Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | renin | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | plasmepsin X | renin | 406 aa | 352 aa | 26.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.3169 | 1 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0059 | 0.2816 | 0.8884 |
Trypanosoma brucei | ATP-binding cassette protein, putative | 0.0063 | 0.3076 | 0.5 |
Echinococcus granulosus | ATP binding cassette sub family G | 0.0063 | 0.3076 | 0.493 |
Plasmodium falciparum | ABC transporter G family member 2 | 0.0063 | 0.3076 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.3169 | 1 |
Brugia malayi | RNA binding protein | 0.0067 | 0.3344 | 1 |
Plasmodium falciparum | plasmepsin I | 0.0059 | 0.2816 | 0.9153 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0059 | 0.2816 | 0.8884 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.3169 | 1 |
Plasmodium vivax | ABC transporter G family member 2, putative | 0.0063 | 0.3076 | 1 |
Plasmodium falciparum | plasmepsin II | 0.0059 | 0.2816 | 0.9153 |
Giardia lamblia | ABC transporter | 0.0062 | 0.303 | 0.5 |
Echinococcus multilocularis | ATP binding cassette sub family G | 0.0063 | 0.3076 | 0.493 |
Trypanosoma brucei | ABC transporter, putative | 0.0063 | 0.3076 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.3169 | 0.3169 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0174 | 1 | 1 |
Plasmodium vivax | plasmepsin IV, putative | 0.0059 | 0.2816 | 0.9153 |
Echinococcus granulosus | ATP binding cassette sub family G | 0.0063 | 0.3076 | 0.493 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0065 | 0.3169 | 1 |
Entamoeba histolytica | ABC transporter, putative | 0.0063 | 0.3076 | 0.5 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Toxoplasma gondii | ATP-binding cassette G family transporter ABCG84 | 0.0063 | 0.3076 | 0.9706 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0065 | 0.3169 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0065 | 0.3169 | 1 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0059 | 0.2816 | 0.9153 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0065 | 0.3169 | 0.6694 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0059 | 0.2816 | 0.8419 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.2816 | 0.8419 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3344 | 0.3344 |
Loa Loa (eye worm) | ABC transporter | 0.0054 | 0.2476 | 0.7404 |
Trypanosoma cruzi | ABC transporter, putative | 0.0063 | 0.3076 | 0.5 |
Plasmodium falciparum | plasmepsin VI | 0.0059 | 0.2816 | 0.9153 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3344 | 0.3344 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.3344 | 1 |
Echinococcus multilocularis | ATP binding cassette sub family G | 0.0063 | 0.3076 | 0.493 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.3344 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.3344 | 1 |
Echinococcus multilocularis | ATP binding cassette sub family G | 0.0063 | 0.3076 | 0.493 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.3169 | 0.3169 |
Trypanosoma cruzi | ATP-binding cassette protein, putative | 0.0063 | 0.3076 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.3344 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.243 | 0.243 |
Plasmodium falciparum | plasmepsin IV | 0.0059 | 0.2816 | 0.9153 |
Brugia malayi | ABC transporter family protein | 0.0054 | 0.2476 | 0.7404 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.3344 | 1 |
Schistosoma mansoni | ATP-binding cassette sub-family g2 (white protein) (abcg2) | 0.0063 | 0.3076 | 0.3076 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.3344 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.3344 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3344 | 0.3344 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3344 | 0.3344 |
Schistosoma mansoni | ABC transporter | 0.0054 | 0.2476 | 0.2476 |
Echinococcus granulosus | ATP binding cassette sub family G | 0.0063 | 0.3076 | 0.493 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0065 | 0.3169 | 0.6694 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0059 | 0.2816 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0059 | 0.2816 | 0.2816 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3344 | 0.3344 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 11 nM | The compound was evaluated for inhibitory activity against monkey plasma renin. | ChEMBL. | No reference |
IC50 (binding) | = 11 nM | The compound was evaluated for inhibitory activity against monkey plasma renin. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.