Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ELOVL fatty acid elongase 6 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | Fatty acid elongase | ELOVL fatty acid elongase 6 | 265 aa | 259 aa | 34.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | GNS1/SUR4 family protein | 0.005 | 0.33 | 0.33 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0018 | 0.0689 | 0.1884 |
Toxoplasma gondii | GNS1/SUR4 family protein | 0.005 | 0.33 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0083 | 0.0083 |
Echinococcus multilocularis | elongation of very long chain fatty acids | 0.001 | 0.0083 | 0.1205 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0018 | 0.0689 | 1 |
Echinococcus multilocularis | elongation of very long chain fatty acids | 0.001 | 0.0083 | 0.1205 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0689 | 1 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.001 | 0.0083 | 0.1205 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0018 | 0.0689 | 0.1884 |
Schistosoma mansoni | fatty acid acyl transferase-related | 0.001 | 0.0083 | 0.1205 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.005 | 0.33 | 1 |
Leishmania major | fatty acid elongase, putative | 0.005 | 0.33 | 1 |
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.001 | 0.0083 | 0.0083 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.005 | 0.33 | 0.33 |
Brugia malayi | fatty acid elongation protein 3 | 0.001 | 0.0083 | 0.0083 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.001 | 0.0083 | 0.1205 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0018 | 0.0689 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0689 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0018 | 0.0689 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0689 | 0.1884 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.005 | 0.33 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0689 | 0.1884 |
Plasmodium falciparum | long chain fatty acid elongation enzyme, putative | 0.005 | 0.33 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0689 | 0.1884 |
Brugia malayi | fatty acid elongation protein 3 | 0.001 | 0.0083 | 0.0083 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0018 | 0.0689 | 0.1884 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.001 | 0.0083 | 0.0083 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0689 | 0.1884 |
Onchocerca volvulus | 0.001 | 0.0083 | 0.5 | |
Onchocerca volvulus | 0.001 | 0.0083 | 0.5 | |
Echinococcus granulosus | elongation of very long chain fatty acids | 0.001 | 0.0083 | 0.1205 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.001 | 0.0083 | 0.1205 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.001 | 0.0083 | 0.0083 |
Toxoplasma gondii | integral membrane protein, GNS1/SUR4 family protein, putative | 0.005 | 0.33 | 1 |
Brugia malayi | Hypothetical 34.1 kDa protein C40H1.4 in chromosome III | 0.001 | 0.0083 | 0.0083 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.001 | 0.0083 | 0.0083 |
Leishmania major | fatty acid elongase, putative | 0.005 | 0.33 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0.0689 | 0.5 |
Loa Loa (eye worm) | ELO-9 protein | 0.001 | 0.0083 | 0.0083 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0018 | 0.0689 | 0.1884 |
Plasmodium vivax | GNS1/SUR4 domain containing protein | 0.005 | 0.33 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0689 | 1 |
Leishmania major | fatty acid elongase, putative | 0.005 | 0.33 | 1 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein 5 homolog | 0.001 | 0.0083 | 0.5 |
Brugia malayi | Isocitrate dehydrogenase | 0.0018 | 0.0689 | 0.0689 |
Plasmodium falciparum | fatty acid elongation protein, GNS1/SUR4 family, putative | 0.005 | 0.33 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0689 | 0.1884 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0018 | 0.0689 | 0.0689 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0689 | 1 |
Brugia malayi | GNS1/SUR4 family protein | 0.001 | 0.0083 | 0.0083 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein homolog | 0.001 | 0.0083 | 0.5 |
Brugia malayi | fatty acid elongation protein 3 | 0.001 | 0.0083 | 0.0083 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.005 | 0.33 | 1 |
Brugia malayi | Fatty acid elongation protein 3 | 0.005 | 0.33 | 0.33 |
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.005 | 0.33 | 0.33 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein homolog | 0.001 | 0.0083 | 0.5 |
Brugia malayi | isocitrate dehydrogenase | 0.0018 | 0.0689 | 0.0689 |
Brugia malayi | fatty acid elongation protein 3 | 0.001 | 0.0083 | 0.0083 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.001 | 0.0083 | 0.1205 |
Trypanosoma brucei | Fatty acid elongase | 0.005 | 0.33 | 1 |
Echinococcus granulosus | elongation of very long chain fatty acids | 0.001 | 0.0083 | 0.1205 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.005 | 0.33 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 130 nM | Inhibition of C-terminal V5-epitope-tagged human ELOVL6 expressed in african green monkey COS7 cells | ChEMBL. | 19596583 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.