Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.001 | 0.017 | 0.0817 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.1101 | 0.1101 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.002 | 0.0896 | 0.4299 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0024 | 0.1216 | 0.5834 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0026 | 0.1326 | 0.6357 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.002 | 0.0873 | 0.4188 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0024 | 0.1216 | 0.5834 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0036 | 0.2085 | 1 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.002 | 0.0924 | 0.4398 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0444 | 0.0181 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0026 | 0.1326 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0026 | 0.1326 | 0.6357 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0024 | 0.1216 | 0.581 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0026 | 0.1326 | 0.6337 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0046 | 0.2789 | 0.2789 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0036 | 0.2085 | 1 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0008 | 0.0012 | 0.0056 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0008 | 0.0064 | 0.0306 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0024 | 0.1216 | 0.5834 |
Mycobacterium ulcerans | thioesterase | 0.002 | 0.0924 | 0.443 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0024 | 0.1163 | 0.5576 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0036 | 0.2085 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0024 | 0.1216 | 0.5834 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.002 | 0.0873 | 0.4155 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0026 | 0.1326 | 0.6357 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2411 | 0.2202 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.002 | 0.0924 | 0.443 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0024 | 0.1216 | 0.5834 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0026 | 0.1326 | 0.6357 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0018 | 0.0722 | 0.3461 |
Loa Loa (eye worm) | fatty acid synthase | 0.0024 | 0.1193 | 0.0951 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0016 | 0.0621 | 0.2941 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0008 | 0.0012 | 0.0056 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0024 | 0.1163 | 0.5576 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0023 | 0.1101 | 0.0856 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0016 | 0.0621 | 0.2981 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0026 | 0.1326 | 0.6357 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0014 | 0.0459 | 0.2199 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.002 | 0.0873 | 0.4188 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0026 | 0.1326 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0017 | 0.071 | 0.3708 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0016 | 0.0599 | 0.2574 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0023 | 0.1101 | 0.528 |
Onchocerca volvulus | 0.0042 | 0.2517 | 0.9285 | |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0024 | 0.1216 | 0.5834 |
Mycobacterium ulcerans | polyketide synthase | 0.0024 | 0.1216 | 0.5834 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0024 | 0.1216 | 0.581 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0026 | 0.1326 | 0.6337 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0024 | 0.1216 | 0.1216 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0044 | 0.2626 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0026 | 0.1326 | 0.6357 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0036 | 0.2085 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0016 | 0.0621 | 0.2981 |
Mycobacterium ulcerans | thioesterase TesA | 0.002 | 0.0924 | 0.443 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0024 | 0.1216 | 0.5834 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of human MMP12 catalytic domain | ChEMBL. | 19665375 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.