protein 0.0042 0.0275 0.0275
Schistosoma mansoni jun-related protein 0.0071 0.0592 0.0592
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.019 0.019
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0048 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.0106 0.0955 0.0955
Brugia malayi Pre-SET motif family protein 0.0202 0.1978 0.1978
Brugia malayi regulator of G-protein signaling egl-10 0.0042 0.0275 0.0275
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0042 0.0275 0.0275
Schistosoma mansoni tyrosinase precursor 0.0106 0.0955 0.0955
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0862 0.0862
Echinococcus multilocularis regulator of G protein signaling 7 0.0042 0.0275 0.0275
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0035 0.0035
Plasmodium falciparum lysophospholipase, putative 0.0026 0.011 0.0228
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0035 0.0035
Schistosoma mansoni opsin-like receptor 0.0019 0.0035 0.0035
Echinococcus granulosus N chimaerin 0.0047 0.033 0.033
Leishmania major monoglyceride lipase, putative 0.0445 0.4574 1
Plasmodium vivax hypothetical protein, conserved 0.0026 0.011 0.0228
Mycobacterium ulcerans hypothetical protein 0.0026 0.011 0.0212
Schistosoma mansoni hypothetical protein 0.0039 0.0251 0.0251
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0042 0.0275 0.0275
Echinococcus granulosus dro:myosuppressin receptor 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.002
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0536 0.1161
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0019 0.0035 0.0035
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.029 0.029
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0106 0.0955 0.0955
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0536 0.1161
Loa Loa (eye worm) hypothetical protein 0.0023 0.0075 0.0075
Schistosoma mansoni peptidase 0.0026 0.011 0.011
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0275 0.0275
Onchocerca volvulus 0.0019 0.0035 0.0121
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0035 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0498 0.1036
Brugia malayi Protein kinase c protein 2 0.0216 0.213 0.213
Loa Loa (eye worm) hypothetical protein 0.0047 0.033 0.033
Brugia malayi hypothetical protein 0.0229 0.2271 0.2271
Schistosoma mansoni hypothetical protein 0.0035 0.0202 0.0202
Echinococcus multilocularis axis inhibition protein axin 0.0042 0.0275 0.0275
Onchocerca volvulus 0.0047 0.0328 0.1129
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0026 0.011 0.011
Schistosoma mansoni amine GPCR 0.0019 0.0035 0.0035
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0035 0.0035
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.0847 0.1841
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0026 0.011 0.011
Entamoeba histolytica hypothetical protein 0.0042 0.0275 0.0588
Echinococcus granulosus g protein coupled receptor 0.0019 0.0035 0.0035
Echinococcus granulosus neuropeptide receptor 0.0019 0.0035 0.0035
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0445 0.4574 1
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.029 0.029
Brugia malayi G-protein coupled receptor 0.0019 0.0035 0.0035
Plasmodium falciparum lysophospholipase, putative 0.0445 0.4574 1
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0345 0.0345
Schistosoma mansoni hypothetical protein 0.0019 0.0035 0.0035
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0115 0.1057 0.2289
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0281 0.2821 0.2821
Echinococcus granulosus unc 13 munc13 0.0053 0.0398 0.0398
Echinococcus multilocularis sex peptide receptor 0.0019 0.0035 0.0035
Entamoeba histolytica diacylglycerol kinase, putative 0.0047 0.033 0.0709
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0075 0.0157
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.019 0.019
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0042 0.0275 0.0275
Brugia malayi Dopamine receptor protein 1 0.0019 0.0035 0.0035
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0035 0.0035
Echinococcus multilocularis G protein coupled receptor 139 0.0019 0.0035 0.0035
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0701 0.0701
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0075 0.0152
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0027 0.0027
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.019 0.019
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0345 0.0345
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Mycobacterium tuberculosis Conserved hypothetical protein 0.0026 0.011 0.0234
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0026 0.011 0.0228
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0035 0.0035
Trichomonas vaginalis set domain proteins, putative 0.0229 0.2275 0.4968
Brugia malayi hypothetical protein 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0034 0.019 0.019
Entamoeba histolytica protein kinase, putative 0.0066 0.0536 0.1161
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Brugia malayi p70 ribosomal S6 kinase beta 0.0066 0.0536 0.0536
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0115 0.1057 0.2183
Echinococcus multilocularis unc 13 (munc13) 0.0053 0.0398 0.0398
Echinococcus granulosus protein kinase c epsilon type 0.0192 0.1874 0.1874
Plasmodium falciparum alpha/beta hydrolase, putative 0.0026 0.011 0.0228
Echinococcus multilocularis serine:threonine protein kinase 38 0.0066 0.0536 0.0536
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0115 0.1057 0.2306
Trypanosoma brucei monoglyceride lipase, putative 0.0445 0.4574 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.005 0.0365 0.0365
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0006 0.0006
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0026 0.011 0.0182
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.019 0.0652
Brugia malayi A-kinase anchor protein 10, precursor 0.0042 0.0275 0.0275
Entamoeba histolytica hypothetical protein 0.0047 0.033 0.0709
Echinococcus multilocularis myotubularin protein 13 0.0047 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0034 0.019 0.019
Plasmodium vivax hypothetical protein, conserved 0.0026 0.011 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0275 0.0588
Brugia malayi putative neuropeptide receptor NPR1 0.0019 0.0035 0.0035
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0026 0.011 0.1966
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0498 0.1036
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0006 0.0006
Brugia malayi protein kinase C3,putative 0.0048 0.0345 0.0345
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0498 0.1036
Schistosoma mansoni axis inhibition protein axin 0.0042 0.0275 0.0275
Plasmodium vivax SET domain protein, putative 0.0029 0.0139 0.0291
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.1978 0.1978
Trichomonas vaginalis conserved hypothetical protein 0.0445 0.4574 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0043 0.029 0.029
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0027 0.0047
Mycobacterium ulcerans amidase 0.0115 0.1057 0.2289
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0053 0.0398 0.0398
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.019 0.019
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0066 0.0536 0.0536
Mycobacterium ulcerans amidase 0.0115 0.1057 0.2289
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0075 0.131
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0115 0.1057 1
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0006 0.002
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0115 0.1057 0.2306
Schistosoma mansoni neuropeptide receptor 0.0019 0.0035 0.0035
Echinococcus granulosus fatty acid amide hydrolase 1 0.0954 1 1
Brugia malayi ecdysteroid receptor 0.0034 0.019 0.019
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0006
Onchocerca volvulus 0.0082 0.0701 0.241
Echinococcus granulosus protein kinase c iota type 0.0113 0.1035 0.1035
Schistosoma mansoni vav2 0.0047 0.033 0.033
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0019 0.0035 0.0035
Brugia malayi Regulator of G protein signaling domain containing protein 0.0042 0.0275 0.0275
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0048 0.0345 0.0345
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0035 0.0035
Leishmania major hypothetical protein, conserved 0.0026 0.011 0.0228
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0106 0.0955 0.0955
Echinococcus granulosus regulator of G protein signaling 3 0.0042 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Brugia malayi putative amidase 0.0115 0.1057 0.1057
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0026 0.011 0.0228
Onchocerca volvulus 0.0019 0.0035 0.0121
Echinococcus multilocularis geminin 0.0164 0.1579 0.1579
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.019 0.019
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0035 0.0035
Echinococcus multilocularis protein kinase c epsilon type 0.0192 0.1874 0.1874
Onchocerca volvulus 0.0016 0.0006 0.002
Echinococcus granulosus orexin receptor type 2 0.0019 0.0035 0.0035
Echinococcus granulosus protein kinase C gamma type 0.0234 0.2322 0.2322
Echinococcus granulosus regulator of G protein signaling 7 0.0042 0.0275 0.0275
Echinococcus multilocularis serine:threonine protein kinase N2 0.0138 0.1306 0.1306
Loa Loa (eye worm) hypothetical protein 0.0042 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0229 0.2271 0.2271
Echinococcus multilocularis expressed conserved protein 0.009 0.0785 0.0785
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.044 0.0951
Echinococcus multilocularis Phospholipase carboxylesterase 0.0026 0.011 0.011
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0019 0.0035 0.0035
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0139 0.2503
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0035 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.011 0.0228
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0536 0.1161
Echinococcus multilocularis protein kinase c eta type 0.0047 0.033 0.033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0035 0.0035
Onchocerca volvulus 0.0106 0.0955 0.3284
Schistosoma mansoni growth hormone secretagogue receptor 0.0019 0.0035 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.019 0.019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.019 0.019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.019 0.019
Plasmodium vivax PST-A protein 0.0445 0.4574 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0019 0.0035 0.0035
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0042 0.0275 0.0588
Onchocerca volvulus 0.0019 0.0035 0.0121
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0047 0.033 0.033
Schistosoma mansoni survival motor neuron protein 0.0047 0.0328 0.0328
Entamoeba histolytica hypothetical protein 0.0035 0.0202 0.0429
Echinococcus granulosus cathepsin l1 0.0016 0.0006 0.0006
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0026 0.011 0.0228
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0026 0.011 0.0228
Plasmodium falciparum exported lipase 2 0.0026 0.011 0.0228
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0026 0.011 0.0182
Loa Loa (eye worm) amidase 0.0115 0.1057 0.1057
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Brugia malayi putative neuropeptide receptor 0.0019 0.0035 0.0035
Loa Loa (eye worm) AGC/PKN protein kinase 0.0066 0.0536 0.0536
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0484 0.0484
Brugia malayi diacylglycerol kinase 0.0047 0.033 0.033
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0006 0.0006
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0027 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0035 0.0035
Brugia malayi neuropeptide F receptor 0.0019 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0034 0.019 0.019
Plasmodium falciparum lysophospholipase, putative 0.0445 0.4574 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0019 0.0035 0.0035
Schistosoma mansoni amine GPCR 0.0019 0.0035 0.0035
Loa Loa (eye worm) cysteine protease 0.0016 0.0006 0.0006
Schistosoma mansoni unc-13 (munc13) 0.0053 0.0398 0.0398
Echinococcus multilocularis N chimaerin 0.0047 0.033 0.033
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.002 0.002
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0498 0.1078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.019 0.019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0019 0.0035 0.0035
Brugia malayi hypothetical protein 0.0035 0.0202 0.0202
Echinococcus granulosus hypothetical protein 0.0019 0.0035 0.0035
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0106 0.0955 0.0955
Echinococcus granulosus regulator of G protein signaling 3 0.0042 0.0275 0.0275
Schistosoma mansoni adenoreceptor 0.0019 0.0035 0.0035
Onchocerca volvulus 0.0106 0.0955 0.3284
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.011 0.0228
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0035 0.0035
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0445 0.4574 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0127 0.0127
Echinococcus multilocularis Rac GTPase activating protein 1 0.0047 0.033 0.033
Brugia malayi Regulator of G protein signaling domain containing protein 0.0042 0.0275 0.0275
Schistosoma mansoni amidase 0.0954 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0498 0.1078
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.002
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0035 0.0035
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0053 0.0398 0.0398
Plasmodium vivax PST-A protein 0.0026 0.011 0.0228
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0088 0.0767 0.0767
Brugia malayi Variant SH3 domain containing protein 0.0047 0.033 0.033
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0115 0.1057 1
Brugia malayi hypothetical protein 0.0019 0.0035 0.0035
Plasmodium vivax unspecified product 0.0026 0.011 0.0228
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0066 0.0536 0.0536
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0484 0.0484
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0066 0.0536 0.0536
Loa Loa (eye worm) hypothetical protein 0.0042 0.0275 0.0275
Echinococcus multilocularis regulator of G protein signaling 7 0.0042 0.0275 0.0275
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0484 0.0484
Echinococcus granulosus geminin 0.0164 0.1579 0.1579
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0075 0.0136
Loa Loa (eye worm) hypothetical protein 0.0336 0.3408 0.3408
Mycobacterium ulcerans hypothetical protein 0.0023 0.0075 0.0136
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0536 0.1161
Entamoeba histolytica protein kinase, putative 0.0066 0.0536 0.1161
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.019 0.0652
Loa Loa (eye worm) PXA domain-containing protein 0.0042 0.0275 0.0275
Echinococcus granulosus tar DNA binding protein 0.0061 0.0484 0.0484
Brugia malayi neuropeptide F receptor 0.0019 0.0035 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0445 0.4574 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Plasmodium falciparum lysophospholipase, putative 0.0026 0.011 0.0228
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0027 0.0027
Echinococcus multilocularis regulator of G protein signaling 0.0042 0.0275 0.0275
Onchocerca volvulus 0.0019 0.0035 0.0121
Brugia malayi G protein-coupled receptor F59B2.13 0.0019 0.0035 0.0035
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.0847 0.0847
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0027 0.0047
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0026 0.011 0.011
Trypanosoma brucei monoglyceride lipase, putative 0.0445 0.4574 1
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0043 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0075 0.0152
Leishmania major cathepsin L-like protease 0.0063 0.0498 0.1078
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Toxoplasma gondii protein c14orf29, putative 0.0026 0.011 0.1966
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0042 0.0275 0.0275
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0006
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.019 0.019
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0075 0.0152
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0042 0.0275 0.0275
Schistosoma mansoni hypothetical protein 0.0039 0.0251 0.0251
Schistosoma mansoni amine GPCR 0.0019 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0047 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Onchocerca volvulus 0.0019 0.0035 0.0121
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0115 0.1057 0.1057
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0202 0.0202
Leishmania major hypothetical protein, conserved 0.0115 0.1057 0.2302
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.019 0.019
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0019 0.0035 0.0035
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0047 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0013
Loa Loa (eye worm) AGC/AKT protein kinase 0.0066 0.0536 0.0536
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0027 0.0047
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0075 0.0152
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0066 0.0536 0.0536
Loa Loa (eye worm) ShTK domain-containing protein 0.0106 0.0955 0.0955
Onchocerca volvulus 0.0023 0.0075 0.0259
Entamoeba histolytica hypothetical protein 0.0035 0.0202 0.0429
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0013
Mycobacterium ulcerans hypothetical protein 0.0026 0.011 0.0212
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Onchocerca volvulus 0.0106 0.0955 0.3284
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0035 0.0035
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0115 0.1057 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.019 0.019
Schistosoma mansoni atypical protein kinase C 0.0113 0.1035 0.1035
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.019 0.019
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0701 0.0701
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.0026 0.011 0.0228
Echinococcus multilocularis somatostatin receptor 0.0019 0.0035 0.0035
Brugia malayi RNA binding protein 0.0061 0.0484 0.0484
Onchocerca volvulus 0.0019 0.0035 0.0121
Schistosoma mansoni alpha-1 adrenergic receptor 0.0019 0.0035 0.0035
Schistosoma mansoni histamine h1 receptor 0.0019 0.0035 0.0035
Toxoplasma gondii exonuclease III APE 0.0018 0.0027 0.0407
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0498 0.1036
Schistosoma mansoni hypothetical protein 0.0039 0.0251 0.0251
Loa Loa (eye worm) fibroinase 0.0016 0.0006 0.0006
Echinococcus granulosus myotubularin protein 13 0.0047 0.033 0.033
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0035 0.0035
Trypanosoma brucei rac serine-threonine kinase, putative 0.0066 0.0536 0.112
Schistosoma mansoni neuropeptide receptor 0.0019 0.0035 0.0035
Brugia malayi hypothetical protein 0.0019 0.0035 0.0035
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0035 0.0035
Plasmodium vivax unspecified product 0.0026 0.011 0.0228
Echinococcus granulosus FTZ F1 alpha 0.0034 0.019 0.019
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0027 0.0047
Trichomonas vaginalis AGC family protein kinase 0.0066 0.0536 0.1161
Entamoeba histolytica hypothetical protein 0.0026 0.011 0.0228
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0035 0.0035
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0034 0.019 0.019
Schistosoma mansoni protein kinase C mu 0.0047 0.033 0.033
Schistosoma mansoni diacylglycerol kinase theta 0.0047 0.033 0.033
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0115 0.1057 0.2183
Echinococcus multilocularis dro:myosuppressin receptor 0.0019 0.0035 0.0035
Echinococcus granulosus Protein kinase C brain isozyme 0.0281 0.2821 0.2821
Loa Loa (eye worm) hypothetical protein 0.0047 0.033 0.033
Schistosoma mansoni biogenic amine receptor 0.0019 0.0035 0.0035
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0019 0.0035 0.0035
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0088 0.0767 0.0767
Echinococcus multilocularis serine:threonine protein kinase N2 0.0066 0.0536 0.0536
Loa Loa (eye worm) hypothetical protein 0.0047 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0013
Echinococcus granulosus abhydrolase domain containing protein 13 0.0026 0.011 0.011
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0066 0.0536 0.0536
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0035 0.0035
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0035 0.0035
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0035 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.011 0.0228
Echinococcus granulosus expressed conserved protein 0.009 0.0785 0.0785
Plasmodium falciparum alpha/beta hydrolase, putative 0.0026 0.011 0.0228
Schistosoma mansoni serine/threonine protein kinase 0.0281 0.2821 0.2821
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0075 0.0157
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0023 0.0075 0.0075
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0035 0.0035
Plasmodium vivax PST-A protein 0.0026 0.011 0.0228
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0202 0.0202
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0161 0.1547 0.1547
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0006
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0042 0.0275 0.0275
Loa Loa (eye worm) RGS-3 protein 0.0042 0.0275 0.0275
Toxoplasma gondii peptidase S15, putative 0.0026 0.011 0.1966
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.019 0.019
Echinococcus granulosus serine:threonine protein kinase N2 0.0074 0.0615 0.0615
Brugia malayi TAR-binding protein 0.0061 0.0484 0.0484
Schistosoma mansoni nuclear hormone receptor 0.0034 0.019 0.019
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0019 0.0035 0.0035
Echinococcus granulosus serotonin receptor 0.0019 0.0035 0.0035
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0701 0.0701
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0484 0.0484
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0027 0.0053
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.2271 0.2271
Loa Loa (eye worm) amidase 0.0115 0.1057 0.1057
Schistosoma mansoni fatty-acid amide hydrolase 0.0954 1 1
Brugia malayi Protein kinase domain containing protein 0.0066 0.0536 0.0536
Echinococcus granulosus g protein coupled receptor 0.0019 0.0035 0.0035
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0035 0.0035
Echinococcus granulosus fatty acid amide hydrolase 1 0.0954 1 1
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0035 0.0035
Brugia malayi hypothetical protein 0.0042 0.0275 0.0275
Brugia malayi follicle stimulating hormone receptor 0.0019 0.0035 0.0035
Echinococcus granulosus raf serine:threonine protein kinase 0.0047 0.033 0.033
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.019 0.019
Schistosoma mansoni protein kinase C mu 0.0048 0.0345 0.0345
Onchocerca volvulus 0.0019 0.0035 0.0121
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0006
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0445 0.4574 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0019 0.0035 0.0035
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0047 0.033 0.033
Echinococcus multilocularis RNA directed DNA polymerase 0.0161 0.1547 0.1547
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0115 0.1057 0.2265
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0115 0.1057 0.1057
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0006 0.0006
Echinococcus multilocularis serotonin receptor 0.0019 0.0035 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0267 0.0571
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0115 0.1057 0.2306
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0027 0.0047
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.019 0.019
Plasmodium vivax PST-A protein 0.0026 0.011 0.0228
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0267 0.0267
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0019 0.0035 0.0035
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0019 0.0035 0.0035
Loa Loa (eye worm) RasGEF domain-containing protein 0.0047 0.033 0.033
Plasmodium vivax lysophospholipase, putative 0.0026 0.011 0.0228
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0013 0.0017
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0605 0.6271 0.6271
Echinococcus multilocularis raf serine:threonine protein kinase 0.0047 0.033 0.033
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0035 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.011 0.0228
Brugia malayi Protein kinase domain containing protein 0.0066 0.0536 0.0536
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0071 0.0592 0.0592
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Loa Loa (eye worm) ShTK domain-containing protein 0.0106 0.0955 0.0955
Entamoeba histolytica protein kinase, putative 0.0066 0.0536 0.1161
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Loa Loa (eye worm) tyrosinase 1 0.0106 0.0955 0.0955
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0035 0.0035
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0035 0.0035
Schistosoma mansoni serine/threonine kinase 0.0066 0.0536 0.0536
Brugia malayi nuclear hormone receptor 0.0034 0.019 0.019
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0027 0.0047
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0202 0.0202
Onchocerca volvulus 0.0053 0.0398 0.1369
Loa Loa (eye worm) hypothetical protein 0.0047 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.019 0.019
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.033 0.033
Schistosoma mansoni hypothetical protein 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0289 0.2909 0.2909
Onchocerca volvulus 0.0016 0.0006 0.002
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0139 0.0139
Brugia malayi RhoGEF domain containing protein 0.0047 0.033 0.033
Plasmodium falciparum esterase, putative 0.0026 0.011 0.0228
Echinococcus granulosus fmrfamide receptor 0.0019 0.0035 0.0035
Brugia malayi hypothetical protein 0.0069 0.0566 0.0566
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Onchocerca volvulus 0.0019 0.0035 0.0121
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0095 0.0847 0.0847
Echinococcus granulosus Rac GTPase activating protein 1 0.0047 0.033 0.033
Entamoeba histolytica diacylglycerol kinase, putative 0.0047 0.033 0.0709
Loa Loa (eye worm) ctsf protein 0.0016 0.0006 0.0006
Onchocerca volvulus 0.0019 0.0035 0.0121
Onchocerca volvulus 0.0019 0.0035 0.0121
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0115 0.1057 0.2302
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0019 0.0035 0.0035
Brugia malayi hypothetical protein 0.0018 0.002 0.002
Echinococcus granulosus neuropeptide s receptor 0.0019 0.0035 0.0035
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0027 0.0027
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.019 0.019
Schistosoma mansoni serine/threonine protein kinase 0.0192 0.1874 0.1874
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0484 0.0484
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.019 0.019
Brugia malayi Melatonin receptor type 1A 0.0019 0.0035 0.0035
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0026 0.011 0.0228
Brugia malayi larval opioid receptor 0.0019 0.0035 0.0035
Mycobacterium tuberculosis Possible lysophospholipase 0.0445 0.4574 1
Schistosoma mansoni hypothetical protein 0.0164 0.1579 0.1579
Echinococcus granulosus serine:threonine protein kinase N2 0.0066 0.0536 0.0536
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Brugia malayi sulfakinin receptor protein 0.0019 0.0035 0.0035
Onchocerca volvulus 0.0019 0.0035 0.0121
Plasmodium falciparum alpha/beta-hydrolase, putative 0.0026 0.011 0.0228
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.0847 0.0847
Schistosoma mansoni ap endonuclease 0.0018 0.0027 0.0027
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0047 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Brugia malayi steroid hormone receptor 0.0034 0.019 0.019
Schistosoma mansoni serine/threonine protein kinase 0.0281 0.2821 0.2821
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0026 0.011 0.0182
Echinococcus multilocularis abhydrolase domain containing 3 0.0026 0.011 0.011
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0006
Echinococcus granulosus Phospholipase carboxylesterase 0.0026 0.011 0.011
Plasmodium falciparum exported lipase 1 0.0026 0.011 0.0228
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0026 0.011 0.0228
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0042 0.0275 0.0275
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0042 0.0275 0.0275
Chlamydia trachomatis acyltransferase family protein 0.0026 0.011 0.0927
Echinococcus granulosus 7TM GPCR rhodopsin 0.0019 0.0035 0.0035
Onchocerca volvulus 0.0016 0.0006 0.002
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0328 0.0328
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.011 0.0228
Loa Loa (eye worm) hypothetical protein 0.0029 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0047 0.033 0.033
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.019 0.019
Brugia malayi RE15519p 0.0019 0.0035 0.0035
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0484 0.0484
Entamoeba histolytica hypothetical protein 0.0026 0.011 0.0228
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0065 0.0521 0.1128
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0035 0.0035
Loa Loa (eye worm) AGC/NDR protein kinase 0.0066 0.0536 0.0536
Mycobacterium ulcerans amidase 0.0115 0.1057 0.2289
Plasmodium falciparum alpha/beta hydrolase, putative 0.0026 0.011 0.0228
Loa Loa (eye worm) TYRA-2 protein 0.0019 0.0035 0.0035
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0115 0.1057 0.1057
Schistosoma mansoni amine GPCR 0.0019 0.0035 0.0035
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.019 0.019
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0115 0.1057 0.2306
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0106 0.0955 0.0955
Brugia malayi Amidase family protein 0.0115 0.1057 0.1057
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0701 0.0701
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.019 0.019
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.019 0.019
Entamoeba histolytica hypothetical protein 0.0035 0.0202 0.0429
Echinococcus granulosus jun protein 0.0088 0.0767 0.0767
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0115 0.1057 0.2302
Echinococcus multilocularis neuropeptide FF receptor 2 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0047 0.033 0.033
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0048 0.0345 0.0345
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0355 0.0765
Brugia malayi Ras association domain family 1 isoform A 0.0047 0.033 0.033
Schistosoma mansoni hypothetical protein 0.0047 0.0328 0.0328
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0019 0.0035 0.0035
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0075 0.131
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Plasmodium falciparum alpha/beta hydrolase, putative 0.0026 0.011 0.0228
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0006 0.0006
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0019 0.0035 0.0035
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0006 0.002
Brugia malayi Common central domain of tyrosinase family protein 0.0106 0.0955 0.0955
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.019 0.0652
Echinococcus multilocularis jun protein 0.0088 0.0767 0.0767
Brugia malayi RhoGAP domain containing protein 0.0047 0.033 0.033
Echinococcus multilocularis G-protein coupled receptor, putative 0.0019 0.0035 0.0035
Entamoeba histolytica hypothetical protein 0.0042 0.0275 0.0588
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0075 0.0136

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 0.72 uM Compound required to double the time to clot formation in reconstituted human plasma, using activated partial thromboplastin time (APTT) ChEMBL. 10715155
Activity (functional) = 0.72 uM Compound required to double the time to clot formation in reconstituted human plasma, using activated partial thromboplastin time (APTT) ChEMBL. 10715155
Activity (functional) = 0.83 uM Compound required to double the time to clot formation in reconstituted human plasma, using the prothromboplastin time (PT) ChEMBL. 10715155
Activity (functional) = 0.83 uM Compound required to double the time to clot formation in reconstituted human plasma, using the prothromboplastin time (PT) ChEMBL. 10715155
K ass (binding) = 0.001 l M-1 Tested for inhibition of Urokinase-type plasminogen activator ChEMBL. 10715155
K ass (binding) = 0.001 l M-1 Tested for inhibition of Urokinase-type plasminogen activator ChEMBL. 10715155
K ass (binding) = 0.004 l M-1 Tested for inhibition of Tissue type plasminogen activator ChEMBL. 10715155
K ass (binding) = 0.004 l M-1 Tested for inhibition of Tissue type plasminogen activator ChEMBL. 10715155
K ass (binding) = 0.013 l M-1 Tested for inhibition of activated protein C ChEMBL. 10715155
K ass (binding) = 0.013 l M-1 Tested for inhibition of activated protein C ChEMBL. 10715155
K ass (binding) = 0.073 l M-1 Tested for inhibition of plasmin ChEMBL. 10715155
K ass (binding) = 0.073 l M-1 Tested for inhibition of plasmin ChEMBL. 10715155
K ass (binding) = 0.65 l M-1 Tested for inhibition of thrombin. ChEMBL. 10715155
K ass (binding) = 0.65 l M-1 Tested for inhibition of thrombin. ChEMBL. 10715155
K ass (binding) = 12 l M-1 Tested for inhibition of trypsin ChEMBL. 10715155
K ass (binding) = 12 l M-1 Tested for inhibition of trypsin ChEMBL. 10715155
K ass (binding) = 470000000 l M-1 Apparent association constant against human Coagulation factor X. ChEMBL. 10715155
K ass (binding) = 470000000 l M-1 Binding affinity for human Coagulation factor X ChEMBL. 10841787
K ass (binding) = 470000000 l M-1 Apparent association constant against human Coagulation factor X. ChEMBL. 10715155
K ass (binding) = 470000000 l M-1 Binding affinity for human Coagulation factor X ChEMBL. 10841787
PT (functional) = 0.83 uM Prothrombin time activity, concentration required to double the time of clot formation in the prothrombin time assay ChEMBL. 10841787
Ratio (binding) = 390 Selectivity of the compound as the ratio of Kass value towards fXa to that of trypsin. ChEMBL. 10715155
Ratio (binding) = 720 Selectivity of the compound as the ratio of Kass value towards fXa to that of thrombin. ChEMBL. 10715155
Ratio (binding) = 6400 Selectivity of the compound as the ratio of Kass value towards fXa to that of plasmin. ChEMBL. 10715155
Ratio (binding) = 12000 Selectivity of the compound as the ratio of Kass value towards fXa to that of tissue plasminogen activator. ChEMBL. 10715155
Ratio (binding) = 36000 Selectivity of the compound as the ratio of Kass value towards fXa to that of aPC. ChEMBL. 10715155
Ratio (binding) = 470000 Selectivity of the compound as the ratio of Kass value towards fXa to that of UK. ChEMBL. 10715155

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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