Detailed information for compound 1076944

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 394.483 | Formula: C24H28NO4+
  • H donors: 0 H acceptors: 0 LogP: 4.22 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC1(CC)c2c(ccc(c2OC)OC)CC2=[N+]1CCc1c2cc2c(c1)OCO2
  • InChi: 1S/C24H28NO4/c1-5-24(6-2)22-16(7-8-19(26-3)23(22)27-4)11-18-17-13-21-20(28-14-29-21)12-15(17)9-10-25(18)24/h7-8,12-13H,5-6,9-11,14H2,1-4H3/q+1
  • InChiKey: OWXQAJSSEMBYPV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0087 0.077 0.0909
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0129 0.1259 0.2277
Brugia malayi Thioredoxin reductase 0.0051 0.0349 0.0401
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.2471 0.2962
Echinococcus granulosus TGF beta signal transducer SmadC 0.005 0.0338 0.1114
Giardia lamblia Kinase, PLK 0.0103 0.0958 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0421 0.4664 0.5607
Echinococcus multilocularis geminin 0.0196 0.2042 0.2031
Schistosoma mansoni tar DNA-binding protein 0.0272 0.2933 0.9426
Echinococcus granulosus Smad4 0.005 0.0338 0.1114
Schistosoma mansoni Smad4 0.0022 0.0016 0.001
Loa Loa (eye worm) MH2 domain-containing protein 0.005 0.0338 0.0389
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0037 0.0189 0.0343
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0133 0.1309 0.4437
Loa Loa (eye worm) bromodomain containing protein 0.0059 0.0442 0.0514
Schistosoma mansoni hypothetical protein 0.0069 0.0557 0.1757
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0958 0.305
Plasmodium vivax SET domain protein, putative 0.0033 0.0145 0.1093
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0191 0.1985 0.2376
Mycobacterium ulcerans beta-lactamase 0.0077 0.0659 1
Toxoplasma gondii thioredoxin reductase 0.0051 0.0349 0.4808
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0191 0.1985 0.2376
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0082 0.008
Mycobacterium tuberculosis Conserved protein 0.0077 0.0659 0.1193
Brugia malayi serine/threonine-protein kinase plk-2 0.0103 0.0958 0.1136
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.005 0.0341 0.0617
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0029 0.0099 0.0179
Mycobacterium tuberculosis Probable thioesterase TesA 0.0043 0.0259 0.0468
Loa Loa (eye worm) MH1 domain-containing protein 0.005 0.0338 0.0389
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0659 0.4569
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0421 0.4664 0.5607
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0329 0.2819
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0329 0.4278
Leishmania major trypanothione reductase 0.0051 0.0349 0.3041
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0659 0.0647
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0272 0.2933 0.3519
Toxoplasma gondii ABC1 family protein 0.0077 0.0659 1
Echinococcus granulosus GPCR family 2 0.0133 0.1309 0.4437
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0659 0.0776
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0048 0.032 0.0366
Schistosoma mansoni zinc finger protein 0.0051 0.035 0.1088
Mycobacterium ulcerans thioesterase 0.0043 0.0259 0.2058
Onchocerca volvulus 0.0033 0.0145 0.0456
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0055 0.0397 0.0718
Onchocerca volvulus 0.009 0.0806 0.2791
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0329 0.2819
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0129 0.1259 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0808 0.2566
Schistosoma mansoni methyl-cpg binding protein mbd 0.0057 0.0418 0.1308
Entamoeba histolytica hypothetical protein 0.0077 0.0658 0.6573
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0351 0.0972
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0129 0.1259 0.2277
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0659 0.1193
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0048 0.032 0.0578
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0103 0.0958 1
Loa Loa (eye worm) hypothetical protein 0.0236 0.2503 0.3
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0131 0.0404
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0958 0.3167
Schistosoma mansoni smad1 5 8 and 0.005 0.0338 0.105
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.1985 0.6366
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0145 0.0427
Echinococcus multilocularis mothers against decapentaplegic 6 0.0022 0.0016 0.0003
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0145 0.1413
Mycobacterium leprae Polyketide synthase Pks13 0.0077 0.0658 0.4555
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.0808 0.2722
Plasmodium falciparum thioredoxin reductase 0.0051 0.0349 1
Schistosoma mansoni hypothetical protein 0.0133 0.1309 0.4183
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0055 0.0397 0.2191
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.1108 0.2004
Schistosoma mansoni tar DNA-binding protein 0.0272 0.2933 0.9426
Loa Loa (eye worm) PHD-finger family protein 0.0069 0.0557 0.0653
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0199 0.2075 0.2065
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0116 0.1108 0.8633
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.1108 0.2004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0659 0.2086
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0421 0.4664 0.5607
Toxoplasma gondii type I fatty acid synthase, putative 0.0055 0.0397 0.5614
Schistosoma mansoni tar DNA-binding protein 0.0272 0.2933 0.9426
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.0808 0.0796
Echinococcus granulosus methyl CpG binding domain protein 2 0.0057 0.0418 0.1388
Brugia malayi MH1 domain containing protein 0.005 0.0338 0.0389
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0659 0.1193
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0052 0.0359 0.1852
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0133 0.1309 0.1297
Schistosoma mansoni smad1 5 8 and 0.005 0.0338 0.105
Toxoplasma gondii type I fatty acid synthase, putative 0.0037 0.0186 0.2082
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.0958 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0659 0.0776
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0055 0.0397 0.4795
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.1985 0.6754
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0659 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0658 0.2208
Schistosoma mansoni kinase 0.0052 0.0367 0.1142
Brugia malayi Pre-SET motif family protein 0.0233 0.2471 0.2962
Echinococcus granulosus flap endonuclease 1 0.0028 0.0082 0.0237
Schistosoma mansoni smad 0.005 0.0338 0.105
Plasmodium vivax glutathione reductase, putative 0.0051 0.0349 0.4615
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0075 0.0632 0.0619
Loa Loa (eye worm) hypothetical protein 0.0133 0.1309 0.1559
Brugia malayi glutathione reductase 0.0051 0.0349 0.0401
Entamoeba histolytica hypothetical protein 0.0077 0.0658 0.6573
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0052 0.0359 0.065
Brugia malayi Flap endonuclease-1 0.0028 0.0082 0.008
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0659 0.1193
Loa Loa (eye worm) Smad1 0.005 0.0338 0.0389
Loa Loa (eye worm) TAR-binding protein 0.0272 0.2933 0.3519
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.1985 0.1975
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0145 0.0427
Brugia malayi hypothetical protein 0.0032 0.0126 0.0132
Trypanosoma brucei trypanothione reductase 0.0051 0.0349 0.3041
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0052 0.0359 0.065
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0958 0.3167
Mycobacterium tuberculosis Conserved protein 0.0077 0.0659 0.1193
Schistosoma mansoni smad1 5 8 and 0.005 0.0338 0.105
Schistosoma mansoni flap endonuclease-1 0.0025 0.0051 0.0122
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0659 0.2087
Schistosoma mansoni hypothetical protein 0.0133 0.1309 0.4183
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0329 0.927
Echinococcus multilocularis mothers against decapentaplegic 2 0.0022 0.0016 0.0003
Brugia malayi MH2 domain containing protein 0.005 0.0338 0.0389
Onchocerca volvulus 0.0077 0.0659 0.2272
Loa Loa (eye worm) MH2 domain-containing protein 0.0733 0.8305 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0042 0.0241 0.0784
Loa Loa (eye worm) nuclear factor I 0.0028 0.0078 0.0075
Schistosoma mansoni methyl-cpg binding protein mbd 0.0057 0.0418 0.1308
Echinococcus granulosus smad 0.005 0.0338 0.1114
Loa Loa (eye worm) acyl carrier protein 0.0024 0.0033 0.0021
Loa Loa (eye worm) hypothetical protein 0.0077 0.0659 0.0776
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0958 0.3167
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0659 0.1193
Loa Loa (eye worm) latrophilin receptor protein 2 0.0133 0.1309 0.1559
Schistosoma mansoni hypothetical protein 0.0196 0.2042 0.6549
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0082 0.0359
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0133 0.1309 0.1297
Echinococcus granulosus tar DNA binding protein 0.0272 0.2933 1
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0659 0.2087
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0349 0.4615
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0659 1
Schistosoma mansoni Smad4 0.0022 0.0016 0.001
Schistosoma mansoni TGF-beta signal transducer Smad2 0.005 0.0338 0.105
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0329 0.927
Echinococcus multilocularis Smad4 0.005 0.0338 0.0326
Mycobacterium tuberculosis Polyketide synthase Pks2 0.005 0.0341 0.0617
Mycobacterium ulcerans thioesterase TesA 0.0043 0.0259 0.2058
Brugia malayi MH1 domain containing protein 0.0028 0.0078 0.0075
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.012 0.1152 0.114
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0958 0.3167
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0199 0.2075 0.7061
Loa Loa (eye worm) hypothetical protein 0.0142 0.1413 0.1685
Brugia malayi Bromodomain containing protein 0.0128 0.1244 0.1481
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.1108 0.2004
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0043 0.0259 0.094
Trypanosoma brucei polo-like protein kinase 0.0103 0.0958 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0659 0.0776
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0057 0.0418 0.0406
Brugia malayi RNA binding protein 0.0272 0.2933 0.3519
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.1108 0.2004
Mycobacterium ulcerans Type I modular polyketide synthase 0.0052 0.0359 0.4052
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0082 0.0069
Loa Loa (eye worm) hypothetical protein 0.0049 0.0329 0.0377
Onchocerca volvulus 0.0265 0.2847 1
Leishmania major hypothetical protein, conserved 0.0049 0.0329 0.2819
Brugia malayi Bromodomain containing protein 0.025 0.2669 0.3201
Onchocerca volvulus 0.0077 0.0659 0.2272
Mycobacterium tuberculosis Probable reductase 0.0116 0.1108 0.2004
Echinococcus granulosus fetal alzheimer antigen falz 0.0075 0.0632 0.2118
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.1985 0.1975
Brugia malayi beta-lactamase 0.0077 0.0659 0.0776
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0133 0.1309 0.4437
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0052 0.0359 0.1852
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0658 0.0646
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0329 0.4483
Mycobacterium tuberculosis Conserved protein 0.0077 0.0659 0.1193
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0077 0.0658 0.119
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0808 0.2566
Schistosoma mansoni tar DNA-binding protein 0.0272 0.2933 0.9426
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0958 0.3167
Loa Loa (eye worm) hypothetical protein 0.0077 0.0659 0.0776
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.1985 0.6754
Echinococcus granulosus mothers against decapentaplegic 5 0.005 0.0338 0.1114
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0659 0.659
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0055 0.0397 0.2191
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0351 0.0972
Loa Loa (eye worm) glutathione reductase 0.0051 0.0349 0.0401
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0103 0.0958 0.0946
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0659 0.2087
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0659 1
Entamoeba histolytica hypothetical protein 0.0077 0.0658 0.6573
Onchocerca volvulus Serine\/threonine kinase homolog 0.0103 0.0958 0.3327
Schistosoma mansoni hypothetical protein 0.0051 0.035 0.1088
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0349 0.0336
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0329 0.2819
Schistosoma mansoni Smad4 0.005 0.0338 0.105
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0042 0.0241 0.1715
Loa Loa (eye worm) hypothetical protein 0.0028 0.0078 0.0075
Mycobacterium ulcerans Type I modular polyketide synthase 0.0052 0.0359 0.4052
Loa Loa (eye worm) hypothetical protein 0.0077 0.0659 0.0776
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0145 0.0133
Brugia malayi RNA recognition motif domain containing protein 0.0272 0.2933 0.3519
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0133 0.1309 0.1559
Onchocerca volvulus 0.0077 0.0659 0.2272
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0958 0.3167
Loa Loa (eye worm) hypothetical protein 0.0136 0.1338 0.1595
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.1985 0.6366
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0659 0.1193
Loa Loa (eye worm) hypothetical protein 0.009 0.0808 0.0955
Schistosoma mansoni hypothetical protein 0.0133 0.1309 0.4183
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0034 0.0147 0.1445
Mycobacterium leprae Probable lipase LipE 0.0077 0.0659 0.4569
Loa Loa (eye worm) hypothetical protein 0.0128 0.1246 0.1484
Mycobacterium ulcerans Type I modular polyketide synthase 0.0052 0.0359 0.4052
Schistosoma mansoni hypothetical protein 0.0288 0.3111 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0052 0.0359 0.065
Loa Loa (eye worm) hypothetical protein 0.0077 0.0659 0.0776
Echinococcus granulosus geminin 0.0196 0.2042 0.6947
Mycobacterium ulcerans hypothetical protein 0.0077 0.0659 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.1259 0.2277
Loa Loa (eye worm) beta-lactamase 0.0077 0.0659 0.0776
Schistosoma mansoni hypothetical protein 0.0196 0.2042 0.6549
Echinococcus granulosus mothers against decapentaplegic 6 0.0022 0.0016 0.0011
Mycobacterium ulcerans polyketide synthase Pks13 0.0077 0.0658 0.9969
Brugia malayi MH1 domain containing protein 0.0028 0.0078 0.0075
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0659 0.2086
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.1108 0.2004
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0495 0.5527 1
Schistosoma mansoni hypothetical protein 0.0077 0.0658 0.2081
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0055 0.0397 0.0718
Echinococcus multilocularis TGF beta signal transducer SmadC 0.005 0.0338 0.0326
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0055 0.0397 0.4795
Entamoeba histolytica hypothetical protein 0.0077 0.0658 0.6573
Trypanosoma brucei ISWI complex protein 0.0051 0.035 0.306
Leishmania major hypothetical protein, conserved 0.0051 0.035 0.306
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0349 0.1149
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0659 0.659
Onchocerca volvulus Fatty acid synthase homolog 0.0093 0.0844 0.2923
Brugia malayi PHD-finger family protein 0.0083 0.0724 0.0853
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0103 0.0958 0.3235
Brugia malayi MH2 domain containing protein 0.0733 0.8305 1
Echinococcus granulosus zinc finger protein 0.0065 0.0516 0.1724
Loa Loa (eye worm) RNA binding protein 0.0272 0.2933 0.3519
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0042 0.0249 0.0451
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0052 0.0359 0.0414
Schistosoma mansoni tar DNA-binding protein 0.0272 0.2933 0.9426
Trichomonas vaginalis set domain proteins, putative 0.0265 0.2847 1
Leishmania major hypothetical protein, conserved 0.0077 0.0659 0.659
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0349 0.0401
Plasmodium falciparum glutathione reductase 0.0051 0.0349 1
Trypanosoma cruzi ISWI complex protein 0.0051 0.035 0.306
Schistosoma mansoni smad 0.0022 0.0016 0.001
Schistosoma mansoni hypothetical protein 0.0133 0.1309 0.4183
Mycobacterium ulcerans lipase LipD 0.0077 0.0659 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0103 0.0958 1
Brugia malayi AMP-binding enzyme family protein 0.0048 0.032 0.0366
Brugia malayi latrophilin 2 splice variant baaae 0.0288 0.3111 0.3734
Echinococcus multilocularis tar DNA binding protein 0.0272 0.2933 0.2924
Brugia malayi beta-lactamase family protein 0.0077 0.0659 0.0776
Brugia malayi Latrophilin receptor protein 2 0.0133 0.1309 0.1559
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0659 0.1193
Loa Loa (eye worm) transcription factor SMAD2 0.0733 0.8305 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0659 0.2213
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0052 0.0359 0.4052
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0103 0.0958 0.1136
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0098 0.09 0.1066
Echinococcus multilocularis zinc finger protein 0.0065 0.0516 0.0504
Brugia malayi beta-lactamase family protein 0.0077 0.0659 0.0776
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.0958 1
Schistosoma mansoni bromodomain containing protein 0.0211 0.2214 0.7105
Brugia malayi MH2 domain containing protein 0.005 0.0338 0.0389
Loa Loa (eye worm) hypothetical protein 0.0029 0.0094 0.0094
Mycobacterium ulcerans polyketide synthase 0.0052 0.0359 0.4052
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0055 0.0397 0.0718
Onchocerca volvulus 0.0048 0.032 0.1072
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0659 0.2087
Brugia malayi Smad1 0.005 0.0338 0.0389
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0958 0.3167
Echinococcus granulosus mothers against decapentaplegic 2 0.0022 0.0016 0.0011
Brugia malayi MH1 domain containing protein 0.005 0.0338 0.0389
Echinococcus multilocularis mothers against decapentaplegic 5 0.005 0.0338 0.0326
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0042 0.0241 0.1715
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.1985 0.6366
Schistosoma mansoni zinc finger protein 0.0065 0.0516 0.1625
Loa Loa (eye worm) hypothetical protein 0.0421 0.4664 0.5607
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0349 0.3041
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0075 0.0632 0.1997
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0077 0.0658 0.119
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0349 0.0631
Loa Loa (eye worm) fatty acid synthase 0.0051 0.0351 0.0404
Brugia malayi hypothetical protein 0.0049 0.0329 0.0377
Loa Loa (eye worm) hypothetical protein 0.0288 0.3111 0.3734
Brugia malayi TAR-binding protein 0.0272 0.2933 0.3519
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.012 0.1152 0.3899
Trypanosoma cruzi ISWI complex protein 0.0051 0.035 0.306
Mycobacterium ulcerans polyketide synthase 0.0055 0.0397 0.4795
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0659 0.2087
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0658 0.2081
Mycobacterium leprae Probable polyketide synthase Pks1 0.0055 0.0397 0.2191
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0659 0.1193
Brugia malayi hypothetical protein 0.0077 0.0658 0.0774
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0659 0.0776
Brugia malayi Pre-SET motif family protein 0.0033 0.0145 0.0156
Trichomonas vaginalis esterase, putative 0.0077 0.0659 0.2087
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0659 0.659
Echinococcus multilocularis GPCR, family 2 0.0133 0.1309 0.1297
Echinococcus multilocularis smad 0.005 0.0338 0.0326

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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