TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 308.328 | Formula: C14H13FN2O3S
H donors: 2 H acceptors: 3 LogP: 1.36 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccc(cc1F)S(=O)(=O)N)Cc1ccccc1
InChi: 1S/C14H13FN2O3S/c15-12-9-11(21(16,19)20)6-7-13(12)17-14(18)8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,17,18)(H2,16,19,20)
InChiKey: NPXJDOTWYYSLEJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	carbonic anhydrase II	Starlite/ChEMBL	References
Homo sapiens	carbonic anhydrase I	Starlite/ChEMBL	References
Homo sapiens	carbonic anhydrase VII	Starlite/ChEMBL	References
Homo sapiens	carbonic anhydrase VB, mitochondrial	Starlite/ChEMBL	References
Homo sapiens	carbonic anhydrase VA, mitochondrial	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania mexicana	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Echinococcus granulosus	carbonic anhydrase II	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma congolense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma brucei gambiense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma brucei	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania major	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Echinococcus multilocularis	carbonic anhydrase II	Get druggable targets OG5_127628	All targets in OG5_127628
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania donovani	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Brugia malayi	Putative carbonic anhydrase 5 precursor	Get druggable targets OG5_127628	All targets in OG5_127628
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	Get druggable targets OG5_127628	All targets in OG5_127628
Loa Loa (eye worm)	carbonic anhydrase 3	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania infantum	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Schistosoma japonicum	ko:K01672 carbonic anhydrase [EC4.2.1.1], putative	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma congolense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania braziliensis	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	carbonic anhydrase-like protein	carbonic anhydrase I	261 aa	281 aa	25.3 %
Leishmania major	carbonic anhydrase-like protein	carbonic anhydrase VA, mitochondrial	305 aa	255 aa	25.9 %
Trypanosoma brucei	carbonic anhydrase-like protein	carbonic anhydrase VB, mitochondrial	317 aa	287 aa	24.7 %
Brugia malayi	Carbonic anhydrase like protein 2 precursor	carbonic anhydrase II	260 aa	259 aa	32.0 %
Brugia malayi	Carbonic anhydrase like protein 2 precursor	carbonic anhydrase VII	208 aa	212 aa	33.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0233	0.1028	0.1028
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0649	0.3034	0.4717
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0038	0.0087	0.0127
Schistosoma mansoni	hypothetical protein	0.0064	0.0212	0.0212
Plasmodium vivax	vivapain-2	0.0033	0.006	0.1209
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0077	0.02
Onchocerca volvulus		0.0039	0.009	0.0239
Schistosoma mansoni	coup transcription factor	0.0041	0.0102	0.0102
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.009	0.009
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0041	0.0102	0.0147
Brugia malayi	Cathepsin L-like precursor	0.0033	0.006	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0235	0.1038	0.1608
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0065	0.0167
Echinococcus granulosus	g protein coupled receptor	0.0039	0.009	0.009
Brugia malayi	mothers against decapentaplegic homolog 3	0.0041	0.0101	0.0145
Brugia malayi	enteropeptidase precursor	0.0137	0.0563	0.0865
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0039	0.009	0.009
Echinococcus multilocularis	neuropeptide receptor A26	0.0039	0.009	0.009
Schistosoma mansoni	alpha glucosidase	0.0038	0.0087	0.0087
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0041	0.0102	0.015
Toxoplasma gondii	thioredoxin reductase	0.0049	0.0139	0.1723
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0137	0.0563	0.0865
Loa Loa (eye worm)	steroid hormone receptor	0.0041	0.0102	0.015
Echinococcus granulosus	tm gpcr rhodopsin	0.0039	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0039	0.009	0.009
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.002	0.0047
Schistosoma mansoni	bromodomain containing protein	0.0066	0.0218	0.0218
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0041	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0563	0.0868
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.009	0.009
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0039	0.009	0.0129
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0037	0.0037
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0087	0.0228
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.006	0.0151
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0039	0.009	0.009
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0124	0.0503	0.2756
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0041	0.0102	0.015
Echinococcus multilocularis	neuropeptide Y receptor	0.0039	0.009	0.009
Onchocerca volvulus		0.0039	0.009	0.0239
Echinococcus multilocularis	neuropeptide s receptor	0.0039	0.009	0.009
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.009	0.009
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0233	0.1028	0.1028
Schistosoma mansoni	Smad4	0.0041	0.0101	0.0101
Brugia malayi	AKH receptor	0.0039	0.009	0.0129
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0039	0.009	0.009
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0395	0.1808	0.2807
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Brugia malayi	follicle stimulating hormone receptor	0.0039	0.009	0.0129
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0145	0.0601	0.3282
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0041	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.009	0.009
Entamoeba histolytica	cysteine protease, putative	0.0033	0.006	0.0346
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0064	0.0212	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Schistosoma mansoni	retinoic acid receptor RXR	0.0041	0.0102	0.0102
Echinococcus multilocularis	GPCR, family 2	0.0064	0.0212	0.0212
Echinococcus granulosus	low density lipoprotein receptor ldl	0.0137	0.0563	0.0563
Brugia malayi	hypothetical protein	0.0334	0.1514	0.2347
Entamoeba histolytica	hypothetical protein	0.0334	0.1514	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0062	0.0201	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0008	0.0004
Brugia malayi	larval opioid receptor	0.0039	0.009	0.0129
Schistosoma mansoni	smad	0.0041	0.0101	0.0101
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0039	0.009	0.009
Brugia malayi	Dopamine receptor protein 2	0.0039	0.009	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0563	0.0868
Trypanosoma cruzi	cysteine peptidase, putative	0.0124	0.0503	0.2735
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0039	0.009	0.009
Brugia malayi	Papain family cysteine protease containing protein	0.0033	0.006	0.0081
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0039	0.009	0.009
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0124	0.0503	0.2756
Brugia malayi	Cathepsin L-like precursor	0.0033	0.006	0.0081
Onchocerca volvulus		0.0039	0.009	0.0239
Brugia malayi	hypothetical protein	0.0039	0.009	0.0129
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0137	0.0563	0.0865
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.009	0.009
Brugia malayi	hypothetical protein	0.0039	0.009	0.0129
Loa Loa (eye worm)	G-protein coupled receptor	0.0039	0.009	0.0133
Schistosoma mansoni	hypothetical protein	0.0357	0.1622	0.1622
Leishmania major	cathepsin L-like protease	0.0033	0.006	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0102	0.015
Echinococcus multilocularis	survival motor neuron protein 1	0.0235	0.1038	0.1038
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0087	0.0228
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0039	0.009	0.009
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0045	0.0122	0.0642
Leishmania major	cysteine peptidase A (CPA)	0.0033	0.006	0.0271
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0065	0.0167
Schistosoma mansoni	opsin-like receptor	0.0039	0.009	0.009
Schistosoma mansoni	RAR-like nuclear receptor	0.0041	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Echinococcus granulosus	tumor protein p63	0.1071	0.5068	0.5068
Schistosoma mansoni	neuropeptide F-like receptor	0.0039	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Echinococcus multilocularis	fmrfamide receptor	0.0039	0.009	0.009
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0037	0.0082	0.0082
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0137	0.0563	0.0865
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0041	0.0102	0.0102
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0172	0.0733	0.0733
Onchocerca volvulus		0.0033	0.006	0.0151
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0124	0.0503	0.2756
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0124	0.0503	0.2756
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0124	0.0502	0.687
Onchocerca volvulus		0.0137	0.0563	0.1604
Plasmodium vivax	glutathione reductase, putative	0.0049	0.0139	0.3593
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0137	0.0563	0.0563
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.009	0.009
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0039	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0563	0.0868
Echinococcus multilocularis	geminin	0.0357	0.1622	0.1622
Echinococcus multilocularis	ferritin	0.0044	0.0113	0.0113
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0033	0.006	0.0085
Onchocerca volvulus		0.0041	0.0102	0.0271
Brugia malayi	RNA, U transporter 1	0.0079	0.0284	0.0431
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0563	0.0868
Echinococcus multilocularis	low density lipoprotein receptor protein	0.0137	0.0563	0.0563
Entamoeba histolytica	hypothetical protein	0.0334	0.1514	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0334	0.1514	0.1514
Echinococcus granulosus	mothers against decapentaplegic 6	0.0041	0.0101	0.0101
Toxoplasma gondii	hypothetical protein	0.0049	0.014	0.1744
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0712	0.11
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0041	0.0102	0.0102
Plasmodium vivax	vivapain-2	0.0033	0.006	0.1209
Brugia malayi	MH1 domain containing protein	0.0051	0.0148	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0563	0.0868
Echinococcus multilocularis	cathepsin L cysteine protease	0.0033	0.006	0.006
Brugia malayi	steroid hormone receptor	0.0041	0.0102	0.0147
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.006	0.0151
Schistosoma mansoni	carbonic anhydrase-related	0.0168	0.0712	0.0712
Brugia malayi	CUB domain containing protein	0.0137	0.0563	0.0865
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0122	0.0329
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0039	0.009	0.009
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0039	0.009	0.009
Schistosoma mansoni	apoferritin-2	0.0044	0.0113	0.0113
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0041	0.0102	0.015
Schistosoma mansoni	apoferritin-2	0.0044	0.0113	0.0113
Schistosoma mansoni	biogenic amine receptor	0.0039	0.009	0.009
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0111	0.0437	0.0437
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.006	0.0151
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0137	0.0563	0.0868
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.002	0.0076
Loa Loa (eye worm)	MH2 domain-containing protein	0.0092	0.0347	0.0532
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0033	0.006	0.058
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0041	0.0102	0.0102
Onchocerca volvulus		0.0039	0.009	0.0239
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.006	0.0151
Brugia malayi	MH2 domain containing protein	0.0092	0.0347	0.0528
Schistosoma mansoni	hypothetical protein	0.0039	0.009	0.009
Schistosoma mansoni	hypothetical protein	0.0039	0.009	0.009
Echinococcus granulosus	carbonic anhydrase II	0.0395	0.1808	0.1808
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0112	0.0442	0.5807
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0041	0.0102	0.0102
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.006	0.0151
Echinococcus granulosus	neuropeptide FF receptor 2	0.0039	0.009	0.009
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0064	0.0212	0.0212
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.006	0.0151
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0039	0.009	0.009
Echinococcus multilocularis	carbonic anhydrase II	0.0395	0.1808	0.1808
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0038	0.0087	0.0524
Echinococcus multilocularis	serotonin receptor	0.0039	0.009	0.009
Brugia malayi	Calcium binding EGF domain containing protein	0.0137	0.0563	0.0865
Echinococcus multilocularis	Low density lipoprotein receptor, class A, cysteine rich	0.0137	0.0563	0.0563
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0008	0.0004
Echinococcus multilocularis	allatostatin A receptor	0.0039	0.009	0.009
Schistosoma mansoni	hypothetical protein	0.0021	0.0005	0.0005
Echinococcus multilocularis	serotonin receptor	0.0039	0.009	0.009
Schistosoma mansoni	smad1 5 8 and	0.0092	0.0347	0.0347
Onchocerca volvulus		0.0033	0.006	0.0151
Echinococcus granulosus	cathepsin l1	0.0033	0.006	0.006
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0045	0.0122	0.0615
Brugia malayi	basement membrane proteoglycan precursor	0.0137	0.0563	0.0865
Echinococcus granulosus	somatostatin receptor	0.0039	0.009	0.009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0065	0.0167
Onchocerca volvulus		0.0039	0.009	0.0239
Echinococcus granulosus	neuropeptide s receptor	0.0039	0.009	0.009
Brugia malayi	Cathepsin L-like precursor	0.0033	0.006	0.0081
Mycobacterium tuberculosis	Probable reductase	0.0112	0.0442	0.5807
Leishmania major	carbonic anhydrase-like protein	0.0395	0.1808	1
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0038	0.0087	0.0228
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0039	0.009	0.009
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0039	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Loa Loa (eye worm)	neuropeptide F receptor	0.0039	0.009	0.0133
Loa Loa (eye worm)	MH2 domain-containing protein	0.0041	0.0101	0.0149
Schistosoma mansoni	growth hormone secretagogue receptor	0.0039	0.009	0.009
Trypanosoma cruzi	target of rapamycin kinase 3	0.0036	0.0077	0.0366
Echinococcus granulosus	neuropeptide receptor	0.0039	0.009	0.009
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0039	0.009	0.0239
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0087	0.0228
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.006	0.0151
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0203	0.088	0.136
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0045	0.0122	0.0178
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0064	0.0212	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0011	0.001
Brugia malayi	Cathepsin L-like precursor	0.0033	0.006	0.0081
Echinococcus multilocularis	expressed protein	0.0044	0.0113	0.0113
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0039	0.009	0.0133
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0124	0.0503	0.2756
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0045	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.006	0.0151
Schistosoma mansoni	ferritin	0.0044	0.0113	0.0113
Onchocerca volvulus		0.0039	0.009	0.0239
Mycobacterium tuberculosis	Probable oxidoreductase	0.0124	0.0502	0.687
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.009	0.009
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0041	0.0102	0.0147
Brugia malayi	Dopamine receptor	0.0039	0.009	0.0129
Loa Loa (eye worm)	neuropeptide F receptor	0.0039	0.009	0.0133
Schistosoma mansoni	hypothetical protein	0.0334	0.1514	0.1514
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0087	0.0228
Echinococcus granulosus	expressed protein	0.0044	0.0113	0.0113
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.009	0.009
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.006	0.0151
Brugia malayi	latrophilin 2 splice variant baaae	0.0139	0.0571	0.0878
Echinococcus granulosus	dro:myosuppressin receptor	0.0039	0.009	0.009
Giardia lamblia	GTOR	0.0045	0.0122	0.5
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0039	0.009	0.009
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0039	0.009	0.009
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0039	0.009	0.009
Echinococcus granulosus	hypothetical protein	0.0039	0.009	0.009
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0137	0.0563	0.0563
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0556	0.2585	0.2585
Brugia malayi	Nuclear hormone receptor-like 1	0.0041	0.0102	0.0147
Brugia malayi	Thioredoxin reductase	0.0049	0.0139	0.0205
Echinococcus granulosus	low density lipoprotein receptor ldl	0.0137	0.0563	0.0563
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0062	0.0201	0.0201
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0037	0.0037
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0093	0.0351	0.0351
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0041	0.0101	0.0101
Onchocerca volvulus	Mothers against decapentaplegic homolog	0.0041	0.0101	0.0269
Onchocerca volvulus		0.0039	0.009	0.0239
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0395	0.1808	1
Echinococcus multilocularis	Smad4	0.0092	0.0347	0.0347
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.006	0.0151
Brugia malayi	Bromodomain containing protein	0.0078	0.0277	0.042
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.006	0.0151
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.0044	0.0113	0.5
Loa Loa (eye worm)	low-density lipoprotein receptor domain class A containing protein	0.0137	0.0563	0.0868
Echinococcus granulosus	histone lysine methyltransferase setb	0.0111	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Trypanosoma brucei	glucosidase, putative	0.0038	0.0087	0.0448
Brugia malayi	G protein-coupled receptor	0.0039	0.009	0.0129
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0124	0.0503	0.2756
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0007	0.0003
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0022	0.0007	0.0007
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0233	0.1028	0.1028
Loa Loa (eye worm)	Smad1	0.0092	0.0347	0.0532
Echinococcus granulosus	tm gpcr rhodopsin	0.0039	0.009	0.009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0021	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0102	0.015
Echinococcus multilocularis	sex peptide receptor	0.0039	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Echinococcus multilocularis	somatostatin receptor	0.0039	0.009	0.009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.002	0.0037
Brugia malayi	Melatonin receptor type 1A	0.0039	0.009	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0233	0.1028	0.1028
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0038	0.0087	0.0087
Loa Loa (eye worm)	G-protein coupled receptor	0.0039	0.009	0.0133
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0064	0.0212	0.0321
Schistosoma mansoni	neuropeptide receptor	0.0039	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0102	0.015
Loa Loa (eye worm)	hypothetical protein	0.0033	0.006	0.0085
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0041	0.0102	0.0102
Brugia malayi	GnHR receptor homolog	0.0039	0.009	0.0129
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0145	0.0601	0.3302
Echinococcus multilocularis	FTZ F1 alpha	0.0041	0.0102	0.0102
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0033	0.0074
Onchocerca volvulus		0.0137	0.0563	0.1604
Brugia malayi	hypothetical protein	0.0039	0.009	0.0129
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0033	0.006	0.0085
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0039	0.009	0.0239
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0124	0.0503	0.2756
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0115	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0563	0.0868
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0037	0.0244
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0041	0.0102	0.015
Echinococcus granulosus	low density lipoprotein receptor protein	0.0137	0.0563	0.0563
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0137	0.0563	0.0865
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0041	0.0102	0.0271
Onchocerca volvulus		0.0739	0.3467	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.009	0.009
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0039	0.009	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0712	0.11
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0039	0.009	0.009
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0033	0.006	0.006
Echinococcus granulosus	ferritin	0.0044	0.0113	0.0113
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0039	0.009	0.0133
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0049	0.0139	0.046
Leishmania major	trypanothione reductase	0.0049	0.0139	0.0711
Echinococcus granulosus	cathepsin l1	0.0022	0.0008	0.0008
Leishmania major	mitochondrial DNA polymerase beta	0.0306	0.1379	0.7611
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0039	0.009	0.009
Echinococcus multilocularis	ecdysone induced protein 78C	0.0041	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0024	0.002	0.0022
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0306	0.1379	0.7618
Brugia malayi	MH2 domain containing protein	0.0092	0.0347	0.0528
Echinococcus granulosus	carbonic anhydrase	0.0168	0.0712	0.0712
Onchocerca volvulus		0.0157	0.0658	0.1881
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0092	0.0347	0.0347
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0064	0.0212	0.0212
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0041	0.0102	0.0147
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0233	0.1028	0.1028
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0033	0.006	0.058
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0077	0.02
Echinococcus multilocularis	cathepsin L cysteine protease	0.0033	0.006	0.006
Brugia malayi	G-protein coupled receptor	0.0039	0.009	0.0129
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0045	0.0122	0.0122
Trichomonas vaginalis	alpha-glucosidase, putative	0.0038	0.0087	0.0228
Brugia malayi	Dopamine receptor protein 1	0.0039	0.009	0.0129
Trypanosoma brucei	trypanothione reductase	0.0049	0.0139	0.0738
Schistosoma mansoni	opsin-like receptor	0.0039	0.009	0.009
Echinococcus granulosus	sex peptide receptor	0.0039	0.009	0.009
Schistosoma mansoni	hypothetical protein	0.0048	0.0134	0.0134
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.009	0.009
Echinococcus granulosus	biogenic amine 5HT receptor	0.0039	0.009	0.009
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0034	0.0065	0.0661
Loa Loa (eye worm)	glutathione reductase	0.0049	0.0139	0.0208
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0233	0.1028	0.1028
Schistosoma mansoni	importin beta-1	0.0028	0.0037	0.0037
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0137	0.0563	0.0865
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0039	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0306	0.1379	0.7611
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0112	0.0442	0.5807
Schistosoma mansoni	biogenic amine receptor	0.0039	0.009	0.009
Onchocerca volvulus		0.0137	0.0563	0.1604
Echinococcus multilocularis	tumor protein p63	0.1071	0.5068	0.5068
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0092	0.0347	0.0347
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0041	0.0101	0.0101
Echinococcus granulosus	7tm_1 domain containing protein	0.0039	0.009	0.009
Schistosoma mansoni	ferritin	0.0044	0.0113	0.0113
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0124	0.0503	0.2756
Brugia malayi	hypothetical protein	0.0024	0.002	0.0019
Echinococcus multilocularis	cysteine protease	0.0033	0.006	0.006
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0114	0.045	0.2445
Brugia malayi	ORL1-like opioid receptor	0.0039	0.009	0.0129
Schistosoma mansoni	hypothetical protein	0.0357	0.1622	0.1622
Leishmania major	hypothetical protein, conserved	0.0024	0.002	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0008	0.0004
Schistosoma mansoni	amine GPCR	0.0039	0.009	0.009
Brugia malayi	ecdysteroid receptor	0.0041	0.0102	0.0147
Plasmodium falciparum	glutathione reductase	0.0049	0.0139	0.1723
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0563	0.0868
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.009	0.009
Brugia malayi	hypothetical protein	0.0039	0.009	0.0129
Onchocerca volvulus	Terribly reduced optic lobes homolog	0.0137	0.0563	0.1604
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0233	0.1028	0.1028
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0087	0.042
Echinococcus granulosus	g protein coupled receptor	0.0039	0.009	0.009
Echinococcus granulosus	allatostatin A receptor	0.0039	0.009	0.009
Schistosoma mansoni	Smad4	0.0092	0.0347	0.0347
Brugia malayi	nuclear hormone receptor	0.0041	0.0102	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0395	0.1808	0.1808
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0112	0.0442	0.5807
Brugia malayi	hypothetical protein	0.0039	0.009	0.0129
Brugia malayi	nuclear receptor NHR-88	0.0041	0.0102	0.0147
Schistosoma mansoni	hypothetical protein	0.0139	0.0571	0.0571
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0021	0.0038
Echinococcus multilocularis	Low density lipoprotein receptor, class A, cysteine rich	0.0137	0.0563	0.0563
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0033	0.006	0.0151
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.006	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0007	0.0003
Echinococcus granulosus	mothers against decapentaplegic 5	0.0092	0.0347	0.0347
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0039	0.009	0.009
Echinococcus multilocularis	smad	0.0092	0.0347	0.0347
Schistosoma mansoni	hypothetical protein	0.0297	0.1337	0.1337
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0563	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Echinococcus granulosus	fmrfamide receptor	0.0039	0.009	0.009
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0022	0.0007	0.0007
Brugia malayi	glutathione reductase	0.0049	0.0139	0.0205
Onchocerca volvulus		0.0033	0.006	0.0151
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0077	0.02
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0039	0.009	0.009
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0137	0.0563	0.0865
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0043	0.011	0.0549
Schistosoma mansoni	neuropeptide f receptor 76f	0.0039	0.009	0.009
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.009	0.009
Onchocerca volvulus		0.0033	0.006	0.0151
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0039	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Echinococcus multilocularis	low density lipoprotein receptor (ldl)	0.0137	0.0563	0.0563
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0563	0.0868
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0041	0.0102	0.015
Brugia malayi	MH1 domain containing protein	0.0092	0.0347	0.0528
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0041	0.0102	0.0147
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.009	0.009
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0043	0.011	0.0549
Schistosoma mansoni	cathepsin F (C01 family)	0.0033	0.006	0.006
Schistosoma mansoni	cathepsin F (C01 family)	0.0022	0.0008	0.0008
Echinococcus granulosus	G protein coupled receptor 139	0.0039	0.009	0.009
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0041	0.0102	0.0147
Treponema pallidum	bacterioferrin (TpF1)	0.0044	0.0113	0.5
Brugia malayi	sulfakinin receptor protein	0.0039	0.009	0.0129
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0045	0.0122	0.0642
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0065	0.0167
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0092	0.0347	0.0347
Schistosoma mansoni	alpha-glucosidase	0.0148	0.0618	0.0618
Onchocerca volvulus		0.0093	0.0351	0.0994
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0039	0.009	0.009
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0041	0.0102	0.0147
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0021	0.0038
Schistosoma mansoni	carbonic anhydrase-related	0.0168	0.0712	0.0712
Onchocerca volvulus		0.0039	0.009	0.0239
Brugia malayi	putative neuropeptide receptor NPR1	0.0039	0.009	0.0129
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0124	0.0503	0.2756
Echinococcus granulosus	mothers against decapentaplegic 2	0.0041	0.0101	0.0101
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.009	0.009
Echinococcus granulosus	carbonic anhydrase	0.0168	0.0712	0.0712
Onchocerca volvulus	Arrow homolog	0.0137	0.0563	0.1604
Echinococcus granulosus	neuropeptide receptor	0.0039	0.009	0.009
Schistosoma mansoni	smad1 5 8 and	0.0092	0.0347	0.0347
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0039	0.009	0.009
Echinococcus multilocularis	g-protein coupled receptor	0.0039	0.009	0.009
Brugia malayi	Pre-SET motif family protein	0.0093	0.0351	0.0536
Schistosoma mansoni	hypothetical protein	0.0137	0.0563	0.0563
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0037	0.051
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0297	0.1337	0.2073
Brugia malayi	MH1 domain containing protein	0.0051	0.0148	0.0219
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0038	0.0087	0.0524
Schistosoma mansoni	Smad4	0.0041	0.0101	0.0101
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0038	0.0087	0.0228
Echinococcus granulosus	neuropeptide receptor A26	0.0039	0.009	0.009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0032	0.007
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0395	0.1808	0.2805
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0093	0.0351	0.0351
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0022	0.0007	0.0007
Onchocerca volvulus		0.0039	0.009	0.0239
Trypanosoma cruzi	trypanothione reductase, putative	0.0049	0.0139	0.0711
Onchocerca volvulus		0.0039	0.009	0.0239
Echinococcus multilocularis	carbonic anhydrase	0.0168	0.0712	0.0712
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0039	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0102	0.015
Onchocerca volvulus		0.0137	0.0563	0.1604
Schistosoma mansoni	amine GPCR	0.0039	0.009	0.009
Brugia malayi	G protein-coupled receptor F59B2.13	0.0039	0.009	0.0129
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0515	0.2386	0.2386
Echinococcus multilocularis	neuropeptides capa receptor	0.0039	0.009	0.009
Schistosoma mansoni	alpha-glucosidase	0.0148	0.0618	0.0618
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0039	0.009	0.0129
Plasmodium vivax	SET domain protein, putative	0.0093	0.0351	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0122	0.0329
Onchocerca volvulus		0.0137	0.0563	0.1604
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0563	0.0868
Echinococcus multilocularis	snurportin 1	0.0297	0.1337	0.1337
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.009	0.009
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0039	0.009	0.009
Loa Loa (eye worm)	fibroinase	0.0033	0.006	0.0085
Plasmodium falciparum	thioredoxin reductase	0.0049	0.0139	0.1723
Trichomonas vaginalis	set domain proteins, putative	0.0739	0.3467	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0039	0.009	0.0133
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0168	0.0712	0.1097
Loa Loa (eye worm)	calcium binding EGF domain-containing protein	0.0137	0.0563	0.0868
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0112	0.0442	0.5807
Schistosoma mansoni	neuropeptide receptor	0.0039	0.009	0.009
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.006	0.0151
Brugia malayi	MH1 domain containing protein	0.0092	0.0347	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Onchocerca volvulus		0.0039	0.009	0.0239
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0161	0.068	1
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0045	0.0122	0.0756
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0134	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0203	0.088	0.1363
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0041	0.0102	0.0147
Plasmodium falciparum	carbonic anhydrase	0.0168	0.0712	1
Brugia malayi	neuropeptide F receptor	0.0039	0.009	0.0129
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0039	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0102	0.015
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0039	0.009	0.009
Loa Loa (eye worm)	nuclear factor I	0.0051	0.0148	0.0222
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0039	0.009	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0037	0.017
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0137	0.0563	0.0563
Schistosoma mansoni	neuropeptide receptor	0.0039	0.009	0.009
Brugia malayi	Serotonin receptor	0.0039	0.009	0.0129
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0041	0.0102	0.015
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0041	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0106	0.0156
Loa Loa (eye worm)	hypothetical protein	0.004	0.0094	0.0138
Onchocerca volvulus		0.0039	0.009	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Echinococcus multilocularis	carbonic anhydrase	0.0168	0.0712	0.0712
Schistosoma mansoni	ferritin	0.0044	0.0113	0.0113
Echinococcus granulosus	Smad4	0.0092	0.0347	0.0347
Schistosoma mansoni	neuropeptide receptor	0.0039	0.009	0.009
Schistosoma mansoni	smad	0.0092	0.0347	0.0347
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.006	0.0151
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0038	0.0087	0.0228
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0168	0.0712	0.11
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.006	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0148	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0007	0.0003
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0203	0.088	0.136
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0306	0.1379	0.7611
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0041	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0049
Echinococcus granulosus	thioredoxin glutathione reductase	0.0049	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0658	0.1017
Mycobacterium ulcerans	hypothetical protein	0.0161	0.068	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0041	0.0102	0.0102
Schistosoma mansoni	amine GPCR	0.0039	0.009	0.009
Trypanosoma cruzi	cruzipain precursor, putative	0.0124	0.0503	0.2735
Loa Loa (eye worm)	transcription factor SMAD2	0.1353	0.6427	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0039	0.009	0.009
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0041	0.0102	0.0147
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0039	0.009	0.009
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0124	0.0503	0.2756
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.006	0.0151
Echinococcus multilocularis	G protein coupled receptor 139	0.0039	0.009	0.009
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0041	0.0102	0.0147
Schistosoma mansoni	histamine h1 receptor	0.0039	0.009	0.009
Loa Loa (eye worm)	phosphatidylinositol 3	0.0045	0.0122	0.0181
Trypanosoma cruzi	cysteine peptidase, putative	0.0124	0.0503	0.2735
Schistosoma mansoni	hypothetical protein	0.0168	0.0712	0.0712
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0233	0.1028	0.1592
Plasmodium vivax	thioredoxin reductase, putative	0.0049	0.0139	0.3593
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0168	0.0712	0.1097
Echinococcus granulosus	basement membrane specific heparan sulfate	0.0137	0.0563	0.0563
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0036	0.0077	0.0394
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0023	0.0015	0.0015
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0039	0.009	0.0133
Schistosoma mansoni	smad1 5 8 and	0.0092	0.0347	0.0347
Echinococcus granulosus	g-protein coupled receptor	0.0039	0.009	0.009
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0039	0.009	0.009
Brugia malayi	neuropeptide F receptor	0.0039	0.009	0.0129
Brugia malayi	Low-density lipoprotein receptor-related protein, putative	0.0137	0.0563	0.0865
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0033	0.006	0.058
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.006	0.0151
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0089	0.0237
Schistosoma mansoni	cellular tumor antigen P53	0.0157	0.0658	0.0658
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.006	0.0346
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0065	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Leishmania major	cathepsin L-like protease	0.0124	0.0503	0.2735
Brugia malayi	Cathepsin L-like precursor	0.0033	0.006	0.0081
Schistosoma mansoni	hypothetical protein	0.0515	0.2386	0.2386
Brugia malayi	hypothetical protein	0.0235	0.1038	0.1605
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0112	0.0442	0.8453
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.006	0.0151
Loa Loa (eye worm)	ctsf protein	0.0033	0.006	0.0085
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0794	0.3733	0.3733
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0168	0.0712	0.1097
Plasmodium falciparum	importin beta, putative	0.0028	0.0037	0.0244
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0563	0.0868
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0395	0.1808	1
Echinococcus multilocularis	neuropeptide receptor	0.0039	0.009	0.009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0033	0.0074
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0038	0.0087	0.0968
Schistosoma mansoni	thyroid hormone receptor	0.0556	0.2585	0.2585
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0011	0.001
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0712	0.11
Leishmania major	cathepsin L-like protease	0.0033	0.006	0.0271
Onchocerca volvulus		0.0137	0.0563	0.1604
Brugia malayi	Bromodomain containing protein	0.004	0.0094	0.0134
Brugia malayi	MH2 domain containing protein	0.1353	0.6427	1
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0437	0.0672
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0563	0.0868
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0039	0.009	0.0129
Schistosoma mansoni	hypothetical protein	0.0064	0.0212	0.0212
Echinococcus granulosus	ecdysone induced protein 78C	0.0041	0.0102	0.0102
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0043	0.011	0.0576
Schistosoma mansoni	hypothetical protein	0.0064	0.0212	0.0212
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.006	0.0346
Echinococcus granulosus	orexin receptor type 2	0.0039	0.009	0.009
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0045	0.0122	0.0615
Onchocerca volvulus	Cathepsin L homolog	0.0033	0.006	0.0151
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.006	0.0151
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0124	0.0502	1
Schistosoma mansoni	ferritin	0.0044	0.0113	0.0113
Echinococcus multilocularis	cysteine protease	0.0033	0.006	0.006
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0064	0.0212	0.0318
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0045	0.0122	0.0615
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0137	0.0563	0.0865
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0256	0.039
Brugia malayi	putative neuropeptide receptor	0.0039	0.009	0.0129
Brugia malayi	PHD-finger family protein	0.0026	0.0027	0.003
Brugia malayi	MH2 domain containing protein	0.0041	0.0101	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0007	0.0003
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0032	0.007
Echinococcus multilocularis	dro:myosuppressin receptor	0.0039	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Echinococcus granulosus	geminin	0.0357	0.1622	0.1622
Echinococcus granulosus	basement membrane specific heparan sulfate	0.0137	0.0563	0.0563
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.006	0.0151
Brugia malayi	Serotonin receptor	0.0039	0.009	0.0129
Schistosoma mansoni	hypothetical protein	0.0137	0.0563	0.0563
Schistosoma mansoni	neuropeptide F-like receptor	0.0039	0.009	0.009
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0045	0.0122	0.0122
Brugia malayi	hypothetical protein	0.0039	0.009	0.0129
Echinococcus multilocularis	low density lipoprotein receptor (ldl)	0.0137	0.0563	0.0563
Schistosoma mansoni	carbonic anhydrase-related	0.0168	0.0712	0.0712
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0102	0.015
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0041	0.0102	0.0102
Schistosoma mansoni	biogenic amine receptor	0.0039	0.009	0.009
Echinococcus granulosus	5'partial\|Low density lipoprotein receptor class A cysteine rich	0.0137	0.0563	0.0563
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Leishmania major	cathepsin L-like protease	0.0033	0.006	0.0271
Schistosoma mansoni	hypothetical protein	0.0039	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0563	0.0868
Echinococcus granulosus	neuropeptide Y receptor	0.0039	0.009	0.009
Trypanosoma cruzi	cysteine peptidase, putative	0.0124	0.0503	0.2735
Schistosoma mansoni	transcription factor LCR-F1	0.0334	0.1514	0.1514
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0039	0.009	0.009
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0049	0.0139	0.0139
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0092	0.0347	0.0347
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0041	0.0102	0.015
Trypanosoma brucei	carbonic anhydrase-like protein	0.0395	0.1808	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0052	0.0155	0.0802
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0039	0.009	0.009
Echinococcus multilocularis	fmrfamide receptor	0.0039	0.009	0.009
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0124	0.0502	0.687
Echinococcus granulosus	lysosomal alpha glucosidase	0.0172	0.0733	0.0733
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0045	0.0122	0.0122
Onchocerca volvulus		0.0039	0.009	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0137	0.0563	0.0563
Echinococcus granulosus	neutral alpha glucosidase AB	0.0038	0.0087	0.0087
Leishmania major	alpha glucosidase II subunit, putative	0.0038	0.0087	0.042
Loa Loa (eye worm)	carbonic anhydrase 3	0.0395	0.1808	0.2807
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0033	0.0074
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0111	0.0437	0.0437
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0037	0.017
Brugia malayi	Steroid receptor seven-up type 2	0.0041	0.0102	0.0147
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0087	0.042
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0065	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Brugia malayi	Smad1	0.0092	0.0347	0.0528
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.002	0.0037
Brugia malayi	Importin beta-1 subunit	0.0028	0.0037	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0021	0.0038
Echinococcus granulosus	fetal alzheimer antigen falz	0.0023	0.0015	0.0015
Schistosoma mansoni	ferritin light chain	0.0044	0.0113	0.0113
Schistosoma mansoni	hypothetical protein	0.0039	0.009	0.009
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0039	0.009	0.009
Loa Loa (eye worm)	cysteine protease	0.0033	0.006	0.0085
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.009	0.009
Echinococcus granulosus	FTZ F1 alpha	0.0041	0.0102	0.0102
Leishmania major	cathepsin L-like protease	0.0033	0.006	0.0271
Echinococcus granulosus	neuropeptides capa receptor	0.0039	0.009	0.009
Onchocerca volvulus	Bile acid receptor homolog	0.0041	0.0102	0.0271
Brugia malayi	Cathepsin L-like precursor	0.0033	0.006	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0102	0.015
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0395	0.1808	0.1808
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0007	0.0007
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0168	0.0712	0.1097
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0041	0.0102	0.0147
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0039	0.009	0.0129
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0023	0.0015	0.0015
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0011	0.001
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0041	0.0102	0.0102
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0203	0.088	0.1363
Echinococcus granulosus	snurportin 1	0.0297	0.1337	0.1337
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.009	0.009
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.009	0.009
Loa Loa (eye worm)	MH2 domain-containing protein	0.1353	0.6427	1
Echinococcus multilocularis	g protein coupled receptor	0.0039	0.009	0.009
Echinococcus multilocularis	carbonic anhydrase	0.0168	0.0712	0.0712
Trypanosoma cruzi	major cysteine proteinase, putative	0.0098	0.0374	0.202
Schistosoma mansoni	opsin-like receptor	0.0039	0.009	0.009
Echinococcus granulosus	7TM GPCR rhodopsin	0.0039	0.009	0.009
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0041	0.0102	0.0102
Echinococcus multilocularis	neuropeptide receptor	0.0039	0.009	0.009
Schistosoma mansoni	nuclear hormone receptor	0.0041	0.0102	0.0102
Echinococcus multilocularis	g protein coupled receptor	0.0039	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Onchocerca volvulus	Cathepsin F homolog	0.0033	0.006	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0124	0.0503	0.2756
Echinococcus granulosus	survival motor neuron protein 1	0.0235	0.1038	0.1038
Brugia malayi	hypothetical protein	0.0039	0.009	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0045	0.0122	0.0615
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0168	0.0712	0.1097
Echinococcus multilocularis	neuropeptides capa receptor	0.0039	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0563	0.0868
Echinococcus multilocularis	neuropeptide Y receptor	0.0039	0.009	0.009
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0033	0.006	0.006
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0036	0.0077	0.0366
Loa Loa (eye worm)	low-density lipoprotein receptor domain class A containing protein	0.0137	0.0563	0.0868
Onchocerca volvulus	Cathepsin L homolog	0.0033	0.006	0.0151
Echinococcus granulosus	carbonic anhydrase	0.0168	0.0712	0.0712
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0038	0.0087	0.0228
Onchocerca volvulus		0.0048	0.0134	0.0365
Loa Loa (eye worm)	melatonin receptor type 1A	0.0039	0.009	0.0133
Echinococcus granulosus	neuropeptide Y receptor	0.0039	0.009	0.009
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0145	0.0601	0.3282
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0093	0.0351	0.4795
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0039	0.009	0.009
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0137	0.0563	0.0563
Loa Loa (eye worm)	MH1 domain-containing protein	0.0092	0.0347	0.0532
Schistosoma mansoni	amine GPCR	0.0039	0.009	0.009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0122	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Onchocerca volvulus		0.0033	0.006	0.0151
Brugia malayi	hypothetical protein	0.0039	0.009	0.0129
Leishmania major	cathepsin L-like protease	0.0124	0.0503	0.2735
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0134	0.0134
Trypanosoma cruzi	cysteine peptidase, putative	0.0033	0.006	0.0271
Brugia malayi	G-protein coupled receptor	0.0039	0.009	0.0129
Echinococcus multilocularis	g protein coupled receptor	0.0039	0.009	0.009
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0111	0.0437	0.0437
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.006	0.0151
Onchocerca volvulus		0.0039	0.009	0.0239
Echinococcus granulosus	neuropeptides capa receptor	0.0039	0.009	0.009
Brugia malayi	Pre-SET motif family protein	0.0649	0.3034	0.4715
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0041	0.0102	0.0102
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0172	0.0733	0.0733
Entamoeba histolytica	hypothetical protein	0.0023	0.0011	0.0023
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0039	0.009	0.009
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0033	0.006	0.0151
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0049	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0101	0.0149
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0039	0.009	0.009
Onchocerca volvulus		0.0039	0.009	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0571	0.0881
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0039	0.009	0.009
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.002	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0172	0.0733	0.1131
Schistosoma mansoni	amine GPCR	0.0039	0.009	0.009
Schistosoma mansoni	hypothetical protein	0.0064	0.0212	0.0212
Loa Loa (eye worm)	low-density lipoprotein receptor domain class A containing protein	0.0137	0.0563	0.0868
Entamoeba histolytica	hypothetical protein	0.0334	0.1514	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0039	0.009	0.009
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0041	0.0102	0.0102
Onchocerca volvulus		0.0033	0.006	0.0151
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0137	0.0563	0.1604
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0515	0.2386	0.2386
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0039	0.009	0.0129
Leishmania major	cathepsin L-like protease	0.0033	0.006	0.0271
Brugia malayi	Low-density lipoprotein receptor domain class A containing protein	0.0137	0.0563	0.0865
Brugia malayi	hypothetical protein	0.0039	0.009	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Onchocerca volvulus		0.01	0.0383	0.1085
Schistosoma mansoni	thyroid hormone receptor	0.0556	0.2585	0.2585
Brugia malayi	hypothetical protein	0.0039	0.009	0.0129
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0395	0.1808	0.2805
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Loa Loa (eye worm)	MH1 domain-containing protein	0.0041	0.0101	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Brugia malayi	photoreceptor-specific nuclear receptor	0.0041	0.0102	0.0147
Echinococcus granulosus	tm gpcr rhodopsin	0.0039	0.009	0.009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0077	0.02
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0212	0.0321
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0039	0.009	0.009
Loa Loa (eye worm)	thioredoxin reductase	0.0049	0.0139	0.0208
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0033	0.006	0.006
Trichomonas vaginalis	ferritin, putative	0.0044	0.0113	0.0304
Toxoplasma gondii	cathepsin CPL	0.0033	0.006	0.058
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0041	0.0102	0.0102
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0037	0.0082	0.0082
Brugia malayi	RE15519p	0.0039	0.009	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0007	0.0003
Echinococcus granulosus	GPCR family 2	0.0064	0.0212	0.0212
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0041	0.0102	0.0147
Schistosoma mansoni	adenoreceptor	0.0039	0.009	0.009
Toxoplasma gondii	hypothetical protein	0.0168	0.0712	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0038	0.0087	0.0123
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.002	0.0037
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0041	0.0102	0.0147
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.009	0.0335	0.0335
Schistosoma mansoni	ferritin light chain	0.0044	0.0113	0.0113
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0334	0.1514	0.1514
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0102	0.015
Onchocerca volvulus		0.0039	0.009	0.0239
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0041	0.0102	0.0102
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0137	0.0563	0.0563
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0065	0.0167
Echinococcus granulosus	biogenic amine 5HT receptor	0.0039	0.009	0.009
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.006	0.0151
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0041	0.0102	0.0102
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0041	0.0102	0.0102
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0043	0.011	0.0549
Schistosoma mansoni	cathepsin F (C01 family)	0.0033	0.006	0.006
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0033	0.006	0.006
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.009	0.009
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0039	0.009	0.009
Onchocerca volvulus		0.0039	0.009	0.0239
Entamoeba histolytica	hypothetical protein	0.0334	0.1514	1
Leishmania major	cathepsin L-like protease	0.0124	0.0503	0.2735
Schistosoma mansoni	myosin xvIII	0.0039	0.009	0.009
Echinococcus granulosus	smad	0.0092	0.0347	0.0347
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0033	0.006	0.0151
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.009	0.009
Brugia malayi	Latrophilin receptor protein 2	0.0064	0.0212	0.0318
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0041	0.0102	0.0102
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0233	0.1028	0.1589
Echinococcus granulosus	g protein coupled receptor	0.0039	0.009	0.009
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0022	0.0007	0.0003
Echinococcus granulosus	rhodopsin orphan GPCR	0.0039	0.009	0.009
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0093	0.0351	0.0351
Echinococcus granulosus	serotonin receptor	0.0039	0.009	0.009
Echinococcus multilocularis	orexin receptor type 2	0.0039	0.009	0.009
Echinococcus granulosus	Low density lipoprotein receptor class A cysteine rich	0.0137	0.0563	0.0563
Onchocerca volvulus		0.0033	0.006	0.0151
Echinococcus multilocularis	Low density lipoprotein receptor, class A, cysteine rich	0.0137	0.0563	0.0563
Mycobacterium tuberculosis	Probable dehydrogenase	0.0112	0.0442	0.5807
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0041	0.0102	0.0147
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0039	0.009	0.009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0077	0.02
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0045	0.0122	0.0756
Schistosoma mansoni	carbonic anhydrase	0.0168	0.0712	0.0712
Loa Loa (eye worm)	hypothetical protein	0.0039	0.009	0.0133
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0172	0.0733	0.1134
Onchocerca volvulus	Protein ultraspiracle homolog	0.0041	0.0102	0.0271
Loa Loa (eye worm)	TYRA-2 protein	0.0039	0.009	0.0133

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 5.4 nM	Inhibition of human recombinant carbonic anhydrase 7 by stopped flow CO2 hydration method	ChEMBL.	19435663
Ki (binding)	= 8.1 nM	Inhibition of human recombinant full length mitochondrial carbonic anhydrase 5B by stopped-flow CO2 hydration assay	ChEMBL.	19539481
Ki (binding)	= 8.3 nM	Inhibition of human recombinant full length mitochondrial carbonic anhydrase 5A by stopped-flow CO2 hydration assay	ChEMBL.	19539481
Ki (binding)	= 61 nM	Inhibition of human recombinant cytosolic carbonic anhydrase 2 by stopped-flow CO2 hydration assay	ChEMBL.	19539481
Ki (binding)	= 61 nM	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method	ChEMBL.	19435663
Ki (binding)	= 67 nM	Inhibition of human recombinant cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay	ChEMBL.	19539481
Ki (binding)	= 67 nM	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method	ChEMBL.	19435663

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL575660

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 1076133