Detailed information for compound 107658

Basic information

Technical information
  • TDR Targets ID: 107658
  • Name: N-ethyl-N-(2-hydroxyethyl)-4-[(8-phenethyl-8- azabicyclo[3.2.1]octan-3-ylidene)-phenylmethy l]benzamide
  • MW: 494.667 | Formula: C33H38N2O2
  • H donors: 1 H acceptors: 2 LogP: 6.13 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCN(C(=O)c1ccc(cc1)/C(=C/1\CC2CCC(C1)N2CCc1ccccc1)/c1ccccc1)CC
  • InChi: 1S/C33H38N2O2/c1-2-34(21-22-36)33(37)28-15-13-27(14-16-28)32(26-11-7-4-8-12-26)29-23-30-17-18-31(24-29)35(30)20-19-25-9-5-3-6-10-25/h3-16,30-31,36H,2,17-24H2,1H3
  • InChiKey: DZSSNPPKARQQAQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-ethyl-N-(2-hydroxyethyl)-4-[(8-phenethyl-8-azabicyclo[3.2.1]octan-3-ylidene)-phenyl-methyl]benzamide
  • N-ethyl-N-(2-hydroxyethyl)-4-[phenyl-[8-(2-phenylethyl)-8-azabicyclo[3.2.1]octan-3-ylidene]methyl]benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens opioid receptor, delta 1 Starlite/ChEMBL References
Homo sapiens opioid receptor, mu 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_139759 All targets in OG5_139759
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_139759 All targets in OG5_139759
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0024 0.0038
Loa Loa (eye worm) hypothetical protein 0.0406 0.1143 0.1219
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0015 0.0002 0.0026
Loa Loa (eye worm) RNA binding protein 0.0063 0.0143 0.0152
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.0132 0.337
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0103 0.0261 0.0415
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0124 0.0321 0.8878
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0699 0.9276
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0406 0.1143 0.1821
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0406 0.1143 0.122
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0129 0.0337 0.0595
Echinococcus multilocularis netrin receptor unc 5 0.0017 0.0008 0.0013
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0041 0.008 0.2034
Onchocerca volvulus Netrin receptor homolog 0.0017 0.0008 0.0008
Loa Loa (eye worm) DR-78 0.0191 0.0518 0.0552
Loa Loa (eye worm) glutathione reductase 0.0054 0.0118 0.0126
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0191 0.0518 0.0825
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0056 0.0089
Schistosoma mansoni hypothetical protein 0.0018 0.0013 0.0019
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0027 0.0039 0.0884
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0013 0.0013
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.0118 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0027 0.0039 0.0872
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0024 0.0322
Echinococcus granulosus thyroid hormone receptor alpha 0.0356 0.0998 0.1589
Echinococcus multilocularis conserved hypothetical protein 0.0793 0.2272 0.4019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0079 0.1054
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.003
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0191 0.0518 0.0825
Schistosoma mansoni nuclear receptor 0.0191 0.0518 0.0825
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0052 0.011 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.008 0.0141
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0024 0.053
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0103 0.0259 0.0277
Schistosoma mansoni lamin 0.0031 0.005 0.0079
Onchocerca volvulus 0.0191 0.0518 0.0518
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0023 0.0542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.001 0.0134
Giardia lamblia GTOR 0.0052 0.011 0.8151
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0253 0.0699 0.0745
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0027 0.0042
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0067 0.0071
Loa Loa (eye worm) hypothetical protein 0.0406 0.1143 0.1219
Onchocerca volvulus 0.0031 0.005 0.005
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.0031 0.0702
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0017 0.001 0.0156
Toxoplasma gondii cytochrome p450 superfamily protein 0.0027 0.0039 0.097
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0027 0.0039 0.0872
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0024 0.0038
Echinococcus granulosus intermediate filament protein 0.0031 0.005 0.0079
Echinococcus multilocularis Ankyrin 0.0017 0.0008 0.0014
Schistosoma mansoni hypothetical protein 0.0023 0.0026 0.0041
Toxoplasma gondii aldehyde dehydrogenase 0.0129 0.0337 1
Schistosoma mansoni coup transcription factor 0.0406 0.1143 0.1821
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0002 0.0026
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0027 0.0039 0.0872
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0074 0.0079
Brugia malayi glutathione reductase 0.0054 0.0118 0.0126
Plasmodium falciparum thioredoxin reductase 0.0019 0.0015 0.0336
Brugia malayi hypothetical protein 0.0116 0.0299 0.0319
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.0329
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.006 0.0095
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0027 0.0029
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0024 0.0038
Brugia malayi hypothetical protein 0.0187 0.0507 0.054
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0145 0.0383 0.0408
Echinococcus granulosus cytochrome P450 2K1 0.0027 0.0039 0.0062
Brugia malayi nuclear receptor NHR-67 0.0191 0.0518 0.0553
Schistosoma mansoni hypothetical protein 0.0145 0.0382 0.0607
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0008
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.0132 0.0233
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0063 0.0145 0.023
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0191 0.0518 0.0916
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0052 0.011 0.2797
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0124 0.0321 0.8858
Echinococcus granulosus expressed protein 0.0429 0.121 0.1927
Schistosoma mansoni cytochrome P450 0.0027 0.0039 0.0062
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0042 0.0083 0.0089
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0069 0.1751
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.0015 0.0216
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0024 0.041
Brugia malayi Thioredoxin reductase 0.0054 0.0118 0.0126
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0027 0.0039 0.0872
Entamoeba histolytica hypothetical protein 0.0022 0.0024 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0406 0.1143 0.1219
Brugia malayi PXA domain containing protein 0.0022 0.0024 0.0025
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0052 0.011 0.0175
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0639 0.1823 0.3225
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0055 0.1338
Brugia malayi conserved hypotetical protein 0.0191 0.0518 0.0553
Brugia malayi hypothetical protein 0.0022 0.0024 0.0025
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0027 0.0039 0.0872
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0044 0.1114
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0023 0.004
Echinococcus granulosus RUN 0.0023 0.0026 0.0041
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.0132 0.021
Echinococcus granulosus fatty acid binding protein FABP2 0.023 0.0631 0.1004
Echinococcus granulosus single minded 2 0.0045 0.0092 0.0146
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0253 0.0699 0.0745
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0124 0.0321 0.8858
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0024 0.053
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0132 0.1751
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0023 0.03
Toxoplasma gondii thioredoxin reductase 0.0054 0.0118 0.3359
Brugia malayi nuclear receptor RXR 0.0191 0.0518 0.0553
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.005 0.0658
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0191 0.0518 0.0518
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0024 0.0457
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0024 0.0316
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0002 0.0026
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0052 0.011 1
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.0008 0.0012
Schistosoma mansoni lipoxygenase 0.0023 0.0026 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0079 0.1054
Mycobacterium tuberculosis Probable dehydrogenase 0.0124 0.0321 0.8858
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0067 0.0106
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.003
Brugia malayi TAR-binding protein 0.0063 0.0143 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0002 0.0026
Brugia malayi hypothetical protein 0.0019 0.0014 0.0015
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.0026 0.161
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0027 0.0042
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0052 0.011 0.2839
Brugia malayi hypothetical protein 0.0191 0.0518 0.0553
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0023 0.1333
Schistosoma mansoni ap endonuclease 0.0022 0.0023 0.0036
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.0025
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0124 0.0321 0.8858
Echinococcus multilocularis aryl hydrocarbon receptor 0.0015 0.0002 0.0003
Echinococcus granulosus GPCR family 2 0.0018 0.0013 0.0019
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.001 0.0011
Brugia malayi Nuclear hormone receptor-like 1 0.0214 0.0585 0.0624
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.006 0.0095
Echinococcus multilocularis fatty acid binding protein FABP2 0.023 0.0631 0.1115
Loa Loa (eye worm) hypothetical protein 0.0406 0.1143 0.1219
Mycobacterium tuberculosis Probable reductase 0.0124 0.0321 0.8858
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0024 0.053
Entamoeba histolytica hypothetical protein 0.0041 0.008 0.657
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0028 0.0732
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0026 0.0027
Mycobacterium tuberculosis Probable oxidoreductase 0.0138 0.0361 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0024 0.0188
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0406 0.1143 0.1821
Brugia malayi hypothetical protein 0.0191 0.0518 0.0553
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0022 0.0024 0.0316
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0239 0.0657 0.0701
Trypanosoma cruzi target of rapamycin kinase 3 0.0041 0.008 0.2034
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0028 0.003
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0406 0.1143 0.2022
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0445 0.5902
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.005 0.0053
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0024 0.0042
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0003 0.0005
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0017 0.001 0.0156
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0406 0.1143 0.1821
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0024 0.0038
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.0445 0.0444
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0005 0.0081
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0017 0.001 0.0016
Brugia malayi hypoxia-induced factor 1 0.0173 0.0464 0.0495
Loa Loa (eye worm) hypothetical protein 0.0191 0.0518 0.0552
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0027 0.0039 0.0872
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0143 0.0228
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0042 0.0083 0.0088
Echinococcus multilocularis dna polymerase eta 0.0022 0.0024 0.0043
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0027 0.0039 0.0884
Loa Loa (eye worm) hypothetical protein 0.0214 0.0585 0.0624
Leishmania major phosphatidylinositol 3-kinase, putative 0.0017 0.001 0.0213
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0406 0.1143 0.122
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0143 0.0152
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0024 0.0038
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.0118 0.0126
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.0026 0.1377
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0067 0.0884
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0138 0.0361 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.2166 0.6279 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0024 0.0042
Brugia malayi ecdysteroid receptor 0.0406 0.1143 0.122
Brugia malayi Nuclear hormone receptor E75 0.0191 0.0518 0.0553
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0445 0.5902
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0027 0.0039 0.0872
Schistosoma mansoni single-minded 0.0056 0.0123 0.0195
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0024 0.0025
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0015 0.011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0024 0.0585
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0015 0.0025
Loa Loa (eye worm) hypothetical protein 0.0406 0.1143 0.1219
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.008 0.0127
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0026 0.0041
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0132 0.1751
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.003
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0028 0.0533
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.0026
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.0132 0.021
Onchocerca volvulus 0.0023 0.0026 0.0025
Schistosoma mansoni DNA polymerase eta 0.0022 0.0024 0.0038
Schistosoma mansoni retinoic acid receptor RXR 0.2166 0.6279 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0028 0.069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0072 0.095
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0024 0.0042
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0024 0.053
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0027 0.0039 0.0884
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0024 0.041
Echinococcus granulosus bloom syndrome protein 0.0025 0.0031 0.0049
Echinococcus granulosus dna polymerase eta 0.0022 0.0024 0.0038
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0024 0.0585
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0021 0.0022 0.0474
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.0132 0.3409
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0024 0.0038
Leishmania major cytochrome p450-like protein 0.0027 0.0039 0.0981
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0406 0.1143 0.122
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.0069 0.1751
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.0015 0.0216
Loa Loa (eye worm) hypothetical protein 0.0406 0.1143 0.1219
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0044 0.328
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0015 0.0272
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0027 0.0039 0.0981
Loa Loa (eye worm) hypothetical protein 0.0191 0.0518 0.0552
Leishmania major cytochrome p450-like protein 0.0037 0.0069 0.1751
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0024 0.0026
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0023 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0027 0.0039 0.0872
Echinococcus granulosus Nuclear hormone receptor HR96 0.0191 0.0518 0.0825
Schistosoma mansoni lipoxygenase 0.0063 0.0145 0.023
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0191 0.0518 0.0552
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0024 0.0038
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0027 0.0039 0.0884
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0015 0.0596
Loa Loa (eye worm) hypothetical protein 0.0191 0.0518 0.0552
Brugia malayi SET domain containing protein 0.0014 0.0002 0.0002
Loa Loa (eye worm) intermediate filament protein 0.0031 0.005 0.0053
Schistosoma mansoni hypothetical protein 0.0018 0.0013 0.0019
Echinococcus granulosus nuclear factor of activated T cells 5 0.0085 0.0206 0.0328
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0027 0.0039 0.0884
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.006 0.0105
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0052 0.011 0.2797
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0024 0.0038
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0027 0.0039 0.0884
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0699 0.9276
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0406 0.1143 0.122
Schistosoma mansoni hypothetical protein 0.0103 0.0259 0.0413
Onchocerca volvulus Bile acid receptor homolog 0.0406 0.1143 0.1143
Schistosoma mansoni nuclear hormone receptor 0.0191 0.0518 0.0825
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0072 0.095
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0047 0.0098 0.0155
Brugia malayi hypothetical protein 0.0504 0.1429 0.1524
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0027 0.0039 0.0872
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0028 0.069
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0069 0.0073
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0027 0.0039 0.0884
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0027 0.0028
Onchocerca volvulus 0.0406 0.1143 0.1143
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0027 0.0039 0.0872
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0027 0.0039 0.0872
Onchocerca volvulus 0.0024 0.0028 0.0028
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0027 0.0039 0.0884
Schistosoma mansoni loxhd1 0.0023 0.0026 0.0041
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0067 0.1695
Loa Loa (eye worm) hypothetical protein 0.0191 0.0518 0.0552
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0015 0.011
Loa Loa (eye worm) nuclear hormone receptor 0.0191 0.0518 0.0552
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0024 0.053
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0023 0.0036
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.0008 0.0013
Giardia lamblia DINP protein human, muc B family 0.0022 0.0024 0.0832
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0023 0.0486
Brugia malayi nuclear hormone receptor family member nhr-6 0.0191 0.0518 0.0553
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0005 0.0081
Loa Loa (eye worm) hypothetical protein 0.0116 0.0299 0.0319
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0072 0.095
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0026 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0079 0.1054
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0023 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0406 0.1143 0.1219
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0024 0.0457
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0015 0.0272
Schistosoma mansoni hypothetical protein 0.0041 0.008 0.0127
Trypanosoma brucei protein kinase, putative 0.0059 0.0132 0.337
Brugia malayi bHLH-PAS transcription factor 0.0041 0.008 0.0086
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0023 0.0691
Loa Loa (eye worm) RecQ helicase 0.0025 0.0031 0.0033
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0031 0.0033
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0191 0.0518 0.0825
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0024 0.0585
Schistosoma mansoni microtubule-associated protein tau 0.0793 0.2272 0.3618
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0406 0.1143 0.1821
Brugia malayi Pre-SET motif family protein 0.0034 0.006 0.0064
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0067 1
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0027 0.0039 0.0884
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0024 0.0038
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.0329
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0103 0.0261 0.0415
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0011 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0041 0.0541
Loa Loa (eye worm) hypothetical protein 0.0191 0.0518 0.0552
Plasmodium falciparum glutathione reductase 0.0054 0.0118 1
Schistosoma mansoni hypothetical protein 0.0027 0.0039 0.0062
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0127 0.0135
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0406 0.1143 0.122
Plasmodium falciparum glutathione reductase 0.0019 0.0015 0.0336
Echinococcus granulosus dna polymerase kappa 0.0022 0.0024 0.0038
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0027 0.0039 0.0884
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0024 0.0585
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0028 0.069
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0044 0.1052
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0191 0.0518 0.0552
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0027 0.0039 0.0981
Trypanosoma brucei trypanothione reductase 0.0054 0.0118 0.3005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.0329
Echinococcus granulosus aryl hydrocarbon receptor 0.0015 0.0002 0.0003
Loa Loa (eye worm) cytochrome P450 family protein 0.0071 0.0167 0.0178
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0044 0.3094
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.0132 0.014
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0017 0.0008 0.0013
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0015 0.0016
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0145 0.0382 0.0674
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0044 0.3094
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0027 0.0039 0.0872
Brugia malayi Cytochrome P450 family protein 0.0037 0.0069 0.0073
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0024 0.0043
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.006 0.1586
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0024 0.0316
Echinococcus multilocularis survival motor neuron protein 1 0.0504 0.1429 0.2527
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0445 0.5902
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.0329
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0028 0.0533
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0024 0.0585
Brugia malayi Cytochrome P450 family protein 0.0027 0.0039 0.0042
Echinococcus multilocularis geminin 0.0195 0.0527 0.0933
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0026 0.0041
Entamoeba histolytica hypothetical protein 0.0022 0.0024 0.0139
Loa Loa (eye worm) hypothetical protein 0.0504 0.1429 0.1524
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0024 0.053
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0085 0.0206 0.0365
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0008 0.0009
Brugia malayi Doublecortin family protein 0.0023 0.0026 0.0027
Echinococcus multilocularis GPCR, family 2 0.0018 0.0013 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0072 0.095
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0001
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0027 0.0039 0.0884
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0044 0.1105
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0002 0.0026
Echinococcus granulosus fatty acid binding protein FABP2 0.023 0.0631 0.1004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0041 0.0543
Echinococcus granulosus geminin 0.0195 0.0527 0.084
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.0337 1
Leishmania major protein kinase, putative 0.0016 0.0005 0.0081
Brugia malayi ecdysone receptor 0.0191 0.0518 0.0553
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.0015 0.0193
Echinococcus multilocularis mitogen activated protein kinase 11 0.0145 0.0383 0.0677
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.011 0.1463
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0024 0.0043
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0067 0.0117
Plasmodium vivax glutathione reductase, putative 0.0054 0.0118 1
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0445 0.5902
Loa Loa (eye worm) hypothetical protein 0.0406 0.1143 0.1219
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0022 0.1074
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0024 0.053
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.0337 1
Echinococcus multilocularis lamin 0.0031 0.005 0.0088
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0013 0.0022
Loa Loa (eye worm) inositol-1 0.0037 0.0067 0.0071
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0015 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.001 0.0134
Schistosoma mansoni nuclear hormone receptor 0.0191 0.0518 0.0825
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0063 0.0145 0.0255
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0015 0.0329
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0024 0.053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0041 0.0543
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0053
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.0132 0.3409
Loa Loa (eye worm) lipocalin/cytosolic fatty-acid binding protein family protein 0.023 0.0631 0.0673
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0366 0.1026 0.1634
Schistosoma mansoni hypothetical protein 0.0018 0.0013 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.011 0.1463
Entamoeba histolytica hypothetical protein 0.0041 0.008 0.657
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.0118 0.3045
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0015 0.0181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0406 0.1143 0.1219
Schistosoma mansoni hypothetical protein 0.0195 0.0527 0.084
Brugia malayi hypothetical protein 0.0214 0.0585 0.0624
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0024 0.0038
Brugia malayi hypothetical protein 0.0023 0.0026 0.0027
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0132 0.021
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0406 0.1143 0.1821
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0095 0.015
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0132 0.3409
Brugia malayi hypothetical protein 0.0041 0.008 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0406 0.1143 0.122
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0406 0.1143 0.122
Brugia malayi Nuclear hormone receptor-like 1 0.0214 0.0585 0.0624
Brugia malayi Lipocalin / cytosolic fatty-acid binding protein family protein 0.023 0.0631 0.0673
Onchocerca volvulus 0.0116 0.0299 0.0299
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0406 0.1143 0.1821
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0015 0.0336
Echinococcus granulosus Nuclear hormone receptor HR96 0.0191 0.0518 0.0825
Schistosoma mansoni hypothetical protein 0.0039 0.0074 0.0117
Schistosoma mansoni hypothetical protein 0.0195 0.0527 0.084
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0024 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0041 0.0543
Schistosoma mansoni lamin 0.0031 0.005 0.0079
Echinococcus multilocularis nuclear receptor nhr 48 0.0191 0.0518 0.0916
Brugia malayi nuclear hormone receptor family member odr-7 0.0191 0.0518 0.0553
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0471 0.6248
Echinococcus granulosus microtubule associated protein 2 0.0793 0.2272 0.3618
Mycobacterium ulcerans hypothetical protein 0.0024 0.0028 0.0533
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0057 0.0761
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0013
Brugia malayi Cytochrome P450 family protein 0.0037 0.0069 0.0073
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0013 0.0019
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.001 0.0213
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0015 0.0002 0.0003
Onchocerca volvulus 0.0023 0.0026 0.0025
Echinococcus multilocularis FTZ F1 alpha 0.0406 0.1143 0.2022
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0075 0.0996
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0015 0.0272
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.0132 0.3779
Loa Loa (eye worm) hypoxia-induced factor 1 0.0173 0.0464 0.0495
Leishmania major protein kinase, putative 0.0021 0.0021 0.0509
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0024 0.0038
Echinococcus granulosus lamin 0.0031 0.005 0.0079
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.0132 0.0233
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0145 0.0383 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0044 0.1105
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0024 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.005 0.0658
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0024 0.0026
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0132 0.1751
Brugia malayi Nuclear hormone receptor-like 1 0.0406 0.1143 0.122
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.0015 0.0193
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0024 0.0026
Echinococcus multilocularis fatty acid binding protein FABP2 0.023 0.0631 0.1115
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0026 0.0045
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.0337 0.0536
Brugia malayi hypothetical protein 0.0214 0.0585 0.0624
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0024 0.0042
Echinococcus multilocularis mitogen activated protein kinase 14 0.0145 0.0383 0.0677
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0699 0.9276
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0027
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0023 0.03
Brugia malayi photoreceptor-specific nuclear receptor 0.0406 0.1143 0.122
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0191 0.0518 0.0916
Schistosoma mansoni hypothetical protein 0.0017 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.0214 0.0585 0.0624
Echinococcus multilocularis 0.0027 0.0039 0.0069
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0132 0.1751
Echinococcus granulosus ecdysone induced protein 78C 0.0406 0.1143 0.1821
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0027 0.0039 0.0884
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0049 0.0646
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0145 0.0383 1
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0366 0.1026 0.1634
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0027 0.0039 0.0872
Brugia malayi nuclear hormone receptor 0.3227 0.9375 1
Brugia malayi intermediate filament protein 0.0031 0.005 0.0053
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0015 0.011
Onchocerca volvulus 0.0031 0.005 0.005
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0075 0.0996
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0041 0.0543
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0028 0.0732
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0028 0.003
Trypanosoma brucei cytochrome P450, putative 0.0037 0.0069 0.1702
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0024 0.053
Mycobacterium ulcerans putative regulatory protein 0.0041 0.008 0.2127
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0024 0.0025
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0406 0.1143 0.2022
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0002 0.0026
Echinococcus multilocularis thyroid hormone receptor alpha 0.055 0.1565 0.2768
Loa Loa (eye worm) hypothetical protein 0.0039 0.0074 0.0078
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0026 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0024 0.0316
Onchocerca volvulus Protein ultraspiracle homolog 0.0406 0.1143 0.1143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0072 0.095
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0406 0.1143 0.2022
Onchocerca volvulus 0.0015 0.0002 0.0002
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0005 0.0081
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0023 0.0542
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.0118 0.3112
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0003 0.0005
Echinococcus granulosus death domain containing protein 0.0017 0.0008 0.0012
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.001 0.0213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0061 0.0805
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.0008 0.0012
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0129 0.0337 0.8786
Trypanosoma brucei unspecified product 0.0022 0.0024 0.053
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0028 0.0571
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0024 0.0316
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0067 0.0884
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0001
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0016 0.0025
Entamoeba histolytica hypothetical protein 0.0041 0.008 0.657
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0026 0.0045
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0015 0.0329
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0067 0.502
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0031 0.0413
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0011 0.0269
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0028 0.0645
Brugia malayi PAS domain containing protein 0.0056 0.0123 0.0131
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.006 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0406 0.1143 0.122
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0008
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0145 0.0383 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.001 0.0134
Echinococcus granulosus survival motor neuron protein 1 0.0504 0.1429 0.2275
Entamoeba histolytica hypothetical protein 0.0022 0.0024 0.0139
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.0025
Loa Loa (eye worm) hypothetical protein 0.0214 0.0585 0.0624
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0031 0.0055
Schistosoma mansoni aryl hydrocarbon receptor 0.0056 0.0123 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0079 0.1054
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.0025
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0027 0.0039 0.0872
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0027 0.0039 0.0872
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0088 0.117
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0406 0.1143 0.2022
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0027 0.0039 0.0927
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0366 0.1026 0.1094
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0027 0.0047
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0145 0.0383 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0002 0.0026
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0024 0.0038
Brugia malayi nuclear receptor NHR-88 0.0406 0.1143 0.122
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0028 0.0533
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0067 0.1646
Brugia malayi M-phase phosphoprotein, mpp8 0.0116 0.0299 0.0319
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0013 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0041 0.0541
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0445 0.5902
Loa Loa (eye worm) hypothetical protein 0.0214 0.0585 0.0624
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0015 0.0023
Brugia malayi Nuclear hormone receptor E75 0.0191 0.0518 0.0553
Mycobacterium leprae Conserved hypothetical protein 0.0027 0.0039 0.104
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0027 0.0039 0.0981
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0023 0.0359
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0027 0.0039 0.0884
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0013 0.0013
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0017 0.001 0.0016
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0052 0.011 0.2839
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.0337 1
Schistosoma mansoni rab6-interacting 0.0023 0.0026 0.0041
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0406 0.1143 0.1219
Loa Loa (eye worm) hypothetical protein 0.0191 0.0518 0.0552
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0027 0.0039 0.0884
Echinococcus multilocularis transfer RNA-Lys 0.0041 0.008 0.0142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0079 0.1054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0406 0.1143 0.1219
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.0118 0.0208
Onchocerca volvulus 0.0047 0.0098 0.0098
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0011 0.7133
Loa Loa (eye worm) CYP4Cod1 0.0037 0.0069 0.0073
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0027 0.0042
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.0025
Loa Loa (eye worm) hypothetical protein 0.0214 0.0585 0.0624
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0024 0.0585
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0406 0.1143 0.1821
Onchocerca volvulus 0.0103 0.0259 0.0259
Schistosoma mansoni inositol monophosphatase 0.0037 0.0067 0.0106
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0024 0.0038
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0015 0.0002 0.0003
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0041 0.008 0.1987
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0024 0.0038
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0015 0.0336
Leishmania major trypanothione reductase 0.0054 0.0118 0.3045
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0015 0.0329
Schistosoma mansoni hypothetical protein 0.0119 0.0306 0.0487
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.011 0.1463
Brugia malayi Uncoordinated protein 44 0.0017 0.0008 0.0008
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0024 0.0025
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0027 0.0028
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.008 0.0127
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0031 0.0413
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0143 0.0152
Echinococcus multilocularis RUN 0.0023 0.0026 0.0045
Brugia malayi Cytochrome P450 family protein 0.0071 0.0167 0.0178
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0024 0.0038
Leishmania major hypothetical protein, conserved 0.0029 0.0044 0.1105
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0024 0.0038
Loa Loa (eye worm) hypothetical protein 0.0191 0.0518 0.0552
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0015 0.0596
Entamoeba histolytica hypothetical protein 0.0041 0.008 0.657
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.005 0.0658
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0028 0.0571
Schistosoma mansoni thyroid hormone receptor 0.055 0.1565 0.2493
Echinococcus granulosus tm gpcr rhodopsin 0.0639 0.1823 0.2904
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0145 0.0382 0.0607
Schistosoma mansoni zinc finger protein 0.0191 0.0518 0.0825
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0103 0.0261 0.0415
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0024 0.053
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0406 0.1143 0.2022
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0027 0.0039 0.0884
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0005 0.0081
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0024 0.0038
Brugia malayi Pre-SET motif family protein 0.0239 0.0657 0.0701
Echinococcus multilocularis musashi 0.0031 0.005 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0024 0.053
Schistosoma mansoni ap endonuclease 0.0022 0.0023 0.0036
Schistosoma mansoni thyroid hormone receptor 0.055 0.1565 0.2493
Loa Loa (eye worm) hypothetical protein 0.0191 0.0518 0.0552
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.0329
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0067 0.1695
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0027 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0406 0.1143 0.122
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0138 0.0361 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0013 0.0019
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0124 0.0321 0.8858
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0024 0.053
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0366 0.1026 0.1094
Plasmodium falciparum thioredoxin reductase 0.0054 0.0118 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0055 0.1486
Loa Loa (eye worm) hypothetical protein 0.0034 0.006 0.0063
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0699 0.9276
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0143 0.0253
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0017 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0072 0.095
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0406 0.1143 0.1821
Loa Loa (eye worm) hypothetical protein 0.0406 0.1143 0.1219
Echinococcus granulosus tar DNA binding protein 0.0063 0.0143 0.0228
Trichomonas vaginalis adenylate cyclase, putative 0.0015 0.0002 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0406 0.1143 0.1219
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.0329
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.0025
Brugia malayi Death domain containing protein 0.0017 0.0008 0.0008
Mycobacterium leprae putative cytochrome p450 0.0027 0.0039 0.104
Echinococcus multilocularis lamin dm0 0.0031 0.005 0.0088
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0143 0.0228
Schistosoma mansoni rab6-interacting 0.0023 0.0026 0.0041
Schistosoma mansoni inositol monophosphatase 0.0037 0.0067 0.0106
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0052 0.011 0.2839
Onchocerca volvulus 0.0041 0.008 0.008
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0052 0.011 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0024 0.053
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0024 0.053
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0214 0.0585 0.0931
Loa Loa (eye worm) phosphatidylinositol 3 0.0052 0.011 0.0117
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0406 0.1143 0.1821
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0027 0.0039 0.0884
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.0132 0.3409
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0037 0.0069 0.1773
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0028 0.0645
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0023 0.1558
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0406 0.1143 0.2022
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0445 0.5902
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0191 0.0518 0.0825
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0406 0.1143 0.1821
Loa Loa (eye worm) hypothetical protein 0.0057 0.0127 0.0135
Trichomonas vaginalis set domain proteins, putative 0.0272 0.0753 1
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0027 0.0039 0.0884
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0027 0.0039 0.0884
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0129 0.0337 0.9306
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.0329
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.006 0.0105
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0024 0.0042
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0406 0.1143 0.122
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0191 0.0518 0.0916
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0191 0.0518 0.0916
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0132 0.3409
Echinococcus granulosus mitogen activated protein kinase 14 0.0145 0.0383 0.061
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0024 0.0038
Echinococcus granulosus hypothetical protein 0.0807 0.2313 0.3683
Schistosoma mansoni intermediate filament proteins 0.0031 0.005 0.0079
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0143 0.0153
Schistosoma mansoni netrin receptor unc5 0.0017 0.0008 0.0012
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0023 0.0411
Leishmania major DNA polymerase eta, putative 0.0022 0.0024 0.0585
Plasmodium vivax SET domain protein, putative 0.0034 0.006 0.4694
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0366 0.1026 0.1814
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.005 0.0053
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.0132 0.3409
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0002 0.0026
Echinococcus granulosus mitogen activated protein kinase 11 0.0145 0.0383 0.061
Loa Loa (eye worm) steroid hormone receptor 0.057 0.1623 0.1731
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0041 0.0541
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0699 0.9276
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0024 0.0042
Brugia malayi PXA domain containing protein 0.0022 0.0024 0.0025
Schistosoma mansoni nuclear receptor nhr-48 0.0191 0.0518 0.0825
Loa Loa (eye worm) cytochrome P450 0.0027 0.0039 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0072 0.095
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0143 0.0228
Schistosoma mansoni nuclear hormone receptor 0.0406 0.1143 0.1821
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0214 0.0585 0.0931
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0017 0.001 0.0213
Echinococcus multilocularis mitogen activated protein kinase 14 0.0145 0.0383 0.0677
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0027 0.0039 0.0872
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0138 0.0361 1
Schistosoma mansoni polycystin 1-related 0.0023 0.0026 0.0041
Schistosoma mansoni steroid hormone receptor ad4bp 0.0406 0.1143 0.1821
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0017 0.001 0.0017
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0024 0.0025
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0023 0.0024
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0042 0.0083 0.0147
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0024 0.0025
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0028 0.0645
Loa Loa (eye worm) hypothetical protein 0.0191 0.0518 0.0552
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0028 0.003
Schistosoma mansoni RAR-like nuclear receptor 0.0406 0.1143 0.1821
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.001 0.0134
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0024 0.0042
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0067 0.1695
Brugia malayi P38 map kinase family protein 2 0.0145 0.0383 0.0409
Loa Loa (eye worm) hypothetical protein 0.0023 0.0026 0.0027
Brugia malayi orphan nuclear receptor NR2E1 0.0191 0.0518 0.0553
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0024 0.0042
Echinococcus granulosus FTZ F1 alpha 0.0406 0.1143 0.1821
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0095 0.015
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0027 0.0039 0.0872
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0406 0.1143 0.122
Loa Loa (eye worm) hypothetical protein 0.0191 0.0518 0.0552
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0028 0.0533
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0214 0.0585 0.0624
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0024 0.0038
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0015 0.0329
Loa Loa (eye worm) nuclear receptor NHR-67 0.0191 0.0518 0.0552
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0027 0.0039 0.0872
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0027 0.0039 0.0981
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0143 0.0228
Brugia malayi nuclear hormone receptor 0.0406 0.1143 0.122
Brugia malayi Inositol-1 0.0037 0.0067 0.0071
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0129 0.0337 0.0536
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0143 0.0228
Toxoplasma gondii target of rapamycin (TOR), putative 0.0038 0.0072 0.1949
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0067 0.0884
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0406 0.1143 0.1821
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0024 0.0316
Echinococcus granulosus nuclear receptor nhr 48 0.0191 0.0518 0.0825
Loa Loa (eye worm) hypothetical protein 0.003 0.0048 0.0051
Schistosoma mansoni fatty acid binding protein 0.023 0.0631 0.1004
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0023 0.1093
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0002 0.0026
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0042 0.0083 0.0132
Echinococcus granulosus Ankyrin 0.0017 0.0008 0.0013
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0024 0.0322
Onchocerca volvulus 0.0116 0.0299 0.0299
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0127 0.0135
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0024 0.0038
Brugia malayi nuclear receptor RXR 0.0214 0.0585 0.0624
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0024 0.0038
Schistosoma mansoni fatty acid binding protein 0.023 0.0631 0.1004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0406 0.1143 0.1219
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0027 0.0039 0.0872
Echinococcus granulosus netrin receptor unc 5 0.0017 0.0008 0.0012
Echinococcus granulosus lamin dm0 0.0031 0.005 0.0079
Brugia malayi hypothetical protein 0.0023 0.0026 0.0027
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0052 0.011 0.2839
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0013 0.0013
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0103 0.0261 0.0461
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0028 0.0533
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0052 0.011 0.0118
Loa Loa (eye worm) hypothetical protein 0.0116 0.0299 0.0319
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0214 0.0585 0.1034
Echinococcus multilocularis mitogen activated protein kinase 11 0.0145 0.0383 0.0677
Loa Loa (eye worm) nuclear receptor nhr-7B 0.3227 0.9375 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0067 0.1708
Brugia malayi tailless protein 0.0191 0.0518 0.0553
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0127 0.0135
Schistosoma mansoni survival motor neuron protein 0.0103 0.0259 0.0413
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0024 0.0025
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.0118 0.0188
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0015 0.0329
Loa Loa (eye worm) hypothetical protein 0.0187 0.0507 0.054
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.0132 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0017
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.1952 0.5653 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.001 0.0011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0406 0.1143 0.122
Schistosoma mansoni hypothetical protein 0.0018 0.0013 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0445 0.5902
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0008 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0406 0.1143 0.1219
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0019 0.0015 1
Brugia malayi steroid hormone receptor 0.057 0.1623 0.1732
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0471 0.6248
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0015 0.0329
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0191 0.0518 0.0518
Echinococcus multilocularis ecdysone induced protein 78C 0.0406 0.1143 0.2022
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0015 0.0002 0.0026
Toxoplasma gondii exonuclease III APE 0.0022 0.0023 0.0463
Echinococcus multilocularis microtubule associated protein 2 0.0793 0.2272 0.4019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.001 0.0134
Brugia malayi hypothetical protein 0.0029 0.0044 0.0047
Brugia malayi cytochrome P450 0.0027 0.0039 0.0042
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0191 0.0518 0.0553
Echinococcus multilocularis expressed protein 0.0429 0.121 0.2141
Leishmania major cytochrome p450-like protein 0.0027 0.0039 0.0981
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0015 0.0023
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0047
Schistosoma mansoni nuclear receptor 0.0191 0.0518 0.0825
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0024 0.0316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0049 0.0646
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0023 0.0542
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0699 0.9276
Brugia malayi Protein kinase domain containing protein 0.0018 0.0011 0.0012
Brugia malayi hypothetical protein 0.0022 0.0024 0.0025
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0015 0.0002 0.0002
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0024 0.0025
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0214 0.0585 0.0931
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0406 0.1143 0.122
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0406 0.1143 0.1821
Brugia malayi RNA binding protein 0.0063 0.0143 0.0153
Brugia malayi Steroid receptor seven-up type 2 0.0406 0.1143 0.122
Leishmania major DNA polymerase kappa, putative 0.0022 0.0024 0.0585
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0028 0.0533
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.0337 0.0536
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.006 0.0095
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0027 0.0039 0.0872
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0011
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0027 0.0039 0.0884
Loa Loa (eye worm) hypothetical protein 0.0191 0.0518 0.0552
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0052 0.011 0.0175
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0027 0.0039 0.0884
Onchocerca volvulus 0.0191 0.0518 0.0518
Loa Loa (eye worm) hypothetical protein 0.3036 0.8816 0.9404
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0024 0.0042
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0067 0.1797
Onchocerca volvulus 0.0272 0.0754 0.0754
Brugia malayi MAP kinase sur-1 0.0059 0.0132 0.0141
Brugia malayi nuclear receptor NHR-88 0.0191 0.0518 0.0553
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0028 0.0533
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0069 0.0073

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 548 nM Effective concentration against stimulation of [35S]-GTP-gammaS, binding in CHO cells transfected with the human opioid receptor delta 1 ChEMBL. 15080989
EC50 (functional) = 548 nM Effective concentration against stimulation of [35S]-GTP-gammaS, binding in CHO cells transfected with the human opioid receptor delta 1 ChEMBL. 15080989
Ki (binding) = 3.2 nM Binding affinity for delta opioid receptor ChEMBL. 15080989
Ki (binding) = 3.2 nM Binding affinity for delta opioid receptor ChEMBL. 15080989
Ki (binding) = 291 nM Binding affinity for mu opioid receptor ChEMBL. 15080989
Ki (binding) = 291 nM Binding affinity for mu opioid receptor ChEMBL. 15080989
Relative efficacy (functional) = 0.77 Efficacy relative to stimulation of [35S]-GTP-gammaS, binding by SNC80 was calculated for human delta opioid receptor ChEMBL. 15080989
Relative efficacy (functional) = 0.77 Efficacy relative to stimulation of [35S]-GTP-gammaS, binding by SNC80 was calculated for human delta opioid receptor ChEMBL. 15080989

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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