Detailed information for compound 1075970

Basic information

Technical information
  • TDR Targets ID: 1075970
  • Name: 1-[4-amino-2,6-di(propan-2-yl)phenyl]-3-[1-bu tyl-4-[3-(3-hydroxypropoxy)phenyl]-2-oxo-1,8- naphthyridin-3-yl]urea
  • MW: 585.736 | Formula: C34H43N5O4
  • H donors: 4 H acceptors: 4 LogP: 5.2 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCn1c(=O)c(NC(=O)Nc2c(cc(cc2C(C)C)N)C(C)C)c(c2c1nccc2)c1cccc(c1)OCCCO
  • InChi: 1S/C34H43N5O4/c1-6-7-15-39-32-26(13-9-14-36-32)29(23-11-8-12-25(18-23)43-17-10-16-40)31(33(39)41)38-34(42)37-30-27(21(2)3)19-24(35)20-28(30)22(4)5/h8-9,11-14,18-22,40H,6-7,10,15-17,35H2,1-5H3,(H2,37,38,42)
  • InChiKey: HNRUUMLUBDTZHX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-amino-2,6-diisopropyl-phenyl)-3-[1-butyl-4-[3-(3-hydroxypropoxy)phenyl]-2-oxo-1,8-naphthyridin-3-yl]urea
  • 1-(4-amino-2,6-diisopropylphenyl)-3-[1-butyl-4-[3-(3-hydroxypropoxy)phenyl]-2-oxo-1,8-naphthyridin-3-yl]urea
  • 1-(4-amino-2,6-diisopropyl-phenyl)-3-[1-butyl-4-[3-(3-hydroxypropoxy)phenyl]-2-keto-1,8-naphthyridin-3-yl]urea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Acyl coenzyme A:cholesterol acyltransferase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni sterol O-acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
Schistosoma japonicum ko:K00637 sterol O-acyltransferase [EC2.3.1.26], putative Get druggable targets OG5_133487 All targets in OG5_133487
Echinococcus multilocularis sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Echinococcus granulosus sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Neospora caninum sterol O-acyltransferase, putative Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 510 aa 21.2 %
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 510 aa 24.1 %
Dictyostelium discoideum diacylglycerol O-acyltransferase 1 Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 547 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0086 0.1855 0.1852
Echinococcus multilocularis glycine receptor subunit beta 0.0086 0.1855 0.1883
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.018 0.4248 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0675 0.0673
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0967 0.4013
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0322 0.0327
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0086 0.1855 0.1852
Loa Loa (eye worm) hypothetical protein 0.0086 0.1855 0.1852
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0127 0.0129
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0224 0.0221
Echinococcus granulosus chromobox protein 1 0.0068 0.1401 0.1422
Brugia malayi Thioredoxin reductase 0.0103 0.2289 0.2287
Schistosoma mansoni acetylcholine receptor subunit beta 0.004 0.0675 0.0661
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0086 0.1855 0.1852
Mycobacterium tuberculosis Probable reductase 0.0235 0.565 0.8912
Echinococcus multilocularis peregrin 0.0032 0.0479 0.0486
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.004 0.0675 0.0673
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0143 0.0145
Onchocerca volvulus Putative nachr subunit 0.0086 0.1855 0.8269
Plasmodium vivax glutathione reductase, putative 0.0103 0.2289 1
Schistosoma mansoni nAChR subunit 0.004 0.0675 0.0661
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0707 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0042 0.0043
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0112 0.0406
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0046 0.0845 0.0833
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0026 0.0027
Echinococcus granulosus nAChR subunit 0.0046 0.0845 0.0858
Echinococcus multilocularis zinc finger protein 0.0022 0.0236 0.024
Echinococcus multilocularis thioredoxin glutathione reductase 0.0103 0.2289 0.2324
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0967 0.4013
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0086 0.1855 0.1861
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0026 0.0023
Brugia malayi MBOAT family protein 0.0026 0.0322 0.0319
Trypanosoma cruzi GUP1, putative 0.0026 0.0322 0.1094
Loa Loa (eye worm) hypothetical protein 0.0366 0.899 0.899
Echinococcus multilocularis tar DNA binding protein 0.0135 0.3109 0.3157
Brugia malayi Bromodomain containing protein 0.0081 0.1737 0.1734
Loa Loa (eye worm) hypothetical protein 0.0086 0.1855 0.1852
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0575 0.224
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.1323 0.1343
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0708 0.0719
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0112 0.0406
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0086 0.1855 0.1852
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0086 0.1855 0.1883
Loa Loa (eye worm) hypothetical protein 0.003 0.0428 0.0425
Loa Loa (eye worm) hypothetical protein 0.004 0.0675 0.0673
Echinococcus multilocularis dual specificity protein kinase clk2 0.006 0.1181 0.1199
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0575 0.7484
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0026 0.0027
Brugia malayi Inositol-1 0.0041 0.0707 0.0704
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.004 0.0675 0.0686
Brugia malayi Bromodomain containing protein 0.0041 0.0703 0.07
Schistosoma mansoni neurotransmitter gated ion channel 0.0046 0.0845 0.0833
Entamoeba histolytica protein kinase domain containing protein 0.0087 0.1891 0.4205
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.006 0.1181 0.4742
Loa Loa (eye worm) hypothetical protein 0.0086 0.1855 0.1852
Plasmodium vivax serine/threonine kinase-1, putative 0.006 0.1181 0.4742
Plasmodium falciparum thioredoxin reductase 0.0103 0.2289 1
Brugia malayi Protein kinase domain containing protein 0.006 0.1181 0.1178
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0086 0.1855 0.1861
Plasmodium falciparum glutathione reductase 0.0036 0.0575 0.1865
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0967 0.4013
Schistosoma mansoni zinc finger protein 0.0022 0.0236 0.0214
Loa Loa (eye worm) hypothetical protein 0.0086 0.1855 0.1852
Loa Loa (eye worm) hypothetical protein 0.004 0.0675 0.0673
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0026 0.0027
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0029 0.0003
Leishmania major protein kinase, putative 0.006 0.1181 0.4985
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0707 0.2493
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0112 0.0406
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0086 0.1855 0.1852
Loa Loa (eye worm) hypothetical protein 0.007 0.1444 0.1442
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0086 0.1855 0.1883
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0026 0.0322 0.0327
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0575 0.224
Plasmodium falciparum protein serine/threonine kinase-1 0.006 0.1181 0.4742
Brugia malayi glutathione reductase 0.0103 0.2289 0.2287
Brugia malayi Uncoordinated protein 44 0.0014 0.0026 0.0023
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0639 0.0648
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0322 0.0344
Loa Loa (eye worm) hypothetical protein 0.004 0.0675 0.0673
Loa Loa (eye worm) RNA binding protein 0.0135 0.3109 0.3107
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0322 0.0327
Echinococcus granulosus Ankyrin 0.0014 0.0029 0.003
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0707 0.3186
Schistosoma mansoni nAChR subunit 0.0086 0.1855 0.1861
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0415 0.0421
Trichomonas vaginalis porcupine, putative 0.0026 0.0322 0.1386
Loa Loa (eye worm) hypothetical protein 0.0046 0.0845 0.0842
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0042 0.0016
Schistosoma mansoni sterol O-acyltransferase 1 0.0264 0.6381 0.6468
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0086 0.1855 0.1883
Schistosoma mansoni hypothetical protein 0.0032 0.0489 0.0471
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0086 0.1855 0.1883
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0046 0.0845 0.0842
Brugia malayi MAP kinase sur-1 0.0051 0.0967 0.0964
Onchocerca volvulus 0.004 0.0675 0.2936
Echinococcus multilocularis chromobox protein 1 0.0068 0.1401 0.1422
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.004 0.0675 0.0673
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0575 0.224
Loa Loa (eye worm) hypothetical protein 0.0238 0.5725 0.5724
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0322 0.0319
Loa Loa (eye worm) CMGC/CLK protein kinase 0.006 0.1181 0.1178
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0086 0.1855 0.1852
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0707 0.2839
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0489 0.0486
Echinococcus granulosus glycine receptor subunit beta 0.0086 0.1855 0.1883
Loa Loa (eye worm) hypothetical protein 0.0086 0.1855 0.1852
Onchocerca volvulus 0.0086 0.1855 0.8269
Brugia malayi hypothetical protein 0.004 0.0675 0.0673
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0087 0.1891 0.82
Echinococcus multilocularis muscleblind protein 0.0312 0.7596 0.7712
Loa Loa (eye worm) hypothetical protein 0.004 0.0675 0.0673
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0026 0.0322 0.0327
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0707 0.0718
Entamoeba histolytica vacuolar protein sorting 26 0.0026 0.0322 0.0344
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0026 0.0322 0.0301
Loa Loa (eye worm) hypothetical protein 0.0046 0.0845 0.0842
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0967 0.4398
Schistosoma mansoni tar DNA-binding protein 0.0135 0.3109 0.3138
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.006 0.1181 0.4985
Schistosoma mansoni tar DNA-binding protein 0.0135 0.3109 0.3138
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0665 0.0662
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0087 0.1891 0.82
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0098 0.2166 1
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.006 0.1181 0.4985
Schistosoma mansoni survival motor neuron protein 0.0053 0.1025 0.1017
Brugia malayi MBOAT family protein 0.0026 0.0322 0.0319
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0322 0.0327
Leishmania major glycerol uptake protein, putative 0.0026 0.0322 0.1094
Loa Loa (eye worm) glutathione reductase 0.0103 0.2289 0.2287
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0489 0.0496
Echinococcus multilocularis GPCR, family 2 0.0032 0.0489 0.0496
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0967 0.3724
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0489 0.0486
Brugia malayi hypothetical protein 0.004 0.0675 0.0673
Schistosoma mansoni zinc finger protein 0.0016 0.008 0.0055
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0575 0.0584
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.004 0.0675 0.0686
Brugia malayi Protein kinase domain containing protein 0.0087 0.1891 0.1889
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0086 0.1855 0.1883
Loa Loa (eye worm) hypothetical protein 0.0086 0.1855 0.1852
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0967 0.4013
Brugia malayi hypothetical protein 0.004 0.0675 0.0673
Loa Loa (eye worm) hypothetical protein 0.0086 0.1855 0.1852
Echinococcus multilocularis dual specificity 0.0087 0.1891 0.192
Echinococcus granulosus cpg binding protein 0.0032 0.0473 0.048
Loa Loa (eye worm) hypothetical protein 0.0046 0.0845 0.0842
Onchocerca volvulus 0.0028 0.0381 0.1603
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0707 0.2839
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0575 0.224
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0707 0.3186
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.1513 0.1536
Leishmania major protein kinase, putative 0.006 0.1181 0.4985
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0086 0.1855 0.1883
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0575 0.224
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1183 0.1177
Schistosoma mansoni hypothetical protein 0.0032 0.0489 0.0471
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0235 0.565 0.8912
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0086 0.1855 0.1852
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0415 0.1106
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0354 0.1539
Echinococcus granulosus glycine receptor subunit alpha 1 0.0086 0.1855 0.1883
Echinococcus granulosus nAChR subunit 0.0086 0.1855 0.1883
Loa Loa (eye worm) hypothetical protein 0.0101 0.2237 0.2235
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0638 0.2864
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0086 0.1855 0.1852
Brugia malayi Cation transporter family protein 0.0086 0.1855 0.1852
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0086 0.1855 0.1883
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0046 0.0845 0.0833
Schistosoma mansoni nAChR subunit 0.0086 0.1855 0.1861
Loa Loa (eye worm) hypothetical protein 0.0086 0.1855 0.1852
Brugia malayi Death domain containing protein 0.0014 0.0026 0.0023
Loa Loa (eye worm) hypothetical protein 0.004 0.0675 0.0673
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0235 0.565 0.8912
Schistosoma mansoni inositol monophosphatase 0.0041 0.0707 0.0693
Loa Loa (eye worm) hypothetical protein 0.0086 0.1855 0.1852
Schistosoma mansoni serine/threonine protein kinase 0.006 0.1181 0.1176
Schistosoma mansoni tar DNA-binding protein 0.0135 0.3109 0.3138
Loa Loa (eye worm) hypothetical protein 0.018 0.4248 0.4246
Loa Loa (eye worm) LGC-31 protein 0.0086 0.1855 0.1852
Loa Loa (eye worm) hypothetical protein 0.0046 0.0845 0.0842
Loa Loa (eye worm) acetylcholine receptor protein 0.004 0.0675 0.0673
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.004 0.0675 0.0673
Brugia malayi CAAX amino terminal protease family protein 0.0098 0.2166 0.2164
Schistosoma mansoni zinc finger protein 0.0026 0.0322 0.0301
Loa Loa (eye worm) hypothetical protein 0.0026 0.0322 0.0319
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0712 0.3209
Loa Loa (eye worm) hypothetical protein 0.0102 0.2267 0.2265
Loa Loa (eye worm) hypothetical protein 0.0029 0.0415 0.0412
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0967 0.4398
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0086 0.1855 0.1852
Toxoplasma gondii hypothetical protein 0.0026 0.0322 0.0664
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0707 0.3186
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0415 0.1106
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0707 0.2839
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0322 0.1094
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0086 0.1855 0.1852
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0381 0.0378
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0638 0.2767
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0967 0.315
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0112 0.0406
Echinococcus multilocularis survival motor neuron protein 1 0.0262 0.6332 0.6429
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0086 0.1855 0.1852
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0354 0.1539
Loa Loa (eye worm) hypothetical protein 0.0086 0.1855 0.1852
Brugia malayi PHD-finger family protein 0.0028 0.0381 0.0378
Brugia malayi MBOAT family protein 0.0026 0.0322 0.0319
Echinococcus multilocularis chromobox protein 1 0.0068 0.1401 0.1422
Loa Loa (eye worm) hypothetical protein 0.0046 0.0845 0.0842
Echinococcus granulosus glycine receptor subunit alpha 1 0.0086 0.1855 0.1883
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0112 0.0406
Echinococcus granulosus zinc finger protein 0.0022 0.0236 0.024
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0322 0.1386
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0261 0.6318 1
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0086 0.1855 0.1883
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0575 0.2569
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0575 0.224
Treponema pallidum alginate O-acetylation protein (algI) 0.0026 0.0322 0.3559
Plasmodium falciparum phd finger protein, putative 0.0029 0.0415 0.1106
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0575 0.1865
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0086 0.1855 0.1883
Brugia malayi CHD4 protein 0.0015 0.0042 0.0039
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0026 0.0322 0.0327
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0322 0.0301
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0638 0.2864
Loa Loa (eye worm) hypothetical protein 0.0058 0.1147 0.1144
Onchocerca volvulus 0.0086 0.1855 0.8269
Echinococcus multilocularis nAChR subunit 0.0086 0.1855 0.1883
Onchocerca volvulus 0.004 0.0675 0.2936
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0127 0.0129
Brugia malayi MBOAT family protein 0.0026 0.0322 0.0319
Trypanosoma cruzi trypanothione reductase, putative 0.0103 0.2289 1
Brugia malayi Hhat protein 0.0026 0.0322 0.0319
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0026 0.0322 0.0301
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0026 0.0322 0.0664
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0575 0.224
Mycobacterium tuberculosis Probable oxidoreductase 0.0261 0.6318 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0334 0.0331
Echinococcus multilocularis cpg binding protein 0.0032 0.0473 0.048
Plasmodium falciparum glutathione reductase 0.0103 0.2289 1
Loa Loa (eye worm) hypothetical protein 0.0312 0.7596 0.7596
Onchocerca volvulus 0.0053 0.1025 0.4519
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0322 0.0327
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0575 0.1865
Schistosoma mansoni nAChR subunit 0.004 0.0675 0.0661
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0103 0.2289 0.3434
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0026 0.000000021283
Loa Loa (eye worm) hypothetical protein 0.004 0.0675 0.0673
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0026 0.0322 0.0327
Leishmania major glycerol uptake protein, putative 0.0026 0.0322 0.1094
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0086 0.1855 0.1883
Entamoeba histolytica hypothetical protein 0.0046 0.0845 0.1631
Schistosoma mansoni acetylcholine receptor-related 0.004 0.0675 0.0661
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0026 0.0322 0.0327
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0575 0.0558
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0235 0.565 0.8912
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0322 0.0344
Plasmodium vivax thioredoxin reductase, putative 0.0103 0.2289 1
Onchocerca volvulus 0.0046 0.0845 0.3702
Loa Loa (eye worm) hhat protein 0.0026 0.0322 0.0319
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0575 0.7484
Loa Loa (eye worm) hypothetical protein 0.0388 0.9547 0.9547
Leishmania major hypothetical protein, conserved 0.0026 0.0322 0.1094
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.004 0.0675 0.0673
Echinococcus granulosus dual specificity 0.0087 0.1891 0.192
Loa Loa (eye worm) hypothetical protein 0.0026 0.0322 0.0319
Schistosoma mansoni cpg binding protein 0.0032 0.0473 0.0455
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0322 0.1094
Brugia malayi Bromodomain containing protein 0.0032 0.0479 0.0476
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0967 0.4013
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0639 0.0648
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0967 0.0981
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0135 0.3109 0.3107
Onchocerca volvulus 0.0086 0.1855 0.8269
Schistosoma mansoni tar DNA-binding protein 0.0135 0.3109 0.3138
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0967 0.0964
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0322 0.1094
Loa Loa (eye worm) hypothetical protein 0.0086 0.1855 0.1852
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0575 0.1865
Schistosoma mansoni cpg binding protein 0.0028 0.0381 0.0361
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0322 0.0344
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0086 0.1855 0.1883
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0086 0.1855 0.1852
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0026 0.0322 0.0327
Loa Loa (eye worm) hypothetical protein 0.0086 0.1855 0.1852
Loa Loa (eye worm) hhat protein 0.0026 0.0322 0.0319
Brugia malayi Protein kinase domain containing protein 0.0016 0.0061 0.0058
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.004 0.0675 0.0686
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0967 0.4013
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0967 0.0981
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0112 0.0406
Schistosoma mansoni inositol monophosphatase 0.0041 0.0707 0.0693
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.004 0.0675 0.0686
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0967 0.4398
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0575 0.2569
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.2119 0.2151
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.006 0.1181 0.4985
Loa Loa (eye worm) hypothetical protein 0.004 0.0675 0.0673
Loa Loa (eye worm) hypothetical protein 0.0086 0.1855 0.1852
Schistosoma mansoni cpg binding protein 0.0032 0.0473 0.0455
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0026 0.0322 0.0301
Onchocerca volvulus 0.0101 0.2237 1
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0086 0.1855 0.1883
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1085 0.4284
Brugia malayi RNA recognition motif domain containing protein 0.0135 0.3109 0.3107
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0575 0.224
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0037 0.0055
Brugia malayi hypothetical protein 0.0262 0.6332 0.6331
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0086 0.1855 0.1852
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0086 0.1855 0.1861
Schistosoma mansoni hypothetical protein 0.0029 0.0415 0.0395
Schistosoma mansoni hypothetical protein 0.007 0.1444 0.1443
Loa Loa (eye worm) hypothetical protein 0.0262 0.6332 0.6331
Schistosoma mansoni hypothetical protein 0.0022 0.0224 0.0202
Echinococcus granulosus sterol O acyltransferase 1 0.0264 0.6381 0.6478
Echinococcus granulosus GPCR family 2 0.0032 0.0489 0.0496
Loa Loa (eye worm) hypothetical protein 0.004 0.0675 0.0673
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0322 0.1386
Echinococcus multilocularis 0.0058 0.1147 0.1164
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0575 0.7484
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0181 0.0178
Trypanosoma brucei trypanothione reductase 0.0103 0.2289 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0037 0.0055
Trichomonas vaginalis chromobox protein, putative 0.0068 0.1401 0.6424
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0322 0.0319
Loa Loa (eye worm) hypothetical protein 0.0086 0.1855 0.1852
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0086 0.1855 0.1852
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0086 0.1855 0.1852
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0322 0.1094
Loa Loa (eye worm) hypothetical protein 0.004 0.0675 0.0673
Loa Loa (eye worm) inositol-1 0.0041 0.0707 0.0704
Loa Loa (eye worm) hypothetical protein 0.0026 0.0322 0.0319
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0101 0.2237 0.2251
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.2119 0.2151
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.004 0.0675 0.0673
Leishmania major glycerol uptake protein, putative 0.0026 0.0322 0.1094
Loa Loa (eye worm) hypothetical protein 0.0041 0.0705 0.0702
Loa Loa (eye worm) TAR-binding protein 0.0135 0.3109 0.3107
Schistosoma mansoni neurotransmitter gated ion channel 0.004 0.0675 0.0661
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0322 0.0327
Loa Loa (eye worm) hypothetical protein 0.004 0.0675 0.0673
Loa Loa (eye worm) hypothetical protein 0.0086 0.1855 0.1852
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0127 0.0103
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0575 0.1865
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.004 0.0675 0.0686
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0708 0.0719
Trypanosoma cruzi GUP1, putative 0.0026 0.0322 0.1094
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0026 0.0322 0.0664
Brugia malayi TAR-binding protein 0.0135 0.3109 0.3107
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0086 0.1855 0.1883
Trichomonas vaginalis CMGC family protein kinase 0.006 0.1181 0.54
Echinococcus granulosus death domain containing protein 0.0014 0.0026 0.0027
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0665 0.065
Echinococcus granulosus survival motor neuron protein 1 0.0262 0.6332 0.6429
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.004 0.0675 0.0673
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0098 0.2166 0.2178
Echinococcus granulosus tar DNA binding protein 0.0135 0.3109 0.3157
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.2267 0.2265
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0575 0.224
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0042 0.0039
Echinococcus multilocularis dnaJ subfamily B 0.04 0.985 1
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0087 0.1891 0.1889
Schistosoma mansoni bromodomain containing protein 0.0069 0.142 0.1418
Brugia malayi diacylglycerol acyltransferase 0.0026 0.0322 0.0319
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0026 0.0322 0.0319
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0575 0.224
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0665 0.065
Brugia malayi MBOAT family protein 0.0026 0.0322 0.0319
Entamoeba histolytica hypothetical protein, conserved 0.0026 0.0322 0.0344
Schistosoma mansoni hypothetical protein 0.0032 0.0489 0.0471
Loa Loa (eye worm) hypothetical protein 0.0032 0.0489 0.0486
Brugia malayi Trypsin family protein 0.0101 0.2237 0.2235
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0575 0.0914
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0712 0.3101
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0026 0.0322 0.0664
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0261 0.6318 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0086 0.1855 0.1861
Loa Loa (eye worm) hypothetical protein 0.0075 0.158 0.1578
Leishmania major glycerol uptake protein, putative 0.0026 0.0322 0.1094
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0575 0.0572
Plasmodium falciparum thioredoxin reductase 0.0036 0.0575 0.1865
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.006 0.1181 0.4985
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0712 0.3209
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0112 0.0406
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0088 0.0063
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0575 0.224
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0026 0.0322 0.0664
Loa Loa (eye worm) hypothetical protein 0.004 0.0675 0.0673
Echinococcus multilocularis nAChR subunit 0.0046 0.0845 0.0858
Onchocerca volvulus 0.003 0.0428 0.1817
Loa Loa (eye worm) hypothetical protein 0.0046 0.0845 0.0842
Echinococcus multilocularis glycine receptor subunit beta 0.0086 0.1855 0.1883
Brugia malayi CXXC zinc finger family protein 0.0028 0.0381 0.0378
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.1444 0.1442
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0575 0.224
Echinococcus multilocularis muscleblind protein 1 0.0312 0.7596 0.7712
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0144 0.0141
Loa Loa (eye worm) hypothetical protein 0.0101 0.2237 0.2235
Brugia malayi jmjC domain containing protein 0.0039 0.0665 0.0662
Schistosoma mansoni hypothetical protein 0.0016 0.008 0.0055
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0575 0.224
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0086 0.1855 0.1883
Echinococcus granulosus thioredoxin glutathione reductase 0.0103 0.2289 0.2324
Echinococcus granulosus CAAX prenyl protease 2 0.0098 0.2166 0.2199
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0046 0.0845 0.0842
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0322 0.0319
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0415 0.0421
Loa Loa (eye worm) hypothetical protein 0.0086 0.1855 0.1852
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0322 0.0327
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0086 0.1855 0.1852
Brugia malayi jmjC domain containing protein 0.0096 0.2119 0.2117
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0489 0.0496
Loa Loa (eye worm) hypothetical protein 0.0046 0.0845 0.0842
Trichomonas vaginalis chromobox protein, putative 0.0068 0.1401 0.6424
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0042 0.0043
Schistosoma mansoni nAChR subunit 0.0086 0.1855 0.1861
Loa Loa (eye worm) hypothetical protein 0.0086 0.1857 0.1855
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.1212 0.121
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0026
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0415 0.0412
Loa Loa (eye worm) ACC-1 protein 0.0086 0.1855 0.1852
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0087 0.1891 0.82
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0489 0.0496
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0086 0.1855 0.1883
Loa Loa (eye worm) hypothetical protein 0.0264 0.6381 0.638
Loa Loa (eye worm) thioredoxin reductase 0.0103 0.2289 0.2287
Loa Loa (eye worm) hypothetical protein 0.0312 0.7596 0.7596
Giardia lamblia Hypothetical protein 0.0098 0.2166 1
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0086 0.1855 0.1852
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0026 0.0322 0.0327
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0261 0.6318 1
Echinococcus granulosus glycine receptor subunit beta 0.0086 0.1855 0.1883
Onchocerca volvulus 0.0026 0.0322 0.1335
Echinococcus granulosus muscleblind protein 0.0312 0.7596 0.7712
Onchocerca volvulus Alhambra homolog 0.0029 0.0415 0.1757
Loa Loa (eye worm) hypothetical protein 0.0086 0.1855 0.1852
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0098 0.2166 0.2178
Entamoeba histolytica hypothetical protein 0.0087 0.1891 0.4205
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0036 0.0575 0.0641
Brugia malayi hypothetical protein 0.004 0.0675 0.0673
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0026 0.0322 0.0327
Echinococcus granulosus dnaJ subfamily B 0.04 0.985 1
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0086 0.1855 0.1883
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0317 0.0322
Brugia malayi excitatory GABA receptor EXP-1A 0.0086 0.1855 0.1852
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0322 0.1386
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0575 0.224
Onchocerca volvulus 0.0086 0.1855 0.8269
Onchocerca volvulus 0.0046 0.0845 0.3702
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0317 0.0322
Loa Loa (eye worm) hypothetical protein 0.0047 0.0861 0.0858
Leishmania major trypanothione reductase 0.0103 0.2289 1
Echinococcus multilocularis CAAX prenyl protease 2 0.0098 0.2166 0.2199
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0098 0.2166 0.9444
Loa Loa (eye worm) ACC-1 protein 0.0086 0.1855 0.1852
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.006 0.1181 0.4985
Schistosoma mansoni hypothetical protein 0.0032 0.0489 0.0471
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0143 0.0119
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0086 0.1855 0.1852
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0575 0.1865
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0101 0.2237 0.2251
Loa Loa (eye worm) hypothetical protein 0.0038 0.0638 0.0635
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0026 0.0027
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0086 0.1855 0.1861
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0415 0.1106
Loa Loa (eye worm) hypothetical protein 0.0086 0.1857 0.1855
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0143 0.0119
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.018 0.4248 1
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0026 0.0322 0.0327
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0086 0.1855 0.1852
Echinococcus granulosus dual specificity protein kinase clk2 0.006 0.1181 0.1199
Trypanosoma brucei protein kinase, putative 0.0051 0.0967 0.4013
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0334 0.0331
Trichomonas vaginalis transmembrane protein nessy, putative 0.0026 0.0322 0.1386
Mycobacterium tuberculosis Probable dehydrogenase 0.0235 0.565 0.8912
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0575 0.224
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0967 0.4013
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0086 0.1855 0.1852
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0572 0.0581
Echinococcus granulosus hypothetical protein 0.0058 0.1147 0.1164
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0127 0.0103
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.004 0.0675 0.0673
Schistosoma mansoni nAChR subunit 0.0086 0.1855 0.1861
Schistosoma mansoni hypothetical protein 0.04 0.985 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.1513 0.1536
Schistosoma mansoni hypothetical protein 0.0053 0.1025 0.1017
Onchocerca volvulus 0.004 0.0675 0.2936
Echinococcus multilocularis Ankyrin 0.0014 0.0029 0.003
Loa Loa (eye worm) hypothetical protein 0.0046 0.0845 0.0842
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0707 0.1292
Brugia malayi Cation transporter family protein 0.0086 0.1855 0.1852
Loa Loa (eye worm) hypothetical protein 0.0043 0.0769 0.0766
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.1025 0.1023
Onchocerca volvulus 0.0086 0.1855 0.8269
Giardia lamblia Kinase, CMGC CLK 0.006 0.1181 0.4375
Schistosoma mansoni neurotransmitter gated ion channel 0.004 0.0675 0.0661
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0235 0.565 0.8833
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0026 0.0322 0.0319
Echinococcus granulosus peregrin 0.0032 0.0479 0.0486
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0086 0.1855 0.1883
Schistosoma mansoni nAChR subunit 0.0086 0.1855 0.1861
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0707 0.0718
Brugia malayi Heterochromatin protein 1 0.0068 0.1401 0.1398
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0575 0.224
Entamoeba histolytica protein kinase, putative 0.0087 0.1891 0.4205
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0046 0.0845 0.0842
Brugia malayi PHD-finger family protein 0.0029 0.0415 0.0412
Brugia malayi chromobox protein homolog 3 0.0038 0.0638 0.0635
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0026 0.0322 0.0327
Echinococcus granulosus glycine receptor subunit alpha 1 0.0086 0.1855 0.1883
Echinococcus multilocularis sterol O acyltransferase 1 0.0264 0.6381 0.6478
Entamoeba histolytica protein kinase, putative 0.0087 0.1891 0.4205
Entamoeba histolytica hypothetical protein 0.0026 0.0322 0.0344
Echinococcus granulosus chromobox protein 1 0.0068 0.1401 0.1422
Onchocerca volvulus 0.0086 0.1855 0.8269
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0046 0.0845 0.0842
Toxoplasma gondii thioredoxin reductase 0.0103 0.2289 1
Schistosoma mansoni nAChR subunit 0.0086 0.1855 0.1861
Loa Loa (eye worm) hypothetical protein 0.005 0.095 0.0947
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0489 0.0496
Brugia malayi Muscleblind-like protein 0.0312 0.7596 0.7596
Schistosoma mansoni chromobox protein 0.0068 0.1401 0.1399
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0575 0.224
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0322 0.0301
Entamoeba histolytica CAAX prenyl protease family 0.0098 0.2166 0.4881
Brugia malayi Cation transporter family protein 0.0086 0.1855 0.1852
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0143 0.0145
Brugia malayi hypothetical protein 0.004 0.0675 0.0673
Trypanosoma brucei CAAX amino terminal protease, putative 0.0098 0.2166 0.9444
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0112 0.0406
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0086 0.1855 0.1883
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0026 0.0023
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.1323 0.1343
Schistosoma mansoni chromobox protein 0.0068 0.1401 0.1399
Leishmania major glycerol uptake protein, putative 0.0026 0.0322 0.1094
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0967 0.4398
Schistosoma mansoni tar DNA-binding protein 0.0135 0.3109 0.3138
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0086 0.1855 0.1852
Loa Loa (eye worm) hypothetical protein 0.004 0.0675 0.0673
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0235 0.565 0.8912
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0415 0.0395
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0967 0.0957
Loa Loa (eye worm) hypothetical protein 0.0014 0.0026 0.0023
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0317 0.0296
Schistosoma mansoni nAChR subunit 0.0086 0.1855 0.1861
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0665 0.0675
Loa Loa (eye worm) hypothetical protein 0.004 0.0675 0.0673
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.004 0.0675 0.0673
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0575 0.0584
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0575 0.1865
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0489 0.0486
Schistosoma mansoni serine/threonine protein kinase 0.006 0.1181 0.1176
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0707 1
Onchocerca volvulus 0.0094 0.207 0.9242
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.1401 0.1398
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0967 0.0981
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0098 0.2166 0.9444
Brugia malayi RNA binding protein 0.0135 0.3109 0.3107
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0598 0.0678
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.2267 0.2265
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.1891 0.1899
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0967 0.0981
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0098 0.2166 0.9444
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0086 0.1855 0.1861
Schistosoma mansoni jumonji domain containing protein 0.0077 0.1615 0.1617
Schistosoma mansoni hypothetical protein 0.0026 0.0322 0.0301
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.006 0.1181 0.4985
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0036 0.0575 1
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0087 0.1891 0.82
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0322 0.0301
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0707 0.2839
Loa Loa (eye worm) GABA receptor subunit 0.0046 0.0845 0.0842
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0322 0.1094
Loa Loa (eye worm) hypothetical protein 0.004 0.0675 0.0673
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.2267 0.2265
Loa Loa (eye worm) hypothetical protein 0.0098 0.2166 0.2164
Treponema pallidum NADH oxidase 0.0036 0.0575 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0143 0.014

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 31 nM Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester after 24 hrs ChEMBL. 19464189

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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