Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0176155 | 1 | 0.5 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0082 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0176155 | 1 | 0.5 |
Schistosoma mansoni | apoptosis regulator bax | 0.0082 | 0 | 0.5 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0082 | 0 | 0.5 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0176155 | 1 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0176155 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0176155 | 1 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0176155 | 1 | 0.5 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0082 | 0 | 0.5 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0082 | 0 | 0.5 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0082 | 0 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.0176155 | 1 | 0.5 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.0082 | 0 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0176155 | 1 | 0.5 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.0082 | 0 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0176155 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 1.6 uM | Growth inhibition of human HT-29 cells by sulforhodamine B assay | ChEMBL. | 19743809 |
GI50 (functional) | = 2.1 uM | Growth inhibition of human A549 cells by sulforhodamine B assay | ChEMBL. | 19743809 |
GI50 (functional) | = 3.8 uM | Growth inhibition of human MDA-MB-231 cells by sulforhodamine B assay | ChEMBL. | 19743809 |
IC50 (functional) | = 0.2 uM | Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1/Columbia infected in human erythrocytes assessed as inhibition of [G-3H]hypoxanthine incorporation after 24 hrs by scintillation counting | ChEMBL. | 19743809 |
LC50 (functional) | = 5.7 uM | Growth inhibition of human HT-29 cells by sulforhodamine B assay | ChEMBL. | 19743809 |
LC50 (functional) | = 8.6 uM | Growth inhibition of human A549 cells by sulforhodamine B assay | ChEMBL. | 19743809 |
LC50 (functional) | = 11.4 uM | Growth inhibition of human MDA-MB-231 cells by sulforhodamine B assay | ChEMBL. | 19743809 |
TC50 (functional) | = 4.7 uM | Cytotoxicity against human HeLa cells by sulforhodamine B assay | ChEMBL. | 19743809 |
TGI (functional) | = 3.2 uM | Growth inhibition of human HT-29 cells by sulforhodamine B assay | ChEMBL. | 19743809 |
TGI (functional) | = 4.6 uM | Growth inhibition of human A549 cells by sulforhodamine B assay | ChEMBL. | 19743809 |
TGI (functional) | = 6.4 uM | Growth inhibition of human MDA-MB-231 cells by sulforhodamine B assay | ChEMBL. | 19743809 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | 19743809 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.